Human intestinal epithelial cell survival: differentiation state-specific control mechanisms

The Bcl-2 Protein Family: Arbiters of Cell Survival

1998 • 5,359 citations

Cellular survival: a play in three Akts

1999 • 4,229 citations

Integrin Signaling

1999 • 3,705 citations

PD 098059 Is a Specific Inhibitor of the Activation of Mitogen-activated Protein Kinase Kinase in Vitro and in Vivo

1995 • 3,456 citations

A specific inhibitor of phosphatidylinositol 3-kinase, 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002).

1994 • 3,249 citations

Programmed Cell Death in Animal Development

1997 • 2,690 citations

Enterocyte-like differentiation and polarization of the human colon carcinoma cell line Caco-2 in culture

1983 • 1,765 citations

The PI3K–PDK1 connection: more than just a road to PKB

2000 • 1,563 citations

Integrins and anoikis

1997 • 1,145 citations

Regulation of cell number in the mammalian gastrointestinal tract: the importance of apoptosis

1994 • 820 citations

Serine/Threonine Protein Kinases and Apoptosis

2000 • 692 citations

Integrin-dependent phosphorylation and activation of the protein tyrosine kinase pp125FAK in platelets.

1992 • 669 citations

Immunohistochemical determination of in vivo distribution of Bax, a dominant inhibitor of Bcl-2.

1994 • 664 citations

Immunohistochemical analysis of in vivo patterns of Bcl-X expression.

1994 • 429 citations

BCL-2 family proteins: Regulators of cell death involved in the pathogenesis of cancer and resistance to therapy

1996 • 420 citations

MEK/ERK signaling pathway regulates the expression of Bcl-2, Bcl-XL, and Mcl-1 and promotes survival of human pancreatic cancer cells

2000 • 403 citations

Regulation of Bad Phosphorylation and Association with Bcl-xL by the MAPK/Erk Kinase

1999 • 385 citations

The significance of spontaneous and induced apoptosis in the gastrointestinal tract of mice

1992 • 334 citations

Elevated expression of Bcl-X and reduced Bak in primary colorectal adenocarcinomas.

1996 • 325 citations

Immunohistochemical analysis of Mcl-1 protein in human tissues. Differential regulation of Mcl-1 and Bcl-2 protein production suggests a unique role for Mcl-1 in control of programmed cell death in vivo.

1995 • 317 citations

Differential expression of bcl-2 in intestinal epithelia correlation with attenuation of apoptosis in colonic crypts and the incidence of colonic neoplasia

1995 • 308 citations

Transient mosaic patterns of morphological and functional differentiation in the Caco-2 cell line

1992 • 219 citations

Caco‐2 cells cultured in serum‐free medium as a model for the study of enterocytic differentiation in vitro

1991 • 216 citations

Immunohistochemical analysis of in vivo patterns of Bak expression, a proapoptotic member of the Bcl-2 protein family.

1996 • 207 citations

Merosin and laminin in myogenesis; specific requirement for merosin in myotube stability and survival.

1996 • 205 citations

Epithelial cell growth and differentiation. II. Intestinal apoptosis

1997 • 190 citations

Physiology and pathophysiology of apoptosis in epithelial cells of the liver, pancreas, and intestine

1997 • 186 citations

Regulation of intestinal epithelial proliferation: a few answers, many questions

1993 • 185 citations

Integrins (alpha7beta1) in muscle function and survival. Disrupted expression in merosin-deficient congenital muscular dystrophy.

1997 • 184 citations

The p42/p44 MAP Kinase Pathway Prevents Apoptosis Induced by Anchorage and Serum Removal

2000 • 179 citations

Bi-directional signal transduction by integrin receptors

2000 • 159 citations

Kinase cascades regulating entry into apoptosis

1997 • 157 citations

α5β1 Integrin Protects Intestinal Epithelial Cells from Apoptosis through a Phosphatidylinositol 3-Kinase and Protein Kinase B–dependent Pathway

2000 • 155 citations

Clonal analysis of sucrase-isomaltase expression in the human colon adenocarcinoma Caco-2 cells

1991 • 151 citations

Human cell models to study small intestinal functions: Recapitulation of the crypt-villus axis

2000 • 140 citations

A specific function for phosphatidylinositol 3-kinase α (p85α-p110α) in cell survival and for phosphatidylinositol 3-kinase β (p85α-p110β) in de novo DNA synthesis of human colon carcinoma cells

2000 • 132 citations

Requirement of the MAP kinase cascade for cell cycle progression and differentiation of human intestinal cells

1999 • 128 citations

Sequential and rapid activation of select caspases during apoptosis of normal intestinal epithelial cells

1998 • 119 citations

Integrins and human intestinal cell functions

1999 • 118 citations

Two Independent Signaling Pathways Mediate the Antiapoptotic Action of Macrophage-Stimulating Protein on Epithelial Cells

2000 • 108 citations

Damage-induced apoptosis in intestinal epithelia from bcl-2-null and bax-null mice: investigations of the mechanistic determinants of epithelial apoptosis in vivo

1999 • 104 citations

bcl-2 and bak may play a pivotal role in sodium butyrate-induced apoptosis in colonic epithelial cells; however overexpression of bcl-2 does not protect against bak-mediated apoptosis

1997 • 100 citations

Extracellular heterotrimeric laminin promotes differentiation in human enterocytes

1995 • 80 citations

Downregulation of the pro-apoptotic protein Bak is required for the ras-induced transformation of intestinal epithelial cells

1998 • 76 citations

Increased Intestinal Bak Expression Results in Apoptosis

1996 • 74 citations

Bcl-w expression in colorectal adenocarcinoma

2000 • 65 citations

Human Caco-2 motility redistributes FAK and paxillin and activates p38 MAPK in a matrix-dependent manner

2000 • 63 citations

Cell cycle protein suppression and p21 induction in differentiating Caco-2 cells

1996 • 59 citations

Relation between integrin alpha7Bbeta1 expression in human intestinal cells and enterocytic differentiation

1997 • 54 citations

Expression of Functionally Distinct Variants of the β4A Integrin Subunit in Relation to the Differentiation State in Human Intestinal Cells

1999 • 50 citations

Inhibition of sucrose-isomaltase expression by EGF in the human colon adenocarcinoma cells Caco-2

1991 • 49 citations

Integrins and human intestinal cell functions

1999 • 42 citations

Enterocytic differentiation of the human Caco-2 cell line correlates with alterations in integrin signaling

1998 • 41 citations

Human Intestinal Brush Border Membrane Hydrolases

1994 • 40 citations

Early establishment of epithelial apoptosis in the developing human small intestine.

2000 • 39 citations

Epithelial cell growth and differentiation. I. Intestinal growth factors

1997 • 36 citations

Early acquisition of bowel segment-specific Bcl-2 homolog expression profiles during development of the human ileum and colon.

2001 • 24 citations

Biochemical Analysis of Integrin-Mediated Shc Signaling

2003 • 22 citations

Immunohistochemical localization of BAX and BAD in the normal and BCL-2 null gastrointestinal tract

1996 • 16 citations

Methods for Studying Anoikis

2003 • 15 citations

Deleted Work

1955 • 0 citations