Differential regulation of tumour necrosis factor receptors (TNF-R) by IL-4; upregulation of P55 and P75 TNF-R on synovial joint mononuclear cells

THE ATTRACTIONS OF PROTEINS FOR SMALL MOLECULES AND IONS

1949 • 19,979 citations

Transgenic mice expressing human tumour necrosis factor: a predictive genetic model of arthritis.

1991 • 1,630 citations

A highly sensitive cell line, WEHI 164 clone 13, for measuring cytotoxic factor/tumor necrosis factor from human monocytes

1986 • 1,282 citations

INHIBITORY EFFECT OF TNF$alpha; ANTIBODIES ON SYNOVIAL CELL INTERLEUKIN-1 PRODUCTION IN RHEUMATOID ARTHRITIS

1989 • 1,137 citations

Characterization of receptors for human tumour necrosis factor and their regulation by γ-interferon

1985 • 896 citations

Potential antiinflammatory effects of interleukin 4: suppression of human monocyte tumor necrosis factor alpha, interleukin 1, and prostaglandin E2.

1989 • 741 citations

A tumor necrosis factor-binding protein purified to homogeneity from human urine protects cells from tumor necrosis factor toxicity

1989 • 442 citations

Increased expression of Ia antigens on resting B cells: an additional role for B-cell growth factor.

1984 • 438 citations

Interleukin-4 (IL-4) inhibits secretion of IL-1 beta, tumor necrosis factor alpha, and IL-6 by human monocytes

1990 • 438 citations

IL-4 down-regulates IL-1 and TNF gene expression in human monocytes.

1989 • 421 citations

TNFα—A PIVOTAL ROLE IN RHEUMATOID ARTHRITIS?

1992 • 377 citations

Increased levels of soluble tumor necrosis factor receptors in the sera and synovial fluid of patients with rheumatic diseases

1992 • 341 citations

Modulation of cytokine production by transforming growth factor-beta.

1989 • 331 citations

Coordinated antiinflammatory effects of interleukin 4: interleukin 4 suppresses interleukin 1 production but up-regulates gene expression and synthesis of interleukin 1 receptor antagonist.

1992 • 324 citations

Expression of granulocyte‐macrophage colony‐stimulating factor in rheumatoid arthritis: Regulation by tumor necrosis factor‐α

1991 • 290 citations

A human inhibitor of tumor necrosis factor alpha.

1988 • 264 citations

Recombinant interleukin 4 promotes the growth of human T cells.

1987 • 252 citations

Isolation and characterization of a tumor necrosis factor binding protein from urine

1989 • 249 citations

Increased serum levels of soluble receptors for tumor necrosis factor in cancer patients.

1991 • 234 citations

IL-4 increases human endothelial cell adhesiveness for T cells but not for neutrophils.

1990 • 217 citations

Localization of tumor necrosis factor receptors in the synovial tissue and cartilage‐pannus junction in patients with rheumatoid arthritis. Implications for local actions of tumor necrosis factor α

1992 • 216 citations

B cell growth-promoting activity of recombinant human interleukin 4.

1987 • 211 citations

Suppression of metalloproteinase biosynthesis in human alveolar macrophages by interleukin-4.

1992 • 172 citations

Detection of activated T cell products in the rheumatoid joint using cDNA probes to Interleukin-2 (IL-2) IL-2 receptor and IFN-gamma.

1988 • 147 citations

Cytokine production in culture by cells isolated from the synovial membrane

1989 • 135 citations

Macrophages rapidly internalize their tumor necrosis factor receptors in response to bacterial lipopolysaccharide

1989 • 131 citations

IL-1 expression in human monocytes is transcriptionally and posttranscriptionally regulated by IL-4.

1991 • 102 citations

Enhanced expression of tumor necrosis factor receptor mRNA and protein in mononuclear cells isolated from rheumatoid arthritis synovial joints

1992 • 93 citations

Antagonistic control of tumor necrosis factor receptors by protein kinases A and C. Enhancement of TNF receptor synthesis by protein kinase A and transmodulation of receptors by protein kinase C.

1989 • 74 citations

Interleukin 4 induces interleukin 6 production by endothelial cells: Synergy with interferon‐γ

1991 • 74 citations

Regulation of lymphocyte tumor necrosis factor receptors by IL-2.

1989 • 59 citations

Inverse Ir gene control of the antibody and T cell proliferative responses to human basement membrane collagen.

1987 • 46 citations

Increased expression of Ia antigens on resting B cells: An additional role for B-cell growth factor

1985 • 30 citations

Interleukin 4 (IL) 4 up‐regulates gene and surface IL 1 receptor type I in murine T helper type 2 cells

1992 • 22 citations

Inhibition of interleukin 4 receptor expression on human lymphoid cells by cyclosporin

1990 • 15 citations