Interaction of prefrontal cortical and hypothalamic systems in the pathogenesis of depression

Psychopharmacology: The Fourth Generation of Progress

1995 • 2,920 citations

Subgenual prefrontal cortex abnormalities in mood disorders

1997 • 2,646 citations

Reciprocal Limbic-Cortical Function and Negative Mood: Converging PET Findings in Depression and Normal Sadness

1999 • 2,351 citations

Psychopharmacology: The Fourth Generation of Progress

1995 • 1,676 citations

The role of corticotropin-releasing factor in depression and anxiety disorders

1999 • 1,371 citations

Limbic connections of the orbital and medial prefrontal cortex in macaque monkeys

1995 • 1,216 citations

Rapid-rate transcranial magnetic stimulation of left dorsolateral prefrontal cortex in drug-resistant depression

1996 • 1,204 citations

The role of the medial prefrontal cortex (cingulate gyrus) in the regulation of hypothalamic-pituitary-adrenal responses to stress

1993 • 1,118 citations

MOOD DISORDERS IN STROKE PATIENTS: IMPORTANCE OF LOCATION OF LESION

1984 • 1,079 citations

Antidepressants and Hypothalamic-Pituitary-Adrenocortical Regulation

1996 • 829 citations

The anatomy of mood disorders—review of structural neuroimaging studies

1997 • 764 citations

MRI-defined vascular depression

1997 • 759 citations

Developmental traumatology part I: biological stress systems∗∗See accompanying Editorial, in this issue.

1999 • 735 citations

The combined dexamethasone/CRH test: A refined laboratory test for psychiatric disorders

1994 • 663 citations

PSYCHONEUROENDOCRINOLOGY OF DEPRESSION

1998 • 659 citations

Increased Numbers of Corticotropin-Releasing Hormone Expressing Neurons in the Hypothalamic Paraventricular Nucleus of Depressed Patients

1994 • 657 citations

Cortisol regulation in posttraumatic stress disorder and major depression: A chronobiological analysis

1996 • 637 citations

Mood Improvement Following Daily Left Prefrontal Repetitive Transcranial Magnetic Stimulation in Patients With Depression: A Placebo-Controlled Crossover Trial

1997 • 568 citations

The corticotropin-releasing factor (CRF) hypothesis of depression: new findings and new directions.

1996 • 547 citations

Reduced Corticotropin Releasing Factor Binding Sites in the Frontal Cortex of Suicide Victims

1988 • 547 citations

Therapeutic Efficacy of Right Prefrontal Slow Repetitive Transcranial Magnetic Stimulation in Major Depression

1999 • 529 citations

INCREASED SEROTONIN-2 BINDING SITES IN FRONTAL CORTEX OF SUICIDE VICTIMS

1983 • 527 citations

Prefrontal cortical projections to the hypothalamus in Macaque monkeys

1998 • 521 citations

Childhood Sexual Abuse as a Risk Factor for Depression in Women: Psychosocial and Neurobiological Correlates

1999 • 516 citations

A Polymorphism in the Glucocorticoid Receptor Gene May Be Associated with an Increased Sensitivity to Glucocorticoidsin Vivo¹

1998 • 512 citations

Serum thyrotropin response to thyrotropin-releasing hormone in psychiatric patients: a review

1982 • 504 citations

Triiodothyronine Augmentation in the Treatment of Refractory Depression

1996 • 483 citations

Anatomical and functional demonstration of a multisynaptic suprachiasmatic nucleus adrenal (cortex) pathway

1999 • 483 citations

Effects of Thyroxine as Compared with Thyroxine plus Triiodothyronine in Patients with Hypothyroidism

1999 • 473 citations

Distribution of glucocorticoid receptor immunoreactivity and mRNA in the rat brain: an immunohistochemical and in situ hybridization study

1996 • 467 citations

Overproduction of corticotropin-releasing factor in transgenic mice: a genetic model of anxiogenic behavior

1994 • 462 citations

Quantitative Cerebral Anatomy in Depression

1993 • 458 citations

Linking Mind and Brain in the Study of Mental Illnesses: A Project for a Scientific Psychopathology

1997 • 445 citations

Increased Number of Vasopressin- and Oxytocin-Expressing Neurons in the Paraventricular Nucleus of the Hypothalamus in Depression

1996 • 419 citations

Subcortical and temporal structures in affective disorder and schizophrenia: A magnetic resonance imaging study

1992 • 410 citations

Corticotropin-releasing hormone mRNA levels in the paraventricular nucleus of patients with Alzheimer's disease and depression

1995 • 398 citations

Circadian rhythms in depression and recovery: Evidence for blunted amplitude as the main chronobiological abnormality

1989 • 392 citations

Do antidepressants stabilize mood through actions on the hypothalamic-pituitary-adrenocortical system?

1995 • 391 citations

The functional neuroanatomy of mood disorders

1997 • 388 citations

Altered Hypothalamic-Pituitary-Adrenocortical Regulation in Healthy Subjects at High Familial Risk for Affective Disorders

1995 • 374 citations

Complex Interaction of the Sleep-Wake Cycle and Circadian Phase Modulates Mood in Healthy Subjects

1997 • 365 citations

Magnetic Resonance Imaging of the Caudate Nuclei in Depression

1992 • 361 citations

Glucocorticoids and the Genesis of Depressive Illness a Psychobiological Model

1994 • 338 citations

Long-term antidepressant administration alters corticotropin-releasing hormone, tyrosine hydroxylase, and mineralocorticoid receptor gene expression in rat brain. Therapeutic implications.

1991 • 338 citations

Regional brain function, emotion and disorders of emotion

1999 • 338 citations

Bright Light Treatment of Winter Depression

1998 • 338 citations

Chronic treatment of rats with the antidepressant amitriptyline attenuates the activity of the hypothalamic-pituitary-adrenocortical system.

1993 • 335 citations

Neural correlates of self-induced dysphoria

1993 • 329 citations

The neuroendocrinology of depression and chronic stress

1996 • 318 citations

Dehydroepiandrosterone (DHEA) treatment of depression

1997 • 317 citations

24-Hour Profiles of Adrenocorticotropin, Cortisol, and Growth Hormone in Major Depressive Illness: Effect of Antidepressant Treatment*

1987 • 315 citations

Prefrontal dysfunction in depressed patients performing a complex planning task: a study using positron emission tomography

1997 • 308 citations

SEASONAL AND CIRCADIAN MONOAMINE VARIATIONS IN HUMAN BRAINS EXAMINED POST MORTEM

1980 • 303 citations

Plasma Levels of Arginine Vasopressin Elevated in Patients with Major Depression

1997 • 300 citations

Replacement therapy for hypothyroidism with thyroxine alone does not ensure euthyroidism in all tissues, as studied in thyroidectomized rats.

1995 • 282 citations

Adrenal secretion during major depression in 8- to 16-year-olds, I. Altered diurnal rhythms in salivary cortisol and dehydroepiandrosterone (DHEA) at presentation

1996 • 279 citations

Vasopressin and the regulation of hypothalamic-pituitary-adrenal axis function: Implications for the pathophysiology of depression

1998 • 279 citations

Association of fluoxetine treatment with reductions in CSF concentrations of corticotropin-releasing hormone and arginine vasopressin in patients with major depression

1993 • 277 citations

Covariation of Activity in Habenula and Dorsal Raphé Nuclei Following Tryptophan Depletion

1999 • 277 citations

Positron Emission Tomography Measurement of Cerebral Metabolic Correlates of Tryptophan Depletion—Induced Depressive Relapse

1997 • 275 citations

A Placebo-Controlled Comparison of Lithium and Triiodothyronine Augmentation of Tricyclic Antidepressants in Unipolar Refractory Depression

1993 • 267 citations

A magnetic resonance imaging study of putamen nuclei in major depression

1991 • 259 citations

Double-Blind Controlled Investigation of Transcranial Magnetic Stimulation for the Treatment of Resistant Major Depression

1999 • 255 citations

Delayed sleep phase syndrome: a review of its clinical aspects

1995 • 252 citations

Interperson Variability but Intraperson Stability of Baseline Plasma Cortisol Concentrations, and Its Relation to Feedback Sensitivity of the Hypothalamo-Pituitary-Adrenal Axis to a Low Dose of Dexamethasone in Elderly Individuals¹

1998 • 250 citations

Cognitive impairment and cerebral structure by MRI in bipolar disorder

1990 • 249 citations

A Polymorphism in the Glucocorticoid Receptor Gene May Be Associated with an Increased Sensitivity to Glucocorticoids in Vivo

1998 • 249 citations

Incidence of silent cerebral infarction in patients with major depression.

1993 • 241 citations

The antidepressants fluoxetine, idazoxan and phenelzine alter corticotropin-releasing hormone and tyrosine hydroxylase mRNA levels in rat brain: therapeutic implications

1992 • 238 citations

Pituitary Size in Depression*

1991 • 237 citations

Hypofrontality and negative symptoms in major depressive disorder.

1998 • 237 citations

With aging in humans the activity of the hypothalamus-pituitary-adrenal system increases and its diurnal amplitude flattens

1997 • 232 citations

Pattern of activation of the hypothalamic-pituitary-adrenal axis in acute stroke. Relation to acute confusional state, extent of brain damage, and clinical outcome.

1994 • 231 citations

Topographic organization of connections between the hypothalamus and prefrontal cortex in the rhesus monkey

1998 • 230 citations

MRI findings in patients with affective disorder: a meta‐analysis

1997 • 229 citations

Neuroanatomical circuits in depression: implications for treatment mechanisms.

1992 • 227 citations

The Longitudinal Course of Psychopathology in Cushing’s Syndrome after Correction of Hypercortisolism

1997 • 225 citations

Reduced anxiety-like and cognitive performance in mice lacking the corticotropin-releasing factor receptor 11Published on the World Wide Web on 27 November 1998.1

1999 • 224 citations

Nitric oxide synthase-containing neurons in the human hypothalamus: reduced number of immunoreactive cells in the paraventricular nucleus of depressive patients and schizophrenics

1998 • 224 citations

Light treatment for nonseasonal depression: speed, efficacy, and combined treatment1Presented at American Psychiatric Association Symposium 54, San Diego, California, May 20, 1997. Supported by AG12364, HL55983, ES08930, and the Sam and Rose Stein Institute for Research on Aging.1

1998 • 223 citations

Depression in Parkinson's Disease

1994 • 223 citations

Time course of prefrontal lobe dysfunction in severely depressed in-patients: a longitudinal neuropsychological study

1995 • 223 citations

Vasopressin-containing neurons of the suprachiasmatic nuclei inhibit corticosterone release

1992 • 221 citations

The Thyroid Axis and Depression

1998 • 218 citations

Cerebrospinal fluid and plasma free cortisol concentrations in depression

1976 • 210 citations

Transcranial Magnetic Stimulation in Mania: A Controlled Study

1998 • 205 citations

The Effects of Electroconvulsive Therapy on Quantitative Electroencephalograms

1996 • 205 citations

Corticotropin Releasing Hormone in the Pathophysiology of Melancholic and Atypical Depression and in the Mechanism of Action of Antidepressant Drugs

1995 • 205 citations

Corticosteroid Receptor Function Is Decreased in Depressed Patients

1997 • 204 citations

Increased 24‐hour urinary cortisol excretion in patients with post‐traumatic stress disorder and patients with major depression, but not h patients with fibromyalgia

1998 • 203 citations

Prenatal stress increases corticotropin-releasing factor (CRF) content and release in rat amygdala minces

1995 • 200 citations

Size at birth and adrenocortical function in childhood

1996 • 199 citations

Reduced Volume of Limbic System–Affiliated Basal Ganglia in Mood Disorders:

1999 • 197 citations

Late-onset minor and major depression: early evidence for common neuroanatomical substrates detected by using MRI

1998 • 193 citations

Major Depression in Individuals With a History of Childhood Physical or Sexual Abuse: Relationship to Neurovegetative Features, Mania, and Gender

1998 • 191 citations

Adrenal steroid secretion and major depression in 8- to 16-year-olds, III. Influence of cortisol/DHEA ratio at presentation on subsequent rates of disappointing life events and persistent major depression

1998 • 187 citations

The role of thyroid hormones in depression

1998 • 185 citations

Demonstration in vivo of reduced serotonin responsivity in the brain of untreated depressed patients [published erratum appears in Am J Psychiatry 1996 Apr;153(4):588]

1996 • 184 citations

Frontal lobe hypometabolism and depression in Alzheimer's disease

1998 • 178 citations

Relationship between sleep and mood in patients with rapid-cycling bipolar disorder

1996 • 176 citations

SPECT and PET imaging in mood disorders.

1993 • 173 citations

Abnormal neural response to feedback on planning and guessing tasks in patients with unipolar depression

1998 • 172 citations

α2-Adrenoceptors in the brain of suicide victims: increased receptor density associated with major depression

1992 • 171 citations

Clinical and Magnetic Resonance Imaging Correlates of Hypothalamic–Pituitary–Adrenal Axis Function in Depression and Alzheimer's Disease

1996 • 170 citations

24-Hour cortisol measures in adolescents with major depression: A controlled study

1991 • 169 citations

The neurobiology of suicide risk: a review for the clinician.

1999 • 169 citations

Prognostic value of the stress response following stroke

1977 • 167 citations

Melatonin for the Treatment of Sleep Disturbances in Major Depressive Disorder

1998 • 165 citations

Lesion location and poststroke depression

1996 • 164 citations

Effects of Rapid Tryptophan Depletion in Patients With Seasonal Affective Disorder in Remission After Light Therapy

1996 • 164 citations

Cortisol Response to a Combined Dexamethasone‐Human Corticotrophin‐Releasing Hormone Challenge in Patients with Depression

1989 • 162 citations

Abnormalities at different levels of the hypothalamic-pituitary-adrenocortical axis early after stroke.

1992 • 161 citations

Chapter 21 The role of corticotropin-releasing hormone in the pathogenesis of Cushing's disease, anorexia nervosa, alcoholism, affective disorders and dementia

1992 • 160 citations

Interperson Variability but Intraperson Stability of Baseline Plasma Cortisol Concentrations, and Its Relation to Feedback Sensitivity of the Hypothalamo-Pituitary-Adrenal Axis to a Low Dose of Dexamethasone in Elderly Individuals

1998 • 159 citations

Effects of Tryptophan Depletion vs Catecholamine Depletion in Patients With Seasonal Affective Disorder in Remission With Light Therapy

1998 • 158 citations

Depression and Endocrine Disorders: Focus on the Thyroid and Adrenal System

1996 • 157 citations

Which depressed patients will respond to interpersonal psychotherapy? The role of abnormal EEG sleep profiles

1997 • 157 citations

A comparison of triiodothyronine and thyroxine in the potentiation of tricyclic antidepressants

1990 • 156 citations

Seasonal Changes in Mood and Behavior

1996 • 152 citations

Programming of the hypothalamo-pituitary-adrenal axis and the fetal origins of adult disease hypothesis

1998 • 150 citations

Frontostriatal deficits in unipolar major depression

1998 • 150 citations

Psychopathology in patients with endogenous Cushing's syndrome: ‘atypical’ or melancholic features

1995 • 147 citations

Increased Diurnal Plasma Concentrations of Dehydroepiandrosterone in Depressed Patients

1998 • 146 citations

Transcranial magnetic stimulation: a neuropsychiatric tool for the 21st century

1996 • 146 citations

Melatonin effects on sleep, mood, and cognition in elderly with mild cognitive impairment

1998 • 145 citations

Oxytocin as a possible mediator of SSRI-induced antidepressant effects

1999 • 145 citations

Chronic treatment of rats with the antidepressant amitriptyline attenuates the activity of the hypothalamic-pituitary-adrenocortical system

1993 • 144 citations

Are Autoimmune Thyroid Dysfunction and Depression Related?¹

1998 • 142 citations

Effects of Tryptophan Depletion on Drug-Free Patients With Seasonal Affective Disorder During a Stable Response to Bright Light Therapy

1997 • 135 citations

Brain mechanisms associated with depressive relapse and associated cognitive impairment following acute tryptophan depletion

1999 • 134 citations

Antiglucocorticoid therapies in major depression: A review

1997 • 134 citations

The effects of prenatal stress on the development of hypothalamic paraventricular neurons in fetal rats

1999 • 133 citations

Brain Glucose Metabolism During Non—Rapid Eye Movement Sleep in Major Depression

1996 • 131 citations

Maternal separation in neonatal rats elicits activation of the hypothalamic-pituitary-adrenocortical axis: A putative role for corticotropin-releasing factor

1993 • 130 citations

Serum cortisol and outcome of ischemic brain infarction

1993 • 124 citations

Cerebral Glucose Metabolic Response to Combined Total Sleep Deprivation and Antidepressant Treatment in Geriatric Depression

1999 • 122 citations

Is the Mechanism of Prefrontal Hypofunction in Depression the Same as in Schizophrenia?

1993 • 121 citations

Adrenal gland volume in major depression: Relationship to basal and stimulated pituitary-adrenal cortical axis function

1996 • 121 citations

Cortisol in the CSF of Depressed and Suicidal Patients

1980 • 118 citations

The role of Corticotropin Releasing Factor in Depressive Illness: a Critical Review

1998 • 114 citations

Melatonin treatment of winter depression: a pilot study

1998 • 113 citations

Effects of Intrathecal Thyrotropin-Releasing Hormone (Protirelin) in Refractory Depressed Patients

1997 • 112 citations

Low Levels of Transthyretin in the CSF of Depressed Patients

1999 • 108 citations

The Longitudinal Course of Psychopathology in Cushing's Syndrome after Correction of Hypercortisolism

1997 • 107 citations

Adrenal weight and morphology in victims of completed suicide

1994 • 102 citations

Diurnal and Seasonal Rhythms of Neuronal Activity in the Suprachiasmatic Nucleus of Humans

1993 • 102 citations

Depression in dementia of the Alzheimer type and in multi-infarct dementia

1990 • 100 citations

Right frontal lobe slow frequency repetitive transcranial magnetic stimulation (SF r-TMS) is an effective treatment for depression: a case-control pilot study of safety and efficacy

1999 • 100 citations

Circadian Rest-Activity Disturbances in Seasonal Affective Disorder

1997 • 99 citations

Clinical and chronobiological effects of light therapy on nonseasonal affective disorders

1995 • 98 citations

Urinary free Cortisol excretion shortly after ischaemic stroke

1990 • 98 citations

Structural Abnormalities in Brain Magnetic Resonance Images of Depressed Children

1996 • 94 citations

The circadian system and the therapeutics of the affective disorders

1995 • 92 citations

Seasonal and circadian rhythms in suicide in Cagliari, Italy

1999 • 91 citations

Cerebrospinal fluid neuropeptides in mood disorder and dementia

1992 • 90 citations

Side Effects of Short-Term 10,000-Lux Light Therapy

1998 • 90 citations

Hypercortisolism after stroke — partly cytokine-mediated?

1997 • 88 citations

A controlled study of light therapy for bulimia nervosa

1994 • 87 citations

Corticotropin-Releasing Hormone Inhibits Melatonin Secretion in Healthy Volunteers – A Potential Link to Low-Melatonin Syndrome in Depression?

1997 • 85 citations

Dexamethasone augmentation in treatment‐resistant depression

1997 • 82 citations

Hypothalamic connections with the cerebral cortex

2000 • 82 citations

Arginine Vasopressin Is Associated with Hypercortisolemia and Suicide Attempts in Depression

1997 • 82 citations

Thyroid hormones and the treatment of depression: An examination of basic hormonal actions in the mature mammalian brain

1997 • 80 citations

Long-Term Stress Degenerates, But Imipramine Regenerates, Noradrenergic Axons in the Rat Cerebral Cortex

1997 • 79 citations

An evaluation of basal hypothalamic-pituitary-thyroid axis function in depression: Results of a large-scaled and controlled study

1993 • 78 citations

Are Autoimmune Thyroid Dysfunction and Depression Related?

1998 • 77 citations

Seasonal patterns of bulimia nervosa

1992 • 76 citations

Plasma arginine vasopressin and motor activity in major depression

1998 • 76 citations

Different linkage of depression to hypercortisolism early versus late after stroke. A 3-year longitudinal study.

1993 • 75 citations

Plasma corticotropin-releasing factor in depressive disorders

1998 • 75 citations

The novel antidepressant, tianeptine, reduces stress-evoked stimulation of the hypotalamo-pituitary-adrenal axes

1991 • 74 citations

Effect of desipramine on cerebrospinal fluid concentrations of corticotropin-releasing factor in human subjects

1993 • 73 citations

Effect of white matter disease on functional connections in the aging brain.

1994 • 73 citations

Inverse relationship of peripheral thyrotropin-stimulating hormone levels to brain activity in mood disorders

1997 • 72 citations

Decreased cerebral glucose metabolism in patients with brain tumors: an effect of corticosteroids

1995 • 72 citations

Postmortem Neurochemical Studies in Depression

1986 • 72 citations

Natural bright light exposure in the summer and winter in subjects with and without complaints of seasonal mood variations

1998 • 71 citations

Annual variations in the vasopressin neuron population of the human suprachiasmatic nucleus

1993 • 70 citations

Distribution of thyrotropin‐releasing hormone (TRH)‐containing cells and fibers in the human hypothalamus

1994 • 70 citations

Hypothalamic integration of circadian rhythms

1996 • 66 citations

Melatonin: A clinical perspective

1997 • 65 citations

The role of genetic factors in the etiology of seasonal affective disorder and seasonality

1999 • 65 citations

Regional cerebral blood flow abnormalities in late‐life depression:Relation to refractoriness and chronification

1998 • 64 citations

Chronobiological Theories of Nonseasonal Affective Disorders and Their Implications for Treatment

1994 • 61 citations

HPA axis dysfunction in depression: Correlation with monoamine system abnormalities

1997 • 58 citations

Effect of Antidepressant Medication on Morning and Evening Thyroid Function Tests During a Major Depressive Episode

1996 • 57 citations

Neurohypophysial hormone and melatonin secretion over the natural and suppressed menstrual cycle in premenopausal women

1998 • 56 citations

Thyroid hormones in the treatment of affective disorders

1988 • 55 citations

Glucocorticoid Resistant Syndromes—Molecular Basis andClinical Presentations

1996 • 53 citations

Cloning of glucocorticoid receptor and mineralocorticoid receptor cDNA and gene expression in the central nervous system of the tree shrew (Tupaia belangeri)

1998 • 53 citations

Melatonin : a universal photoperiodic signal with diverse actions

1996 • 52 citations

Corticotropin-releasing factor binding sites in cortex of depressed suicides

1997 • 51 citations

Changes in regional brain activity in major depression after successful treatment with antidepressant drugs

1998 • 51 citations

Infants of depressed and nondepressed mothers exhibit differences in frontal brain electrical activity during the expression of negative emotions.

1997 • 51 citations

Circadian profiles of cortisol, prolactin, and thyrotropin in seasonal affective disorder

1996 • 49 citations

The hypothalamic‐pituitary‐thyroid axis in major depression

1997 • 49 citations

Bright light exposure and pituitary hormone secretion

1998 • 49 citations

Ageing of the Human Hypothalamus

1995 • 48 citations

Regional distribution of norepinephrine and dopamine in brains of depressive suicides and alcoholic suicides.

1975 • 48 citations

Bright light therapy in focus: lamp emission spectra and ocular safety

1996 • 47 citations

Prophylactic treatment of seasonal affective disorder (SAD) by using light visors: bright white or infrared light?

1999 • 47 citations

Glucocorticoid Feedback Resistance

1997 • 47 citations

Seasonal Variation in Bipolar Disorder

1996 • 46 citations

PSYCHONEUROENDOCRINOLOGY OF DEPRESSION

1998 • 46 citations

Affective Disorders and Endocrine Disease

1994 • 44 citations

Serotonergic, noradrenergic, and dopaminergic measures in suicide brains

1997 • 42 citations

The Zurich study

1992 • 41 citations

Antiglucocorticoid treatments in psychiatry

1997 • 40 citations

Melatonin as a Therapeutic Agent in the Treatment of Sleep Disturbance in Depression

1997 • 38 citations

Increased Diurnal Plasma Concentrations of Dehydroepiandrosterone in Depressed Patients

1998 • 38 citations

Neurohypophyseal Peptides and Psychopathology

1992 • 37 citations

Decreased brain glucose utilization in patients with Cushing's disease.

1998 • 37 citations

Chapter 14 The role of melatonin and light in the human circadian system

1996 • 36 citations

Post-stroke depression: Relationships with morphological damage and cognition over time

1995 • 36 citations

Effects of the Seasons and of Bright Light Administered at Different Times of Day on Sleep EEG and Mood in Patients with Seasonal Affective Disorder

1997 • 36 citations

Nocturnal Serum Melatonin Profile in Major Depression in Children and Adolescents

1996 • 36 citations

Brain shrinkage and subdural effusion associated with ACTH administration

1982 • 34 citations

TRH and LH-RH distribution in discrete nuclei of the human hypothalamus: evidence for a left prominence of TRH

1986 • 32 citations

Changes in norepinephrine output following light therapy for fall/winter seasonal depression

1992 • 32 citations

Circadian profiles of melatonin in melancholic depressed patients and healthy subjects in relation to cortisol secretion and sleep

1997 • 32 citations

Cortisol in light treatment of seasonal and non‐seasonal depression: relationship between melatonin and Cortisol

1997 • 32 citations

Dawn simulation vs. lightbox treatment in winter depression: a comparative study

1998 • 32 citations

Effect of Cerebral Vascular Accident on the Level of 17‐Hydroxycorticosteroids in Plasma

1956 • 30 citations

Arginine vasopressin (AVP) depletion in neurons of the suprachiasmatic nuclei affects the AVP content of the paraventricular neurons and stimulates adrenocorticotrophic hormone release

1997 • 27 citations

Corticotropin-Releasing Factor Neurons Innervate Dopamine Neurons in the Periventricular Hypothalamus of Juvenile Macaques

1989 • 25 citations

An Open Study of Triiodothyronine Augmentation of Tricyclic Antidepressants in Inpatients with Refractory Depression

1997 • 23 citations

Psychopathology and plasma cortisol responses to dexamethasone in prepubertal psychiatric inpatients

1989 • 23 citations

Differences in CSF concentrations of thyrotropin-releasing hormone in depressed patients and normal subjects: negative findings

1994 • 23 citations

Testing the Hypothesis of a Circadian Phase Disturbance Underlying Depressive Mood in Nonseasonal Depression

1998 • 23 citations

Neuropeptides and Alzheimer's disease

1995 • 23 citations

Chapter 30 Neurohypophyseal peptides and psychopathology

1992 • 21 citations

Hyperthyroxinemia in major affective disorders

1991 • 20 citations

Corticotropin-Releasing Factor Antagonists

1999 • 20 citations

Clozapine for refractory schizophrenia: the Illinois experience.

1999 • 19 citations

Clinical evidence for thyroid dysfunction in patients with seasonal affective disorder

1992 • 19 citations

Lack of seasonal variation in abnormal TSH secretion in patients with seasonal affective disorder

1994 • 18 citations

Seasonal Variation in Neuroendocrine and Mood Responses to IV L-Tryptophan in Depressed Patients and Healthy Subjects

1996 • 15 citations

Chronobiological approach for treatment-resistant rapid cycling affective disorders

1995 • 15 citations

Neuropeptides and Alzheimer's disease

1995 • 13 citations

Interrelationship between cortisol levels in plasma and the circadian rhythm of temperature, pulse and blood pressure in depressed patients with good and disturbed sleep

1995 • 12 citations

The Potential Ocular Phototoxicity of Antidepressant Drugs

1992 • 11 citations

Depression: immunological resignation of the will to live?

1998 • 10 citations

Multi-Component Physiological Response Mediates Therapeutic Benefits of Bright Light in Winter Seasonal Affective Disorder

1998 • 9 citations

The dark side of light treatment for seasonal affective disorder

1998 • 8 citations

Seasonal Affective Disorder: Are the DSM-III-R Criteria Valid ?

1994 • 7 citations

CREOSOTE IN CHOLERA.

1837 • 7 citations

Pineal Function in Psychiatric Disorders

2015 • 5 citations

Thyrotropin-releasing hormone and corticotropin-releasing hormone-- what's the message?

1995 • 5 citations

Disappearance of hypothalamic TRH asymmetry in suicide patients

1992 • 3 citations