Direct detection of activated platelets and platelet-derived microparticles in humans

[1] Preparation of monoclonal antibodies: Strategies and procedures

1981 • 1,787 citations

A better cell line for making hybridomas secreting specific antibodies

1978 • 1,649 citations

The Nature and Significance of Platelet Products in Human Plasma

1967 • 1,471 citations

Complement Activation during Cardiopulmonary Bypass

1981 • 1,163 citations

Platelet Activation in Unstable Coronary Disease

1986 • 1,161 citations

[28] Enzyme immunoassay ELISA and EMIT

1980 • 1,014 citations

Changes in the platelet membrane glycoprotein IIb.IIIa complex during platelet activation.

1985 • 968 citations

Exposure of platelet fibrinogen receptors by ADP and epinephrine.

1979 • 868 citations

Coronary Vasospasm as a Possible Cause of Myocardial Infarction

1978 • 845 citations

Detection of activated platelets in whole blood using activation- dependent monoclonal antibodies and flow cytometry

1987 • 736 citations

Mechanism of abnormal bleeding in patients undergoing cardiopulmonary bypass: acquired transient platelet dysfunction associated with selective alpha-granule release.

1980 • 677 citations

Complement proteins C5b-9 cause release of membrane vesicles from the platelet surface that are enriched in the membrane receptor for coagulation factor Va and express prothrombinase activity.

1988 • 663 citations

Release of Prostaglandins and Thromboxane into the Coronary Circulation in Patients with Ischemic Heart Disease

1981 • 597 citations

Hypothermia-induced Reversible Platelet Dysfunction

1987 • 571 citations

Platelet surface glycoproteins. Studies on resting and activated platelets and platelet membrane microparticles in normal subjects, and observations in patients during adult respiratory distress syndrome and cardiac surgery.

1986 • 457 citations

A monoclonal antibody to a membrane glycoprotein binds only to activated platelets.

1984 • 456 citations

Marked platelet activation in vivo after intravenous streptokinase in patients with acute myocardial infarction.

1988 • 441 citations

A platelet membrane protein expressed during platelet activation and secretion. Studies using a monoclonal antibody specific for thrombin-activated platelets.

1984 • 426 citations

Shear-induced platelet aggregation requires von Willebrand factor and platelet membrane glycoproteins Ib and IIb-IIIa

1987 • 291 citations

Studies with a monoclonal antibody against activated platelets: evidence that a secreted 53,000-molecular weight lysosome-like granule protein is exposed on the surface of activated platelets in the circulation

1987 • 282 citations

11-Dehydrothromboxane B2: a quantitative index of thromboxane A2 formation in the human circulation.

1986 • 281 citations

Isolation of human platelet membrane microparticles from plasma and serum

1982 • 281 citations

Inhibition of fibrinogen binding to stimulated human platelets by a monoclonal antibody.

1983 • 280 citations

Does the conformation of adsorbed fibrinogen dictate platelet interactions with artificial surfaces?

1986 • 243 citations

Induction of the fibrinogen receptor on human platelets by intracellular mediators.

1987 • 240 citations

Elevated plasma fibrinopeptide A and thromboxane B2 levels during cardiopulmonary bypass.

1980 • 187 citations

Diagnosis of Bernard-Soulier syndrome and Glanzmann's thrombasthenia with a monoclonal assay on whole blood.

1983 • 185 citations

Biochemical evidence of platelet activation in patients with persistent unstable angina

1987 • 178 citations

Coronary artery thrombosis in patients with unstable angina.

1981 • 168 citations

Expression of coagulant activity in human platelets: Release of membranous vesicles providing platelet factor 1 and platelet factor 3

1985 • 119 citations

Increased thromboxane biosynthesis in a human preparation of platelet activation: biochemical and functional consequences of selective inhibition of thromboxane synthase.

1986 • 114 citations

Acquired decrease in platelet secretory ADP associated with increased postoperative bleeding in post-cardiopulmonary bypass patients and in patients with severe valvular heart disease

1978 • 113 citations

Platelet membrane microparticles in blood bank fresh frozen plasma and cryoprecipitate

1986 • 105 citations

Evidence for tissue factor-dependent activation of the classic extrinsic coagulation mechanism in blood obtained from bleeding time wounds

1988 • 99 citations

Biosynthesis of thromboxane in patients with systemic sclerosis and Raynaud's phenomenon.

1986 • 89 citations

Heterogeneity of platelet secretion in response to thrombin demonstrated by fluorescence flow cytometry

1987 • 88 citations

Red-Cell and Platelet Fragmentation in Idiopathic Autoimmune Thrombocytopenic Purpura

1977 • 85 citations

Microthrombocytosis and Platelet Fragmentation Associated with Idiopathic/Autoimmune Thrombocytopenic Purpura

1975 • 74 citations

Fibrinogen receptors in platelet adhesion to surfaces of extracorporeal circuit

1987 • 70 citations

Identification of platelet glycoprotein IIb/IIIa as the major binding site for released platelet-von Willebrand factor [published erratum appears in Blood 1987 Jun;69(6):1789]

1986 • 67 citations

Investigation of the Interaction of Blood Platelets with the Coagulation System at the Site of Plug Formation In Vivo in Man - Effect of Low-Dose Aspirin

1987 • 67 citations

Expression of fibrinogen receptors during activation and subsequent desensitization of human platelets by epinephrine

1986 • 59 citations

The in vitro synthesis of polypeptides for the platelet membrane glycoproteins IIb and IIIa

1987 • 58 citations

Identification of platelet glycoprotein IIb/IIIa as the major binding site for released platelet-von Willebrand factor [published erratum appears in Blood 1987 Jun;69(6):1789]

1986 • 51 citations

Stimulus–Response Coupling Mechanisms

1986 • 51 citations

Antithrombotic therapy: role of platelet-inhibitor drugs. I. Current concepts of thrombogenesis: role of platelets. (first of three parts).

1981 • 47 citations

The release of β‐ thromboglobulin and platelet factor 4 during extracorporeal circulation for open heart surgery

1981 • 45 citations

Hematologic aspects of cardiotomy suction in cardiac operations

1980 • 42 citations

Human platelet fibrinogen: purification and hemostatic properties

1985 • 38 citations

The effect of thrombin on the density distribution of blood platelets: detection of activated platelets in the circulation

1983 • 37 citations

Platelet storage lesion: Formation of platelet fragments with platelet factor 3 activity

1987 • 36 citations

von Willebrand factor is present on the surface of platelets stimulated in plasma by ADP

1987 • 27 citations

Secreted Platelet Proteins as Markers for Pathological Disorders

1986 • 23 citations

Platelet alpha granule depletion: Findings in patients with prosthetic heart valves and following cardiopulmonary bypass surgery

1983 • 20 citations

Biosynthesis of thromboxane in patients with systemic sclerosis and Raynaud's phenomenon

1987 • 13 citations

Review of antiplatelet drug use in preventing restenosis following percutaneous transluminal coronary angioplasty.

1988 • 9 citations

Expression, regulation and detection of fibrinogen receptors on activated human platelets.

1988 • 7 citations