The Electrophysiological and Biochemical Pharmacology of the Mesolimbic and Mesocortical Dopamine Neurons

EVIDENCE FOR THE EXISTENCE OF MONOAMINE-CONTAINING NEURONS IN THE CENTRAL NERVOUS SYSTEM. I. DEMONSTRATION OF MONOAMINES IN THE CELL BODIES OF BRAIN STEM NEURONS.

1964 • 5,110 citations

Stereotaxic Mapping of the Monoamine Pathways in the Rat Brain*

1971 • 3,816 citations

Handbook of Psychopharmacology

1988 • 2,778 citations

Effect of Chlorpromazine or Haloperidol on Formation of 3‐Methoxytyramine and Normetanephrine in Mouse Brain

1963 • 2,148 citations

The Biochemical Basis of Neuropharmacology.

1974 • 1,911 citations

An autoradiographic analysis of the differential ascending projections of the dorsal and median raphe nuclei in the rat

1978 • 1,887 citations

The projections of the ventral tegmental area and adjacent regions: A combined fluorescent retrograde tracer and immunofluorescence study in the rat

1982 • 1,693 citations

Cognitive Deficit Caused by Regional Depletion of Dopamine in Prefrontal Cortex of Rhesus Monkey

1979 • 1,496 citations

Dopaminergic neurons: effect of antipsychotic drugs and amphetamine on single cell activity.

1973 • 1,272 citations

Advances in biochemical psychopharmacology

1970 • 1,186 citations

Psychopharmacology : a generation of progress

1978 • 1,168 citations

Inhibition of both noradrenergic and serotonergic neurons in brain by the α-adrenergic agonist clonidine

1975 • 1,010 citations

Intracellular and extracellular electrophysiology of nigral dopaminergic neurons—1. Identification and characterization

1983 • 925 citations

Efferent connections and nigral afferents of the nucleus accumbens septi in the rat

1978 • 868 citations

The Dopamine Hypothesis of Schizophrenia: A Review*

1976 • 862 citations

The role of dopamine in locomotor activity and learning

1983 • 849 citations

Drugs, Neurotransmitters, and Schizophrenia

1974 • 832 citations

Serotonin neurons of the midbrain raphe: Ascending projections

1978 • 795 citations

PRE AND POSTSYNAPTIC RECEPTORS

1976 • 778 citations

Advances in Biochemical Psychopharmacology

1970 • 760 citations

Nucleotide sequences of cloned cDNAs for two types of bovine brain substance P precursor

1983 • 751 citations

An Anatomy of Schizophrenia?

1973 • 721 citations

Typical and atypical neuroleptics: differential effects of chronic administration on the activity of A9 and A10 midbrain dopaminergic neurons

1983 • 680 citations

Animal models in psychiatry and neurology

1978 • 648 citations

Self-inhibition by Dopaminergic Neurons

1975 • 645 citations

Noradrenergic neurons of the locus coeruleus: inhibition by epinephrine and activation by the α-antagonist piperoxane

1976 • 638 citations

Differential Effects of Classical and Atypical Antipsychotic Drugs on A9 and A10 Dopamine Neurons

1983 • 589 citations

Tissue-specific generation of two preprotachykinin mRNAs from one gene by alternative RNA splicing

1984 • 563 citations

Afferent projections to the ventral tegmental area of Tsai and interfascicular nucleus: A horseradish peroxidase study in the rat

1979 • 550 citations

Acute and chronic haloperidol treatment: Comparison of effects on nigral dopaminergic cell activity

1978 • 550 citations

Gilles de la Tourette Syndrome

2021 • 545 citations

Dopamine ?Autoreceptors?: Pharmacological characterization by microiontophoretic single cell recording studies

1977 • 544 citations

Effect of lesion of cortical dopamine terminals on subcortical dopamine receptors in rats

1980 • 544 citations

Dopamine Auto- and Postsynaptic Receptors: Electrophysiological Evidence for Differential Sensitivity to Dopamine Agonists

1979 • 502 citations

Antidromic identification of dopaminergic and other output neurons of the rat substantia nigra

1978 • 498 citations

Pharmacology of mesocortical dopamine neurons.

1983 • 478 citations

The tachykinin peptide family

1981 • 470 citations

Frontiers in Catecholamine Research

1976 • 451 citations

Comparison of Effects of L-Dopa, Amphetamine and Apomorphine on Firing Rate of Rat Dopaminergic Neurones

1973 • 436 citations

Suppression of firing activity of 5-HT neurons in the dorsal raphe by alpha-adrenoceptor antagonists

1980 • 435 citations

Catecholamines in the Brain as Mediators of Amphetamine Psychosis

1972 • 428 citations

Differential effects of inescapable footshocks and of stimuli previously paired with inescapable footshocks on dopamine turnover in cortical and limbic areas of the rat

1982 • 424 citations

Diagnosis and drug treatment of psychiatric disorders : adults and children

1980 • 422 citations

Evidence for a receptor-mediated feedback control of striatal tyrosine hydroxylase activity

1972 • 421 citations

Organization of catecholamine neurons projecting to the frontal cortex in the rat

1978 • 415 citations

Effects of chlorpromazine, haloperidol and reserpine on the levels of phenolic acids in rabbit corpus striatum

1964 • 414 citations

Role of ?-aminobutyric acid (GABA) in the extrapyramidal motor system

1971 • 409 citations

Efferents and afferents of the ventral tegmental-A10 region studied after local injection of [3H]leucine and horseradish peroxidase

1979 • 405 citations

Paradoxical GABA excitation of nigral dopaminergic cells: Indirect mediation through reticulata inhibitory neurons

1979 • 393 citations

Handbook of Psychopharmacology

1983 • 389 citations

Blockage of caudate-evoked inhibition of neurons in the substantia nigra by picrotoxin

1971 • 387 citations

The Biochemical Basis of Neuropharmacology

2003 • 376 citations

Dopaminergic innervation of the rat prefrontal cortex: A fluorescence histochemical study

1976 • 375 citations

Substance P in the Nervous System

1983 • 370 citations

Dopaminergic A10 neurones are involved in cognitive functions

1980 • 362 citations

Novel neuropeptides, neurokinin .ALPHA. and .BETA., isolated from porcine spinal cord.

1983 • 357 citations

Footshock and conditioned stress increase 3, 4-dihydroxyphenylacetic acid (DOPAC) in the ventral tegmental area but not substantia nigra

1985 • 355 citations

Dopaminergic neurons: An in vivo system for measuring drug interactions with presynaptic receptors

1976 • 350 citations

Antipsychotic drug actions: a clue to the neuropathology of schizophrenia?

1973 • 336 citations

Blockade by benzodiazepines of the selective high increase in dopamine turnover induced by stress in mesocortical dopaminergic neurons of the rat

1979 • 328 citations

Evidence for the absence of impulse-regulating somatodendritic and synthesis-modulating nerve terminal autoreceptors on subpopulations of mesocortical dopamine neurons

1984 • 312 citations

Induction of depolarization block in midbrain dopamine neurons by repeated administration of haloperidol: analysis using in vivo intracellular recording.

1986 • 309 citations

Stress-induced increase in 3,4-dihydroxyphenylacetic acid (DOPAC) levels in the cerebral cortex and in n. accumbens: Reversal by diazepam

1978 • 291 citations

Behavioral Pharmacology: The Current Status

1985 • 281 citations

Histochemical confirmation for dopaminergic innervation of the rat cerebral cortex after destruction of the noradrenergic ascending pathways

1974 • 278 citations

Activity of mesencephalic dopamine and non-dopamine neurons across stages of sleep and waking in the rat

1983 • 265 citations

Topographic projections of substance P and GABA pathways in the striato- and pallido-nigral system: A biochemical and immunohistochemical study

1978 • 264 citations

Relationship between the locomotor hyperactivity induced by A10 lesions and the destruction of the frontocortical dopaminergic innervation in the rat

1978 • 253 citations

Gilles de la Tourette Syndrome

1983 • 248 citations

Psychopharmacology: A Generation of Progress

1978 • 242 citations

Nigral Dopamine Neurons: Intracellular Recording and Identification with L-Dopa Injection and Histofluorescence

1980 • 239 citations

Distribution of GABA‐T‐Intensive neurons in the hat forebrain and midbrain

1983 • 237 citations

Firing properties of substantia nigra dopaminergic neurons in freely moving rats

1985 • 235 citations

Regional gamma-aminobutyric acid levels in rat brain determined after microwave fixation.

1975 • 235 citations

Biochemical evidence for γ-aminobutyrate containing fibres from the nucleus accumbens to the substantia nigra and ventral tegmental area in the rat

1980 • 232 citations

CENTRAL DOPAMINERGIC NEURONS: NEUROPHYSIOLOGICAL IDENTIFICATION AND RESPONSES TO DRUGS**This research was supported by NIMH Grant MH-17871, USPHS Research Scientist Development Award MH-14459 (to G. K. A.), and the State of Connecticut.

1973 • 230 citations

Psychopathology and Brain Dysfunction

1978 • 226 citations

Autoradiographic distribution of substance P receptors in rat central nervous system

1983 • 225 citations

Behavioural and biochemical effects of dopamine and noradrenaline depletion within the medial prefrontal cortex of the rat

1980 • 223 citations

Persistent Dyskinesia

1973 • 222 citations

Pharmacological characterization of dopamine autoreceptors in the rat ventral tegmental area: microiontophoretic studies.

1984 • 220 citations

Animal models in psychiatry and neurology

1977 • 213 citations

Comparison of the effects of chronic haloperidol treatment on A9 and A10 dopamine neurons in the rat

1983 • 212 citations

Differential regional development of tolerance to increase in dopamine turnover upon repeated neuroleptic administration

1977 • 212 citations

REGIONAL γ‐AMINOBUTYRIC ACID LEVELS IN RAT BRAIN DETERMINED AFTER MICROWAVE FIXATION

1975 • 210 citations

Dopaminergic neurons: similar biochemical and histochemical effects of gamma-hydroxybutyrate and acute lesions of the nigro-neostriatal pathway.

1973 • 209 citations

Demonstration of a pallido‐nigral projection innervating dopaminergic neurons

1975 • 207 citations

Antidopaminergic properties of yohimbine.

1980 • 205 citations

A10 dopamine neurons: Role of autoreceptors in determining firing rate and sensitivity to dopamine agonists

1984 • 203 citations

Autoradiographic tracing of nucleus accumbens efferents in the rat

1976 • 200 citations

Collateralization of monoamine neurons: mesotelencephalic dopamine projections to caudate, septum, and frontal cortex

1981 • 199 citations

Mesocortical dopamine neurons. Lack of autoreceptors modulating dopamine synthesis.

1981 • 194 citations

The Neurobiology of dopamine

1979 • 193 citations

CNS Dopamine Autoreceptors: Distribution, Pharmacology, and Function^a

1984 • 185 citations

Electrophysiological studies of neurons in the ventral tegmental area of tsai

1980 • 181 citations

Pharmaco-histochemical evidence of the existence of dopamine nerve terminals in the limbic cortex

1974 • 173 citations

d-Amphetamine-induced depression of central dopamine neurons: Evidence for mediation by both autoreceptors and a striato-nigral feedback pathway

1978 • 165 citations

Effects of muscimol and picrotoxin on single unit activity of substantia nigra neurons

1980 • 165 citations

Activity of A9 and A10 dopaminergic neurons in unrestrained rats: further characterization and effects of apomorphine and cholecystokinin

1987 • 164 citations

Substantia nigra and ventral tegmental area projections to cortex: Topography and collateralization

1984 • 159 citations

Dopamine-containing ventral tegmental area neurons in freely moving cats: Activity during the sleep-waking cycle and effects of stress

1984 • 159 citations

d -Amphetamine-Induced Inhibition of Central Dopaminergic Neurons: Mediation by a Striato-Nigral Feedback Pathway

1976 • 153 citations

Two-color immunohistochemistry for dopamine and GABA neurons in rat substantia nigra and zona incerta

1982 • 149 citations

Substance P content of substantia nigra after chronic treatment with antischizophrenic drugs

1978 • 149 citations

Regulation of dopamine synthesis in the medial prefrontal cortex is mediated by release modulating autoreceptors: studies in vivo.

1986 • 145 citations

LOCALIZATION OF GABAERGIC, CHOLINERGIC AND AMINERGIC STRUCTURES IN THE MESOLIMBIC SYSTEM

1977 • 143 citations

Acceleration by stress of dopamine synthesis and metabolism in prefrontal cortex: Antagonism by diazepam

1982 • 137 citations

Evidence for an inhibitory gabergic control of the meso-limbic dopamine neurons: possibility of improving treatment of schizophrenia by combined treatment with neuroleptics and gabergic drugs.

1975 • 136 citations

Activity of substantia nigra units across the sleep-waking cycle in freely moving cats

1981 • 133 citations

Adenylate‐Cyclase Receptors for Adrenergic Neurotransmitters in Rat Cerebral Cortex

1973 • 133 citations

Selective activation of the mesocortico-frontal dopaminergic neurons induced by lesion of the habenula in the rat

1980 • 131 citations

LSD as an agonist of dopamine receptors in the striatum

1974 • 129 citations

Psychopathology and brain dysfunction

1977 • 128 citations

Effect of lisuride and other ergot derivatives on monoaminergic mechanisms in rat brain

1977 • 127 citations

Immunohistochemical studies on monoamine-containing cell systems

1973 • 125 citations

Dopaminergic neurons: Role of presynaptic receptors in the regulation of transmitter biosynthesis

1978 • 124 citations

Effects of lisuride and LSD on cerebral monoamine systems and hallucinosis

1978 • 120 citations

Electrophysiological identification of mesencephalic ventromedial tegmental (VMT) neurons projecting to the frontal cortex, septum and nucleus accumbens

1980 • 120 citations

The action of Baclofen on neurons of the substantia nigra and of the ventral tegmental area

1977 • 119 citations

The autoradiographic distribution of kassinin and substance K binding sites is different from the distribution of substance P binding sites in rat brain

1984 • 118 citations

Accumulation and disappearance of catecholamines formed from tyrosine-14C in mouse brain; effect of some psychotropic drugs

1968 • 117 citations

Influence of ventral mesencephalic lesions on various spontaneous and conditioned behaviors in the rat

1969 • 114 citations

The Neurobiology of Dopamine

1980 • 113 citations

Effect of antipsychotic drugs on the firing of dorsal raphe cells. I. Role of adrenergic system

1976 • 111 citations

Unique response to antipsychotic drugs is due to absence of terminal autoreceptors in mesocortical dopamine neurones

1982 • 111 citations

Postsynaptic receptors are not essential for dopaminergic feedback regulation

1977 • 110 citations

Behavioral effects of lesions in the A10 dopaminergic area of the rat

1977 • 107 citations

Haloperidol increases and apomorphine decreases striatal dopamine metabolism after destruction of striatal dopamine-sensitive adenylate cyclase by kainic acid

1977 • 104 citations

Antipsychotic Drug Action in Schizophrenic Patients: Effect on Cortical Dopamine Metabolism After Long-Term Treatment

1979 • 102 citations

Dopamine autoreceptors: pharmacology, function and comparison with post-synaptic dopamine receptors.

1979 • 102 citations

Haloperidol-induced reduction of nigral substance P-like immunoreactivity: a probe for the interactions between dopamine and substance P neuronal systems.

1981 • 102 citations

Selective increase in dopamine metabolism in the prefrontal cortex by the anxiogenic beta-carboline FG 7142

1985 • 101 citations

Electrophysiological examination of the ventral tegmental (A10) area in the rat

1980 • 100 citations

Dopamine metabolism in the mesolimbic and mesocortical dopaminergic systems after single or repeated administrations of neuroleptics

1976 • 100 citations

Dopaminergic neurons: Effect of acute and chronic morphine administration on single cell activity and transmitter metabolism

1978 • 95 citations

Pharmacology of dopamine neurons innervating the prefrontal, cingulate and piriform cortices

1983 • 95 citations

Dopaminergic Systems and their Regulation

1986 • 95 citations

Relevance of Dopamine Autoreceptors for Psychiatry: Preclinical and Clinical Studies

1980 • 94 citations

Immunohistochemical evidence for a “neurotoxic” action of (D‐Pro², D‐Trp^7,9)‐substance P, an analogue with substance P antagonistic activity

1981 • 93 citations

Increased utilization of dopamine in the nucleus accumbens but not in the cerebral cortex after dorsal raphe lesion in the rat

1979 • 86 citations

Neurochemical changes following kainic acid lesions of the nucleus accumbens: Implications for a gabaergic accumbal-ventral tegmental pathway

1978 • 78 citations

Substance K and substance P differentially modulate mesolimbic and mesocortical systems

1985 • 77 citations

Selective activation of mesolimbic and mesocortical dopamine metabolism in rat brain by infusion of a stable substance P analogue into the ventral tegmental area

1986 • 76 citations

Effects of the unilateral nigral modulation of substance P transmission on the activity of the two nigro-striatal dopaminergic pathways

1979 • 75 citations

GABAergic inhibition of neurons in the ventral tegmental area

1978 • 74 citations

Effect of picrotoxin and nipecotic acid on inhibitory response of dopaminergic neurons in the ventral tegmental area to stimulation of the nucleus accumbens

1980 • 71 citations

Effect of the immunoneutralization of substance P in the cat substantia nigra on the release of dopamine from dendrites and terminals of dopamine-ergic neurons

1978 • 69 citations

Regional sensitivity of primate brain dopaminergic neurons to haloperidol: alterations following chronic treatment

1978 • 68 citations

The localization and characterization of substance P and substance K in striatonigral neurons

1986 • 68 citations

Intravenous GABA agonist administration stimulates firing of A10 dopaminergic neurons

1980 • 64 citations

Response of dopamine neurons in substantia nigra to muscimol

1978 • 64 citations

Effect of muscimol on single unit activity of substantia nigra dopamine neurons

1978 • 64 citations

Neurochemical Studies of the Mesolimbic Dopaminergic Pathway: Somatodendritic Mechanisms and GABAergic Neurones in the Rat Ventral Tegmentum

1980 • 61 citations

Response of striatonigral substance P systems to a dopamine receptor agonist and antagonist

1981 • 58 citations

Single unit activity of dopaminergic neurons in freely moving cats

1981 • 56 citations

Chronic haloperidol or fluphenazine: effects on dopamine metabolism in brain, cerebrospinal fluid and plasma of Cercopithecus aethiops (vervet monkey).

1980 • 56 citations

Organization of mesencephalic dopamine neurons projecting to neocortex and septum.

1977 • 54 citations

Predictability in psychopharmacology: Preclinical and clinical correlations

1977 • 52 citations

Differential sensitivity of presumed dopaminergic and non-dopaminergic neurones in rat substantia nigra to electrophoretically applied substance P

1982 • 52 citations

Involvement of the D-2 dopamine receptor in the neuroleptic-induced decrease in nigral substance P

1984 • 52 citations

Lack of involvement of α2-adrenoceptors in the regulation of striatal dopaminergic transmission

1983 • 52 citations

Dopamine neurons projecting to the medial prefrontal cortex possess release-modulating autoreceptors

1987 • 51 citations

Actions of substance P, MIF, TRH and related peptides in the substantia nigra, caudate nucleus and nucleus accumbens

1983 • 50 citations

Evaluation of (d-Pro2, d-Trp7,9)-substance P as an antagonist of substance P responses in the rat central nervous system

1982 • 50 citations

Evidence for dopamine autoreceptors in mesocortical dopamine neurons

1984 • 49 citations

Tolerance to fluphenazine and supersensitivity to apomorphine in central dopaminergic systems after chronic fluphenazine decanoate treatment

1980 • 48 citations

Lisuride and LSD: Dopaminergic and serotonergic interactions in the ?serotonin syndrome?

1979 • 48 citations

Acidic dopamine metabolites in cortical areas of the rat brain: localization and effects of drugs

1976 • 47 citations

A subpopulation of mesocortical dopamine neurons possesses autoreceptors

1984 • 47 citations

Influence of lithium on biochemical manifestations of striatal dopamine target cell supersensitivity induced by prolonged haloperidol treatment

1983 • 45 citations

Suppression of cell firing in the substantia nigra by caudate nucleus stimulation

1972 • 44 citations

Apparent feedback from the caudate nucleus to the substantia nigra following amphetamine administration

1975 • 43 citations

The interaction of lisuride, an ergot derivative, with serotonergic and dopaminergic receptors in rabbit brain.

1981 • 43 citations

Effects of Aminooxyacetic Acid and Baclofen on the Catalepsy and on the Increase of Mesolimbic and Striatal Dopamine Turnover Induced by Haloperidol in Rats

1976 • 43 citations

The effect of γ-acetylenic GABA, an enzyme-activated irreversible inhibitor of GABA-transaminase, on dopamine pathways of the extrapyramidal and limbic systems

1978 • 41 citations

Effect of clonidine on dopaminergic neuron activity in the substantia nigra: possible indirect mediation by noradrenergic regulation of the serotonergic raphé system.

1982 • 38 citations

Studies on mesocortical dopamine systems.

1978 • 36 citations

Action of the palmitic ester of pipotiazine on dopamine metabolism in the nigro-striatal, meso-limbic and meso-cortical systems

1977 • 35 citations

Caudate evoked synaptic activities in nigral neurons

1975 • 33 citations

Evidence that nigral substance P controls the activity of the nigrotectal GABAergic pathway

1984 • 33 citations

EFFECTS OF ERGOLINES ON DOPAMINERGIC AND SEROTONERGIC SINGLE UNIT ACTIVITY

1979 • 32 citations

Quantitative lineage analysis of the frog's nervous system. I. Lineages of Rohon-Beard neurons and primary motoneurons

1984 • 31 citations

Antipsychotic drug effects on dopamine and serotonin receptors: in vitro binding and in vivo turnover studies.

1981 • 31 citations

Treatment of schizophrenia

1979 • 28 citations

Predictability in psychopharmacology: Preclinical and clinical correlations

1976 • 27 citations

Comparison of the effects of LSD and lisuride on A10 dopamine neurons in the rat

1983 • 25 citations

Acute changes in nigral substance P content induced by drugs acting on dopamine, muscarine and GABA receptors

1983 • 24 citations

Neonatal enzymic development in the interpeduncular nucleus and surrounding ventral tegmentum

1976 • 23 citations

Midbrain dopamine neurons: differential responses to amphetamine isomers

1981 • 23 citations

Free and conjugated dihydroxyphenylacetic acid: effect of alterations in impulse flow in rat neostriatum and frontal cortex.

1976 • 22 citations

Dopamine-acetylcholine-GABA neuronal linkages in the extrapyramidal and limbic systems.

1977 • 22 citations

Receptor Feedback and Dopamine Turnover in CNS

1975 • 19 citations

Antipsychotic drugs: differential effects on dopamine neurons in basal ganglia and mesocortex following chronic administration in human and nonhuman primates.

1980 • 18 citations

Serotoninergic modulation of mesolimbic and frontal cortical dopamine neurons

1980 • 18 citations

Apomorphine-haloperidol interactions: Different types of antagonism in cortical and subcortical brain regions

1981 • 16 citations

Histochemical identification and localization of dopaminergic axons in rat and human cerebral cortex.

1977 • 16 citations

Changes in substance P concentrations after protein synthesis inhibition provide an index of substance P utilization

1984 • 13 citations

LSD: Effect of monoamine metabolites in rat prefrontal cortex

1982 • 10 citations

Effects of neuroleptics on the nigroneostriatal and mesocortical dopaminergic systems.

1975 • 9 citations

Differential influence of GABA-ergic agents on dopamine metabolism in extrapyramidal and limbic systems of the rat

1980 • 6 citations

Dopamine Autoreceptors: Studies on their Distribution and Mode of Action

1986 • 4 citations

Tolerance to haloperidol effect on dopamine (DA) synthesis is independent from postsynaptic da receptors

1980 • 3 citations

Deleted Work

1955 • 0 citations