Conjunctive enhancement of enzymatic thrombolysis and prevention of thrombotic reocclusion with the selective factor Xa inhibitor, tick anticoagulant peptide. Comparison to hirudin and heparin in a canine model of acute coronary artery thrombosis.

Thrombolysis in Myocardial Infarction (TIMI) Trial, Phase I: A comparison between intravenous tissue plasminogen activator and intravenous streptokinase. Clinical findings through hospital discharge.

1987 • 2,245 citations

Clot-bound thrombin is protected from inhibition by heparin-antithrombin III but is susceptible to inactivation by antithrombin III-independent inhibitors.

1990 • 1,132 citations

MEDICAL SCIENCE GISSI-2: A factorial randomised trial of alteplase versus streptokinase and heparin versus no heparin among 12 490 patients with acute myocardial infarction

1990 • 911 citations

Surface-dependent reactions of the vitamin K-dependent enzyme complexes

1990 • 853 citations

Para-aminosalicylic acid in tuberculosis; early results of clinical trials.

1947 • 797 citations

Assembly of the Platelet Prothrombinase Complex Is Linked to Vesiculation of the Platelet Plasma Membrane

1989 • 597 citations

Kinetics of the inhibition of thrombin by hirudin

1986 • 581 citations

Thrombolytic Therapy: Current Status

1988 • 556 citations

Properties of the factor Xa binding site on human platelets.

1978 • 443 citations

A Comparison between Heparin and Low-Dose Aspirin as Adjunctive Therapy with Tissue Plasminogen Activator for Acute Myocardial Infarction

1990 • 430 citations

Tick Anticoagulant Peptide (TAP) Is a Novel Inhibitor of Blood Coagulation Factor Xa

1990 • 414 citations

Fibrin monomer protects thrombin from inactivation by heparin-antithrombin III: implications for heparin efficacy.

1989 • 348 citations

Anticoagulant activities of heparin oligosaccharides and their neutralization by platelet factor 4

1984 • 344 citations

Interruption of acute platelet-dependent thrombosis by the synthetic antithrombin D-phenylalanyl-L-prolyl-L-arginyl chloromethyl ketone.

1988 • 274 citations

Thrombin structure and function

1991 • 250 citations

Antithrombotic effect of a monoclonal antibody to the platelet glycoprotein IIb/IIIa receptor in an experimental animal model

1986 • 232 citations

The binding of thrombin by fibrin.

1979 • 223 citations

Binding of thrombin to subendothelial extracellular matrix. Protection and expression of functional properties.

1989 • 212 citations

Role of thrombin and thromboxane A2 in reocclusion following coronary thrombolysis with tissue-type plasminogen activator.

1989 • 180 citations

Effect of Intravenous Streptokinase as Compared with That of Tissue Plasminogen Activator on Left Ventricular Function after First Myocardial Infarction

1989 • 180 citations

Increased thromboxane biosynthesis during coronary thrombolysis. Evidence that platelet activation and thromboxane A2 modulate the response to tissue-type plasminogen activator in vivo.

1989 • 171 citations

The complete amino acid sequence of hirudin, a thrombin specific inhibitor

1984 • 170 citations

Effects of monoclonal antibodies against the platelet glycoprotein IIb/IIIa complex on thrombosis and hemostasis in the baboon.

1988 • 167 citations

Hirudin interruption of heparin-resistant arterial thrombus formation in baboons

1991 • 139 citations

Development of Hirudin as an Antithrombotic Agent

1989 • 123 citations

Protection of factor Xa from neutralization by the heparin-antithrombin complex.

1983 • 120 citations

Evaluation of the inhibition by heparin and hirudin of coagulation activation during r-tPA-induced thrombolysis

1989 • 118 citations

Heparin with two binding sites for antithrombin or platelet factor 4.

1982 • 110 citations

Comparison of the In Vivo Anticoagulant Properties of Standard Heparin and the Highly Selective Factor Xa Inhibitors Antistasin and Tick Anticoagulant Peptide (TAP) in a Rabbit Model of Venous Thrombosis

1991 • 107 citations

Characterization of recombinant tick anticoagulant peptide. A highly selective inhibitor of blood coagulation factor Xa.

1990 • 104 citations

In vivo models of arterial thrombosis and thrombolysis

1990 • 84 citations

Tick anticoagulant peptide: kinetic analysis of the recombinant inhibitor with blood coagulation factor X.alpha.

1990 • 69 citations

Augmentation of Streptokinase-Induced Thrombolysis by Heparin and Prostacyclin

1985 • 60 citations

Heparin as an adjunctive treatment after thrombolytic therapy for acute myocardial infarction

1991 • 55 citations

The Anticoagulant and Antithrombotic Properties of Hirudins

1990 • 54 citations

Mode of action of heparin and related drugs.

1991 • 24 citations

Remission of FeLV-associated lymphosarcoma and persistent viral infection after extracorporeal immunoadsorption of plasma using staphylococcal protein A columns: details of immune response.

1989 • 17 citations

Mechanisms of Pathogenesis of Arterial Thrombosis: Potential Sites of Inhibition by Therapeutic Compounds

1988 • 7 citations

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