Insulin‐like growth factor (IGF)‐I rescues breast cancer cells from chemotherapy‐induced cell death – proliferative and anti‐apoptotic effects

Akt Phosphorylation of BAD Couples Survival Signals to the Cell-Intrinsic Death Machinery

1997 • 5,665 citations

Serine Phosphorylation of Death Agonist BAD in Response to Survival Factor Results in Binding to 14-3-3 Not BCL-XL

1996 • 2,627 citations

The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase

1995 • 2,024 citations

Taxol stabilizes microtubules in mouse fibroblast cells.

1980 • 1,942 citations

Adriamycin-Induced DNA Damage Mediated by Mammalian DNA Topoisomerase II

1984 • 1,477 citations

Antiapoptotic Signalling by the Insulin-Like Growth Factor I Receptor, Phosphatidylinositol 3-Kinase, and Akt

1997 • 1,051 citations

A study of some variables in a tetrazolium dye (MTT) based assay for cell growth and chemosensitivity

1987 • 940 citations

The IGF-I receptor in cell growth, transformation and apoptosis

1997 • 446 citations

Taxol: Mechanisms of Action and Resistancea

1986 • 415 citations

Taxol binds to cellular microtubules.

1982 • 408 citations

Mechanisms of Taxol-induced cell death are concentration dependent.

1998 • 387 citations

Microtubule-interfering Agents Activate c-Jun N-terminal Kinase/Stress-activated Protein Kinase through Both Ras and Apoptosis Signal-regulating Kinase Pathways

1998 • 353 citations

Insulin-like growth factor receptor expression and function in human breast cancer.

1990 • 321 citations

Insulin-like growth factor I (IGF-I) and the IGF-I receptor prevent etoposide-induced apoptosis.

1995 • 286 citations

A dominant negative mutant of the insulin-like growth factor-I receptor inhibits the adhesion, invasion, and metastasis of breast cancer.

1998 • 274 citations

Mitogenic Signaling of Insulin-like Growth Factor I in MCF-7 Human Breast Cancer Cells Requires Phosphatidylinositol 3-Kinase and Is Independent of Mitogen-activated Protein Kinase

1997 • 262 citations

Identification of Domains of the Insulin-Like Growth Factor I Receptor That Are Required for Protection from Apoptosis

1997 • 258 citations

Activation of estrogen receptor-mediated gene transcription by IGF-I in human breast cancer cells

1997 • 183 citations

Insulin Receptor Substrate-1 is the Predominant Signaling Molecule Activated by Insulin-like Growth Factor-I, Insulin, and Interleukin-4 in Estrogen Receptor-positive Human Breast Cancer Cells

1998 • 174 citations

Requirement for phosphatidylinositol 3'-kinase to protect hemopoietic progenitors against apoptosis depends upon the extracellular survival factor.

1996 • 171 citations

The effects of chemotherapy on morphology, cellular proliferation, apoptosis and oncoprotein expression in primary breast carcinoma

1994 • 146 citations

The Insulin-Like Growth Factor-I Receptor Signaling Pathways Are Important for Tumorigenesis and Inhibition of Apoptosis

1997 • 137 citations

Paclitaxel-induced apoptosis in MCF-7 breast-cancer cells

1997 • 115 citations

Adriamycin activates c-jun N-terminal kinase in human leukemia cells: a relevance to apoptosis

1996 • 104 citations

Role of IGF-I in normal mammary development

1998 • 93 citations

Expression of the insulin-like growth factor I receptor C terminus as a myristylated protein leads to induction of apoptosis in tumor cells.

1998 • 60 citations

Insulin-like growth factor-I promotes multidrug resistance in MCLM colon cancer cells

1998 • 54 citations

The Role of the Insulin‐like Growth Factor I Receptor in Transformation and Apoptosis

1998 • 53 citations

Impairment of survival factor function potentiates chemotherapy-induced apoptosis in tumor cells.

1998 • 37 citations

Insulin-like Growth Factor-1 Inhibits Cell Death Induced by Anticancer Drugs in the MCF-7 Cells: Involvement of Growth Factors in Drug Resistance

1995 • 32 citations