Neuronal and microglial involvement in beta-amyloid protein deposition in Alzheimer's disease.

The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor

1987 • 4,544 citations

Diagnosis of Alzheimer's Disease

1985 • 2,482 citations

Amyloid β Protein Gene: cDNA, mRNA Distribution, and Genetic Linkage Near the Alzheimer Locus

1987 • 1,589 citations

Novel precursor of Alzheimer's disease amyloid protein shows protease inhibitory activity

1988 • 1,093 citations

A new A4 amyloid mRNA contains a domain homologous to serine proteinase inhibitors

1988 • 1,052 citations

Relationship of microglia and astrocytes to amyloid deposits of Alzheimer disease

1989 • 904 citations

Precursor of amyloid protein in Alzheimer disease undergoes fast anterograde axonal transport.

1990 • 735 citations

Beta-amyloid precursor protein of Alzheimer disease occurs as 110- to 135-kilodalton membrane-associated proteins in neural and nonneural tissues.

1988 • 584 citations

The secreted form of the Alzheimer's amyloid precursor protein with the Kunitz domain is protease nexin-II

1989 • 460 citations

Expression of β-amyloid precursor protein in reactive astrocytes following neuronal damage

1989 • 345 citations

Localization of Amyloid β Protein Messenger RNA in Brains from Patients with Alzheimer's Disease

1987 • 297 citations

A variety of cerebral amyloid deposits in the brains of the Alzheimer-type dementia demonstrated by? protein immunostaining

1988 • 280 citations

Ultrastructural Studies of the Cells Forming Amyloid Fibers in Classical Plaques

1989 • 238 citations

Production and characterization of monoclonal antibodies recognizing the alpha-chain subunits of human ia alloantigens.

1983 • 159 citations

Immunocytochemical localization of the precursor protein for β-amyloid in the rat central nervous system

1988 • 153 citations

THE IMMUNOHISTOCHEMICAL DEMONSTRATION OF SUBSEQUENCES OF THE PRECURSOR OF THE AMYLOID A4 PROTEIN IN SENILE PLAQUES IN ALZHEIMER'S DISEASE

1989 • 119 citations

Neurofibrillary degeneration and neuronal loss in alzheimer's disease

1989 • 106 citations

CELLULAR LOCALIZATION OF MESSENGER RNA ENCODING AMYLOID-BETA-PROTEIN IN NORMAL TISSUE AND IN ALZHEIMER DISEASE

1988 • 104 citations

Molecular pathology of amyloidogenic proteins and the role of vascular amyloidosis in Alzheimer's disease

1989 • 90 citations

Soluble derivatives of the β amyloid protein precursor of Alzheimer's disease are labeled by antisera to the β amyloid protein

1989 • 85 citations

EARLY SENILE PLAQUES IN DOWN'S SYNDROME BRAINS SHOW A CLOSE RELATIONSHIP WITH CELL BODIES OF NEURONS

1989 • 84 citations

Monoclonal antibodies to a synthetic peptide homologous with the first 28 amino acids of Alzheimer's disease beta-protein recognize amyloid and diverse glial and neuronal cell types in the central nervous system.

1989 • 68 citations

Alzheimer's disease: glycolytic pretreatment dramatically enhances immunolabeling of senile plaques and cerebrovascular amyloid substance.

1989 • 16 citations