Signal Transduction Mechanisms Involved in Salivary Gland Regulated Exocytosis

Handbook of Physiology.

1960 • 10,428 citations

G PROTEINS: TRANSDUCERS OF RECEPTOR-GENERATED SIGNALS

1987 • 6,374 citations

Inositol phosphates and cell signalling

1989 • 4,058 citations

A model for receptor-regulated calcium entry

1986 • 2,535 citations

THE STRUCTURE AND REGULATION OF PROTEIN PHOSPHATASES

1989 • 2,518 citations

Inositol phospholipids and cell surface receptor function

1975 • 2,458 citations

The role of hormone receptors and GTP-regulatory proteins in membrane transduction

1980 • 1,750 citations

ACTIN AND ACTIN-BINDING PROTEINS. A CRITICAL EVALUATION OF MECHANISMS AND FUNCTIONS

1986 • 1,493 citations

Pirenzepine distinguishes between different subclasses of muscarinic receptors

1980 • 1,299 citations

The βγ subunits of GTP-binding proteins activate the muscarinic K+ channel in heart

1987 • 1,186 citations

Receptor-effector coupling by G proteins

1990 • 1,117 citations

A membrane form of guanylate cyclase is an atrial natriuretic peptide receptor

1989 • 996 citations

The Cellular Functions of Small GTP-Binding Proteins

1990 • 881 citations

Cyclic GMP synthesis and function.

1987 • 871 citations

Primary sequence of cyclic nucleotide phosphodiesterase isozymes and the design of selective inhibitors

1990 • 860 citations

The Glucagon-sensitive Adenyl Cyclase System in Plasma Membranes of Rat Liver

1971 • 811 citations

Cloning and expression of the human and rat m5 muscarinic acetylcholine receptor genes

1988 • 792 citations

The yeast GTP-binding YPT1 protein and a mammalian counterpart are associated with the secretion machinery

1988 • 699 citations

The Pharmacological and Physiological Role of Cyclic GMP in Vascular Smooth Muscle Relaxation

1985 • 685 citations

Protein p38: an integral membrane protein specific for small vesicles of neurons and neuroendocrine cells.

1986 • 671 citations

ADP ribosylation of the specific membrane protein of C6 cells by islet-activating protein associated with modification of adenylate cyclase activity.

1982 • 600 citations

A GTP-binding protein required for secretion rapidly associates with secretory vesicles and the plasma membrane in yeast

1988 • 592 citations

PROTEIN KINASES IN THE BRAIN

1985 • 559 citations

Molecular Properties of the Muscarinic Acetylcholine Receptor

1987 • 478 citations

Discovery of A Ca²⁺‐and calmodulin‐dependent protein phosphatase

1982 • 476 citations

Vasoactive intestinal polypeptide in cholinergic neurons of exocrine glands: Functional significance of coexisting transmitters for vasodilation and secretion

1980 • 471 citations

"Calciosome," a cytoplasmic organelle: the inositol 1,4,5-trisphosphate-sensitive Ca2+ store of nonmuscle cells?

1988 • 451 citations

Aggregation of chromaffin granules by calpactin at micromolar levels of calcium

1988 • 443 citations

5-Hydroxytryptamine stimulates inositol phosphate production in a cell-free system from blowfly salivary glands. Evidence for a role of GTP in coupling receptor activation to phosphoinositide breakdown.

1985 • 429 citations

Small GTP-binding proteins in vesicular transport

1990 • 381 citations

Protein activator of cyclic 3′:5′-nucleotide phosphodiesterase of bovine or rat brain also activates its adenylate cyclase

1975 • 361 citations

Molecular Characterization of a Functional cDNA Encoding the Rat Substance P Receptor

1990 • 355 citations

Stimulation of phospholipase A2 activity in bovine rod outer segments by the beta gamma subunits of transducin and its inhibition by the alpha subunit.

1987 • 344 citations

A Synaptic Vesicle Protein with a Novel Cytoplasmic Domain and Four Transmembrane Regions

1987 • 326 citations

Effects of cations on affinity of calmodulin for calcium: ordered binding of calcium ions allows the specific activation of calmodulin-stimulated enzymes. Theoretical approach to study of multiple ligand binding to a macromolecule

1981 • 321 citations

Salivary secretion of electrolytes.

1972 • 312 citations

Protein kinase C — a family affair

1989 • 289 citations

GE: A GTP-Binding Protein Mediating Exocytosis

1990 • 256 citations

Acetylcholine increases the breakdown of triphosphoinositide of rabbit iris muscle prelabelled with [32P] phosphate

1977 • 256 citations

Identification of Cellular Activation Mechanisms Associated with Salivary Secretion

1986 • 253 citations

Capacitative calcium entry in parotid acinar cells

1989 • 234 citations

The influence of calcium on the secretory response of the submaxillary gland to acetylcholine or to noradrenaline

1963 • 220 citations

Relaxation of vascular and tracheal smooth muscle by cyclic nucleotide analogs that preferentially activate purified cGMP-dependent protein kinase.

1988 • 218 citations

Effects of MeCh, thapsigargin, and La3+ on plasmalemmal and intracellular Ca2+ transport in lacrimal acinar cells

1990 • 207 citations

Regulation of parotid gland function by cyclic nucleotides and calcium.

1980 • 199 citations

Two G-proteins act in series to control stimulus-secretion coupling in mast cells: use of neomycin to distinguish between G-proteins controlling polyphosphoinositide phosphodiesterase and exocytosis.

1987 • 197 citations

Identification of chromaffin granule-binding proteins. Relationship of the chromobindins to calelectrin, synhibin, and the tyrosine kinase substrates p35 and p36.

1987 • 175 citations

Requirements for cholera toxin-dependent ADP-ribosylation of the purified regulatory component of adenylate cyclase.

1982 • 172 citations

How do inositol phosphates regulate calcium signaling?

1989 • 171 citations

Modulation by islet-activating protein of adenylate cyclase activity in C6 glioma cells.

1982 • 164 citations

Inositol 1,3,4,5-tetrakisphosphate is essential for sustained activation of the Ca2+-dependent K+ current in single internally perfused mouse lacrimal acinar cells

1989 • 163 citations

Antibodies to the GTP binding protein, Go, antagonize noradrenaline-induced calcium current inhibition in NG108-15 hybrid cells

1989 • 159 citations

Activation of the inhibitory GTP-binding protein of adenylate cyclase, Gi, by beta-adrenergic receptors in reconstituted phospholipid vesicles.

1984 • 158 citations

Potassium Release Mediated by the Epinephrine α-Receptor in Rat Parotid Slices

1973 • 158 citations

Cyclic GMP mediates the agonist-stimulated increase in plasma membrane calcium entry in the pancreatic acinar cell.

1990 • 138 citations

Presence of three pertussis toxin substrates and G_oα immunoreactivity in both plasma and granule membranes of chromaffin cells

1987 • 138 citations

Interaction of calmodulin with the calmodulin binding domain of the plasma membrane calcium pump

1990 • 137 citations

Rapid increases in cytosolic free calcium in response to muscarinic stimulation of rat parotid acinar cells.

1987 • 124 citations

Ca2+-activated synexin forms highly selective, voltage-gated Ca2+ channels in phosphatidylserine bilayer membranes.

1988 • 124 citations

Nature of the receptor‐regulated calcium pool in the rat parotid gland.

1982 • 119 citations

Annexins—New family of Ca2+-regulated-phospholipid binding protein

1987 • 117 citations

Pharmacologic differentiation between inositol-1,4,5-trisphosphate-induced Ca2+ release and Ca2+- or caffeine-induced Ca2+ release from intracellular membrane systems.

1989 • 111 citations

Identification of a single α₁‐adrenoceptor corresponding to the α_1A‐subtype in rat submaxillary gland

1989 • 110 citations

beta-Adrenergic regulation of protein phosphorylation and its relationship to exocrine secretion in dispersed rat parotid gland acinar cells.

1981 • 110 citations

Extracellular ATP increases free cytosolic calcium in rat parotid acinar cells. Differences from phospholipase C-linked receptor agonists.

1988 • 99 citations

A major role for protein kinase C in calcium‐activated exocytosis in permeabilised adrenal chromaffin cells

1988 • 97 citations

Exocytosis induction in Paramecium tetraurelia cells by exogenous phosphoprotein phosphatase in vivo and in vitro: possible involvement of calcineurin in exocytotic membrane fusion.

1987 • 96 citations

Adrenergic receptors. Models for regulation of signal transduction processes.

1990 • 96 citations

A guanine nucleotide-dependent regulatory protein couples substance P receptors to phospholipase C in rat parotid gland

1986 • 95 citations

Secretory Vesicle-Associated Proteins and Their Role in Exocytosis

1990 • 90 citations

Evidence implicating protein kinase C in exocytosis from electropermeabilized bovine chromaffin cells

1988 • 89 citations

Is calcium the final mediator of exocytosis in the rat parotid gland?

1977 • 89 citations

Substance P receptor on parotid cell membranes

1981 • 85 citations

Microinjection of calmodulin antibodies into cultured chromaffin cells blocks catecholamine release in response to stimulation

1985 • 84 citations

Secretory response of dispersed rat submandibular cells. II. Mucin secretion

1980 • 84 citations

Two Ca2+-dependent ATPases in rat liver plasma membrane. The previously purified (Ca2+-Mg2+)-ATPase is not a Ca2+-pump but an ecto-ATPase.

1988 • 83 citations

Properties of receptor-controlled inositol trisphosphate formation in parotid acinar cells

1985 • 83 citations

Effect of substance P and eledoisin on K+ efflux, amylase release and cyclic nucleotide levels in slices of rat parotid gland

1976 • 81 citations

Phorbol ester-induced protein secretion in rat parotid gland. Relationship to the role of inositol lipid breakdown and protein kinase C activation in stimulus-secretion coupling.

1984 • 77 citations

Beta-adrenergic receptor stimulation induces inositol trisphosphate production and Ca2+ mobilization in rat parotid acinar cells.

1988 • 76 citations

Changes in cytosolic free calcium concentration in isolated rat parotid cells by cholinergic and β-adrenergic agonists

1985 • 76 citations

How do inositol 1,4,5-trisphosphate and inositol 1,3,4,5-tetrakisphosphate regulate intracellular Ca2+?

1989 • 74 citations

Specific Protein Phosphorylation during Stimulation of Amylase Secretion by β‐Agonists or Dibutyryl Adenosine 3′,5′‐Monophosphate in the Rat Parotid Gland

1980 • 74 citations

Role of calcium and cAMP in the regulation of rat submandibular mucin secretion

1981 • 70 citations

Regulation of autonomic receptors in rat submandibular gland.

1982 • 69 citations

Potentiation of the effects of sodium nitroprusside and of isoproterenol by selective phosphodiesterase inhibitors.

1983 • 61 citations

[11] Use of synergistic pairs of site-selective cAMP analogs in intact cells

1988 • 60 citations

A specific interaction in vitro between pancreatic zymogen granules and plasma membranes: stimulation by G-protein activators but not by Ca2+.

1989 • 59 citations

Vasoactive Intestinal Peptide Binding to Specific Receptors on Rat Parotid Acinar Cells Induces Amylase Secretion Accompanied by Intracellular Accumulation of Cyclic Adenosine 3′-5′-Monophosphate

1985 • 58 citations

Cholecystokinin activates Gi1-, Gi2-, Gi3- and several Gs-proteins in rat pancreatic acinar cells

1990 • 57 citations

Hormone-induced protein phosphorylation. I. Relationship between secretagogue action and endogenous protein phosphorylation in intact cells from the exocrine pancreas and parotid.

1982 • 56 citations

Identification and characterization of beta1-adrenergic receptors in rat parotid membranes

1977 • 54 citations

Phosphorylation of the same specific protein during amylase release evoked by beta-adrenergic or cholinergic agonists in rat and mouse parotid glands.

1981 • 53 citations

Hormone-induced protein phosphorylation. II. Localization to the ribosomal fraction from rat exocrine pancreas and parotid of a 29,000-dalton protein phosphorylated in situ in response to secretagogues.

1982 • 52 citations

Different tachykinin receptor subtypes are coupled to the phosphoinositide or cyclic AMP signal transduction pathways in rat submandibular cells

1988 • 51 citations

Recruitment of cytosolic proteins to a secretory granule membrane depends on Ca2+-calmodulin

1983 • 51 citations

Autonomic receptors in the developing submandibular glands of neonatal rats

1982 • 50 citations

The rat submaxillary gland contains predominantly P-type tachykinin binding sites

1985 • 49 citations

Calcium dependence of the binding of synexin to isolated chromaffin granules

1983 • 48 citations

The rate-determining step in cAMP-mediated exocytosis in the rat parotid and submandibular glands appears to involve analogous 26-kDa integral membrane phosphoproteins.

1985 • 45 citations

Characterization and relationship to exocrine secretion of rat parotid gland cyclic AMP-dependent protein kinase

1981 • 45 citations

Sympathetic stimulation of amylase secretion during a parasympathetic background activity in the rat parotid gland

1985 • 43 citations

Mucin release and calcium fluxes in isolated rat submandibular acini

1984 • 42 citations

Calcium-Dependent Calmodulin Binding to Chromaffin Granule Membranes: Presence of a 65-Kilodalton Calmodulin-Binding Protein

1985 • 41 citations

Regulation of Substance P Receptor Affinity by Guanine Nucleotide‐Binding Proteins

1989 • 35 citations

Phosphorylation of the ribosomal protein S6 in response to secretagogues in the guinea pig exocrine pancreas, parotid and lacrimal gland

1983 • 35 citations

REVIEW

1986 • 34 citations

Stimulus-secretion coupling: second messenger-regulated exocytosis.

1988 • 34 citations

Calcium-activated, phospholipid-dependent protein kinase in pancreatic acinar cells

1985 • 34 citations

Calcium-dependent adenylate cyclase of pituitary tumor cells

1982 • 33 citations

Phorbol ester stimulates amylase secretion from rat parotid cells

1986 • 33 citations

Subcellular location of stimulus-affected endogenous phosphoproteins in the rat parotid gland.

1984 • 33 citations

Muscarinic, α1 and peptidergic agonists stimulate phosphoinositide hydrolysis and regulate mucin secretion in rat submandibular gland cells

1987 • 32 citations

Muscarinic M3 receptors are coupled to two signal transduction pathways in rat submandibular cells

1990 • 32 citations

Rat parotid gland protein kinase activation. Relationship to enzyme secretion.

1982 • 32 citations

Low molecular weight GTP-binding proteins associated with zymogen granule membranes from rat pancreas

1991 • 31 citations

The influence of vasoactive intestinal peptide receptors in dispersed acini from rat submandibular gland on cyclic AMP production and mucin release

1990 • 31 citations

Regulation of cAMP metabolism in mouse parotid gland by cGMP and calcium.

1990 • 30 citations

Does cyclic AMP mobilize Ca2+ for amylase secretion from rat parotid cells?

1986 • 30 citations

Does β-adrenoceptor activation stimulate Ca2+ mobilization and inositol trisphosphate formation in parotid acinar cells?

1989 • 29 citations

The effect of calcium and cyclic AMP on amylase release in digitonin-permeabilized parotid gland cells

1987 • 29 citations

Activation of protein kinase activity in pancreatic acini by calcium and cAMP

1984 • 29 citations

Amylase Secretion from Saponin-Permeabilized Parotid Cells Evoked by Cyclic AMP1

1988 • 27 citations

Role of protein phosphorylation in regulating rat submandibular mucin secretion

1983 • 27 citations

Calcium mediation of cholinergic-stimulated amylase release from mouse parotid gland

1979 • 26 citations

Mechanism of action of extracellular calcium on isoprenaline‐evoked amylase secretion from isolated rat parotid glands.

1985 • 24 citations

Refractoriness to muscarinic and adrenergic agonists in the rat parotid: responses of adenosine and guanosine cyclic 3', 5'-monophosphates.

1977 • 23 citations

Binding in vitro of vasoactive intestinal peptide on isolated acini of rat parotid glands

1985 • 23 citations

Evidence for the Involvement of cAMP-Dependent Protein Kinase in the Exocytosis of Amylase from Parotid Acinar Cells1

1990 • 23 citations

Chromobindin A. A Ca2+ and ATP regulated chromaffin granule binding protein.

1987 • 23 citations

Amylase secretion from the rat parotid: refractoriness to muscarinic and adrenergic agonists.

1978 • 23 citations

Basic Biological Sciences Effect of Substance P on Exocrine Secretion by Rat Submandibular Gland Cells

1984 • 22 citations

Alpha adrenergic and cholinergic-muscarinic regulation of adenosine cyclic 3',5'-monophosphate levels in the rat parotid.

1978 • 22 citations

Calmodulin and Calcium-Binding Proteins: Evolutionary Diversification of Structure and Function

1982 • 22 citations

Calmodulin activation and calcium regulation of parotid gland adenylate cyclase

1986 • 21 citations

INTRACELLULAR CALCIUM RECEPTOR MECHANISMS

1986 • 21 citations

The effect of autonomic agonists and nerve stimulation on protein secretion from the rat submandibular gland.

1985 • 20 citations

Role of cyclic AMP-dependent protein kinase activation in regulating rat submandibular mucin secretion

1983 • 18 citations

Inositol 1,2-cyclic 4,5-trisphosphate is formed in the rat parotid gland on muscarinic stimulation

1987 • 18 citations

Does cyclic GMP mediate amylase release from mouse parotid acini?

1982 • 18 citations

G regulatory proteins and muscarinic receptor signal transduction in mucous acini of rat submandibular gland

1989 • 17 citations

Evidence against a role for a pertussis toxin-sensitive G protein in Ca2+ mobilization in rat parotid acinar cells

1990 • 16 citations

Specific phosphorylation of a protein in calcium accumulating endoplasmic reticulum from rat parotid glands following stimulation by agonists involving cAMP as second messenger

1984 • 16 citations

Detection of a calmodulin-sensitive cyclic nucleotide phosphodiesterase in rat parotid gland

1980 • 15 citations

The role of protein kinase C on amylase secretion from rat parotid gland

1988 • 15 citations

Characterization of the vasoactive intestinal peptide receptor in rat submandibular gland: radioligand binding assay in membrane preparations.

1987 • 15 citations

Augmented amylase release from rat parotid gland slices, in vitro

1980 • 14 citations

Introduction of cyclic AMP phosphodiesterase into rat submandibular acini prevents isoproterenol-stimulated cyclic AMP rise without affecting mucin secretion

1989 • 13 citations

Protein phosphatases of the guinea‐pig parotid gland

1987 • 12 citations

Activation and distribution of rat parotid cAMP-dependent protein kinase following beta-adrenergic receptor stimulation in vitro

1989 • 12 citations

Interactions of the Complex Secretory Vesicle Binding Protein Chromobindin A with Nucleotides

1990 • 11 citations

Augmentation of cholinergic-mediated amylase release by forskolin in mouse parotid gland

1985 • 11 citations

Contribution of Extracellular and Intracellular Calcium to the Enhanced Effect of an a-Adrenergic Agonist on Amylase Release from Dispersed Rat Parotid Cells

1985 • 10 citations

Role of Protein Phosphorylation in Rat Salivary Gland Exocytosis

1987 • 10 citations

Purification and characterization of a 22‐kDa microsomal protein from rat parotid gland which is phosphorylated following stimulation by agonists involving cAMP as second messenger

1988 • 10 citations

Cyclic nucleotide phosphodiesterase in rat parotid gland

1981 • 10 citations

Subcellular distribution and activation of rat submandibular cAMP-dependent protein kinase following β-adrenergic receptor stimulation

1988 • 10 citations

Augmentation of isoproterenol-stimulated tissue cyclic AMP level by cholinergic agonists in rat parotid gland.

1985 • 9 citations

Calcium-dependent Protein Kinase Reactions Associated with Parotid Gland Secretory Granule Membranes

1987 • 8 citations

Purification of calmodulin from bovine parotid gland.

1983 • 8 citations

Early steps in the light-triggered activation of the cyclic GMP enzymatic pathway in rod photoreceptors.

1984 • 7 citations

Characterization of rat parotid protein kinase C

1988 • 7 citations

Synergistic interactions between forskolin, isoprenaline and substance P as secretagogues in rat parotid glands

1987 • 7 citations

Light-mediated cyclic GMP hydrolysis controls important aspects of kinetics of retinal rod voltage response

1983 • 6 citations

Mediation of β-adrenergic stimulated amylase release from mouse parotid gland

1980 • 6 citations

Regulated phosphorylation of secretory granule membrane proteins of the rat parotid gland

1990 • 5 citations

Electrophoretic identification of calmodulin in rat parotid gland

1986 • 4 citations

Regulation of cyclic nucleotide phosphodiesterase activity in the submandibular gland of developing rat

1980 • 4 citations

Regulation of cyclic GMP phosphodiesterase in the submandibular gland of adult rat

1983 • 4 citations

Effects of cholinergic and adrenergic nerve stimulations on amylase release from superfused small segment of rat parotid gland.

1986 • 2 citations