Regulation of HLA Class II Gene Expression

A conserved AU sequence from the 3′ untranslated region of GM-CSF mRNA mediates selective mRNA degradation

1986 • 4,200 citations

Antigen-Presenting Function of the Macrophage

1984 • 1,164 citations

In vivo sequence requirements of the SV40 early promoter region

1981 • 1,156 citations

Epstein-Barr virus receptor of human B lymphocytes is the C3d receptor CR2.

1984 • 936 citations

B Lineage—Specific Interactions of an Immunoglobulin Enhancer with Cellular Factors in Vivo

1985 • 859 citations

Astrocytes present myelin basic protein to encephalitogenic T-cell lines

1984 • 773 citations

A multiplicity of CCAAT box-binding proteins

1987 • 745 citations

A lymphoid-specific protein binding to the octamer motif of immunoglobulin genes

1986 • 740 citations

Immune interferon activates multiple class II major histocompatibility complex genes and the associated invariant chain gene in human endothelial cells and dermal fibroblasts.

1984 • 579 citations

Prostaglandins modulate macrophage Ia expression

1982 • 545 citations

Histocompatibility Testing 1984

1985 • 535 citations

Regulation of murine macrophage Ia antigen expression by a lymphokine with immune interferon activity.

1982 • 481 citations

Insulin-dependent diabetes mellitus induced in transgenic mice by ectopic expression of class II MHC and interferon-gamma

1988 • 476 citations

Genes of the Major Histocompatibility Complex of the Mouse

1983 • 445 citations

Increased expression of Ia antigens on resting B cells: an additional role for B-cell growth factor.

1984 • 438 citations

An octamer oligonucleotide upstream of a TATA motif is sufficient for lymphoid-specific promoter activity

1987 • 398 citations

Specific DNA methylation sites in the vicinity of the chicken β-globin genes

1979 • 365 citations

Mouse monoclonal antibodies against rat major histocompatibility antigens. Two Ia antigens and expression of Ia and class I antigens in rat thymus

1982 • 364 citations

Linkage map of the human major histocompatibility complex including the tumor necrosis factor genes.

1987 • 351 citations

Diabetes and tolerance in transgenic mice expressing class II MHC molecules in pancreatic beta cells

1988 • 343 citations

DO beta: a new beta chain gene in HLA-D with a distinct regulation of expression.

1985 • 340 citations

Requirement of stereospecific alignments for initiation from the simian virus 40 early promoter

1986 • 336 citations

Two-gene control of the expression of a murine Ia antigen.

1978 • 328 citations

Surface antigens of melanocytes and melanomas. Markers of melanocyte differentiation and melanoma subsets.

1982 • 327 citations

Transcription cell type specificity is conferred by an immunoglobulin VH gene promoter that includes a functional consensus sequence

1985 • 313 citations

Membrane insertion and oligomeric assembly of HLA-DR histocompatibility antigens

1982 • 308 citations

Interaction of cell-type-specific nuclear proteins with immunoglobulin VH promoter region sequences

1986 • 298 citations

Organ‐Specific Autoimmunity: A 1986 Overview

1986 • 274 citations

The Human la System

1980 • 272 citations

Quantitative variation in la antigen expression plays a central role in immune regulation

1984 • 270 citations

Isotypic and allotypic variation of human class II histocompatibility antigen α-chain genes

1984 • 261 citations

Antigen-presenting capabilities of human monocytes correlates with their expression of HLA-DS, an Ia determinant distinct from HLA-DR.

1983 • 260 citations

Expression of human class II major histocompatibility complex antigens using retrovirus vectors.

1987 • 257 citations

EXPRESSION OF Ia-LIKE ANTIGENS IN NORMAL HUMAN NONLYMPHOID TISSUES

1981 • 239 citations

Expression of cell-surface HLA-DR, HLA-ABC and glycophorin during erythroid differentiation

1981 • 234 citations

Induction of Ia and H-2 antigens on a macrophage cell line by immune interferon.

1983 • 227 citations

Surface antigens of melanoma and melanocytes. Specificity of induction of Ia antigens by human gamma-interferon.

1984 • 224 citations

Histocompatibility Testing

2000 • 219 citations

Heterogeneity in surface antigen and glycoprotein expression of cell lines derived from different melanoma metastases of the same patient. Implications for the study of tumor antigens.

1981 • 213 citations

Conserved major histocompatibility complex class II boxes--X and Y--are transcriptional control elements and specifically bind nuclear proteins.

1987 • 212 citations

Human B cell variants immunoselected against a single Ia antigen subset have lost expression of several Ia antigen subsets.

1983 • 205 citations

Effects of interferon-gamma and tumor necrosis factor-alpha on the expression of an Ia antigen on a murine macrophage cell line.

1986 • 199 citations

A trans-acting class II regulatory gene unlinked to the MHC controls expression of HLA class II genes

1985 • 191 citations

Both alpha and beta chains of HLA-DC class II histocompatibility antigens display extensive polymorphism in their amino-terminal domains.

1984 • 190 citations

Mapping of the class II region of the human major histocompatibility complex by pulsed-field gel electrophoresis

1986 • 184 citations

Sequence polymorphism of HLA DRβ1 alleles relating to T-cell-recognized determinants

1985 • 183 citations

The murine Eα immune response gene

1983 • 180 citations

Graft-vs.-host disease elicits expression of class I and class II histocompatibility antigens and the presence of scattered T lymphocytes in rat central nervous system.

1987 • 178 citations

Gene expression: DNA methylation — how important in gene control?

1984 • 178 citations

Multiple sclerosis: relevance of Class I and Class II MHC-expressing cells to lesion development

1987 • 169 citations

Six HLA-D region alpha-chain genes on human chromosome 6: polymorphisms and associations of DC alpha-related sequences with DR types.

1984 • 163 citations

Cell type-specific enhancer element associated with a mouse MHC gene, Eβ

1984 • 162 citations

Complete primary structures of the E beta chain and gene of the mouse major histocompatibility complex.

1983 • 161 citations

Massive induction of donor-type class I and class II major histocompatibility complex antigens in rejecting cardiac allografts in the rat.

1985 • 160 citations

Regulation of a transfected human class II major histocompatibility complex gene in human fibroblasts.

1986 • 159 citations

The human HLA class II alpha chain gene DZ alpha is distinct from genes in the DP, DQ and DR subregions.

1985 • 149 citations

Variable expression of Ia antigens on the vascular endothelium of mouse skin allografts

1983 • 143 citations

Transgenic mice selectively lacking MHC class II (I-E) antigen expression on B cells: An in vivo approach to investigate la gene function

1987 • 134 citations

I-A antigens on cloned alloreactive murine T lymphocytes are acquired passively.

1982 • 128 citations

Megabase-Scale Mapping of the HLA Gene Complex by Pulsed Field Gel Electrophoresis

1987 • 126 citations

Upstream DNA sequences required for tissue-specific expression of the HLA-DR alpha gene.

1987 • 126 citations

Developmental activation of the H-2K gene is correlated with an increase in DNA methylation

1983 • 115 citations

Structure and polymorphism of the HLA class II SB light chain genes.

1984 • 115 citations

Differential regulation of HLA-DR mRNAs and cell surface antigens by interferon.

1983 • 112 citations

Biosynthesis and maturation of HLA-DR antigens in vivo.

1981 • 111 citations

Stable variants affecting B cell alloantigens in human lymphoid cells

1978 • 109 citations

aIr-1, a newly found locus on mouse chromosome 16 encoding a trans-acting activator factor for MHC class II gene expression.

1986 • 106 citations

Class II genes of the human major histocompatibility complex. Comparisons of the DQ and DX alpha and beta genes.

1987 • 103 citations

Sequence-specific interactions of nuclear factors with conserved sequences of human class II major histocompatibility complex genes.

1987 • 103 citations

Genetics and Expression of Mouse Ia Antigens

1985 • 99 citations

Gamma-interferon induces expression of the HLA-D antigens on normal and leukemic human myeloid cells.

1984 • 92 citations

Expression and synthesis of murine immune response-associated (Ia) antigens by brain cells.

1981 • 85 citations

Class II histocompatibility antigen expression in human melanocytes transformed by Harvey murine sarcoma virus (Ha-MSV) and Kirsten MSV retroviruses.

1986 • 81 citations

Structure and expression of HLA-DQ ? and -DX ? genes: interallelic alternate splicing of the HLA-DQ ? gene and functional splicing of the HLA-DX ? gene using a retroviral vector

1987 • 80 citations

Bare lymphocyte syndrome: Altered HLA class II expression in B cell lines derived from two patients

1989 • 79 citations

Identification of a trans-acting function regulating HLA-DR expression in a DR-negative B cell variant

1980 • 78 citations

Identification of an interferon-gamma response region 5' of the human histocompatibility leukocyte antigen DR alpha chain gene which is active in human glioblastoma multiforme lines.

1987 • 78 citations

The Immunologic Function of Skin

1985 • 78 citations

Trans-acting element(s) operating across species barriers positively regulate expression of major histocompatibility complex class II genes.

1985 • 73 citations

Complex regulation of class II gene expression: analysis with class II mutant cell lines.

1985 • 67 citations

Mutant human B cell lines deficient in class II major histocompatibility complex transcription.

1987 • 63 citations

Review: Class II molecules of the major histocompatibility complex considered as differentiation markers

1986 • 60 citations

HLA DR, DQ, and DP antigen expression in rheumatoid synovial cells: a biochemical and quantitative study.

1987 • 57 citations

Differential presentation of HLA-DR, DQ, and DP restriction elements by interferon-gamma-treated dermal fibroblasts.

1987 • 56 citations

Interaction between I region loci influences the expression of a cell surface Ia antigen.

1980 • 55 citations

Evidence for two trans-acting genes regulating HLA class II antigen expression.

1985 • 52 citations

Diagnosis and classification of severe combined immunodeficiency disease.

1983 • 49 citations

Structure of the human Ia-associated invariant (gamma)-chain gene: identification of 5' sequences shared with major histocompatibility complex class II genes.

1986 • 46 citations

Transcriptional regulation of HLA class II and invariant chain genes.

1985 • 42 citations

An ordered sequence of expression of human MHC class-II antigens during B-cell maturation?

1983 • 40 citations

Genotyping with DNA Probes in Combined Immunodeficiency Syndrome with Defective Expression of HLA

1985 • 37 citations

Defective HLA class II expression in a regulatory mutant is partially complemented by activated ras oncogenes.

1987 • 37 citations

Methylation of the HLA-DR alpha gene is positively correlated with expression

1987 • 36 citations

A tissue-specific transcriptional enhancer is found in the body of the HLA-DR alpha gene.

1987 • 32 citations

Expression patterns of MHC class II genes in rabbit tissues indicate close homology to human counterparts.

1987 • 29 citations

HLA-DR antigens of autologous melanoma and B lymphoblastoid cell lines: differences in glycosylation but not protein structure.

1984 • 29 citations

Expression of HLA-DR by a human monocyte cell line is under transcriptional control.

1984 • 27 citations

Differential Ia antigen expression by autologous human erythroid and B lymphoblastoid cell lines.

1985 • 27 citations

Low expression of human histocompatibility leukocyte antigen-DR is associated with hypermethylation of human histocompatibility leukocyte antigen-DR alpha gene regions in B cells from patients with systemic lupus erythematosus.

1985 • 26 citations

DNA Methylation and Expression of HLA-DRα

1984 • 26 citations

Phenotypical and functional analysis of B lymphocytes of two siblings with combined immunodeficiency and defective expression of major histocompatibility complex (MHC) class II antigens on mononuclear cells

1987 • 26 citations

Distinct mechanisms regulate MHC class II gene expression in B cells and macrophages.

1987 • 25 citations

Revertants from the HLA class II regulatory mutant 6.1.6: implications for the regulation of Ia gene expression.

1984 • 22 citations

Lack of correlation between hypomethylation and expression of the HLA‐DRα gene

1986 • 22 citations

Bare lymphocyte syndrome. Consequences of absent class II major histocompatibility antigen expression for B lymphocyte differentiation and function.

1988 • 22 citations

Stable integration of mouse DNA into Ia-negative human B-lymphoma cells causes reexpression of the human Ia-positive phenotype.

1986 • 21 citations

Different roles for cytosine methylation in HLA class ii gene expression

1985 • 21 citations

Chromatin Structure of the HLA-DR α Gene in Different Functional States of Major Histocompatibility Complex Class II Gene Expression

1987 • 20 citations

Methylation patterns of HLA-DR alpha genes in six mononuclear cell lines

1986 • 19 citations

DNA methylation and expression of HLA-DR alpha.

1984 • 18 citations

Evidence for methylation as a regulatory mechanism in HLA-DR x gene expression

1985 • 17 citations

Thirty International Cases of Bare Lymphocyte Syndrome: Biological Significance of HLA Antigens

1985 • 17 citations

Interferon-induced expression of class II major histocompatibility antigens in the major histocompatibility complex (MHC) class II deficiency syndrome

1988 • 14 citations

Defective Expression of HLA-D-Region Determinants in Children with Congenital Agammaglobulinemia and Malabsorption: A New Syndrome

1984 • 13 citations

Defect of Expression of MHC Genes Responsible for an Abnormal HLA Class I Phenotype and the Class II Negative Phenotype of Lymphocytes from Patients with Combined Immunodeficiency

1984 • 10 citations

Chromatin structure of the HLA-DR alpha gene in different functional states of major histocompatibility complex class II gene expression.

1987 • 8 citations

Defective expression of mononuclear cell membrane HLA antigens associated with combined immunodeficiency: impaired cellular interactions.

1983 • 8 citations

Regulation of HLA Class II Genes: Identification of a Regulatory Promoter Binding Protein Missing in Class II-Deficient Congenital Immunodeficiency

1989 • 3 citations

The Stability of Merchant Steamships

1883 • 3 citations

Bare Lymphocyte Syndrome Transcriptional Regulation of HLA Class II Expression

1989 • 1 citations

Activated Ras Oncogenes Partially Complement the Transcriptional Defects in Class II-Negative Mutant B-Cell Lines

1989 • 1 citations