Adenoviral Vector-Mediated Overexpression of IL-4 in the Knee Joint of Mice with Collagen-Induced Arthritis Prevents Cartilage Destruction

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction

1987 • 45,673 citations

Randomised double-blind comparison of chimeric monoclonal antibody to tumour necrosis factor α (cA2) versus placebo in rheumatoid arthritis

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Autoimmunity to type II collagen an experimental model of arthritis.

1977 • 1,599 citations

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Immunisation against heterologous type II collagen induces arthritis in mice

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Interleukin-1 Type II Receptor: A Decoy Target for IL-1 That Is Regulated by IL-4

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Inhibition of the production and effects of interleukins‐1 and tumor necrosis factor α in rheumatoid arthritis

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Quantitative analysis of cytokine gene expression in rheumatoid arthritis.

1990 • 610 citations

Anticytokine treatment of established type II collagen-induced arthritis in DBA/1 mice: A comparative study using anti-TNFα, anti-IL-1α/β and IL-1Ra

2008 • 514 citations

Role of interleukin‐4 and interleukin‐10 in murine collagen‐induced arthritis. Protective effect of interleukin‐4 and interleukin‐10 treatment on cartilage destruction

1997 • 404 citations

Role of interleukin‐1, tumor necrosis factor α, and interleukin‐6 in cartilage proteoglycan metabolism and destruction effect of in situ blocking in murine antigen‐ and zymosan‐induced arthritis

1995 • 376 citations

Anticytokine treatment of established type II collagen–induced arthritis in DBA/1 mice: A comparative study using anti‐TNFα, anti–IL‐1α/β, and IL‐1Ra

1996 • 370 citations

Interleukin (IL) 4 and IL-13 act on human lung fibroblasts. Implication in asthma.

1998 • 353 citations

Collagen-induced arthritis, an animal model of autoimmunity

1997 • 308 citations

Direct adenovirus-mediated gene transfer of interleukin 1 and tumor necrosis factor α soluble receptors to rabbit knees with experimental arthritis has local and distal anti-arthritic effects

1998 • 285 citations

Th1/Th2 cytokine balance in arthritis

1997 • 259 citations

Amelioration of established murine collagen-induced arthritis with anti-IL-1 treatment

1994 • 251 citations

THE THERAPEUTIC EFFECTS OF AN ENGINEERED HUMAN ANTI-TUMOUR NECROSIS FACTOR ALPHA ANTIBODY (CDP571) IN RHEUMATOID ARTHRITIS

1995 • 234 citations

Anti-Tumor Necrosis Factor-α Therapy of Rheumatoid Arthritis

1997 • 233 citations

Transfer of granulocyte-macrophage colony-stimulating factor gene to rat lung induces eosinophilia, monocytosis, and fibrotic reactions.

1996 • 229 citations

Autoantibody specificities of immune complexes sequestered in articular cartilage of patients with rheumatoid arthritis and osteoarthritis

1985 • 207 citations

Balance of IL-1 receptor antagonist/IL-1 beta in rheumatoid synovium and its regulation by IL-4 and IL-10.

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Nature and specificity of the immune response to collagen in type II collagen-induced arthritis in mice.

1982 • 189 citations

Prevention of murine collagen‐induced arthritis in the knee and ipsilateral paw by local expression of human interleukin‐1 receptor antagonist protein in the knee

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Adenoviral-mediated gene transfer to rabbit synovium in vivo.

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Elastase and cathepsin G of human monocytes. Quantification of cellular content, release in response to stimuli, and heterogeneity in elastase-mediated proteolytic activity.

1989 • 185 citations

Inhibition of the production of proinflammatory cytokines and immunoglobulins by interleukin‐4 in an ex vivo model of rheumatoid synovitis

1992 • 184 citations

Prevention and reversal of cartilage degradation in rheumatoid arthritis by interleukin‐10 and interleukin‐4

1996 • 174 citations

Suppression of monocyte function and differential regulation of IL-1 and IL-1ra by IL-4 contribute to resolution of experimental arthritis.

1993 • 173 citations

Suppression of metalloproteinase biosynthesis in human alveolar macrophages by interleukin-4.

1992 • 172 citations

Dual role of IL-12 in early and late stages of murine collagen type II arthritis.

1997 • 152 citations

Direct gene delivery to synovium: An evaluation of potential vectors in vitro and in vivo

1996 • 151 citations

Fibroblast chemotaxis induction by human recombinant interleukin-4. Identification by synthetic peptide analysis of two chemotactic domains residing in amino acid sequences 70-88 and 89-122.

1991 • 145 citations

Electrical charge of the antigen determines intraarticular antigen handling and chronicity of arthritis in mice.

1984 • 127 citations

VDIPEN, a metalloproteinase-generated neoepitope, is induced and immunolocalized in articular cartilage during inflammatory arthritis.

1995 • 125 citations

An update on interleukin-4 and its receptor.

1997 • 117 citations

Reduced cartilage proteoglycan loss during zymosan-induced gonarthritis in NOS2-deficient mice and in anti-interleukin-1-treated wild-type mice with unabated joint inflammation

1998 • 116 citations

Therapeutic effects of interleukin-4 gene transfer in experimental inflammatory bowel disease.

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Restricted cytokine expression in rheumatoid arthritis

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Lymphokine regulation of inflammatory processes: Interleukin-4 stimulates fibroblast proliferation

1988 • 98 citations

Inhibition of Interleukin-1-Induced Effects in Synoviocytes Transduced with the Human IL-1 Receptor Antagonist cDNA Using an Adenoviral Vector

1995 • 93 citations

REGULATORY ROLE OF INTERLEUKIN 10 IN JOINT INFLAMMATION AND CARTILAGE DESTRUCTION IN MURINE STREPTOCOCCAL CELL WALL (SCW) ARTHRITIS. MORE THERAPEUTIC BENEFIT WITH IL-4/IL-10 COMBINATION THERAPY THAN WITH IL-10 TREATMENT ALONE

1998 • 88 citations

Anti-T Cell Receptor Monoclonal Antibody Prolongs Transgene Expression Following Adenovirus-MediatedIn VivoGene Transfer to Mouse Synovium

1996 • 84 citations

THE ROLE OF IL-4 AND IL-6 IN IL-1-DEPENDENT CARTILAGE MATRIX DEGRADATION

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Interaction of polymorphonuclear leukocytes with immune complexes trapped in rheumatoid articular cartilage

1983 • 77 citations

Interleukin-1 receptor antagonist prevents expression of the metalloproteinase-generated neoepitope VDIPEN in antigen-induced arthritis

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Elastase secreted by activated polymorphonuclear leucocytes causes chondrocyte damage and matrix degradation in intact articular cartilage: escape from inactivation by alpha-1-proteinase inhibitor.

1987 • 56 citations

New Insights into the Pathogenesis and Treatment of Rheumatoid Arthritis

1997 • 51 citations

Quantification of mRNA levels in joint capsule and articular cartilage of the murine knee joint by RT-PCR: Kinetics of stromelysin and IL-1 mRNA levels during arthritis

1997 • 51 citations

Transgene-induced production of IL-4 alters the development and collagen expression of T helper cell 1-type pulmonary granulomas.

1997 • 46 citations

Antigen handling in antigen-induced arthritis in mice: an autoradiographic and immunofluorescence study using whole joint sections.

1982 • 46 citations

Interleukin-4, an inhibitor of cartilage breakdown in bovine articular cartilage explants.

1995 • 44 citations

Differential regulation of tumour necrosis factor receptors (TNF-R) by IL-4; upregulation of P55 and P75 TNF-R on synovial joint mononuclear cells

1993 • 37 citations

Tissue-specific expression of interleukin-4 induces extracellular matrix accumulation and extravasation of B cells.

1997 • 36 citations

Interleukin-4 blocks the release of collagen fragments from bovine nasal cartilage treated with cytokines

1996 • 34 citations

Interleukin-4 is chemotactic for mouse macrophages

1992 • 32 citations

Immune deposits in articular cartilage of patients with rheumatoid arthritis have a granular pattern not seen in osteoarthritis

1990 • 26 citations

Adhesion and TNF Priming in Neutrophil-Mediated Cartilage Damage

1996 • 20 citations

Elastase secreted by activated polymorphonuclear leukocytes causes chondrocyte damage and matrix degradation in intact articular cartilage

1988 • 20 citations

ADENOVIRUS-MEDIATED GENE TRANSFER IN RAT LIVER OF INTERLEUKIN 4 BUT NOT INTERLEUKIN 10 PRODUCES SEVERE ACUTE HEPATITIS

1997 • 20 citations

Inhibition by Interleukin-4 of Stromelysin Expression in Human Skin Fibroblasts: Role of PKC

1996 • 19 citations

Immobilization aggravates cartilage damage during antigen-induced arthritis in mice. Attachment of polymorphonuclear leukocytes to articular cartilage.

1990 • 11 citations