Probing Keratinocyte and Differentiation Specificity of the Human K5 Promoter in Vitro and in Transgenic Mice

A Rapid and Sensitive Method for the Quantitation of Microgram Quantities of Protein Utilizing the Principle of Protein-Dye Binding

1976 • 225,752 citations

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

1976 • 200,127 citations

Molecular cloning: A laboratory manual

1990 • 85,659 citations

Recombinant genomes which express chloramphenicol acetyltransferase in mammalian cells.

1982 • 8,069 citations

Rapid and efficient site-specific mutagenesis without phenotypic selection.

1985 • 7,573 citations

The catalog of human cytokeratins: Patterns of expression in normal epithelia, tumors and cultured cells

1982 • 5,272 citations

CAT constructions with multiple unique restriction sites for the functional analysis of eukaryotic promoters and regulatory elements

1987 • 1,792 citations

The “initiator” as a transcription control element

1989 • 1,597 citations

Differentiation-related expression of a major 64K corneal keratin in vivo and in culture suggests limbal location of corneal epithelial stem cells.

1986 • 1,378 citations

Changes in keratin gene expression during terminal differentiation of the keratinocyte

1980 • 1,059 citations

Promoter-specific activation of RNA polymerase II transcription by Sp1

1986 • 1,054 citations

Transcriptional repression by YY1, a human GLI-Krüippel-related protein, and relief of repression by adenovirus E1A protein

1991 • 1,023 citations

Widespread occurrence of intermediate-sized filaments of the vimentin-type in cultured cells from diverse vertebrates

1979 • 642 citations

Transcription factor AP-2 is expressed in neural crest cell lineages during mouse embryogenesis.

1991 • 593 citations

Developmental Expression of Sp1 in the Mouse

1991 • 533 citations

Cooperative interaction of an initiator-binding transcription initiation factor and the helix–loop–helix activator USF

1991 • 505 citations

YY1 is an initiator sequence-binding protein that directs and activates transcription in vitro

1991 • 465 citations

Transgenic mice provide new insights into the role of TGF-alpha during epidermal development and differentiation.

1991 • 407 citations

Spontaneous calcium release from inositol trisphosphate-sensitive calcium stores

1991 • 366 citations

Tissue-specific and differentiation-specific expression of a human K14 keratin gene in transgenic mice.

1989 • 365 citations

Isolation of a candidate repressor/activator, NF-E1 (YY-1, delta), that binds to the immunoglobulin kappa 3' enhancer and the immunoglobulin heavy-chain mu E1 site.

1991 • 357 citations

The 50- and 58-kdalton keratin classes as molecular markers for stratified squamous epithelia: cell culture studies.

1983 • 355 citations

Transcriptional regulation of the human papillomavirus-16 E6-E7 promoter by a keratinocyte-dependent enhancer, and by viral E2 trans-activator and repressor gene products: implications for cervical carcinogenesis.

1987 • 327 citations

Cell type heterogeneity of cytokeratin expression in complex epithelia and carcinomas as demonstrated by monoclonal antibodies specific for cytokeratins nos. 4 and 13

1986 • 310 citations

A liver-specific factor essential for albumin transcription differs between differentiated and dedifferentiated rat hepatoma cells.

1988 • 307 citations

Delta, a transcription factor that binds to downstream elements in several polymerase II promoters, is a functionally versatile zinc finger protein.

1991 • 303 citations

Expression of epidermal keratins and filaggrin during human fetal skin development.

1985 • 284 citations

A sensitive method for the detection of beta-galactosidase in transfected mammalian cells.

1991 • 283 citations

A new small (40 kd) keratin filament protein made by some cultured human squamous cell carcinomas

1981 • 254 citations

Transcription factor AP2 and its role in epidermal-specific gene expression.

1991 • 234 citations

Interleukin 6: insights to its function in skin by overexpression in transgenic mice.

1992 • 221 citations

Patterns of expression of trichocytic and epithelial cytokeratins in mammalian tissues II. Concomitant and mutually exclusive synthesis of trichocytic and epithelial cytokeratins in diverse human and bovine tissues (hair follicle, nail bed and matrix, lingual papilla, thymic reticulum)

1988 • 189 citations

Regulated expression of differentiation-associated keratins in cultured epidermal cells detected by monospecific antibodies to unique peptides of mouse epidermal keratins

1987 • 187 citations

The Molecular Biology of Intermediate Filament Proteins

1992 • 177 citations

A new look into an old problem: keratins as tools to investigate determination, morphogenesis, and differentiation in skin.

1989 • 155 citations

Cachexia and graft-vs.-host-disease-type skin changes in keratin promoter-driven TNF alpha transgenic mice.

1992 • 150 citations

Regulation of a human epidermal keratin gene: sequences and nuclear factors involved in keratinocyte-specific transcription.

1990 • 144 citations

Complete sequence of a gene encoding a human type I keratin: sequences homologous to enhancer elements in the regulatory region of the gene.

1985 • 142 citations

A variant nuclear protein in dedifferentiated hepatoma cells binds to the same functional sequences in the beta fibrinogen gene promoter as HNF-1.

1988 • 139 citations

Keratins of the human hair follicle: “Hyperproliferative” keratins consistently expressed in outer root sheath cells in vivo and in vitro

1987 • 135 citations

Expression of hair-related keratins in a soft epithelium: Subpopulations of human and mouse dorsal tongue keratinocytes express keratin markers for hair-, skin- and esophageal-types of differentiation

1989 • 127 citations

A downstream initiation element required for efficient TATA box binding and in vitro function of TFIID

1990 • 127 citations

A DEVELOPMENTAL STUDY OF THE DISTRIBUTION AND FREQUENCY OF LANGERHANS CELLS IN RELATION TO FORMATION OF PATTERNING IN MOUSE TAIL EPIDERMIS

1977 • 123 citations

Patterns of expression of trichocytic and epithelial cytokeratins in mammalian tissues

1988 • 121 citations

Detection of Somatic DNA Recombination in the Transgenic Mouse Brain

1991 • 121 citations

Expression of keratin 5 as a distinctive feature of epithelial and biphasic mesotheliomas

1989 • 116 citations

Differentially expressed bovine cytokeratin genes. Analysis of gene linkage and evolutionary conservation of 5′-upstream sequences.

1987 • 112 citations

Cloning of the human keratin 18 gene and its expression in nonepithelial mouse cells.

1988 • 111 citations

A keratinocyte-specific transcription factor, KRF-1, interacts with AP-1 to activate expression of human papillomavirus type 18 in squamous epithelial cells.

1991 • 103 citations

Retinoid-mediated transcriptional regulation of keratin genes in human epidermal and squamous cell carcinoma cells.

1991 • 100 citations

The erythroid-specific protein cGATA-1 mediates distal enhancer activity through a specialized beta-globin TATA box.

1992 • 98 citations

Enhancer elements directing cell-type-specific expression of cytokeratin genes and changes of the epithelial cytoskeleton by transfections of hybrid cytokeratin genes.

1989 • 97 citations

Nuclear receptors for retinoic acid and thyroid hormone regulate transcription of keratin genes.

1990 • 96 citations

Functional mapping of the human papillomavirus type 11 transcriptional enhancer and its interaction with the trans-acting E2 proteins.

1988 • 93 citations

Isolation, Sequence, and Expression of a Human Keratin K5 Gene: Transcriptional Regulation of Keratins and Insights into Pairwise Control

1989 • 93 citations

Transcription factor AP-2 is tissue-specific in Xenopus and is closely related or identical to Keratin Transcription Factor 1 (KTF-1)

1991 • 91 citations

Transcriptional activators in hepatocytes.

1990 • 90 citations

α-Actinins, Calspectin (Brain Spectrin or Fodrin), and Actin Participate in Adhesion and Movement of Growth Cones

1989 • 89 citations

Identification of a novel constitutive enhancer element and an associated binding protein: implications for human papillomavirus type 11 enhancer regulation

1989 • 83 citations

Intermediate Filament Structure

1990 • 77 citations

Sequence and expression of a type II keratin, K5, in human epidermal cells.

1988 • 74 citations

Transcriptional regulation of a Xenopus embryonic epidermal keratin gene

1989 • 73 citations

Neuronal Expression of chimeric genes in transgenic mice

1988 • 68 citations

The pituitary-specific regulatory gene GHF1 contains a minimal cell type-specific promoter centered around its TATA box.

1991 • 62 citations

Distribution of a special subset of keratinocytes characterized by the expression of cytokeratin 9 in adult and fetal human epidermis of various body sites

1987 • 58 citations

KTF-1, a transcriptional activator of Xenopus embryonic keratin expression

1990 • 57 citations

Differential localization of distinct keratin mRNA-species in mouse tongue epithelium by in situ hybridization with specific cDNA probes.

1986 • 53 citations

A human epidermal differentiation-specific keratin gene is regulated by calcium but not negative modulators of differentiation in transgenic mouse keratinocytes.

1991 • 52 citations

Changes in regional keratin polypeptide patterns during phorbol ester-mediated reversible and permanently sustained hyperplasia of mouse epidermis.

1982 • 48 citations

Transcription of the mouse secretory protease inhibitor p12 gene is activated by the developmentally regulated positive transcription factor Sp1.

1992 • 44 citations

Negative regulation of the major histocompatibility complex class I promoter in embryonal carcinoma cells.

1991 • 43 citations

Keratins 1 and 10 or homologues as regular constituents of inner root sheath and cuticle cells in the human hair follicle.

1990 • 43 citations

Homologous and heterologous enhancers modulate spatial expression but not cell-type specificity of the murine γF-crystallin promoter

1990 • 42 citations

Nuclear Proteins Involved in Transcription of the Human K5 Keratin Gene

1992 • 41 citations

Functional Comparison of the Upstream Regulatory DNA Sequences of Four Human Epidermal Keratin Genes

1991 • 37 citations

Delineation of human papillomavirus type 18 enhancer binding proteins: the intracellular distribution of a novel octamer binding protein p92 is cell cycle regulated

1991 • 35 citations

The intermediate filament system of the keratinizing mouse forestomach epithelium: Coexpression of keratins of internal squamous epithelia and of epidermal keratins in differentiating cells

1988 • 31 citations

An unusual type-II 70-kilodalton keratin protein of mouse epidermis exhibiting postnatal body-site specificity and sensitivity to hyperproliferation

1987 • 27 citations

Identification of murine type I keratin 9 (73 kDa) and its immunolocalization in neonatal and adult mouse foot sole epidermis

1989 • 26 citations

Proliferative units in stratified squamous epithelium

1983 • 25 citations