Inhibition of Interleukin-1-Induced Effects in Synoviocytes Transduced with the Human IL-1 Receptor Antagonist cDNA Using an Adenoviral Vector

A new technique for the assay of infectivity of human adenovirus 5 DNA

1973 • 9,740 citations

A Direct Spectrophotometric Microassay for Sulfated Glycosaminoglycans in Cartilage Cultures

1982 • 1,345 citations

Primary structure and functional expression from complementary DNA of a human interleukin-1 receptor antagonist

1990 • 1,095 citations

In vivo transfer of the human cystic fibrosis transmembrane conductance regulator gene to the airway epithelium

1992 • 953 citations

Expression of cystic fibrosis transmembrane conductance regulator corrects defective chloride channel regulation in cystic fibrosis airway epithelial cells

1990 • 706 citations

The functional relationship of the interleukins.

1980 • 660 citations

Human recombinant interleukin 1 stimulates collagenase and prostaglandin E2 production by human synovial cells.

1986 • 632 citations

Stimulation of rheumatoid synovial cell collagenase and prostaglandin production by partially purified lymphocyte-activating factor (interleukin 1).

1981 • 614 citations

Purification, cloning, expression and biological characterization of an interleukin-1 receptor antagonist protein

1990 • 609 citations

A model system for in vivo gene transfer into the central nervous system using an adenoviral vector

1993 • 588 citations

Localization of Tumor Necrosis Factor α in Synovial Tissues and at the Cartilage–Pannus Junction in Patients With Rheumatoid Arthritis

1991 • 585 citations

ELECTRON MICROSCOPY OF THE HUMAN SYNOVIAL MEMBRANE

1962 • 548 citations

Synergistic interactions between interleukin 1, tumor necrosis factor, and lymphotoxin in bone resorption.

1987 • 527 citations

Anchorage-independent growth of synoviocytes from arthritic and normal joints. Stimulation by exogenous platelet-derived growth factor and inhibition by transforming growth factor-beta and retinoids.

1989 • 320 citations

Intraarticular expression of biologically active interleukin 1-receptor-antagonist protein by ex vivo gene transfer.

1993 • 288 citations

Molecular and cellular mechanisms of joint destruction in rheumatoid arthritis: two cellular mechanisms explain joint destruction?

1993 • 272 citations

Gene Expression (Collagenase, Tissue Inhibitor of Metalloproteinases, Complement, and HLA–DR) in Rheumatoid Arthritis and Osteoarthritis Synovium. Quantitative Analysis and Effect of Intraarticular Corticosteroids

1991 • 262 citations

Adenovirus tripartite leader sequence enhances translation of mRNAs late after infection.

1984 • 234 citations

Pannus and pannocytes

1994 • 224 citations

Cytokines in chronic inflammatory arthritis. V. Mutual antagonism between interferon-gamma and tumor necrosis factor-alpha on HLA-DR expression, proliferation, collagenase production, and granulocyte macrophage colony-stimulating factor production by rheumatoid arthritis synoviocytes.

1990 • 214 citations

Prolonged Transgene Expression in Cotton Rat Lung with Recombinant Adenoviruses Defective in E2a

1994 • 212 citations

An IL-1 inhibitor from human monocytes. Production and characterization of biologic properties.

1989 • 208 citations

Adenovirus-Mediated Transfer of the CFTR Gene to Lung of Nonhuman Primates: Biological Efficacy Study

1993 • 196 citations

LOCALIZATION OF INTERLEUKIN-1α, TYPE 1 INTERLEUKIN-1 RECEPTOR AND INTERLEUKIN-1 RECEPTOR ANTAGONIST IN THE SYNOVIAL MEMBRANE AND CARTILAGE/PANNUS JUNCTION IN RHEUMATOID ARTHRITIS

1992 • 187 citations

Adenoviral-mediated gene transfer to rabbit synovium in vivo.

1993 • 186 citations

Transforming growth factor-beta production by synovial tissues from rheumatoid patients and streptococcal cell wall arthritic rats. Studies on secretion by synovial fibroblast-like cells and immunohistologic localization.

1989 • 161 citations

A urine inhibitor of interleukin 1 activity affects both interleukin 1 alpha and 1 beta but not tumor necrosis factor alpha.

1987 • 142 citations

Release of interleukin‐1 from human synovial tissue in vitro

1985 • 126 citations

Platelet-derived growth factor and IL-1 interactions in rheumatoid arthritis. Regulation of synoviocyte proliferation, prostaglandin production, and collagenase transcription.

1989 • 101 citations

Corticosteroids in rheumatoid arthritis

1989 • 79 citations

Expression of interleukin-1 and interleukin-1 receptor antagonist by human rheumatoid synovial tissue macrophages

1992 • 72 citations

Differential expression of Ia antigens by rheumatoid synovial lining cells.

1987 • 62 citations

Direct effects of a monoclonal B cell differentiation factor and of purified interleukin 1 on B cell differentiation.

1984 • 60 citations

Induction of human interleukin 1 mRNA measured by collagenase‐ and prostaglandin E₂‐stimulating activity in rheumatoid synovial cells

1984 • 59 citations

Human recombinant interleukin‐1β stimulates glycosaminoglycan production in human synovial fibroblast cultures

1987 • 55 citations

The Prevalence and Distribution of Macrophages Bearing FcγR I, FcγR II, and FcγR III in Synovium

1990 • 52 citations

Stimulation of procollagenase synthesis in human rheumatoid synovial fibroblasts by mononuclear cell factor/interleukin 1

1985 • 47 citations

Reduction of inflammation by decreasing production of interleukin-1 or by specific receptor antagonism.

1992 • 46 citations

Interleukin 1 stimulation of synovial cell plasminogen activator production.

1986 • 46 citations

Connective Tissue Activation. II. Abnormalities of Cultured Rheumatoid Synovial Cells

1971 • 43 citations

Modulation of the effects of interleukin‐1 on glycosaminoglycan synthesis by the urine‐derived interleukin‐1 inhibitor, but not by interleukin‐6

1990 • 42 citations

Synovial Membrane in Traumatic Effusion

1966 • 39 citations

Collagenase production by cultures containing multinucleated cells derived from synovial fibroblasts

1978 • 35 citations

Production and modulation of interleukin 6 synthesis by synoviocytes derived from patients with arthritic disease.

1992 • 28 citations

Regulation of the anti-Sm autoantibody response in systemic lupus erythematosus mice by monoclonal anti-Sm antibodies.

1990 • 26 citations