Illusion of reperfusion. Does anyone achieve optimal reperfusion during acute myocardial infarction?

急性心筋梗塞の疑いのある17187症例におけるストレプトキナーゼ静脈内投与,アスピリン経口投与,上記2つの併用または無処置の無作偽試験 ISIS-2

1988 • 2,760 citations

The “No-Reflow” Phenomenon after Temporary Coronary Occlusion in the Dog

1974 • 1,804 citations

Myocardial reperfusion: a double-edged sword?

1985 • 1,355 citations

TRIAL OF TISSUE PLASMINOGEN ACTIVATOR FOR MORTALITY REDUCTION IN ACUTE MYOCARDIAL INFARCTION

1988 • 1,161 citations

Clot-bound thrombin is protected from inhibition by heparin-antithrombin III but is susceptible to inactivation by antithrombin III-independent inhibitors.

1990 • 1,132 citations

A Randomized Trial of Immediate versus Delayed Elective Angioplasty after Intravenous Tissue Plasminogen Activator in Acute Myocardial Infarction

1987 • 964 citations

MEDICAL SCIENCE GISSI-2: A factorial randomised trial of alteplase versus streptokinase and heparin versus no heparin among 12 490 patients with acute myocardial infarction

1990 • 911 citations

RANDOMISED TRIAL OF INTRAVENOUS RECOMBINANT TISSUE-TYPE PLASMINOGEN ACTIVATOR VERSUS INTRAVENOUS STREPTOKINASE IN ACUTE MYOCARDIAL INFARCTION

1985 • 756 citations

Thrombolysis inMyocardial Infarction (TIMI) Trial, Phase I:acomparison between intravenous tissue plasminogen activator andintravenous streptokinase*

1987 • 751 citations

THROMBOLYSIS WITH TISSUE PLASMINOGEN ACTIVATOR IN ACUTE MYOCARDIAL INFARCTION: NO ADDITIONAL BENEFIT FROM IMMEDIATE PERCUTANEOUS CORONARY ANGIOPLASTY

1988 • 669 citations

Effect of Intravenous Streptokinase on Left Ventricular Function and Early Survival after Acute Myocardial Infarction

1987 • 628 citations

A HAEMATOLOGIST

1989 • 567 citations

Salvage of Infarcted Myocardium by Angiogenic Action of Basic Fibroblast Growth Factor

1992 • 519 citations

Platelets and Thrombolytic Therapy

1990 • 485 citations

Differential sensitivity of erythrocyte-rich and platelet-rich arterial thrombi to lysis with recombinant tissue-type plasminogen activator. A possible explanation for resistance to coronary thrombolysis.

1989 • 473 citations

The Western Washington Randomized Trial of Intracoronary Streptokinase in Acute Myocardial Infarction

1985 • 461 citations

A Comparison between Heparin and Low-Dose Aspirin as Adjunctive Therapy with Tissue Plasminogen Activator for Acute Myocardial Infarction

1990 • 430 citations

Intravenous tissue plasminogen activator and size of infarct, left ventricular function, and survival in acute myocardial infarction.

1988 • 386 citations

Prevention of Myocardial Damage in Acute Myocardial Ischemia by Early Treatment with Intravenous Streptokinase

1985 • 382 citations

Intermittent Coronary Occlusion in Acute Myocardial Infarction

1987 • 373 citations

A Randomized Trial of Intravenous Tissue Plasminogen Activator for Acute Myocardial Infarction with Subsequent Randomization to Elective Coronary Angioplasty

1987 • 362 citations

Improved thrombolysis with a modified dose regimen of recombinant tissue-type plasminogen activator

1989 • 308 citations

Effect of early intravenous heparin on coronary patency, infarct size, and bleeding complications after alteplase thrombolysis: results of a randomised double blind European Cooperative Study Group trial.

1992 • 301 citations

The pathogenesis of a coronary thrombus.

1966 • 277 citations

Interruption of acute platelet-dependent thrombosis by the synthetic antithrombin D-phenylalanyl-L-prolyl-L-arginyl chloromethyl ketone.

1988 • 274 citations

Effect of heparin on coronary arterial patency after thrombolysis with tissue plasminogen activator in acute myocardial infarction

1990 • 270 citations

Impact of early perfusion status of the infarct-related artery on short-term mortality after thrombolysis for acute myocardial infarction: Retrospective analysis of four german multicenter studies

1993 • 268 citations

DOUBLE-BLIND RANDOMISED TRIAL OF INTRAVENOUS TISSUE-TYPE PLASMINOGEN ACTIVATOR VERSUS PLACEBO IN ACUTE MYOCARDIAL INFARCTION

1985 • 242 citations

Thrombin is an important mediator of platelet aggregation in stenosed canine coronary arteries with endothelial injury.

1989 • 241 citations

Thrombolytic therapy with tissue plasminogen activator or streptokinase induces transient thrombin activity

1988 • 239 citations

Does thrombolysis in myocardial infarction (TIMI) perfusion grade 2 represent a mostly patent artery or a mostly occluded artery? Enzymatic and electrocardiographic evidence from the TEAM-2 study

1992 • 236 citations

Improved thrombolysis in acute myocardial infarction with front-loaded administration of alteplase: Results of the rt-PA-APSAC patency study (TAPS)

1992 • 233 citations

Intravenous Recombinant Tissue Plasminogen Activator (rt-PA) and Urokinase in Acute Myocardial Infarction: Results of the German Activator Urokinase Study (GAUS)

1988 • 217 citations

Consequences of reperfusion after coronary occlusion

1974 • 214 citations

Coronary thrombosis: Pathogenesis and clinical manifestations

1991 • 212 citations

Proposal for a simple synthesis prognostic staging system in chronic myelogenous leukemia

1990 • 209 citations

Aspirin versus coumadin in the prevention of reocclusion and recurrent ischemia after successful thrombolysis: a prospective placebo-controlled angiographic study. Results of the APRICOT Study.

1993 • 204 citations

A multicenter, randomized, placebo-controlled trial of a new form of intravenous recombinant tissue-type plasminogen activator (activase) in acute myocardial infarction

1987 • 186 citations

Role of thrombin and thromboxane A2 in reocclusion following coronary thrombolysis with tissue-type plasminogen activator.

1989 • 180 citations

Intracoronary adenosine administered after reperfusion limits vascular injury after prolonged ischemia in the canine model.

1989 • 170 citations

Mediation of reocclusion by thromboxane A2 and serotonin after thrombolysis with tissue-type plasminogen activator in a canine preparation of coronary thrombosis.

1988 • 153 citations

DISCREPANCIES BETWEEN THE EFFECTS OF CORONARY REPERFUSION ON SURVIVAL AND LEFT VENTRICULAR FUNCTION

1989 • 151 citations

Interactions of tissue-type plasminogen activator with plasma inhibitors and their pharmacologic implications.

1988 • 138 citations

Recurrent ischemia without warning. Analysis of risk factors for in-hospital ischemic events following successful thrombolysis with intravenous tissue plasminogen activator.

1989 • 124 citations

Effects of severity of the residual stenosis of the infarct-related coronary artery on left ventricular dilation and function after acute myocardial infarction

1992 • 121 citations

Tissue plasminogen activator: Toronto (TPAT) placebo-controlled randomized trial in acute myocardial infarction

1989 • 118 citations

Prevention of Myocardial Infarction by Very Early Treatment with Intracoronary Streptokinase

1984 • 112 citations

Correlation between level of heparinization and patency of the infarct-related coronary artery after treatment of acute myocardial infarction with alteplase (rt-PA)

1992 • 107 citations

Present status of rescue coronary angioplasty: Current polarization of opinion and randomized trials

1992 • 105 citations

The unstable ST segment early after thrombolysis for acute infarction and its usefulness as a marker of recurrent coronary occlusion

1991 • 97 citations

Factors influencing reocclusion after coronary thrombolysis for acute myocardial infarction

1986 • 96 citations

Combination of platelet fibrinogen receptor antagonist and direct thrombin inhibitor at low doses markedly improves thrombolysis.

1994 • 91 citations

Randomized angiographic trial of recombinant tissue-type plasminogen activator (alteplase) in myocardial infarction

1992 • 88 citations

A prospective, randomized trial comparing combination half-dose tissue-type plasminogen activator and streptokinase with full-dose tissue-type plasminogen activator. Kentucky Acute Myocardial Infarction Trial (KAMIT) Group.

1991 • 87 citations

Dynamic QRS complex and ST segment vectorcardiographic monitoring can identify vessel patency in patients with acute myocardial infarction treated with reperfusion therapy

1991 • 84 citations

Antiplatelet antibody [7E3 F(ab')2] prevents rethrombosis after recombinant tissue-type plasminogen activator-induced coronary artery thrombolysis in a canine model.

1990 • 83 citations

Myocardial hemorrhage after coronary reperfusion in pigs

1978 • 77 citations

Improved survival but not left ventricular function with early and prehospital treatment with tissue plasminogen activator in acute myocardial infarction

1990 • 70 citations

Improved infarct-related arterial patency after high dose, weight-adjusted, rapid infusion of tissue-type plasminogen activator in myocardial infarction: Results of a multicenter randomized trial of two dosage regimens

1990 • 70 citations

Accelerated plasminogen activator dose regimens for coronary thrombolysis

1992 • 68 citations

Angiographic patency study of anistreplase versus streptokinase in acute myocardial infarction

1990 • 60 citations

Infarct vessel status after intravenous tissue plasminogen activator and acute coronary angioplasty: Prediction of clinical outcome

1988 • 58 citations

Cardiac tamponade early after thrombolysis for acute myocardial infarction: A rare but not reported hemorrhagic complication

1991 • 46 citations

Mechanisms of early death despite thrombolytic therapy: Experience from the Thrombolysis in Myocardial Infarction Phase II (TIMI II) study

1992 • 43 citations

Antithrombotic Effects of Recombinant Hirudin in Experimental Angioplasty and Intravascular Thrombolysis

1990 • 41 citations

Treatment of recurrent ischemia after thrombolysis and successful reperfusion for acute myocardial infarction: Effect on in-hospital mortality and left ventricular function

1991 • 40 citations

Pathological changes after intravenous streptokinase treatment in eight patients with acute myocardial infarction.

1989 • 37 citations

Coronary patency, infarct size and left ventricular function after thrombolytic therapy for acute myocardial infarction: results from the tissue plasminogen activator: Toronto (TPAT) placebo-controlled trial

1991 • 35 citations

Prediction of early recurrent myocardial ischemia and coronary reocclusion after successful thrombolysis: A qualitative and quantitative angiographic study

1989 • 34 citations

A pilot study of the efficacy and safety of bolus administration of alteplase in acute myocardial infarction.

1991 • 32 citations

Angiographically assessed coronary arterial patency and reocclusion in patients with acute myocardial infarction treated with anistreplase: Results of the anistreplase reocclusion multicenter study (ARMS)

1991 • 27 citations

Catheterization/rescue angioplasty following thrombolysis (craft) study: Acute myocardial infarction treated with recombinant tissue plasminogen activator versus urokinase

1991 • 22 citations

Streptokinase thrombolysis in experimental coronary artery thrombosis: pattern of reflow and effect of a stenosis

1984 • 19 citations

The effect of late patency of the infarct-related coronary artery on left ventricular morphology and regional function after thrombolysis

1992 • 16 citations

Effect of coronary reocclusion after initial reperfusion on ventricular function and infarct size

1991 • 14 citations

Unanswered questions in thrombolysis

1989 • 11 citations