Relevance of Dopamine Autoreceptors for Psychiatry: Preclinical and Clinical Studies

Effect of Chlorpromazine or Haloperidol on Formation of 3‐Methoxytyramine and Normetanephrine in Mouse Brain

1963 • 2,148 citations

THE PHYSIOLOGY OF SYNAPSES

1964 • 1,932 citations

Chemical Nature of Synaptic Transmission in Vertebrates

1974 • 1,613 citations

Dopamine (3-hydroxytyramine) and brain function.

1966 • 1,401 citations

Modification of Parkinsonism — Chronic Treatment with L-Dopa

1969 • 1,253 citations

The organization of the ascending catecholamine neuron systems in the rat brain as revealed by the glyoxylic acid fluorescence method.

1974 • 1,130 citations

Antipsychotic Drugs: Direct Correlation Between Clinical Potency and Presynaptic Action on Dopamine Neurons

1975 • 874 citations

The Dopamine Hypothesis of Schizophrenia: A Review*

1976 • 862 citations

Brain receptors for antipsychotic drugs and dopamine: direct binding assays.

1975 • 695 citations

Self-inhibition by Dopaminergic Neurons

1975 • 645 citations

PRESYNAPTIC RECEPTORS AND THEIR ROLE IN THE REGULATION OF TRANSMITTER RELEASE.

1977 • 616 citations

Acute and chronic haloperidol treatment: Comparison of effects on nigral dopaminergic cell activity

1978 • 550 citations

Dopamine ?Autoreceptors?: Pharmacological characterization by microiontophoretic single cell recording studies

1977 • 544 citations

Dopamine Auto- and Postsynaptic Receptors: Electrophysiological Evidence for Differential Sensitivity to Dopamine Agonists

1979 • 502 citations

Striatal lesions with kainic acid: neurochemical characteristics

1977 • 461 citations

Catecholamines: Basic and clinical frontiers

1981 • 458 citations

Drug‐Induced Changes in the Release of ³H‐Monoamines from Field Stimulated Rat Brain Slices

1971 • 453 citations

Comparison of Effects of L-Dopa, Amphetamine and Apomorphine on Firing Rate of Rat Dopaminergic Neurones

1973 • 436 citations

Evidence for a receptor-mediated feedback control of striatal tyrosine hydroxylase activity

1972 • 421 citations

Evidence for dopamine receptors mediating sedation in the mouse brain

1976 • 421 citations

Dopaminergic neurons: An in vivo system for measuring drug interactions with presynaptic receptors

1976 • 350 citations

Catecholamine receptor agonists

1976 • 318 citations

Dopaminergic hypersensitivity and cholinergic hypofunction in the pathophysiology of tardive dyskinesia

1974 • 245 citations

Effect of dopamine receptor agonists and antagonists on release of dopamine in the rabbit caudate nucleus in vitro

1978 • 242 citations

Presynaptic receptor systems in catecholaminergic transmission

1977 • 239 citations

Schizophrenic Symptoms Improve with Apomorphine

1978 • 228 citations

Dopamine receptor binding in the corpus striatum of mammalian brain.

1975 • 221 citations

The Role of Brain Dopamine in Behavioral Regulation and the Actions of Psychotropic Drugs

1970 • 216 citations

Direct evidence for presynaptic and postsynaptic dopamine receptors in brain

1978 • 210 citations

Dopaminergic neurons: similar biochemical and histochemical effects of gamma-hydroxybutyrate and acute lesions of the nigro-neostriatal pathway.

1973 • 209 citations

Selective increase of brain dopamine induced by gamma-hydroxybutyrate

1966 • 198 citations

The Pathophysiologic Basis of Tardive Dyskinesia

1980 • 190 citations

Biogenic amine metabolism in tourette syndrome

1979 • 182 citations

Neurotransmitters and Anterior Pituitary Function

1977 • 171 citations

Treatment of Parkinson's Disease with Aporphines

1976 • 167 citations

The role of presynaptic receptors in the release and synthesis of 3H-dopamine by slices of rat striatum

1976 • 166 citations

Feedback loop or output pathway in striato-nigral fibres?

1977 • 160 citations

Does dopamine play a role in schizophrenia?

1977 • 160 citations

Comparison of the effects of neuroleptic drugs on pre- and postsynaptic dopaminergic mechanisms in the rat striatum.

1976 • 160 citations

Antagonism by alpha methyltyrosine of the ethanol‐induced stimulation and euphoria in man

1973 • 155 citations

d -Amphetamine-Induced Inhibition of Central Dopaminergic Neurons: Mediation by a Striato-Nigral Feedback Pathway

1976 • 153 citations

A dopaminergic mechanism in mania

1976 • 149 citations

Gilles de la Tourette's Syndrome following Methylphenidate Administration

1974 • 148 citations

THERAPEUTIC EFFICACY OF APOMORPHINE COMBINED WITH AN EXTRACEREBRAL INHIBITOR OF DOPAMINE RECEPTORS IN PARKINSON'S DISEASE

1979 • 141 citations

Comparison of dopamine synthesis regulation in the terminals of nigrostriatal, mesolimbic, tuberoinfundibular and tuberohypophyseal neurons

1979 • 132 citations

Presynaptic subsensitivity as a possible basis for sensitization by long-tern dopamine mimetics

1979 • 129 citations

The pharmacology of extrapyramidal movement disorders.

1973 • 122 citations

Behavioral effects of l-Dopa in schizophrenic patients

1973 • 119 citations

Dopamine receptor binding: Specificity, localization and regulation by ions and guanyl nucleotides

1978 • 119 citations

Long-Term Treatment of Tardive Dyskinesia with Haloperidol and Tetrabenazine

1973 • 116 citations

Paradoxical response to dopamine agonists in tardive dyskinesia

1977 • 112 citations

Nonstriatal dopaminergic neurons

1977 • 106 citations

Effects of Dopamine Agonists and Antagonists in Tourette's Disease

1979 • 106 citations

Suppression by dopamine-agonists of the ethanol-induced stimulation of locomotor activity and brain dopamine synthesis

1974 • 105 citations

Antagonistic effects of apomorphine and haloperidol on rat striatal synaptosomal tyrosine hydroxylase

1974 • 105 citations

Haloperidol increases and apomorphine decreases striatal dopamine metabolism after destruction of striatal dopamine-sensitive adenylate cyclase by kainic acid

1977 • 104 citations

Antipsychotic Drug Action in Schizophrenic Patients: Effect on Cortical Dopamine Metabolism After Long-Term Treatment

1979 • 102 citations

Effects of dopamine agonists in tardive dyskinesia

1977 • 94 citations

Self-inhibitory dopamine receptors: their role in the biochemical and behavioral effects of low doses of apomorphine.

1978 • 93 citations

Evidence on the cellular localization of adenyl cyclase in the neostriatum

1976 • 91 citations

Implications of Amphetamine-Induced Stereotyped Behavior as a Model for Tardive Dyskinesias

1972 • 84 citations

Evidence for dopamine receptors in the human brain mediating sedation and sleep

1977 • 84 citations

Alterations in dopamine receptor sensitivity by chronic ethanol treatment

1977 • 82 citations

Presynaptic dopamine receptors. Development of supersensitivity following treatment with fluphenazine decanoate.

1977 • 80 citations

Antagonism by haloperidol of locomotor depression induced by small doses of apomorphine

1977 • 80 citations

Presynaptic Catecholamine Antagonists as Treatment for Tourette Syndrome

1974 • 78 citations

The effect of long-term ethanol treatment on the sensitivity of the dopamine receptors in the nucleus accumbens

1976 • 78 citations

Gamma-hydroxybutyrate-induced increase in brain dopamine: localization by fluorescence microscopy.

1970 • 70 citations

Sedative, hypnotic, and antipsychotic effects of low doses of apomorphine in man.

1977 • 69 citations

Neuropharmacological studies on the neuroleptic potential of domperidone (R33812)

1979 • 67 citations

Effects of drugs influencing monoamine mechanisms on the increase in brain dopamine produced by axotomy or treatment with gammahydroxybutyric acid

1973 • 66 citations

Changes in the Sensitivity of Dopamine Receptors in the Nucleus Accumbens and in the Striatum Induced by Chronic Ethanol Administration

1978 • 63 citations

THE SYMPTOMATOLOGY AND DIAGNOSIS OF GILLES DE LA TOURETTE'S SYNDROME

1973 • 63 citations

The Movement Pattern of Oral Tardive Dyskinesia in Relation to Anticholinergic and Antidopaminergic Treatment

1976 • 61 citations

Dopamine concentrations in the rat brain following injections into the substantia nigra of baclofen, γ-aminobutyric acid, γ-hydroxybutyric acid, apomorphine and amphetamine

1978 • 61 citations

Correlation of behavioural inhibition or excitation produced by bromocriptine with changes in brain catecholamine turnover

1976 • 58 citations

Evidence for selective and long-lasting stimulation of “regulatory” dopamine-receptors by bromocriptine (CB 154)

1977 • 57 citations

Effect of ergot drugs on central 5-hydroxytryptamine neurons: Evidence for 5-hydroxytryptamine release or 5-hydroxytryptamine receptor stimulation

1975 • 56 citations

Clinical studies with dopamine-receptor stimulants

1975 • 53 citations

Catecholamine synthesis in rat brain after axotomy: Interaction between apomorphine and haloperidol

1977 • 53 citations

Adverse clinical side effects of levodopa therapy.

1971 • 52 citations

Selective labeling of pre-synaptic receptors by 3H-dopamine, 3H-apomorphine and 3H-clonidine; labeling of post-synaptic sites by 3H-neuroleptics.

1978 • 51 citations

Specific distribution of metabolic alterations in cerebral cortex following apomorphine administration

1979 • 50 citations

TREATMENT OF DRUG-INDUCED DYSKINESIAS

1970 • 48 citations

Hormones, dopamine receptors and schizophrenia

1981 • 48 citations

Modification of Tardive Dyskinesia and Spasmodic Torticollis by Apomorphine

1978 • 45 citations

Do neuroleptics prevent the penetration of dopamine agonists into the brain?

1979 • 44 citations

Parkinson Disease Treated With a Suspected Dopamine Receptor Agonist

1974 • 43 citations

Dopa accumulation is a measure of dopamine synthesis in the median eminence and posterior pituitary

1979 • 42 citations

Dopamine and sexual behaviour in female rats. Effects of dopamine receptor agonists and sulpiride

1977 • 42 citations

Binding Interactions of Ergot Alkaloids with Monoaminergic Receptors in the Brain

1978 • 42 citations

High affinity dopamine receptors (D3) in rat brain.

1979 • 42 citations

Lergotrile and lisuride: In vivo dopaminergic agonists which do not stimulate the presynaptic dopamine autoreceptor

1978 • 39 citations

Therapeutical efficacy of a combination of apomorphine with sulpiride or metoclopramide in parkinsonism

1976 • 38 citations

Apomorphine and psychopathology.

1975 • 37 citations

Tremor Inhibition in Parkinson Syndrome After Apomorphine Administration Under L-Dopa and Decarboxylase-Inhibitor Basic Therapy

1972 • 37 citations

A Study of Growth Hormone Release in Depression

1979 • 37 citations

Inhibition by dopamine agonists of dopamine accumulation following γ-hydroxybutyrate treatment

1975 • 36 citations

EFFECTS OF LOW DOSES OF A DOPAMINE-RECEPTOR STIMULATOR IN MANIA

1976 • 35 citations

Treatment of schizophrenia with ergot derivatives

1979 • 34 citations

Dopamine in substantia nigra and cortex after γ-butyrolactone treatment

1976 • 34 citations

Differential actions of dopamine agonists and antagonists on the ?-butyrolactone-induced increase in mouse brain dopamine

1976 • 34 citations

A NOTE ON APOMORPHINE AS A SEDATIVE

1945 • 33 citations

Methylphenidate in Tardive Dyskinesia

1973 • 30 citations

Effects of haloperidol and apomorphine on the K+-depolarized overflow of [3H] dopamine from rat striatal slices

1979 • 30 citations

Alleviation of manic symptoms with catecholamine agonists

1979 • 29 citations

Brom-ergocryptine in the Treatment of Phenothiazine-Induced Galactorrhoea

1975 • 29 citations

The Medical Treatment of Spasmodic Torticollis

1972 • 28 citations

Modification of ethanol intoxication by dopamine agonists and antagonists

1979 • 27 citations

A new centrally acting DA-receptor agonist with selectivity for autoreceptors.

1980 • 24 citations

INHIBITION BY APOMORPHINE OF DOPAMINE DEAMINATION IN THE RAT BRAIN

1974 • 23 citations

Paradoxical Suppression of Chorea by Apomorphine

1974 • 23 citations

LEVODOPA IN HUNTINGTON'S CHOREA

1972 • 23 citations

Apomorphine as an antagonist of the dopamine response from the nucleus accumbens

1976 • 21 citations

Gilles de la Tourette's symptoms induced by L-dopa.

1974 • 21 citations

Apomorphine, pimozide, L-Dopa and the probenecid test in Huntington's chorea.

1973 • 20 citations

A Comparison of -Butyrolactone and Pimozide on Serum Gonadotrophins and Ovulation in the Rat

1976 • 19 citations

Function of nigral dopamine receptors?

1978 • 18 citations

Dopamine receptors and sleep induction in man.

1979 • 15 citations

Behavioral and neuroendocrine effects of low dose ET-495: Antagonism by haloperidol

1979 • 15 citations

Interaction between bromocriptine and levodopa

1977 • 14 citations

Pre- and postsynaptic action of bromocriptine: its pharmacological effects on shcizophrenia and neurological diseases.

1977 • 13 citations

Experimental Depression Caused by Apomorphine and Phenoharmane^*

1972 • 13 citations

Effects of dopaminergic antagonists on striatal DOPAC concentrations and α-methyl-p-tyrosine-induced decline of dopamine following intrastriatal injections of kainic acid

1979 • 13 citations

Effects of intranigral administration of dopamine agonists and antagonists and baclofen on concentrations of dopac and dopamine in the striatum and substantia nigra of the rat

1979 • 12 citations

Haloperidol depresses the accumulation of apomorphine in the striatum of the rat

1978 • 12 citations

Dopamine receptor agonists in psychiatric disease.

1975 • 12 citations

Bromocriptine Treatment of Spasmodic Torticollis

1979 • 12 citations

Nonstriatal dopaminergic neurons: role of presynaptic receptors in the modulation of transmitter synthesis.

1977 • 11 citations

Amantadine and Huntington’s Chorea

1971 • 11 citations

Restatement and Prospectives of Ergot Alkaloids in Clinical Neurology and Psychiatry

1978 • 10 citations

Attenuation of the ?-butyrolactone-induced increase in DOPA accumulation by chronic ethanol administration

1979 • 10 citations

Haloperidol increases DOPAC in the substantia nigra but not in the ventral tegmental area

1979 • 9 citations

Parkinsonism by haloperidol and piribedil

1978 • 9 citations

Mechanism of action of Piribedil on noradrenergic neurons in rat brain

1978 • 9 citations

Effect of gamma-butyrolactone and baclofen on plasma prolactin in male rats

1977 • 9 citations

gamma-Hydroxybutyrate: effects on nonstriatal dopaminergic neurons.

1977 • 9 citations

Evidence for the existence of regulatory DA receptors in the substantia nigra.

1977 • 7 citations

Evidences for a direct action in striatum of dopaminergic receptor antagonists mediating DOPAC formation

1978 • 6 citations

Action of beta(4-chlorphenyl)GABA, gamma-hydroxybutyrolactone, and apomorphine on central dopamine neurons.

1977 • 5 citations

Differential action of dopamine agonists on brain self-stimulation behaviour in rats.

1978 • 4 citations

[Mechanims of thymoleptic drug action studied on the model of apomorphine depression].

1968 • 2 citations

DOPAMINE AGONIST TREATMENT OF SCHIZOPHRENIA

1979 • 2 citations