Evidence that agonist-induced activation of calpain causes the shedding of procoagulant-containing microvesicles from the membrane of aggregating platelets

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications.

1979 • 54,907 citations

The Nature and Significance of Platelet Products in Human Plasma

1967 • 1,471 citations

THE MEMBRANE SKELETON OF HUMAN ERYTHROCYTES AND ITS IMPLICATIONS FOR MORE COMPLEX CELLS

1985 • 673 citations

Assembly of the Platelet Prothrombinase Complex Is Linked to Vesiculation of the Platelet Plasma Membrane

1989 • 597 citations

Generation of Prothrombin‐Converting Activity and the Exposure of Phosphatidylserine at the Outer Surface of Platelets

1982 • 472 citations

Platelet surface glycoproteins. Studies on resting and activated platelets and platelet membrane microparticles in normal subjects, and observations in patients during adult respiratory distress syndrome and cardiac surgery.

1986 • 457 citations

Thrombosis and haemostasis

1988 • 327 citations

Stabilizing Infrastructure of Cell Membranes

1985 • 317 citations

Brain fodrin: substrate for calpain I, an endogenous calcium-activated protease.

1984 • 294 citations

Loss of membrane phospholipid asymmetry in platelets and red cells may be associated with calcium-induced shedding of plasma membrane and inhibition of aminophospholipid translocase

1990 • 290 citations

Isolation of human platelet membrane microparticles from plasma and serum

1982 • 281 citations

Ca2+-dependent protease in human platelets. Specific cleavage of platelet polypeptides in the presence of added Ca2+.

1977 • 274 citations

Synthesis of a new cell penetrating calpain inhibitor (calpeptin)

1988 • 254 citations

Identification of actin-binding protein as the protein linking the membrane skeleton to glycoproteins on platelet plasma membranes.

1985 • 236 citations

Identification of two proteins (actin-binding protein and P235) that are hydrolyzed by endogenous Ca2+-dependent protease during platelet aggregation.

1985 • 236 citations

The formation of plasma membrane blebs in hepatocytes exposed to agents that increase cytosolic Ca²⁺ is mediated by the activation of a non‐lysosomal proteolytic system

1986 • 188 citations

Calcium-dependent proteolysis occurs during platelet aggregation.

1983 • 185 citations

In vitro and in vivo inhibition of cysteine proteinases by EST, a new analog of E-64.

1986 • 175 citations

Linkage of a membrane skeleton to integral membrane glycoproteins in human platelets. Identification of one of the glycoproteins as glycoprotein Ib.

1985 • 173 citations

Role of calcium and calpain in complement-induced vesiculation of the platelet plasma membrane and in the exposure of the platelet factor Va receptor

1990 • 166 citations

On the association of glycoprotein Ib and actin-binding protein in human platelets.

1985 • 165 citations

Role of the membrane skeleton in preventing the shedding of procoagulant-rich microvesicles from the platelet plasma membrane.

1990 • 162 citations

The Presence of Contractile Proteins in Platelet Microparticles Isolated from Human and Animal Platelet-free Plasma

1971 • 139 citations

Calmodulin and calcium-dependent protease I coordinately regulate the interaction of fodrin with actin.

1990 • 131 citations

Human platelet secretion and aggregation induced by calcium ionophores. Inhibition by PGE1 and dibutyryl cyclic AMP.

1975 • 127 citations

Spectrin is associated with membrane-bound actin filaments in platelets and is hydrolyzed by the Ca2+-dependent protease during platelet activation

1987 • 123 citations

Expression of coagulant activity in human platelets: Release of membranous vesicles providing platelet factor 1 and platelet factor 3

1985 • 119 citations

Properties of smooth muscle vinculin.

1984 • 116 citations

Structure of the glycoprotein Ib.IX complex from platelet membranes.

1988 • 114 citations

Platelet membrane microparticles in blood bank fresh frozen plasma and cryoprecipitate

1986 • 105 citations

Inhibition of the proteolysis of rat erythrocyte membrane proteins by a synthetic inhibitor of calpain

1988 • 99 citations

On the mechanism by which complement proteins C5b-9 increase platelet prothrombinase activity.

1986 • 90 citations

Phorbol ester stimulates the phosphorylation of rabbit erythrocyte band 4.1

1984 • 88 citations

Association of factor V activity with membranous vesicles released from human platelets: Requirement for platelet stimulation

1985 • 69 citations

The role of calpain in stimulus-response coupling: evidence that calpain mediates agonist-induced expression of procoagulant activity in platelets

1990 • 66 citations

Isolation and characterization of lipid-protein particles containing platelet factor 3 released from human platelets

1982 • 66 citations

Localization of the domain of actin-binding protein that binds to membrane glycoprotein Ib and actin in human platelets.

1988 • 63 citations

Calpain I remains intact and intracellular during platelet activation. Immunochemical measurements with monoclonal and polyclonal antibodies

1987 • 52 citations

Effects of local anesthetics on human platelets: filopodial suppression and endogenous proteolysis

1979 • 45 citations

Limited proteolysis of the erythrocyte membrane skeleton by calcium-dependent proteinases

1986 • 44 citations

Human platelet calmodulin-binding proteins: identification and calcium-dependent proteolysis upon platelet activation

1987 • 37 citations

Platelet storage lesion: Formation of platelet fragments with platelet factor 3 activity

1987 • 36 citations

Polymorphism of α‐actinin from human blood platelets Homodimeric and heterodimeric forms

1984 • 18 citations

Differentiation of factor V-like coagulant activity from catalytic phospholipid-like surface activity in membrane fractions derived from human platelets

1981 • 15 citations