Signal requirements for the in vitro differentiation of cytotoxic T lymphocytes (CTL): distinct soluble mediators promote preactivation of CTL‐precursors, clonal growth and differentiation into cytotoxic effector cells

A rapid method for the isolation of functional thymus‐derived murine lymphocytes

1973 • 4,203 citations

T Cell Growth Factor: Parameters of Production and a Quantitative Microassay for Activity

1978 • 3,314 citations

Characterization of the Murine Antigenic Determinant, Designated L3T4a, Recognized by Monoclonal Antibody GK 1.5: Expression of L3T4a by Functional T Cell Clones Appears to Correlate Primarily with Class II MHC Antigen‐Reactivity

1983 • 1,040 citations

The Biochemistry, Biology, and Role of Interleukin 2 in the Induction of Cytotoxic T Cell and Antibody-Forming B Cell Responses

1982 • 524 citations

T-T-cell interactions during the vitro cytotoxic allograft responses. I. Soluble products from activated Lyl+ T cells trigger autonomously antigen-primed Ly23+ T cells to cell proliferation and cytolytic activity.

1978 • 330 citations

Purification to apparent homogeneity of murine interleukin 1.

1981 • 257 citations

Cytotoxic Effects of Antigen- and Mitogen-Induced T Cells on Various Targets

1975 • 224 citations

Accessory cell dependence of lectin‐induced proliferation of mouse T lymphocytes

1977 • 206 citations

T-Cell Growth Factor and the Culture of Cloned Functional T Cells

1981 • 188 citations

A differentiation factor required for the expression of cytotoxic T-cell function

1982 • 163 citations

Role of Lymphokine and Antigen in the Control of Specific T Cell Responses

1980 • 147 citations

Purification and properties of L cell-derived colony-stimulating factor.

1979 • 138 citations

Dissection of the proliferative and differentiative signals controlling murine cytotoxic T lymphocyte responses.

1982 • 135 citations

B cell activation: Three steps and their variations

1984 • 130 citations

Antigen-driven helper cell-independent cloned cytolytic T lymphocytes

1981 • 128 citations

A rat monoclonal antibody that binds specifically to mouse T lymphoblasts and inhibits IL 2 receptor functions: a putative anti-IL 2 receptor antibody.

1984 • 121 citations

The differentiation of cytotoxic T cells in vitro. I. Amplifying factor(s) in the primary response is Lyt 1 + cell dependent.

1979 • 92 citations

T-T cell interactions during in vitro cytotoxic T lymphocyte (CTL) responses. II. Helper factor from activated Lyt 1+ T cells is rate limiting i) in T cell responses to nonimmunogenic alloantigen, ii) in thymocyte responses to allogeneic stimulator cells, and III) recruits allo- or H-2-restricted CTL precursors from the Lyt 123+ T subset.

1980 • 88 citations

Preparative nonlytic separation of Lyt2⁺ and Lyt2⁻ T lymphocytes, functional analyses of the separated cells and demonstration of synergy in graft‐vs.‐host reaction of Lyt2⁺ and Lyt2⁻ cells

1981 • 84 citations

The role of accessory cells in polyclonal T cell activation II. Induction of interleukin 2 responsiveness requires cell‐cell contact

1983 • 56 citations

Activation of cytotoxic T lymphocytes requires at least two spleen cell-derived helper factors besides interleukin 2.

1983 • 56 citations

The Differentiation of Cytotoxic T Cells in Vitro

1979 • 53 citations

Generation of alloreactive cytotoxic T lymphocytes: evidence for a differentiation factor distinct from IL 2.

1983 • 50 citations

Three different signals are required for the induction of cytolytic T lymphocytes from resting precursors.

1983 • 43 citations

Induction of cytotoxic T cell function requires sequential action of three different lymphokines.

1983 • 43 citations

Production of high titers of interferon‐gamma by prestimulated murine spleen cells

1982 • 35 citations

Induction of cytotoxic T cell function requires sequential action of three different lymphokines.

1983 • 33 citations

Cytolytic T lymphocyte clones that proliferate autonomously to specific alloantigenic stimulation. II. Relationship of the Lyt-2 molecular complex to cytolytic activity, proliferation, and lymphokine secretion.

1983 • 32 citations

Positively selected Lyt-2+ and Lyt-2- mouse T lymphocytes are comparable, after Con A stimulation, in release of IL 2 and of lymphokines acting on B cells, macrophages, and mast cells, but differ in interferon production.

1983 • 31 citations

Heterogeneity of Cells and Factors Participating in the Concanavalin A-Dependent Activation of T Lymphocytes With Cytotoxic Potential

1982 • 19 citations