Intracellular Transport Using Microtubule-Based Motors

Dynamic instability of microtubule growth

1984 • 3,187 citations

Identification of a novel force-generating protein, kinesin, involved in microtubule-based motility

1985 • 1,930 citations

Endocytosis and the recycling of plasma membrane.

1983 • 1,447 citations

Beyond self-assembly: From microtubules to morphogenesis

1986 • 1,334 citations

Synapsin I (protein I), a nerve terminal-specific phosphoprotein. III. Its association with synaptic vesicles studied in a highly purified synaptic vesicle preparation.

1983 • 1,162 citations

Pathways of Protein Secretion in Eukaryotes

1985 • 1,050 citations

Intracellular transport in neurons.

1980 • 1,011 citations

Cross-linker system between neurofilaments, microtubules and membranous organelles in frog axons revealed by the quick-freeze, deep-etching method

1982 • 672 citations

Filament organization revealed in platinum replicas of freeze-dried cytoskeletons.

1980 • 662 citations

Microtubules and the endoplasmic reticulum are highly interdependent structures.

1986 • 633 citations

Progress in Unraveling Pathways of Golgi Traffic

1985 • 615 citations

Cilia and flagella of eukaryotes.

1981 • 611 citations

A novel brain ATPase with properties expected for the fast axonal transport motor

1985 • 604 citations

The role of guanosine 5′-triphosphate in polypeptide chain elongation

1978 • 559 citations

Distinct populations of microtubules: Tyrosinated and nontyrosinated alpha tubulin are distributed differently in vivo

1984 • 532 citations

Phenotypic analysis of temperature-sensitive yeast actin mutants

1985 • 512 citations

Movement of myosin-coated fluorescent beads on actin cables in vitro

1983 • 502 citations

Journey to the Center of the Cell: Role of the Receptosome

1981 • 500 citations

Tubulin dynamics in cultured mammalian cells.

1984 • 489 citations

The NDA3 gene of fission yeast encodes β-tubulin: A cold-sensitive nda3 mutation reversibly blocks spindle formation and chromosome movement in mitosis

1984 • 473 citations

Different axoplasmic proteins generate movement in opposite directions along microtubules in vitro

1985 • 463 citations

MOLECULAR BIOLOGY AND GENETICS OF TUBULIN

1985 • 455 citations

10 nm filaments in normal and transformed cells

1978 • 449 citations

Gliding movement of and bidirectional transport along single native microtubules from squid axoplasm: evidence for an active role of microtubules in cytoplasmic transport.

1985 • 440 citations

The Mechanism of Muscle Contractio

1986 • 424 citations

Video‐enhanced contrast, differential interference contrast (AVEC‐DIC) microscopy: A new method capable of analyzing microtubule‐related motility in the reticulopodial network of allogromia laticollaris

1981 • 419 citations

Polarization of the Golgi apparatus and the microtubule-organizing center in cultured fibroblasts at the edge of an experimental wound.

1982 • 403 citations

Single microtubules from squid axoplasm support bidirectional movement of organelles

1985 • 363 citations

Organization of the cytoskeleton in early Drosophila embryos.

1986 • 352 citations

The movement of membranous organelles in axons. Electron microscopic identification of anterogradely and retrogradely transported organelles.

1980 • 349 citations

Fast Axonal Transport in Squid Giant Axon

1982 • 347 citations

Organelle, bead, and microtubule translocations promoted by soluble factors from the squid giant axon

1985 • 346 citations

Polarity orientation of axonal microtubules.

1981 • 340 citations

Fast Axonal Transport in Extruded Axoplasm from Squid Giant Axon

1982 • 333 citations

Microtubule dynamics in interphase cells.

1986 • 331 citations

Direction of active sliding of microtubules in Tetrahymena cilia.

1977 • 319 citations

Video image processing greatly enhances contrast, quality, and speed in polarization-based microscopy.

1981 • 303 citations

Identification of kinesin in sea urchin eggs, and evidence for its localization in the mitotic spindle

1985 • 301 citations

Colchicine inhibition of plasma protein release from rat hepatocytes.

1975 • 300 citations

Polarization of the Golgi apparatus and the microtubule-organizing center within cloned natural killer cells bound to their targets.

1983 • 294 citations

Associations of elements of the Golgi apparatus with microtubules.

1984 • 291 citations

Movement of organelles along filaments dissociated from the axoplasm of the squid giant axon

1985 • 289 citations

Spatial relationships of microtubule-organizing centers and the contact area of cytotoxic T lymphocytes and target cells.

1982 • 283 citations

Tubular lysosome morphology and distribution within macrophages depend on the integrity of cytoplasmic microtubules.

1987 • 270 citations

Polarized Intracellular Particle Transport: Saltatory Movements and Cytoplasmic Streaming

1972 • 267 citations

Microtrabecular structure of the axoplasmic matrix: visualization of cross-linking structures and their distribution.

1980 • 239 citations

A polymer-dependent increase in phosphorylation of beta-tubulin accompanies differentiation of a mouse neuroblastoma cell line.

1985 • 237 citations

A microtubule-binding protein associated with membranes of the Golgi apparatus.

1986 • 234 citations

Cytoplasmic structure in rapid-frozen axons.

1982 • 229 citations

EFFECTS OF ANTIMICROTUBULAR AGENTS ON THE SECRETION OF COLLAGEN

1974 • 227 citations

Propulsion of organelles isolated from Acanthamoeba along actin filaments by myosin-I

1986 • 227 citations

Structural comparison of purified dynein proteins with in situ dynein arms

1984 • 225 citations

Identification of a microtubule-based cytoplasmic motor in the nematode C. elegans

1987 • 218 citations

Pathway of the Microtubule-Dynein ATPase and the Structure of Dynein: A Comparison with Actomyosin

1985 • 215 citations

Bovine brain kinesin is a microtubule-activated ATPase.

1986 • 215 citations

Axoplasmic transport in cat dorsal root ganglion cells: As studied with [3H]-L-leucine

1968 • 214 citations

Microtubule-acting drugs lead to the nonpolarized delivery of the influenza hemagglutinin to the cell surface of polarized Madin-Darby canine kidney cells.

1987 • 210 citations

Effect of microtubule assembly status on the intracellular processing and surface expression of an integral protein of the plasma membrane.

1984 • 209 citations

Cytoplasmic microtubules containing acetylated alpha-tubulin in Chlamydomonas reinhardtii: spatial arrangement and properties.

1986 • 199 citations

Video microscopy of fast axonal transport in extruded axoplasm: A new model for study of molecular mechanisms

1985 • 193 citations

Membrane insertion at the leading edge of motile fibroblasts.

1983 • 192 citations

Polarity of axoplasmic microtubules in the olfactory nerve of the frog.

1981 • 188 citations

Cross-bridges mediate anterograde and retrograde vesicle transport along microtubules in squid axoplasm.

1985 • 187 citations

Banding and polarity of actin filaments in interphase and cleaving cells.

1980 • 187 citations

Attachment of transported vesicles to microtubules in axoplasm is facilitated by AMP-PNP

1985 • 184 citations

Intracellular segregation of asialoglycoproteins and their receptor: a prelysosomal event subsequent to dissociation of the ligand-receptor complex.

1984 • 168 citations

Axonal tubulin and axonal microtubules: biochemical evidence for cold stability.

1984 • 167 citations

The short term accumulation of axonally transported organelles in the region of localized lesions of single myelinated axons

1980 • 163 citations

A time-lapse video image intensification analysis of cytoplasmic organelle movements during endosome translocation.

1984 • 158 citations

Bidirectional pigment granule movements of melanophores are regulated by protein phosphorylation and dephosphorylation

1986 • 157 citations

Polarity of microtubules nucleated by centrosomes and chromosomes of Chinese hamster ovary cells in vitro

1980 • 155 citations

Characterization of the microtubule movement produced by sea urchin egg kinesin.

1987 • 153 citations

Dissociation of the actin.subfragment 1 complex by adenyl-5'-yl imidodiphosphate, ADP, and PPi.

1980 • 150 citations

Functions of cytoplasmic fibers in intracellular movements in BHK-21 cells.

1978 • 147 citations

Functional autonomy of monopolar spindle and evidence for oscillatory movement in mitosis.

1982 • 145 citations

Microtubules and actin filaments are not critically involved in the biogenesis of epithelial cell surface polarity.

1986 • 142 citations

Polymerization of tubulin in vivo: direct evidence for assembly onto microtubule ends and from centrosomes.

1985 • 142 citations

The Golgi apparatus remains associated with microtubule organizing centers during myogenesis.

1985 • 141 citations

REVERSAL OF AXONAL TRANSPORT AT A NERVE CRUSH¹

1977 • 138 citations

Role of microtubules in the distribution of the Golgi apparatus: effect of taxol and microinjected anti-alpha-tubulin antibodies.

1983 • 129 citations

Aggregation of microtubule initiation sites preceding neurite outgrowth in mouse neuroblastoma cells

1979 • 116 citations

The effects of colchicine and cytochalasin B on uptake and degradation of asialo-glycoproteins in isolated rat hepatocytes

1979 • 115 citations

Microtubule-organizing centers and cell migration: effect of inhibition of migration and microtubule disruption in endothelial cells.

1983 • 111 citations

Correlation between the ATPase and microtubule translocating activities of sea urchin egg kinesin

1987 • 110 citations

Detection of single microtubules in living cells: particle transport can occur in both directions along the same microtubule.

1984 • 110 citations

Isolation of microtubules and a dynein-like MgATPase from unfertilized sea urchin eggs.

1984 • 105 citations

Kinesin from pig brain studied by electron microscopy

1987 • 96 citations

Bidirectional organelle transport can occur in cell processes that contain single microtubules.

1985 • 95 citations

Mechanisms of human cell-mediated cytotoxicity. III. Dependence of natural killing on microtubule and microfilament integrity.

1982 • 94 citations

Pigment particle translocation in detergent-permeabilized melanophores of Fundulus heteroclitus.

1982 • 93 citations

Isolation and characterization of the gene encoding the heavy chain of Drosophila kinesin.

1988 • 92 citations

The cytotoxic activity of human natural killer cells requires an intact secretory apparatus

1981 • 91 citations

The identification of a dynein ATPase in unfertilized sea urchin eggs

1980 • 91 citations

Translocation of vesicles from squid axoplasm on flagellar microtubules

1985 • 90 citations

THE GOLGI APPARATUS IN CHICK CORNEAL EPITHELIUM: CHANGES IN INTRACELLULAR POSITION DURING DEVELOPMENT

1970 • 89 citations

Rapid transport of foreign particles microinjected into crab axons

1983 • 89 citations

Association of microtubules and intermediate filaments in normal fibroblasts and its disruption upon transformation by a temperature-sensitive mutant of Rous sarcoma virus.

1981 • 85 citations

Microtubules and beta cell function: effect of colchicine on microtubules and insulin secretion in vitro by mouse beta cells.

1982 • 84 citations

Newly synthesized G protein of vesicular stomatitis virus is not transported to the cell surface during mitosis.

1983 • 84 citations

Reactivated melanophore motility: differential regulation and nucleotide requirements of bidirectional pigment granule transport.

1986 • 80 citations

Analysis of transferrin recycling in mitotic and interphase hela cells by quantitative fluorescence microscopy

1984 • 80 citations

Reactivation of organelle movements along the cytoskeletal framework of a giant freshwater ameba.

1986 • 77 citations

Fast axonal transport in permeabilized lobster giant axons is inhibited by vanadate

1983 • 76 citations

Kinesin is associated with a nonmicrotubule component of sea urchin mitotic spindles.

1987 • 73 citations

A functional in vitro model for studies of intracellular motility in digitonin-permeabilized erythrophores.

1982 • 73 citations

Role of microtubules in the organization of the Golgi complex and the secretion of collagen secretory granules by periodontal ligament fibroblasts

1981 • 68 citations

Identification of a MAP 2-like ATP-binding protein associated with axoplasmic vesicles that translocate on isolated microtubules.

1986 • 65 citations

Microtubules and protein secretion in rat lacrimal glands: localization of short-term effects of colchicine on the secretory process.

1982 • 63 citations

Regulation of pigment organelle translocation. I. Phosphorylation of the organelle-associated protein p57.

1986 • 63 citations

Regulation of pigment organelle translocation. II. Participation of a cAMP-dependent protein kinase.

1986 • 62 citations

Cytoplasmic Dynein of the Sea Urchin Egg.1 II. Purification, Characterization and Interactions with Microtubules and Ca-Calmodulin

1983 • 61 citations

Monoclonal antibodies to dynein subunits reveal the existence of cytoplasmic antigens in sea urchin egg.

1984 • 61 citations

Stimulated release of histamine by a rat mast cell line is inhibited during mitosis.

1984 • 60 citations

Cytoplasmic microtubules linked to endoplasmic reticulum with cross-bridges

1971 • 60 citations

The cytoplast: A unit structure in chromatophores

1982 • 58 citations

Microtubule-depolymerizing agents inhibit asialo-orosomucoid delivery to lysosomes but not its endocytosis or degradation in isolated rat hepatocytes

1983 • 58 citations

Microinjected fluorescent polystyrene beads exhibit saltatory motion in tissue culture cells.

1984 • 54 citations

Cytoplasmic dynein-like ATPase cross-links microtubules in an ATP-sensitive manner.

1984 • 54 citations

Binding of dynein 21 S ATPase to microtubules. Effects of ionic conditions and substrate analogs.

1981 • 43 citations

Stable complexes of axoplasmic vesicles and microtubules: protein composition and ATPase activity.

1986 • 43 citations

Fast axonal transport of foreign synaptic vesicles in squid axoplasm.

1985 • 42 citations

Bidirectional transport of fluorescently labeled vesicles introduced into extruded axoplasm of squid Loligo pealei.

1984 • 42 citations

Polarized microtubule gliding and particle saltations produced by soluble factors from sea urchin eggs and embryos

1986 • 42 citations

DEMONSTRATION OF A COLCEMID-SENSITIVE ATTRACTIVE FORCE ACTING BETWEEN THE NUCLEUS AND A CENTER

1971 • 41 citations

Vanadate inhibits saltatory organelle movement in a permeabilized cell model

1982 • 41 citations

Chromatophores--models for studying cytomatrix translocations.

1984 • 37 citations

A novel microtubule-associated protein from mammalian nerve shows ATP-sensitive binding to microtubules.

1986 • 37 citations

Taxol Induces Microtubule-Rough Endoplasmic Reticulum Complexes and Microtubule-Bundles in Cultured Chondroblasts

1983 • 34 citations

Substructure of sidearms on squid axoplasmic vesicles and microtubules visualized by negative contrast electron microscopy

1987 • 34 citations

Retrograde Axonal Transport and Nerve Regeneration

1984 • 32 citations

Identity and origin of the ATPase activity associated with neuronal microtubules. II. Identification of a 50,000-dalton polypeptide with ATPase activity similar to F-1 ATPase from mitochondria.

1983 • 28 citations

ATP-dependent formation and motility of aster-like structures with isolated calf brain microtubule proteins.

1986 • 20 citations

Chapter 15 Acanthamoeba castellanii: Methods and Perspectives for Study of Cytoskeleton Proteins

1982 • 14 citations

The Role of Microtubule Polarity in the Movement of Kinesin and Kinetochores

1986 • 14 citations

Role of Microtubules in the Synthesis, Conversion, and Release of (Pro)Insulin

1979 • 10 citations

Use of muscle contraction formalism for kinesin in fast axonal transport.

1987 • 4 citations