Melatonin: A clinical perspective

Light Suppresses Melatonin Secretion in Humans

1980 • 1,873 citations

Melatonin and the Mammalian Pineal Gland

1994 • 805 citations

Effect of inducing nocturnal serum melatoninconcentrations in daytime on sleep, mood, body temperature, andperformance.

1994 • 577 citations

The immunoneuroendocrine role of melatonin

1993 • 493 citations

Improvement of sleep quality in elderly people by controlled-release melatonin

1995 • 488 citations

Delayed sleep phase syndrome response to melatonin

1991 • 421 citations

Melatonin receptors: Are there multiple subtypes?

1995 • 410 citations

Melatonin: a major regulator of the circadian rhythm of core temperature in humans.

1992 • 364 citations

Melatonin Replacement Therapy of Elderly Insomniacs

1995 • 352 citations

Melatonin and sleep in humans

1993 • 324 citations

Conservation of photoperiod-responsive mechanisms in humans

1993 • 321 citations

Pineal Serotonin N -Acetyltransferase: Expression Cloning and Molecular Analysis

1995 • 317 citations

Melatonin directly resets the rat suprachiasmatic circadian clock in vitro

1991 • 309 citations

Melatonin inhibition and pinealectomy enhancement of 7,12-dimethylbenz(a)anthracene-induced mammary tumors in the rat.

1981 • 299 citations

Sleep-inducing effects of low doses of melatonin ingested in the evening*

1995 • 291 citations

The pineal gland and melatonin in relation to aging: A summary of the theories and of the data

1995 • 287 citations

Pineal control of aging: effect of melatonin and pineal grafting on aging mice.

1994 • 276 citations

The Nuclear Receptor for Melatonin Represses 5-Lipoxygenase Gene Expression in Human B Lymphocytes

1995 • 266 citations

Circadian rhythms of melatonin release from individual superfused chicken pineal glands in vitro.

1980 • 257 citations

ROLE OF PINEAL GLAND IN qTIOLOGY AND TREATMENT OF BREAST CANCER

1978 • 254 citations

Melatonin Administration to Blind People: Phase Advances and Entrainment

1991 • 251 citations

Melatonin protects neurons from singlet oxygen‐induced apoptosis

1995 • 223 citations

Phototherapy of Seasonal Affective Disorder

1986 • 220 citations

Melatonin and circadian control in mammals

1989 • 213 citations

Impaired nocturnal secretion of melatonin in coronary heart disease

1995 • 210 citations

Increased brain damage after stroke or excitotoxic seizures in melatonin‐deficient rats

1996 • 208 citations

Expression of melatonin receptors in arteries involved in thermoregulation.

1990 • 207 citations

Functional Pleiotropy of the Neurohormone Melatonin: Antioxidant Protection and Neuroendocrine Regulation

1995 • 205 citations

Melatonin Possesses Time-Dependent Hypnotic Effects

1994 • 198 citations

Light Therapy in Seasonal Affective Disorder Is Independent of Time of Day or Circadian Phase

1993 • 198 citations

Sleep laboratory investigations on hypnotic properties of melatonin

1990 • 190 citations

The orphan receptor family RZR/ROR, melatonin and 5‐lipoxygenase: An unexpected relationship

1995 • 180 citations

Melatonin Is Able to Influence Its Secretion in Humans: Description of a Phase-Response Curve

1994 • 168 citations

Melatonin rhythm in human milk.

1993 • 167 citations

Improving Adaptation to Simulated Night Shift: Timed Exposure to Bright Light Versus Daytime Melatonin Administration

1995 • 166 citations

Melatonin administration in insomnia.

1990 • 157 citations

Pharmacokinetics of Melatonin in Man: First Pass Hepatic Metabolism

1985 • 156 citations

Entrainment of hamster pup circadian rhythms by prenatal melatonin injections to the mother

1988 • 153 citations

Melatonin: a major regulator of the circadian rhythm of core temperature in humans

1992 • 152 citations

Melatonin Serum Levels and Metabolic Clearance Rate in Patients with Liver Cirrhosis

1982 • 151 citations

Modulation of cancer endocrine therapy by melatonin: a phase II study of tamoxifen plus melatonin in metastatic breast cancer patients progressing under tamoxifen alone

1995 • 149 citations

Melatonin madness

1995 • 146 citations

Disruption of the Diurnal Rhythm of Plasma Melatonin in Cirrhosis

1995 • 136 citations

Daily rhythm of serum melatonin in patients with dementia of the degenerate type

1996 • 136 citations

Correction of non–24‐hour sleep/wake cycle by melatonin in a blind retarded boy

1991 • 133 citations

Melatonin effect on daytime sleep in men: suppression of EEG low frequency activity and enhancement of spindle frequency activity

1995 • 131 citations

Non-24-Hour Sleep-Wake Syndrome in a Sighted Man: Circadian Rhythm Studies and Efficacy of Melatonin Treatment

1996 • 130 citations

Daytime melatonin administration enhances sleepiness and theta/alpha activity in the waking EEG

1996 • 129 citations

The effects of exogenous melatonin on the total sleep time and daytime alertness of chronic insomniacs: A preliminary study

1991 • 129 citations

Factors influencing the development of melatonin rhythmicity in humans.

1996 • 124 citations

The Association between the Nocturnal Sleep Gate and Nocturnal Onset of Urinary 6-Sulfatoxymelatonin

1993 • 122 citations

Sleep Propensity Free-Runs with the Temperature, Melatonin and Cortisol Rhythms in a Totally Blind Person

1992 • 120 citations

Melatonin, and delayed sleep phase syndrome

1994 • 107 citations

Influence of Melatonin Treatment on Human Circadian Rhythmicity before and after a Simulated 9-Hr Time Shift

1991 • 105 citations

Circadian secretion pattern of melatonin in de novo Parkinsonian patients: evidence for phase-shifting properties of l-dopa

1993 • 105 citations

ABNORMAL CIRCADIAN RHYTHM OF MELATONIN IN DIABETIC AUTONOMIC NEUROPATHY

1986 • 104 citations

Clinical aspects of the melatonin action: impact of development, aging, and puberty, involvement of melatonin in psychiatric disease and importance of neuroimmunoendocrine interactions

1993 • 103 citations

High‐affinity binding of melatonin by human circulating T lymphocytes (CD4 ⁺ )

1995 • 101 citations

Magnetic fields and pineal function in humans: Evaluation of nocturnal acute exposure to extremely low frequency magnetic fields on serum melatonin and urinary 6-sulfatoxymelatonin circadian rhythms

1996 • 95 citations

The effect of melatonin on normal sleep

1987 • 94 citations

ASSESSMENT OF CADAVERIC KIDNEYS FOR TRANSPLANTATION

1975 • 94 citations

Melatonin prevents ischemia reperfusion injury in hamster cheek pouch microcirculation

1996 • 92 citations

Melatonin rhythm in human milk

1993 • 86 citations

Melatonin and insomnia

1996 • 85 citations

Melatonin replacement corrects sleep disturbances in a child with pineal tumor

1996 • 79 citations

Melatonin Appears Ineffective in Children With Intellectual Deficits and Fragmented Sleep: Six "N of 1" Trials

1996 • 78 citations

Effects of long-term administration of melatonin and a putative antagonist on the ageing rat

1995 • 74 citations

Disappearance of Plasma Melatonin after Removal of a Neoplastic Pineal Gland

1983 • 70 citations

Melatonin and human puberty: Current perspectives

1993 • 70 citations

Inhibition of melatonin secretion onset by low levels of illumination

1996 • 65 citations

In vitro and in vivo protection against kainate‐induced excitotoxicity by melatonin

1996 • 61 citations

Chapter 8 The organization of the human circadian timing system

1992 • 57 citations

Ethanol inhibits melatonin secretion in healthy volunteers in a dose-dependent randomized double blind cross-over study.

1993 • 56 citations

The Histology and Pathology of the Human Pineal Gland

1979 • 56 citations

Reduction of regional cerebral blood flow by melatonin in young rats

1995 • 55 citations

MELATONIN AND PARKINSONISM

1973 • 54 citations

Melatonin blocks the stimulatory effects of prolactin on human breast cancer cell growth in culture

1995 • 52 citations

Melatonin in Chronic Renal Failure

1992 • 48 citations

Factors influencing the development of melatonin rhythmicity in humans

1996 • 46 citations

Melatonin, cortisol and body temperature rhythms in Lennox-Gastaut patients with or without circadian rhythm sleep disorders

1993 • 41 citations

Urinary 6-Hydroxymelatonin Excretion in Patients with Orthostatic Hypotension

1981 • 40 citations

Melatonin reduces low-Mg2+ epileptiform activity in human temporal slices

1995 • 37 citations

Melatonin hype hard to swallow

1996 • 37 citations

RHYTHMS OF SERUM MELATONIN IN PATIENTS WITH SPINAL LESIONS AT THE CERVICAL, THORACIC OR LUMBAR REGION

1989 • 36 citations

Melatonin rhythms in women with anorexia nervosa and bulimia nervosa.

1993 • 29 citations

Melatonin as an Antiaging Drug: Between Facts and Fantasy

1996 • 26 citations

Acute Cerebral Hemorrhage Changes the Nocturnal Surge of Plasma Melatonin in Humans

1990 • 22 citations

Twenty‐four hour urinary excretion of 6‐hydroxymelatonin sulfate in Down syndrome subjects

1996 • 19 citations

Ethanol inhibits melatonin secretion in healthy volunteers in a dose- dependent randomized double blind cross-over study

1993 • 19 citations

Effect of MR imaging on the normal human pineal body: Measurement of plasma melatonin levels

1994 • 18 citations

Assignment of the chicken tyrosine hydroxylase gene to chromosome 6 by FISH

1992 • 16 citations

Melatonin rhythms in women with anorexia nervosa and bulimia nervosa

1993 • 13 citations

Impaired melatonin secretion in patients with Wernicke‐Korsakoff syndrome

1995 • 12 citations

Pineal research: the decade of transformation.

1978 • 11 citations

Melatonin Secretion in Normal Pressure Hydrocephalus After Cerebral Aneurysm Rupture

1991 • 8 citations

The Influence of Melatonin on the Human Circadian Clock

1995 • 7 citations

Deleted Work

1955 • 0 citations