Affinity of the hepatic insulin receptor is influenced by membrane phospholipids.

PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT

1951 • 319,299 citations

A SIMPLE METHOD FOR THE ISOLATION AND PURIFICATION OF TOTAL LIPIDES FROM ANIMAL TISSUES

1957 • 63,238 citations

Data Reduction and Error Analysis for the Physical Sciences

1969 • 13,865 citations

THE PREPARATION OF 131I-LABELLED HUMAN GROWTH HORMONE OF HIGH SPECIFIC RADIOACTIVITY

1963 • 10,322 citations

The Fluid Mosaic Model of the Structure of Cell Membranes

1972 • 8,835 citations

Two dimensional thin layer chromatographic separation of polar lipids and determination of phospholipids by phosphorus analysis of spots

1970 • 3,260 citations

Physical principles of membrane organization

1980 • 1,381 citations

Insulin-Dependent Regulation of Insulin Receptor Concentrations: A Direct Demonstration in Cell Culture

1974 • 1,037 citations

Regulation of membrane enzymes by lipids

1978 • 906 citations

Isolation of an organ specific protein antigen from cell-surface membrane rat liver

1968 • 883 citations

31P nuclear magnetic resonance and the head group structure of phospholipids in membranes

1978 • 872 citations

Membrane Receptors

1974 • 636 citations

Site-site interactions among insulin receptors. Characterization of the negative cooperativity.

1976 • 601 citations

Membrane receptors for hormones and neurotransmitters.

1976 • 573 citations

The Glucagon-sensitive Adenyl Cyclase System in Plasma Membranes of Rat Liver

1971 • 519 citations

The Glucagon-sensitive Adenyl Cyclase System in Plasma Membranes of Rat Liver

1971 • 473 citations

The Relationship between the Insulin-binding Capacity of Fat Cells and the Cellular Response to Insulin

1971 • 464 citations

Binding and degradation of 125I-insulin by rat hepatocytes.

1975 • 419 citations

Quantitative Aspects of the Insulin-Receptor Interaction in Liver Plasma Membranes

1974 • 378 citations

Human Growth Hormone Radioreceptor Assay using Cultured Human Lymphocytes

1973 • 286 citations

Phospholipase D

1978 • 190 citations

The fate of insulin bound to adipocytes. Evidence for compartmentalization and processing.

1978 • 189 citations

The Role of Membrane Lipids in Receptor Mechanisms

1980 • 188 citations

Unmasking of Insulin Receptors in Fat Cells and Fat Cell Membranes

1971 • 184 citations

The Role of Acidic Phospholipids in Glucagon Action on Rat Liver Adenylate Cyclase

1973 • 182 citations

Lysosomal association of internalized 125I-insulin in isolated rat hepatocytes. Direct demonstration by quantitative electron microscopic autoradiography.

1979 • 174 citations

Receptors for Insulin, NSILA-s, and Growth Hormone: Applications to Disease States in Man

1975 • 174 citations

Perturbation of the Insulin Receptor of Isolated Fat Cells with Proteolytic Enzymes

1971 • 171 citations

Cellular uptake and nuclear binding of insulin in human cultured lymphocytes: evidence for potential intracellular sites of insulin action.

1977 • 171 citations

Insulin Action and the Regulation of Hexose Transport

1980 • 170 citations

Quantitative determination of the lateral diffusion coefficients of the hormone-receptor complexes of insulin and epidermal growth factor on the plasma membrane of cultured fibroblasts.

1978 • 148 citations

Structural organization of the human myelin membrane

1978 • 141 citations

Insulin-receptor interactions in liver cell membranes

1971 • 132 citations

Coordinate modulation of D-glucose transport activity and bilayer fluidity in plasma membranes derived from control and insulin-treated adipocytes.

1980 • 128 citations

Modulation of hexose uptake and insulin action by cell membrane fluidity. The effects of temperature on membrane fluidity, insulin action, and insulin binding.

1979 • 112 citations

The non-stoichiometric floating receptor model for hormone sensitive adenylyl cyclase

1976 • 106 citations

Effect of membrane phospholipid compositional changes on adenylate cyclase in LM cells

1978 • 105 citations

Studies on sphingomyelinase of Bacillus cereus I. Purification and properties

1978 • 92 citations

The specificity of phospholipase A2 and phospholipase C in a mixed micellar system

1978 • 86 citations

Hormone Binding Alters the Conformation of the Insulin Receptor

1980 • 70 citations

Interactions Between Insulin and Its Receptors After the Initial Binding Event: Functional Heterogeneity and Relationships to Insulin Degradation

1979 • 66 citations

Lateral and vertical displacement of integral membrane proteins during lipid phase transition in Anacystis nidulans.

1979 • 64 citations

The two-step model of ligand-receptor interaction

1977 • 63 citations

Formation of a receptor state from which insulin dissociates slowly in hepatic cells and plasma membranes.

1980 • 62 citations

Characterization of the slowly dissociable human growth hormone binding component of isolated rat hepatocytes

1980 • 57 citations

A Phospholipase Specific for Sphingomyelin from Clostridium perfringens

1968 • 57 citations

Effects of phospholipase A2 and filipin on the activation of adenylate cyclase

1979 • 56 citations

Parallel modulation of catecholamine activation of adenylate cyclase and formation of the high-affinity agonist.cntdot.receptor complex in turkey erythrocyte membranes by temperature and cis-vaccenic acid

1980 • 54 citations

Phospholipases as probes for membrane sideness. Selective analysis of the outer monolayer of asymmetric bilayer vesicles

1978 • 50 citations

Unimpaired signal transduction by the adipocyte insulin receptor following its partial proteolytic fragmentation.

1981 • 41 citations

Temperature dependence of .beta. receptor, adenosine receptor, and sodium fluoride stimulated adenylate cyclase from turkey erythrocytes

1980 • 38 citations

Energy-Dependent Steps in Insulin-Hepatocyte Interaction*

1981 • 32 citations

Time-course of insulin degradation in perifused isolated rat adipose cells.

1980 • 31 citations

Involvement of Phospholipids in the d-Glucose Uptake Activity of Isolated Human Erythrocyte Membranes

1972 • 30 citations

[35] Phospholipase C

1969 • 27 citations

Effect of purified phospholipases on the binding of tetrodotoxin to axon plasma membrane

1979 • 9 citations

Phospholipase‐C from Bacillus cereus: Production, purification, and properties

1973 • 7 citations

Negative cooperativity induced by desoctapeptide insulin unmasked by phospholipase C treatment

1980 • 3 citations