Role of T Helper Lymphocytes in Autoimmune Diseases

The foreign antigen binding site and T cell recognition regions of class I histocompatibility antigens

1987 • 2,403 citations

Complementary DNA for a novel human interleukin (BSF-2) that induces B lymphocytes to produce immunoglobulin

1986 • 2,137 citations

Interferon-γ and B Cell Stimulatory Factor-1 Reciprocally Regulate Ig Isotype Production

1987 • 1,936 citations

Murine Models of Systemic Lupus Erythematosus

1985 • 1,572 citations

Pathologic Anatomy of the Pancreas in Juvenile Diabetes Mellitus

1965 • 1,338 citations

Two types of mouse helper T cell clone. III. Further differences in lymphokine synthesis between Th1 and Th2 clones revealed by RNA hybridization, functionally monospecific bioassays, and monoclonal antibodies.

1987 • 1,060 citations

Two types of murine helper T cell clone. II. Delayed-type hypersensitivity is mediated by TH1 clones.

1987 • 966 citations

In Situ Characterization of Autoimmune Phenomena and Expression of HLA Molecules in the Pancreas in Diabetic Insulitis

1985 • 935 citations

The rapid isolation of clonable antigen‐specific T lymphocyte lines capable of mediating autoimmune encephalomyelitis

1981 • 917 citations

Two types of mouse helper T-cell clone

1987 • 813 citations

The Molecular Genetics of the T-Cell Antigen Receptor and T-Cell Antigen Recognition

1986 • 772 citations

Tumour necrosis factors α and β inhibit virus replication and synergize with interferons

1986 • 726 citations

The role of clonal selection and somatic mutation in autoimmunity

1987 • 714 citations

ABERRANT EXPRESSION OF HLA-DR ANTIGEN ON THYROCYTES IN GRAVES' DISEASE: RELEVANCE FOR AUTOIMMUNITY

1983 • 710 citations

OBSERVATIONS ON ATTEMPTS TO PRODUCE ACUTE DISSEMINATED ENCEPHALOMYELITIS IN MONKEYS

1933 • 629 citations

The Role of the T3/Antigen Receptor Complex in T-Cell Activation

1986 • 627 citations

The LY‐1B Cell Lineage

1986 • 603 citations

B-Cell Stimulatory Factor-1/Interleukin 4

1987 • 602 citations

Progress in immunology

1968 • 577 citations

Interleukin 1: An Immunological Perspective

1985 • 576 citations

Syngeneic transfer of autoimmune diabetes from diabetic NOD mice to healthy neonates. Requirement for both L3T4+ and Lyt-2+ T cells.

1987 • 576 citations

Defective production of interleukin 1 and interleukin 2 in patients with systemic lupus erythematosus (SLE).

1983 • 453 citations

HLA class II induction in human islet cells by interferon-γ plus tumour necrosis factor or lymphotoxin

1987 • 451 citations

ENCEPHALOMYELITIS ACCOMPANIED BY MYELIN DESTRUCTION EXPERIMENTALLY PRODUCED IN MONKEYS

1935 • 433 citations

Epithelial cells expressing aberrant MHC class II determinants can present antigen to cloned human T cells

1984 • 432 citations

Experimental allergic encephalomyelitis

1969 • 406 citations

Cloning of complementary DNA encoding T-cell replacing factor and identity with B-cell growth factor II

1986 • 405 citations

THE RAPID PRODUCTION OF ACUTE DISSEMINATED ENCEPHALOMYELITIS IN RHESUS MONKEYS BY INJECTION OF HETEROLOGOUS AND HOMOLOGOUS BRAIN TISSUE WITH ADJUVANTS

1947 • 398 citations

Recurrent diabetes mellitus in the pancreas iso- and allograft. A light and electron microscopic and immunohistochemical analysis of four cases.

1985 • 387 citations

B-cell-stimulatory factor 2 (beta 2 interferon) functions as a second signal for interleukin 2 production by mature murine T cells.

1987 • 357 citations

Functional interaction between human T-cell protein CD4 and the major histocompatibility complex HLA-DR antigen

1987 • 348 citations

Analysis of T cell function in autoimmune murine strains. Defects in production and responsiveness to interleukin 2.

1981 • 334 citations

Reversal of Experimental Allergic Encephalomyelitis with Monoclonal Antibody to a T-Cell Subset Marker

1985 • 328 citations

Human T-Cell Clones from Autoimmune Thyroid Glands: Specific Recognition of Autologous Thyroid Cells

1985 • 326 citations

Affinity-purified human Interleukin I is cytotoxic to isolated islets of Langerhans

1986 • 321 citations

Systemic autoimmune disease arises from polyclonal B cell activation.

1987 • 314 citations

A spontaneous rheumatoid arthritis-like disease in MRL/l mice.

1982 • 303 citations

Immunoregulatory circuits among T-cell sets. II. Physiologic role of feedback inhibition in vivo: absence in NZB mice.

1978 • 296 citations

Destruction of Rat Islet Cell Monolayers by Cytokines: Synergistic Interactions of Interferon-γ, Tumor Necrosis Factor, Lymphotoxin, and Interleukin 1

1988 • 296 citations

Heterogeneity of helper/inducer T lymphocytes. I. Lymphokine production and lymphokine responsiveness.

1987 • 289 citations

T cell priming in vivo: a major role for B cells in presenting antigen to T cells in lymph nodes.

1987 • 286 citations

Evidence in support of a self-perpetuating HLA-DR-dependent delayed-type cell reaction in rheumatoid arthritis.

1982 • 277 citations

The Structure of the CD4 and CD8 Genes

1987 • 276 citations

Organ‐Specific Autoimmunity: A 1986 Overview

1986 • 274 citations

Progress in immunology V

1985 • 268 citations

A systemic lupus erythematosus (SLE)‐like disease in mice induced by abnormal T‐B cell cooperation. Preferential formation of autoantibodies characteristic of SLE

1982 • 267 citations

Identity of cells that imprint H–2-restricted T-cell specificity in the thymus

1986 • 267 citations

Molecular Transductional Mechanisms by which IFNγ and Other Signals Regulate Macrophage Development

1987 • 266 citations

Structure, Function, and Serology of the T-Cell Antigen Receptor Complex

1987 • 264 citations

Expression of Ia antigen on epidermal keratinocytes in graft-versus-host disease

1981 • 262 citations

Autoimmunity - A Perspective

1983 • 260 citations

Recombinant interleukin 4 promotes the growth of human T cells.

1987 • 252 citations

B cell stimulatory factor 1 (interleukin 4) is a potent costimulant for normal resting T lymphocytes.

1987 • 251 citations

The diabetic syndrome of the ?BB? Wistar rat: Possible relevance to Type 1 (insulin-dependent) diabetes in man

1982 • 249 citations

Characterization of murine thymocytes with CDS-associated T-cell receptor structures

1987 • 245 citations

Early Events in T-Cell Maturation

1987 • 242 citations

Immunology of Insulin-Dependent Diabetes Mellitus

1985 • 240 citations

γ-Interferon is one of several direct B cell-maturing lymphokines

1984 • 237 citations

Loss of suppressor T cells in adult NZB/NZW mice.

1976 • 229 citations

ALLERGIC ENCEPHALOMYELITIS IN MONKEYS IN RESPONSE TO INJECTION OF NORMAL MONKEY NERVOUS TISSUE

1947 • 226 citations

Depletion of RT6.1+ T lymphocytes induces diabetes in resistant biobreeding/Worcester (BB/W) rats.

1987 • 224 citations

T cells that help B cell responses to soluble antigen are distinguishable from those producing interleukin 2 on mitogenic or allogeneic stimulation.

1986 • 218 citations

Reversal of advanced murine lupus in NZB/NZW F1 mice by treatment with monoclonal antibody to L3T4.

1987 • 211 citations

Isoallergic Encephalomyelitis and Radiculitis in Guinea Pigs After One Injection of Brain and Mycobacteria in Water-in-Oil Emulsion

1947 • 199 citations

Immunologic Aspects of the Nonobese Diabetic (NOD) Mouse: Abnormalities of Cellular Immunity

1983 • 199 citations

A single stem cell can recolonize an embryonic thymus, producing phenotypically distinct T-cell populations

1985 • 199 citations

The immunopathology of experimental allergic encephalomyelitis. II. Endothelial cell Ia increases prior to inflammatory cell infiltration.

1984 • 198 citations

INCREASED EXPRESSION OF HLA-DR ANTIGENS ON RENAL TUBULAR CELLS IN RENAL TRANSPLANTS: RELEVANCE TO THE REJECTION RESPONSE

1984 • 196 citations

Neonatal Thymectomy Prevents Spontaneous Diabetes Mellitus in the BB/W Rat

1982 • 193 citations

Absence of the Lyt-2-,L3T4+ lineage of T cells in mice treated neonatally with anti-I-A correlates with absence of intrathymic I-A-bearing antigen-presenting cell function.

1985 • 191 citations

Regulation of Autoimmune Disease Physiological and Therapeutic

1986 • 190 citations

Identification of a B cell differentiation factor(s) spontaneously produced by proliferating T cells in murine lupus strains of the lpr/lpr genotype.

1983 • 188 citations

CYCLOSPORIN PREVENTS DIABETES IN BB WISTAR RATS

1983 • 183 citations

Aberrant Expression of HLA-DR Antigens by Insulin-Containing β-Cells in Recent-Onset Type I Diabetes MelIitus

1986 • 180 citations

Antipancreatic Cellular Hypersensitivity in Diabetes Mellitus

1971 • 180 citations

Cytokines Cause Functional and Structural Damage to Isolated Islets of Langerhans

1985 • 180 citations

Interleukin-2 in rheumatoid arthritis: production of and response to interleukin-2 in rheumatoid synovial fluid, synovial tissue and peripheral blood.

1985 • 172 citations

Induction of murine autoimmune disease by chronic polyclonal B cell activation.

1983 • 171 citations

Administration of Silica Prevents Diabetes in BB-Rats

1985 • 170 citations

Splenic immunoglobulin-secreting cells and their regulation in autoimmune mice.

1980 • 166 citations

Myelin Basic Protein: Structure, Function and Antigenic Determinants

1978 • 158 citations

Identification and sequence of a fourth human T cell antigen receptor chain

1987 • 157 citations

Prevention of diabetes in BioBreeding/Worcester rats with monoclonal antibodies that recognize T lymphocytes or natural killer cells.

1986 • 156 citations

Passive Transfer of Diabetes in the BB/W Rat

1983 • 155 citations

Low-Dose Streptozocin-Induced Diabetes in Mice: Electron Microscopy Reveals Single-Cell Insulitis Before Diabetes Onset

1988 • 151 citations

The Panspecific Hemopoietin of Activated T Lymphocytes (Interleukin-3)

1986 • 149 citations

Distribution of histopathology and Ia positive cells in actively induced and passively transferred experimental autoimmune orchitis.

1987 • 147 citations

Intrathyroidal HLA-DR expression and T lymphocyte phenotypes in Graves' thyrotoxicosis, Hashimoto's thyroiditis and nodular colloid goitre.

1984 • 143 citations

An Analysis of Effector T Cell Generation and Function in Mice Exposed to Influenza A or Sendai Viruses

1981 • 137 citations

Expression of genes of the T-cell antigen receptor complex in precursor thymocytes

1985 • 135 citations

Dissection of the proliferative and differentiative signals controlling murine cytotoxic T lymphocyte responses.

1982 • 135 citations

T‐Cell Recognition of Lysozyme: The Biochemical Basis of Presentation

1987 • 133 citations

Influence of thymic genotype on the systemic lupus erythematosus-like disease and T cell proliferation of MRL/Mp-lpr/lpr mice.

1981 • 128 citations

STUDIES OF THE ROLE OF THE THYMIC ENVIRONMENT IN THE INDUCTION OF TOLERANCE TO MHC ANTIGENS

1985 • 127 citations

In situ immune complexes, lymphocyte subpopulations, and HLA-DR-positive epithelial cells in Hashimoto thyroiditis.

1985 • 124 citations

Interleukin 2: Biology and biochemistry

1983 • 122 citations

Thyroiditis in T cell-depleted rats. Influence of strain, radiation dose, adjuvants and antilymphocyte serum.

1975 • 118 citations

Murine autoimmune oophoritis, epididymoorchitis, and gastritis induced by day 3 thymectomy. Immunopathology.

1987 • 117 citations

Preferential induction of autoantibody secretion in polyclonal activation by peptidoglycan and lipopolysaccharide. II. In vivo studies.

1982 • 115 citations

Decreased Synthesis of Interleukin-2 (IL-2) in Insulin-dependent Diabetes Mellitus

1984 • 113 citations

Pre-diabetes in the spontaneously diabetic BB/E rat: lymphocyte subpopulations in the pancreatic infiltrate and expression of rat MHC class II molecules in endocrine cells

1985 • 111 citations

The subdivision of the T4 (CD4) subset on the basis of the differential expression of L-C/T200 antigens.

1987 • 110 citations

B cell dependence on and response to accessory signals in murine lupus strains.

1983 • 108 citations

Vaccination against autoimmune encephalomyelitis (EAE): Attenuated autoimmune T lymphocytes confer resistance to induction of active EAE but not to EAE mediated by the intact T lymphocyte line

1981 • 108 citations

Differential expression and regulation of MHC products in the endocrine and exocrine cells of the human pancreas.

1986 • 105 citations

Genes encoding the T-cell receptor alpha and beta subunits are transcribed in an ordered manner during intrathymic ontogeny.

1985 • 99 citations

Administration of monoclonal anti-T cell antibodies retards murine lupus in BXSB mice.

1986 • 95 citations

Functions of Purified L3T4⁺ and Lyt‐2⁺ Cells in vitro and in vivo

1986 • 92 citations

Immunoregulation in autoimmunity

1980 • 90 citations

Experimental Allergic Encephalomyelitis ‐ Susceptibility and Suppression

1981 • 88 citations

Adoptive transfer of autoimmune diabetes mellitus in biobreeding/Worcester (BB/W) inbred and hybrid rats.

1985 • 87 citations

Immune response of Lewis rats to peptide C1 (residues 68-88) of guinea pig and rat myelin basic proteins.

1977 • 87 citations

Islet Cell Surface Antibodies and Lymphocyte Antibodies in the Spontaneously Diabetic BB Wistar Rat

1982 • 87 citations

Adoptive transfer of murine autoimmune orchitis to naive recipients with immune lymphocytes

1987 • 86 citations

Transfer of experimental autoimmune thyroiditis with T cell clones.

1987 • 85 citations

Signal requirements in the step-wise functional maturation of cytotoxic T lymphocytes

1987 • 84 citations

The genetic origin of autoantibodies

1987 • 83 citations

Deficiency of phenotypic cytotoxic-suppressor T lymphocytes in the BB/W rat.

1986 • 83 citations

The heavy chain genes of a lupus anti-DNA autoantibody are encoded in the germ line of a nonautoimmune strain of mouse and conserved in strains of mice polymorphic for this gene locus.

1987 • 82 citations

Spontaneous thyroiditis in the obese strain of chickens. IV. The effect of thymectomy and thymo-bursectomy on the development of the disease.

1970 • 82 citations

Lymphocytes from diabetics suppress insulin releasein vitro

1981 • 81 citations

DISSEMINATED ENCEPHALOMYELITIS EXPERIMENTALLY PRODUCED BY THE USE OF HOMOLOGOUS ANTIGEN

1947 • 77 citations

Spontaneous diabetes mellitus syndrome in the rat. II. T lymphopenia and its association with clinical disease and pancreatic lymphocytic infiltration.

1983 • 76 citations

Dynamic time course studies of the spontaneously diabetic BB Wistar rat. III. Light-microscopic and ultrastructural observations of pancreatic islets of Langerhans.

1982 • 76 citations

Mechanisms of Pancreatic Islet Cell Destruction Dose‐Dependent Cytotoxic Effect of Soluble Blood Mononuclear Cell Mediators on Isolated Islets of Langerhans

1986 • 76 citations

T Cell Requirement for Experimental Allergic Encephalomyelitis Induction in the Rat

1976 • 74 citations

Spontaneous Diabetes in the Gnotobiotic BB/W Rat

1979 • 74 citations

Immune dysfunction in diabetes-prone BB rats. Interleukin 2 production and other mitogen-induced responses are suppressed by activated macrophages.

1984 • 73 citations

Genetic and Molecular Basis for T‐ and B‐Cell Recognition of Hepatitis B Viral Antigens

1987 • 71 citations

Neuroimmunologic Diseases: Effector Cell Responses and Immunoregulatory Mechanisms

1981 • 70 citations

Autoimmunity and autoimmune disease

1988 • 69 citations

Early appearance of donor-type antigen-presenting cells in the thymuses of 1200 R radiation-induced bone marrow chimeras correlates with self-recognition of donor I region gene products.

1983 • 68 citations

In vitro inhibition of pancreatic B cell function by lymphocytes from diabetics with associated autoimmune diseases: a T cell phenomenon.

1982 • 66 citations

Reactive lymphocytes in lacrimal gland and vasculitic renal lesions of autoimmune MRL/lpr mice express L3T4.

1987 • 66 citations

Antigen-specific immunocompetency, B cell function, and regulatory helper and suppressor T cell activities in spontaneously autoimmune mice.

1979 • 64 citations

Dendritic cell-lymphoid cell aggregation and major histocompatibility antigen expression during rat cardiac allograft rejection.

1986 • 64 citations

Transfer of experimental allergic encephalomyelitis to bone marrow chimeras. Endothelial cells are not a restricting element.

1987 • 63 citations

MACROPHAGE-MEDIATED CYTOTOXICITY AGAINST CULTURED PANCREATIC ISLET CELLS

1984 • 62 citations

Interaction and Activation of Antigen‐Specific T and B Cells

1987 • 59 citations

Immunoregulation and autoimmunity.

1976 • 58 citations

Spontaneous Thyroiditis in the Obese Strain of Chickens

1970 • 58 citations

Requirement for three signals in "T-independent" (lipopolysaccharide-induced) as well as in T-dependent B cell responses.

1982 • 57 citations

Spontaneous thyroiditis in the obese strain of chickens. 3. The effect of bursectomy on the development of the disease.

1970 • 57 citations

B cell stimulatory factor 1 (interleukin 4) is sufficient for the proliferation and differentiation of lectin-stimulated cytolytic T lymphocyte precursors.

1987 • 56 citations

T‐Independent Activation of Single B Cells: An Orderly Analysis of Overlapping Stages in the Activation Pathway

1987 • 55 citations

Murine autoimmune oophoritis, epididymoorchitis, and gastritis induced by day 3 thymectomy. Autoantibodies.

1987 • 55 citations

Regulation of B-Cell Differentiation: Interactions of Factors and Corresponding Receptors

1986 • 52 citations

Immunohistological evidence of perivascular localization of basic protein in early development of experimental allergic encephalomyelitis

1974 • 51 citations

B Cell‐Tropic Interleukins in Murine Systemic Lupus Erythematosus (SLE) 1

1984 • 51 citations

Abnormal expression of T cell receptor genes in Lyt-2- L3T4- lymphocytes of lpr mice: comparison with normal immature thymocytes.

1987 • 51 citations

Further evidence against random polyclonal antibody formation in mice with lupus-like graft-vs-host disease.

1984 • 48 citations

The in vitro and in vivo induction of anti-double-stranded DNA antibodies in normal and autoimmune mice.

1982 • 48 citations

Antigen-Specific Immunocompetency, B Cell Function, and Regulatory Helper and Suppressor T Cell Activities in Spontaneously Autoimmune Mice

1979 • 46 citations

The Human Interleukin‐2 Receptor: Analysis of Structure and Function

1986 • 45 citations

The origin and significance of anti-DNA antibodies

1987 • 40 citations

The role of H-2 and Ia antigens in graft-versus-host reactions (GVHR). Presence of host alloantigens on donor cells after GVHR and suppression of GVHR with an anti-Ia antiserum against hose Ia antigens.

1979 • 40 citations

Monoclonal lupus autoantibodies

1983 • 38 citations

Spontaneous Thyroiditis in the Obese Strain of Chickens

1970 • 38 citations

The lesion of acute experimental autoimmune encephalomyelitis. Isolation and membrane phenotypes of perivascular infiltrates from encephalitic rat brain white matter.

1984 • 36 citations

Polyclonal B cell activation by a B cell differentiation factor, B151-TRF2. III. B151-TRF2 as a B cell differentiation factor closely associated with autoimmune disease.

1987 • 35 citations

Consequences of the Direct Interaction of Helper T Cells with B Cells presenting Antigen

1987 • 34 citations

B-cell hyperactivity in murine lupus I. Immunological abnormalities in lupus-prone strains and the activation of normal B cells

1983 • 34 citations

Requirement of T cells for the development of spontaneous autoimmune thyroiditis in obese strain (OS) chickens.

1981 • 34 citations

Control of the Cell Cycle of Murine B Lymphocytes: The Nature of α‐ and β‐B‐Cell Growth Factors and of B‐Cell Maturation Factors

1987 • 32 citations

Isolation of T-Lymphocyte Lines with Specificity for Islet Cell Antigens from Spontaneously Diabetic (Insulin-dependent) Rats

1984 • 30 citations

Concepts in immunopathology

1985 • 30 citations

B-cell hyperactivity in murine lupus II. Defects in response to and production of accessory signals in lupus-prone mice

1983 • 28 citations

Autoimmune aspects of systemic lupus erythematosus.

1985 • 27 citations

Multiple functions of natural killer cells, including immunoregulation as well as resistance to tumor growth.

1985 • 25 citations

Autoreactivity accelerates the development of autoimmunity and lymphoproliferation in MRL/Mp-lpr/lpr mice.

1987 • 24 citations

Lymphotoxin production in AIDS

1986 • 23 citations

Antigen recognition by T lymphocytes

1987 • 22 citations

AUTOIMMUNITY AND TYPE I (INSULIN-DEPENDENT) DIABETES MELLITUS

1983 • 20 citations

EPITHELIAL CLASS II ANTIGEN EXPRESSION IN CUTANEOUS GRAFT-VERSUS-HOST DISEASE

1987 • 20 citations

T cell hybrids with specificity for islet cell antigens.

1986 • 19 citations

Interleukin 2 Activates BB/W Diabetic Rat Lymphoid Cells Cytotoxic to Islet Cells

1987 • 19 citations

Vascular endothelial cell HLA-DR antigen and myocyte necrosis in human allograft rejection.

1985 • 19 citations

[Concepts of immunopathology].

1988 • 18 citations

Specificity of monoclonal anti-Z-DNA antibodies from unimmunized MRL/Mp-lpr/lpr mice.

1987 • 17 citations

Cellular immune abnormalities and autoreactive T lymphocytes in insulin-dependent diabetes mellitus in rats

1985 • 15 citations

Experimental allergic encephalomyelitis

1981 • 15 citations

Autoimmunity-prone BB rats lack functional cytotoxic T cells

1988 • 14 citations

Gamma Interferon Induces Novel Expression of Ia Antigens by Rat Pancreatic Islet Endocrine Cells

1987 • 14 citations

Increased Plasma IgA, sIgA, and C3- and IgA-Containing Immune Complexes With Renal Glomerular Deposits in Diabetic Rats

1988 • 12 citations

Major Histocompatibility Complex Restriction of T-Lymphocyte Responses to Islet Cell Antigens in IDDM Rats

1987 • 12 citations

Are "activated" macrophages cytotoxic against normal cells?

1981 • 11 citations

Joint inflammation in mice induced by a MT4+ Lyt-2- T cell clone. Characteristics and the induction of flare-up reactions.

1987 • 11 citations

Immunology: Development and modification of the lymphocyte repertoire

1986 • 10 citations

Adoptive Transfer of Insulitis and Diabetes in Neonates of Diabetes-Prone and -Resistant Rats: Tissue Localization of Injected Blasts

1987 • 10 citations

Multigenic basis of autoimmune disease in New Zealand mice.

1987 • 9 citations

T lymphocyte autoimmunity in experimental autoimmune encephalomyelitis.

1985 • 7 citations

Cell-mediated versus humoral immunity in autoimmune diseases and their pharmacologic control with particular reference to type I diabetes mellitus.

1986 • 7 citations

Immunotherapy of autoimmune disease with T cell subset specific antibodies.

1987 • 6 citations

Mature and Immature Thymocytes

1986 • 4 citations