Glucocorticoid Feedback Resistance

Physiological Functions of Glucocorticoids in Stress and Their Relation to Pharmacological Actions*

1984 • 3,073 citations

The Hypothalamic–Pituitary–Adrenal Axis and Immune-Mediated Inflammation

1995 • 2,525 citations

Stress and cognitive function

1995 • 1,830 citations

Effect of Neonatal Handling on Age-Related Impairments Associated with the Hippocampus

1988 • 1,068 citations

Targeted disruption of the glucocorticoid receptor gene blocks adrenergic chromaffin cell development and severely retards lung maturation.

1995 • 926 citations

Molecular Determinants of Glucocorticoid Receptor Function and Tissue Sensitivity to Glucocorticoids

1996 • 889 citations

Brain corticosteroid receptor balance and homeostatic control

1991 • 858 citations

Antidepressants and Hypothalamic-Pituitary-Adrenocortical Regulation

1996 • 829 citations

Anti-inflammatory actions of steroids: molecular mechanisms

1993 • 740 citations

Vasopressinergic Control of Pituitary Adrenocorticotropin Secretion Comes of Age

1993 • 651 citations

Glucocorticoid receptor beta, a potential endogenous inhibitor of glucocorticoid action in humans.

1995 • 636 citations

Selective corticosteroid antagonists modulate specific aspects of spatial orientation learning.

1992 • 589 citations

Corticosterone levels determine individual vulnerability to amphetamine self-administration.

1991 • 572 citations

Selective corticosteroid antagonists modulate specific aspects of spatial orientation learning.

1992 • 512 citations

On the Role of Brain Mineralocorticoid (Type I) and Glucocorticoid (Type II) Receptors in Neuroendocrine Regulation

1989 • 473 citations

Combination IL-2 and IL-4 reduces glucocorticoid receptor-binding affinity and T cell response to glucocorticoids.

1993 • 457 citations

Regulatory Changes in Neuroendocrine Stress-Integrative Circuitry Produced by a Variable Stress Paradigm

1995 • 454 citations

Nuclear Receptor/AP-1 Interaction*

1993 • 435 citations

Control of neuronal excitability by corticosteroid hormones

1992 • 399 citations

Stress, Feedback and Facilitation in the Hypothalamo‐Pituitary‐Adrenal Axis

1992 • 398 citations

Steroid-resistant asthma. Cellular mechanisms contributing to inadequate response to glucocorticoid therapy.

1994 • 394 citations

Mineralocorticoid and glucocorticoid receptors in the brain. Implications for ion permeability and transmitter systems

1994 • 392 citations

Do antidepressants stabilize mood through actions on the hypothalamic-pituitary-adrenocortical system?

1995 • 391 citations

The influence of ovarian steroids on hypothalamic-pituitary-adrenal regulation in the female rat

1995 • 385 citations

Altered Hypothalamic-Pituitary-Adrenocortical Regulation in Healthy Subjects at High Familial Risk for Affective Disorders

1995 • 374 citations

Point mutation causing a single amino acid substitution in the hormone binding domain of the glucocorticoid receptor in familial glucocorticoid resistance.

1991 • 373 citations

The Ontogeny of the Hypothalamic‐Pituitary‐Adrenal Axis. The Influence of Maternal Factorsa

1994 • 341 citations

Altered reactivity of the hypothalamic-pituitary-adrenal axis in the primary fibromyalgia syndrome.

1993 • 329 citations

Stress update

1993 • 323 citations

Pathways to the Secretion of Adrenocorticotropin: A View from the Portal*

1991 • 255 citations

Prospective controlled studies of the behavioral and biological effects of exogenous corticosteroids☆

1994 • 225 citations

Familial glucocorticoid resistance caused by a splice site deletion in the human glucocorticoid receptor gene.

1993 • 224 citations

Chapter 6 Neuroendocrine states and behavioral and physiological stress responses

1987 • 208 citations

Neonatal Maternally Deprived Rats have as Adults Elevated Basal Pituitary‐Adrenal Activity and Enhanced Susceptibility to Apomorphine

1996 • 185 citations

Short Inescapable Stress Produces Long-Lasting Changes in the Brain-Pituitary-Adrenal Axis of Adult Male Rats

1993 • 183 citations

Glucocorticoids, hippocampal corticosteroid receptor gene expression and antidepressant treatment: relationship with spatial learning in young and aged rats

1995 • 174 citations

Roles of type I and II corticosteroid receptors in regulation of basal activity in the hypothalamo-pituitary-adrenal axis during the diurnal trough and the peak: evidence for a nonadditive effect of combined receptor occupation.

1994 • 172 citations

Increased pituitary activation following metyrapone administration in post-traumatic stress disorder

1996 • 167 citations

Anxiolytic-like effects of selective mineralocorticoid and glucocorticoid antagonists on fear-enhanced behavior in the elevated plus-maze

1995 • 164 citations

Feedback and facilitation in the adrenocortical system: unmasking facilitation by partial inhibition of the glucocorticoid response to prior stress.

1992 • 152 citations

Corticosterone, brain mineralocorticoid receptors (MRS) and the activity of the hypothalamic-pituitary-adrenal (hpa) axis: The Lewis rat as an example of increased central MR capacity and a hyporesponsive HPA axis

1995 • 152 citations

Glucocorticoid-biogenic amine interactions in relation to mood and behavior

1987 • 143 citations

The Hippocampus : new vistas

1989 • 143 citations

Familial glucocorticoid resistance caused by a splice site deletion in the human glucocorticoid receptor gene

1993 • 132 citations

Glucocorticoid receptor, mineralocorticoid receptors, 11β-hydroxysteroid dehydrogenase-1 and -2 expression in rat brain and kidney: in situ studies

1995 • 123 citations

Nuclear receptor/AP-1 interaction

1993 • 123 citations

Chapter 9 Biochemical switching in hypothalamic circuits mediating responses to stress

1991 • 122 citations

Differential adaptation of glucocorticoid sensitivity of peripheral blood mononuclear leukocytes in patients with sepsis or septic shock.

1995 • 121 citations

Expression of an mdr gene is associated with a new form of resistance to dexamethasone-induced apoptosis.

1993 • 116 citations

Chronic brain glucocorticoid receptor blockade enhances the rise in circadian and stress-induced pituitary-adrenal activity.

1996 • 89 citations

Patterns of ACTH Secretagog Secretion in Response to Psychological Stimuli

1996 • 79 citations

Roles of type I and II corticosteroid receptors in regulation of basal activity in the hypothalamo-pituitary-adrenal axis during the diurnal trough and the peak: evidence for a nonadditive effect of combined receptor occupation

1994 • 76 citations

Multiple signaling pathways activate the chicken progesterone receptor.

1994 • 75 citations

Feedback and facilitation in the adrenocortical system: unmasking facilitation by partial inhibition of the glucocorticoid response to prior stress

1992 • 72 citations

Neural mechanisms involved in the corticosteroid feedback effects on the hypothalamo-pituitary-adrenocortical axis

1995 • 69 citations

Divergent prolactin and pituitary-adrenal activity in rats selectively bred for different dopamine responsiveness.

1996 • 60 citations

Cortisol receptor resistance: the variability of its clinical presentation and response to treatment

1992 • 58 citations

Endotoxin and Interleukin 1 Decrease the Affinity of Hippocampal Mineralocorticoid (Type I) Receptor in Parallel to Activation of the Hypothalamic-Pituitary-Adrenal Axis

1994 • 56 citations

Glucocorticoid Resistant Syndromes—Molecular Basis andClinical Presentations

1996 • 53 citations

Expression of an mdr gene is associated with a new form of resistance to dexamethasone-induced apoptosis

1993 • 52 citations

Differential adaptation of glucocorticoid sensitivity of peripheral blood mononuclear leukocytes in patients with sepsis or septic shock

1995 • 49 citations

Unique sequences in the guinea pig glucocorticoid receptor induce constitutive transactivation and decrease steroid sensitivity.

1994 • 49 citations

Adrenocortical Hyporesponsiveness and Glucocorticoid Feedback Resistance in Old Male Brown Norway Rats

1995 • 37 citations

Glucocorticosteroid Resistance in Humans. Elucidation of the Molecular Mechanisms and Implications for Pathophysiology

1994 • 36 citations

Chronic brain glucocorticoid receptor blockade enhances the rise in circadian and stress-induced pituitary-adrenal activity

1996 • 35 citations

The genetic basis of glucocorticoid resistance

1995 • 24 citations

Unique sequences in the guinea pig glucocorticoid receptor induce constitutive transactivation and decrease steroid sensitivity [published erratum appears in Mol Endocrinol 1994 Jun;8(6):731]

1994 • 22 citations

Divergent prolactin and pituitary-adrenal activity in rats selectively bred for different dopamine responsiveness

1996 • 21 citations

Multiple signaling pathways activate the chicken progesterone receptor

1994 • 21 citations

Corticosteroid hormones in neuroprotection and brain damage

1996 • 19 citations

11<scp>β</scp>‐Hydroxysteroid Dehydrogenase Activity in the Hippocampus: Implications for in vivo Corticosterone Receptor Binding and Cell Nuclear Retention

1996 • 13 citations

Long-term treatment with RU486 and glucocorticoid receptor resistance Theoretical and therapeutic implications

1992 • 10 citations

The Tale of the Guinea Pig

1994 • 9 citations

Glucocorticoid resistance in humans

1995 • 9 citations

Corticosteroids and the brain

1995 • 6 citations

11beta-Hydroxysteroid Dehydrogenase Activity in the Hippocampus: Implications for in vivo Corticosterone Receptor Binding and Cell Nuclear Retention

1996 • 2 citations