Comparison of a Synthetic Antithrombin III-binding Pentasaccharide and Standard Heparin as an Adjunct to Coronary Thrombolysis

Indications for fibrinolytic therapy in suspected acute myocardial infarction : collaborative overview of early mortality and major morbidity results from all randomised trials of more than 1000 patients

1994 • 2,250 citations

Clot-bound thrombin is protected from inhibition by heparin-antithrombin III but is susceptible to inactivation by antithrombin III-independent inhibitors.

1990 • 1,132 citations

A Comparison between Heparin and Low-Dose Aspirin as Adjunctive Therapy with Tissue Plasminogen Activator for Acute Myocardial Infarction

1990 • 430 citations

Illusion of reperfusion. Does anyone achieve optimal reperfusion during acute myocardial infarction?

1993 • 344 citations

Effect of early intravenous heparin on coronary patency, infarct size, and bleeding complications after alteplase thrombolysis: results of a randomised double blind European Cooperative Study Group trial.

1992 • 301 citations

Assay of heparin in plasma using a chromogenic substrate for activated factor X

1976 • 299 citations

A randomized controlled trial of intravenous tissue plasminogen activator and early intravenous heparin in acute myocardial infarction.

1989 • 276 citations

Effect of heparin on coronary arterial patency after thrombolysis with tissue plasminogen activator in acute myocardial infarction

1990 • 270 citations

Mechanisms of arterial thrombosis in nonparallel streamlines: platelet thrombi grow on the apex of stenotic severely injured vessel wall. Experimental study in the pig model.

1989 • 217 citations

Coronary thrombolysis with intravenously administered human tissue-type plasminogen activator produced by recombinant DNA technology.

1984 • 178 citations

Thrombin activity of fibrin thrombi and soluble plasmic derivatives.

1983 • 170 citations

Pharmacokinetics and Tolerance of the Natural Pentasaccharide (SR90107/ORG31540) with High Affinity to Antithrombin III in Man

1995 • 154 citations

Importance of factor Xa in determining the procoagulant activity of whole-blood clots.

1993 • 153 citations

Conjunctive enhancement of enzymatic thrombolysis and prevention of thrombotic reocclusion with the selective factor Xa inhibitor, tick anticoagulant peptide. Comparison to hirudin and heparin in a canine model of acute coronary artery thrombosis.

1992 • 134 citations

Enhancement of thrombolysis with tissue-type plasminogen activator by pretreatment with heparin.

1986 • 130 citations

Mode of interaction between platelet factor 4 and heparin

1993 • 128 citations

Correlation between level of heparinization and patency of the infarct-related coronary artery after treatment of acute myocardial infarction with alteplase (rt-PA)

1992 • 107 citations

Role of Thrombin Compared With Factor Xa in the Procoagulant Activity of Whole Blood Clots

1995 • 90 citations

Plasma fibrinopeptide A levels in patients with acute myocardial infarction treated with alteplase. Correlation with concomitant heparin, coronary artery patency, and recurrent ischemia. The European Cooperative Study Group.

1992 • 89 citations

Binding of platelet factor 4 to heparin oligosaccharides

1983 • 88 citations

In vivo models of arterial thrombosis and thrombolysis

1990 • 84 citations

Coronary thrombolysis in dogs with intravenously administered human pro-urokinase.

1985 • 77 citations

Induction of marked thrombin activity by pharmacologic concentrations of plasminogen activators in nonanticoagulated whole blood

1989 • 68 citations

Persistent thrombin generation in humans during specific thrombin inhibition with hirudin.

1994 • 57 citations

Potentiation by Heparin Fragments of Thrombolysis Induced with Human Tissue-Type Plasminogen Activator or Human Single-Chain Urokinase-Type Plasminogen Activator

1987 • 47 citations

Thrombolytic and pharmacokinetic properties of chimeric tissue-type and urokinase-type plasminogen activators.

1991 • 45 citations

Antithrombotic Effects of Synthetic Pentasaccharide with High Affinity for Plasma Antithrombin III in Non-Human Primates

1993 • 44 citations

Thrombolysis with recombinant unglycosylated single-chain urokinase-type plasminogen activator (saruplase) in acute myocardial infarction: influence of heparin on early patency rate (LIMITS study)

1995 • 38 citations

Requirement of heparin for arterial and venous thrombolysis with recombinant tissue-type plasminogen activator

1991 • 30 citations

Synthetic Analogues of the Antithrombin III– Binding Pentasaccharide Sequence of Heparin

1995 • 30 citations

Interpretation of Diagnostic Tests. A Handbook Synopsis of Laboratory Medicine.

1971 • 28 citations

Pentasaccharide and Orgaran® Arrest, whereas Heparin Delays Thrombus Formation in a Rat Arteriovenous Shunt

1993 • 26 citations

Comparison of a low-molecular-weight heparin (nadroparin calcium) and unfractionated heparin as adjunct to coronary thrombolysis with alteplase and aspirin in dogs.

1995 • 13 citations

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