Transcription of the mouse secretory protease inhibitor p12 gene is activated by the developmentally regulated positive transcription factor Sp1.

A Rapid and Sensitive Method for the Quantitation of Microgram Quantities of Protein Utilizing the Principle of Protein-Dye Binding

1976 • 225,752 citations

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

1976 • 200,127 citations

[57] Sequencing end-labeled DNA with base-specific chemical cleavages

1980 • 15,302 citations

Organization and Expression of Eucaryotic Split Genes Coding for Proteins

1981 • 4,730 citations

Transcriptional Regulation in Mammalian Cells by Sequence-Specific DNA Binding Proteins

1989 • 3,219 citations

Current protocols in molecular biology

1988 • 2,473 citations

How eukaryotic transcriptional activators work

1988 • 1,924 citations

Isolation of cDNA encoding transcription factor Sp1 and functional analysis of the DNA binding domain

1987 • 1,640 citations

Regulation of Inducible and Tissue-Specific Gene Expression

1987 • 1,640 citations

Purification and Biochemical Characterization of the Promoter-Specific Transcription Factor, Sp1

1986 • 1,473 citations

The promoter-specific transcription factor Sp1 binds to upstream sequences in the SV40 early promoter

1983 • 1,471 citations

Analysis of Sp1 in vivo reveals mutiple transcriptional domains, including a novel glutamine-rich activation motif

1988 • 1,403 citations

The Rous sarcoma virus long terminal repeat is a strong promoter when introduced into a variety of eukaryotic cells by DNA-mediated transfection.

1982 • 1,371 citations

EUKARYOTIC TRANSCRIPTIONAL REGULATORY PROTEINS

1989 • 1,299 citations

Affinity purification of sequence-specific DNA binding proteins.

1986 • 1,255 citations

A cellular DNA-binding protein that activates eukaryotic transcription and DNA replication

1987 • 1,050 citations

Mechanism of transcriptional activation by Sp1: Evidence for coactivators

1990 • 1,029 citations

Activation of the AIDS Retrovirus Promoter by the Cellular Transcription Factor, Sp1

1986 • 741 citations

Cell-Specific Expression of the Rat Insulin Gene: Evidence for Role of Two Distinct 5′ Flanking Elements

1985 • 698 citations

GC box binding induces phosphorylation of Sp1 by a DNA-dependent protein kinase

1990 • 677 citations

Human growth hormone as a reporter gene in regulation studies employing transient gene expression.

1986 • 667 citations

Cell-type specificity of iminunoglobulin gene expression is regulated by at least three DNA sequence elements

1985 • 588 citations

Multiple specific contacts between a mammalian transcription factor and its cognate promoters

1984 • 565 citations

Developmental Expression of Sp1 in the Mouse

1991 • 533 citations

Different activation domains of Sp1 govern formation of multimers and mediate transcriptional synergism.

1991 • 437 citations

Muscle-specific expression of the cardiac alpha-actin gene requires MyoD1, CArG-box binding factor, and Sp1.

1990 • 334 citations

Direct interaction between Sp1 and the BPV enhancer E2 protein mediates synergistic activation of transcription

1991 • 311 citations

Sterol-dependent repression of low density lipoprotein receptor promoter mediated by 16-base pair sequence adjacent to binding site for transcription factor Sp1.

1988 • 271 citations

Transcriptional "silencer" element in rat repetitive sequences associated with the rat insulin 1 gene locus.

1986 • 257 citations

A human protein specific for the immunoglobulin octamer DNA motif contains a functional homeobox domain

1988 • 234 citations

Oncogenic germ-line mutations in Sp1 and ATF sites in the human retinoblastoma gene

1991 • 227 citations

Tissue-specific expression of the human growth hormone gene is conferred in part by the binding of a specific trans-acting factor.

1987 • 218 citations

CAT vectors for analysis of eukaryotic promoters and enhancers

1986 • 184 citations

The 5′ Untranslated Sequence of the c-sis/Platelet-Derived Growth Factor 2 Transcript Is a Potent Translational Inhibitor

1988 • 180 citations

Regulation of rat insulin 1 gene expression: evidence for negative regulation in nonpancreatic cells.

1986 • 178 citations

Contactpoint analysis of the HeLa nuclear factor I recognition site reveals symmetrical binding at one side of the DNA helix.

1987 • 168 citations

Determinants of Rat Albumin Promoter Tissue Specificity Analyzed by an Improved Transient Expression System

1987 • 166 citations

An Improved CAT Assay for Promoter Analysis in Either Transgenic Mice or Tissue Culture Cells

1992 • 162 citations

Binding of the Sp1 Transcription Factor by the Human Harvey ras 1 Proto-Oncogene Promoter

1986 • 150 citations

Activation of skeletal alpha-actin gene transcription: the cooperative formation of serum response factor-binding complexes over positive cis-acting promoter serum response elements displaces a negative-acting nuclear factor enriched in replicating myoblasts and nonmyogenic cells.

1991 • 143 citations

SV40 stimulates expression of the transacting factor Sp1 at the mRNA level.

1990 • 124 citations

Cooperative interactions between transcription factors Sp1 and OTF-1.

1990 • 114 citations

Positive and negative regulatory elements in the mouse albumin enhancer.

1989 • 111 citations

Enhancer and promoter elements directing activation and glucocorticoid repression of the alpha 1-fetoprotein gene in hepatocytes.

1988 • 110 citations

The 5' untranslated sequence of the c-sis/platelet-derived growth factor 2 transcript is a potent translational inhibitor.

1988 • 94 citations

Identification of multiple proteins that interact with functional regions of the human cardiac alpha-actin promoter.

1989 • 93 citations

Interaction of a tissue-specific factor with an essential rat growth hormone gene promoter element.

1987 • 89 citations

Characterization of tissue-specific transcription by the human synapsin I gene promoter.

1991 • 87 citations

A short protocol for micro-purification of nuclear proteins from whole animal tissue.

1991 • 87 citations

Determinants of rat albumin promoter tissue specificity analyzed by an improved transient expression system.

1987 • 84 citations

Evidence that the upstream stimulatory factor and the Sp1 transcription factor bind in vitro to the promoter of the human‐growth‐hormone gene

1989 • 77 citations

Human liver-type arginase gene: structure of the gene and analysis of the promoter region

1988 • 63 citations

The level of expression of the rat growth hormone gene in liver tumor cells is at least eight orders of magnitude less than that in anterior pituitary cells.

1983 • 62 citations

A secretory protease inhibitor requires androgens for its expression in male sex accessory tissues but is expressed constitutively in pancreas.

1987 • 61 citations

Transcription factor Sp1 binds to and activates a human hsp70 gene promoter.

1989 • 58 citations

Mouse DNA polymerase gene promoter: fine mapping and involvement of Sp1-like mouse transcription factor in its function

1988 • 52 citations

Sp1 and thyroid hormone receptor differentially activate expression of human growth hormone and chorionic somatomammotropin genes

1991 • 50 citations

Human cellular retinol‐binding protein gene organization and chromosomal location

1988 • 45 citations

Androgen-regulated expression of secretory protein synthesis in mouse ventral prostate

1987 • 37 citations

The mouse E beta 2 gene: a class II MHC beta gene with limited intraspecies polymorphism and an unusual pattern of transcription.

1986 • 36 citations

Identification of a DNA-binding site for the transcription factor GC2 in the promoter region of the p12 gene and repression of its positive activity by upstream negative regulatory elements.

1990 • 27 citations

Conserved sequence motifs upstream from the co-ordinately expressed vitellogenin and apo VLDLII genes of chicken

1986 • 22 citations

DNAse I Footprint Analysis of Nuclear Proteins from Pituitary and Nonpituitary Cells that Specifically Bind to the Rat Growth Hormone Promoter and 5′-Regulatory Region

1988 • 21 citations

Interaction of a Tissue-Specific Factor with an Essential Rat Growth Hormone Gene Promoter Element

1987 • 18 citations

Transcription of the Promoter of the Rat NF-1 Gene Depends on the Integrity of an Sp1 Recognition Site

1990 • 18 citations

Analysis of regulatory sequences in androgen-responsive genes

1988 • 17 citations

Purification and Properties of the Rous Sarcoma Virus Internal Enhancer Binding Factor

1989 • 17 citations

Using proteases to avoid false identification of DNA-protein complexes in gel shift assays.

1992 • 14 citations

Identification of a protein that interacts with the nuclear factor-1 (NF-1) binding site in cells that do not express NF-1: comparison to NF-1, cellular distribution, and effect on transcription

1991 • 10 citations

The Level of Expression of the Rat Growth Hormone Gene in Liver Tumor Cells Is at Least Eight Orders of Magnitude Less Than That in Anterior Pituitary Cells

1983 • 10 citations

Organization and upstream DNA sequence of the mouse protease inhibitor gene

1988 • 8 citations

Purification and properties of the Rous sarcoma virus internal enhancer binding factor.

1989 • 4 citations