Extracellular human immunodeficiency virus type 1 Tat protein is associated with an increase in both NF-kappa B binding and protein kinase C activity in primary human astrocytes

A Rapid and Sensitive Method for the Quantitation of Microgram Quantities of Protein Utilizing the Principle of Protein-Dye Binding

1976 • 225,752 citations

Intracellular Signaling by Hydrolysis of Phospholipids and Activation of Protein Kinase C

1992 • 4,480 citations

Integrins and Signal Transduction Pathways: the Road Taken

1995 • 3,002 citations

Production of acquired immunodeficiency syndrome-associated retrovirus in human and nonhuman cells transfected with an infectious molecular clone

1986 • 2,918 citations

Isoquinolinesulfonamides, novel and potent inhibitors of cyclic nucleotide-dependent protein kinase and protein kinase C

1984 • 2,728 citations

The bisindolylmaleimide GF 109203X is a potent and selective inhibitor of protein kinase C

1991 • 2,499 citations

A rapid micrqpreparation technique for extraction of DNA-binding proteins from limiting numbers of mammalian cells

1991 • 2,362 citations

Structure, Regulation and Function of NF-kappaB

1994 • 2,110 citations

Inducibility of κ immunoglobulin enhancer-binding protein NF-κB by a posttranslational mechanism

1986 • 2,043 citations

Integrin-mediated signal transduction linked to Ras pathway by GRB2 binding to focal adhesion kinase

1994 • 1,590 citations

Dithiocarbamates as potent inhibitors of nuclear factor kappa B activation in intact cells.

1992 • 1,524 citations

Control of IκB-α Proteolysis by Site-Specific, Signal-Induced Phosphorylation

1995 • 1,443 citations

TNF activates NF-κB by phosphatidylcholine-specific phospholipase C-induced “Acidic” sphingomyelin breakdown

1992 • 1,058 citations

IMF-κB and Rel: Participants in a Multiform Transcriptional Regulatory System

1993 • 967 citations

Tat protein of HIV-1 stimulates growth of cells derived from Kaposi's sarcoma lesions of AIDS patients

1990 • 899 citations

Trans -Activator Gene of Human T-Lymphotropic Virus Type III (HTLV-III)

1985 • 872 citations

Release, uptake, and effects of extracellular human immunodeficiency virus type 1 Tat protein on cell growth and viral transactivation

1993 • 805 citations

Mutual regulation of the transcriptional activator NF-kappa B and its inhibitor, I kappa B-alpha.

1993 • 639 citations

A second post-transcriptional trans-activator gene required for HTLV-III replication

1986 • 639 citations

The trans-activator gene of the human T cell lymphotropic virus type III is required for replication

1986 • 615 citations

Induction of Apoptosis in Uninfected Lymphocytes by HIV-1 Tat Protein

1995 • 581 citations

Synergy between basic fibroblast growth factor and HIV-1 Tat protein in induction of Kaposi's sarcoma

1994 • 571 citations

The HIV tat gene induces dermal lesions resembling Kaposi's sarcoma in transgenic mice

1988 • 532 citations

Endocytosis and targeting of exogenous HIV-1 Tat protein.

1991 • 481 citations

Tumor Necrosis Factor-α Activates the Sphingomyelin Signal Transduction Pathway in a Cell-Free System

1992 • 428 citations

The Tat protein of human immunodeficiency virus type 1, a growth factor for AIDS Kaposi sarcoma and cytokine-activated vascular cells, induces adhesion of the same cell types by using integrin receptors recognizing the RGD amino acid sequence.

1993 • 355 citations

Calcium-dependent killing of immature thymocytes by stimulation via the CD3/T cell receptor complex.

1989 • 315 citations

Identification of a human immunodeficiency virus type 1 Tat epitope that is neuroexcitatory and neurotoxic

1996 • 310 citations

Association of type 3 protein kinase C with focal contacts in rat embryo fibroblasts.

1989 • 310 citations

Evidence for neurotoxic activity of tat from human immunodeficiency virus type 1

1991 • 305 citations

Immunocytochemical Localization of Eight Protein Kinase C Isozymes Overexpressed in NIH 3T3 Fibroblasts

1995 • 302 citations

Inducible phosphorylation of I kappa B alpha is not sufficient for its dissociation from NF-kappa B and is inhibited by protease inhibitors.

1994 • 302 citations

Effects of the human immunodeficiency virus type 1 Tat protein on the expression of inflammatory cytokines

1992 • 289 citations

Human immunodeficiency virus type 1 tat activates non—N‐methyl‐<scp>D</scp>‐aspartate excitatory amino acid receptors and causes neurotoxicity

1995 • 277 citations

Inhibition of DNA Fragmentation in Thymocytes and Isolated Thymocyte Nuclei by Agents That Stimulate Protein Kinase C

1989 • 276 citations

A novel integrin specificity exemplified by binding of the alpha v beta 5 integrin to the basic domain of the HIV Tat protein and vitronectin.

1993 • 264 citations

Persistent human immunodeficiency virus type 1 infection in human fetal glial cells reactivated by T-cell factor(s) or by the cytokines tumor necrosis factor alpha and interleukin-1 beta

1991 • 254 citations

The expression of the interleukin 6 gene is induced by the human immunodeficiency virus 1 TAT protein.

1994 • 250 citations

Absolute dependence on kappa B responsive elements for initiation and Tat-mediated amplification of HIV transcription in blood CD4 T lymphocytes.

1995 • 233 citations

zeta PKC induces phosphorylation and inactivation of I kappa B-alpha in vitro.

1994 • 231 citations

A Dominant Negative Protein Kinase C ζ Subspecies Blocks NF-κ B Activation

1993 • 223 citations

Tat protein of human immunodeficiency virus type 1 represses expression of manganese superoxide dismutase in HeLa cells.

1993 • 212 citations

Pyrrolidine dithiocarbamate, a potent inhibitor of nuclear factor κB (NF-κB) activation, prevents apoptosis in human promyelocytic leukemia HL-60 cells and thymocytes

1994 • 211 citations

Protein kinase C-independent activation of nuclear factor kappa B by tumor necrosis factor.

1990 • 193 citations

Sublethal Levels of Oxidant Stress Stimulate Multiple Serine/Threonine Kinases and Suppress Protein Phosphatases in Jurkat T Cells

1995 • 181 citations

Identification of an Arg-Gly-Asp (RGD) cell adhesion site in human immunodeficiency virus type 1 transactivation protein, tat.

1990 • 177 citations

[14] Assessing oxygen radicals as mediators in activation of inducible eukaryotic transcription factor NF-κB

1994 • 168 citations

Hypoxic activation of nuclear factor-kappa B is mediated by a Ras and Raf signaling pathway and does not involve MAP kinase (ERK1 or ERK2).

1994 • 151 citations

Envelope glycoprotein gp120 of human immunodeficiency virus type 1 alters ion transport in astrocytes: implications for AIDS dementia complex.

1994 • 148 citations

Human immunodeficiency virus type 1 Tat protein protects lymphoid, epithelial, and neuronal cell lines from death by apoptosis.

1993 • 128 citations

Astrocyte cultures from human embryonic brain: Characterization and modulation of surface molecules by inflammatory cytokines

1992 • 122 citations

Human T-cell leukemia virus type I Tax induces expression of the Rel-related family of kappa B enhancer-binding proteins: evidence for a pretranslational component of regulation

1991 • 116 citations

Activation of HIV transcription by Tat

1992 • 111 citations

Sphingomyelinase activates proteolytic I kappa B-alpha degradation in a cell-free system.

1994 • 100 citations

Participation of Tyrosine Phosphorylation in the Cytopathic Effect of Human Immunodeficiency Virus-1

1992 • 98 citations

Specific NF-kappa B subunits act in concert with Tat to stimulate human immunodeficiency virus type 1 transcription

1992 • 98 citations

Extracellular Tax1 protein stimulates tumor necrosis factor-beta and immunoglobulin kappa light chain expression in lymphoid cells

1992 • 87 citations

HIV-1 transactivator protein Tat induces proliferation and TGF beta expression in human articular chondrocytes

1994 • 77 citations

Studies with synthetic peptide substrates derived from the neuronal protein neurogranin reveal structural determinants of potency and selectivity for protein kinase C

1993 • 75 citations

Liver cancer in transgenic mice carrying the human immunodeficiency virus tat gene.

1991 • 70 citations

Adhesion to human neurons and astrocytes of monocytes: the role of interaction of CR3 and ICAM-1 and modulation by cytokines

1995 • 55 citations

Human T-cell leukemia virus type I Tax-protein-mediated activation of NF-kappa B from p100 (NF-kappa B2)-inhibited cytoplasmic reservoirs.

1994 • 55 citations

Early appearance of type II astrocytes in developing human fetal brain

1988 • 54 citations

Chronic human immunodeficiency virus type 1 infection stimulates distinct NF-kappa B/rel DNA binding activities in myelomonoblastic cells

1993 • 50 citations

Proliferation of human and mouse astrocytes in vitro: signalling through the protein kinase C pathway

1992 • 47 citations

Involvement of protein kinase-C in the mitogenic effect of insulin-like growth factor-I on rat astrocytes.

1992 • 46 citations

Differential nuclear localization of protein kinase C isoforms in neuroblastoma × glioma hybrid cells

1994 • 46 citations

Second‐messenger pathways involved in the regulation of survival in germinal‐centre B cells and in burkitt lymphoma lines

1992 • 46 citations

Induction of monocytic differentiation and NF-kappa B-like activities by human immunodeficiency virus 1 infection of myelomonoblastic cells.

1992 • 44 citations

TAR-independent replication of human immunodeficiency virus type 1 in glial cells

1992 • 43 citations

Influence of the human immunodeficiency virus type 1 Tat protein on the proliferation and differentiation of PC12 rat pheochromocytoma cells

1993 • 43 citations

HIV Type 1 Tat Protein Induces Immunoglobulin and Interleukin 6 Synthesis by Uninfected Peripheral Blood Mononuclear Cells

1994 • 42 citations

Stimulation of HIV Type 1 Gene Expression and Induction of NF-κB (p50/p65)-Binding Activity in Tumor Necrosis Factor α-Treated Human Fetal Glial Cells

1994 • 39 citations

A Combination of Calcium Ionophore and 12‐O‐Tetradecanoyl‐Phorbol‐13‐Acetate (TPA) Stimulates the Growth of Purified Resting B Cells

1985 • 39 citations

Protein kinase C activation without membrane contact in platelets stimulated by bryostatin.

1993 • 37 citations

An increase in p50/p65 NF-kB Binding to the HIV-1 LTR Is Not Sufficient to Increase Viral Expression in the Primary Human Astrocyte

1994 • 21 citations

Use of the Synthetic Peptide Neurogranin(28-43) as a Selective Protein Kinase C Substrate in Assays of Tissue Homogenates

1993 • 19 citations

Induction of apoptosis in thymocytes: new evidence for an interaction of PKC and PKA pathways.

1995 • 19 citations

Distribution and characteristics of Ca+2- phosphatidylserine-dependent protein kinase C in subcellular fractions and lamellar bodies of adult rabbit lung

1994 • 3 citations

Deleted Work

1955 • 0 citations