Cell surface proteolysis and down-regulation of the hepatic insulin receptor. Evidence for selective sorting of intact and degraded receptors after internalization.

THE COLORIMETRIC DETERMINATION OF PHOSPHORUS

1925 • 19,115 citations

Tissue fractionation studies. 6. Intracellular distribution patterns of enzymes in rat-liver tissue

1955 • 4,109 citations

Human insulin receptor and its relationship to the tyrosine kinase family of oncogenes

1985 • 2,257 citations

Fluorometric assay of proteins in the nanogram range

1973 • 1,640 citations

The human insulin receptor cDNA: The structural basis for hormone-activated transmembrane signalling

1985 • 1,485 citations

Endocytosis and the recycling of plasma membrane.

1983 • 1,447 citations

Insulin Stimulates the Phosphorylation of the 95,000-Dalton Subunit of Its Own Receptor

1982 • 1,138 citations

Insulin-Dependent Regulation of Insulin Receptor Concentrations: A Direct Demonstration in Cell Culture

1974 • 1,037 citations

Isolation of an organ specific protein antigen from cell-surface membrane rat liver

1968 • 883 citations

The Glucagon-sensitive Adenyl Cyclase System in Plasma Membranes of Rat Liver

1971 • 519 citations

Receptor-mediated endocytosis of transferrin in developmentally totipotent mouse teratocarcinoma stem cells.

1981 • 497 citations

Insulin-stimulated translocation of glucose transport systems in the isolated rat adipose cell. Time course, reversal, insulin concentration dependency, and relationship to glucose transport activity.

1981 • 456 citations

The Molecular Mechanism of Insulin Action

1985 • 424 citations

Binding and degradation of 125I-insulin by rat hepatocytes.

1975 • 419 citations

Fluctuations in the affinity and concentration of insulin receptors on circulating monocytes of obese patients: effects of starvation, refeeding, and dieting.

1976 • 415 citations

Insulin-Receptor Interaction in the Obese-Hyperglycemic Mouse

1973 • 408 citations

Isolation of rat liver lysosomes by isopycnic centrifugation in a metrizamide gradient.

1978 • 335 citations

Isolation of rat hepatocyte plasma membranes. I. Presence of the three major domains.

1983 • 306 citations

Binding of insulin receptors to lectins: evidence for common carbohydrate determinants on several membrane receptors

1981 • 267 citations

Insulin Receptor Deficiency in Genetic and Acquired Obesity

1975 • 262 citations

Insulin-induced receptor loss in cultured human lymphocytes is due to accelerated receptor degradation.

1981 • 217 citations

On the mechanism of ligand-induced down-regulation of insulin receptor level in the liver cell.

1981 • 198 citations

The role of intermediate vesicles in the adsorptive endocytosis and transport of ligand to lysosomes by human fibroblasts.

1983 • 196 citations

Intracellular polypeptide hormone receptors. The demonstration of specific binding sites for insulin and human growth hormone in Golgi fractions isolated from the liver of female rats.

1978 • 196 citations

A simplified method for analysis of inorganic phosphate in the presence of interfering substances

1978 • 190 citations

Down Regulation of Insulin Receptors in Primary Cultures of Adult Rat Hepatocytes in Monolayer*

1978 • 178 citations

Uptake of Insulin and Other Ligands into Receptor-Rich Endocytic Components of Target Cells: The Endosomal Apparatus

1985 • 163 citations

Rapid, reversible internalization of cell surface insulin receptors. Correlation with insulin-induced down-regulation.

1983 • 159 citations

Correlation between insulin receptor binding in isolated fat cells and insulin sensitivity in obese human subjects.

1976 • 147 citations

Internalized insulin receptors are recycled to the cell surface in rat hepatocytes.

1982 • 142 citations

Identification of rat hepatocyte plasma membrane proteins using monoclonal antibodies.

1985 • 140 citations

Kinetics of insulin receptor internalization and recycling in adipocytes. Shunting of receptors to a degradative pathway by inhibitors of recycling.

1985 • 140 citations

Insulin-induced down-regulation of insulin receptors in 3T3-L1 adipocytes. Altered rate of receptor inactivation.

1982 • 139 citations

Role of insulin receptors in insulin-resistant states

1980 • 138 citations

Biochemical and morphological evidence that the insulin receptor is internalized with insulin in hepatocytes.

1982 • 102 citations

Endogenous and exogenous domain markers of the rat hepatocyte plasma membrane.

1985 • 92 citations

Insulin receptors convert to a higher affinity state subsequent to hormone binding. A two-state model for the insulin receptor.

1982 • 89 citations

Ligand-induced translocation of insulin receptors in intact rat liver.

1982 • 85 citations

Internalization and molecular processing of insulin receptors in isolated rat adipocytes.

1982 • 81 citations

Intracellular hormone receptors: evidence for insulin and lactogen receptors in a unique vesicle sedimenting in lysosome fractions of rat liver.

1981 • 70 citations

Kinetics of insulin receptor transit to and removal from the plasma membrane.

1983 • 66 citations

Formation of a receptor state from which insulin dissociates slowly in hepatic cells and plasma membranes.

1980 • 62 citations

Golgi fractions from livers of control and ethanol-intoxicated rats. Enzymic and morphologic properties following rapid isolation

1979 • 59 citations

Postreceptor alterations in the states of insulin resistance

1980 • 56 citations

Affinity of the hepatic insulin receptor is influenced by membrane phospholipids.

1981 • 55 citations

Insulin induced changes in insulin binding and insulin-sensitivity of adipocytes

1978 • 55 citations

Hormone-induced conformational changes in the hepatic insulin receptor.

1983 • 46 citations

A unique trypsin-like protease associated with plasma membranes of rat liver.

1986 • 45 citations

Preparation and Characterization of Mammalian Plasma Membranes

1979 • 27 citations

Relationship between the affinity and proteolysis of the insulin receptor. Evidence that higher affinity receptors are preferentially degraded.

1986 • 15 citations

Insulin binding to liver plasma membranes from rats rendered diabetic by alloxan. A kinetic demonstration of two classes of binding sites in equilibrium with each other

1982 • 9 citations