Loss of Serum Response Element-Binding Activity and Hyperphosphorylation of Serum Response Factor during Cellular Aging

Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei

1983 • 11,902 citations

The serial cultivation of human diploid cell strains

1961 • 7,886 citations

The limited in vitro lifetime of human diploid cell strains

1965 • 5,595 citations

Stimulation of 3T3 cells induces transcription of the c-fos proto-oncogene

1984 • 3,150 citations

The regulation of transcription by phosphorylation

1992 • 1,316 citations

The SRF accessory protein Elk-1 contains a growth factor-regulated transcriptional activation domain

1993 • 1,313 citations

Five intermediate complexes in transcription initiation by RNA polymerase II

1989 • 1,033 citations

Replicative life-span of cultivated human cells. Effects of donor's age, tissue, and genotype.

1970 • 1,002 citations

Identification of a protein-binding site that mediates transcriptional response of the c-fos gene to serum factors

1986 • 883 citations

Replicative Senescence: the Human Fibroblast Comes of Age

1990 • 649 citations

Direct and selective binding of an acidic transcriptional activation domain to the TATA-box factor TFIID

1990 • 620 citations

The SIF binding element confers sis/PDGF inducibility onto the c-fos promoter.

1990 • 615 citations

Complexity of the early genetic response to growth factors in mouse fibroblasts.

1988 • 579 citations

Multiple protein-binding sites in the 5'-flanking region regulate c-fos expression.

1986 • 516 citations

Repression of c- fos Transcription and an Altered Genetic Program in Senescent Human Fibroblasts

1990 • 478 citations

Inducible production of c-fos antisense RNA inhibits 3T3 cell proliferation.

1986 • 468 citations

The serum response element

1992 • 458 citations

Ets-related protein Elk-1 is homologous to the c-fos regulatory factor p62TCF

1991 • 447 citations

The jun and fos protein families are both required for cell cycle progression in fibroblasts.

1991 • 442 citations

Antisense RNA of proto-oncogene c-fos blocks renewed growth of quiescent 3T3 cells.

1987 • 381 citations

Evidence for a relationship between longevity of mammalian species and life spans of normal fibroblasts in vitro and erythrocytes in vivo

1981 • 348 citations

The cdk2 kinase is required for the G1-to-S transition in mammalian cells.

1993 • 307 citations

c-fos Sequence Necessary for Basal Expression and Induction by Epidermal Growth Factor, 12-O-Tetradecanoyl Phorbol-13-Acetate and the Calcium Ionophore

1987 • 304 citations

Microinjection of fos-specific antibodies blocks DNA synthesis in fibroblast cells.

1988 • 266 citations

Cell-free activation of a DNA-binding protein by epidermal growth factor

1993 • 263 citations

A family of immunologically related transcription factors that includes multiple forms of ATF and AP-1.

1988 • 259 citations

Expression of cell cycle-dependent genes in young and senescent WI-38 fibroblasts.

1986 • 247 citations

The c-fos serum response element responds to protein kinase C-dependent and -independent signals but not to cyclic AMP.

1988 • 245 citations

Distinct Protein Targets for Signals Acting at the c- fos Serum Response Element

1991 • 244 citations

Mutation of the c-fos gene dyad symmetry element inhibits serum inducibility of transcription in vivo and the nuclear regulatory factor binding in vitro.

1987 • 238 citations

Replicative senescence of human skin fibroblasts correlates with a loss of regulation and overexpression of collagenase activity

1989 • 237 citations

Multiple sequence elements of a single functional class are required for cyclic AMP responsiveness of the mouse c-fos promoter.

1989 • 220 citations

Autoregulation of fos: the dyad symmetry element as the major target of repression.

1989 • 211 citations

TATA-binding protein is a classless factor

1992 • 202 citations

Diverse gene sequences are overexpressed in werner syndrome fibroblasts undergoing premature replicative senescence.

1991 • 196 citations

Transcription factor AP-1 activity is required for initiation of DNA synthesis and is lost during cellular aging.

1992 • 187 citations

The catalytic subunit of cAMP-dependent protein kinase induces expression of genes containing cAMP-responsive enhancer elements

1988 • 186 citations

Senescent cells fail to express cdc2, cycA, and cycB in response to mitogen stimulation.

1991 • 183 citations

Casein kinase II phosphorylation increases the rate of serum response factor-binding site exchange.

1992 • 165 citations

Synergism in ternary complex formation between the dimeric glycoprotein p67SRF, polypeptide p62TCF and the c-fos serum response element.

1990 • 157 citations

Two distinct cellular phosphoproteins bind to the c-fos serum response element.

1989 • 140 citations

c-fos sequence necessary for basal expression and induction by epidermal growth factor, 12-O-tetradecanoyl phorbol-13-acetate and the calcium ionophore.

1987 • 126 citations

A 57,000-mol-wt protein uniquely present in nonproliferating cells and senescent human fibroblasts.

1985 • 125 citations

Fibronectin expression increases during in vitro cellular senescence: Correlation with increased cell area

1991 • 113 citations

The serum response factor is extensively modified by phosphorylation following its synthesis in serum-stimulated fibroblasts.

1991 • 92 citations

Mutation of serum response factor phosphorylation sites and the mechanism by which its DNA-binding activity is increased by casein kinase II.

1991 • 88 citations

The nuclear protooncogenes c-jun and c-fos as regulators of DNA replication.

1991 • 81 citations

Cellular aging and senescence

1991 • 54 citations

Down-regulation of cdc2 in senescent human and hamster cells.

1991 • 46 citations

Renewed DNA synthesis in senescent WI‐38 cells by expression of an inducible chimeric c‐fos construct

1992 • 33 citations

Transcription factor activity during cellular aging of human diploid fibroblasts

1992 • 30 citations

Identification of a highly abundant cDNA isolated from senescent WI-38 cells

1989 • 29 citations

Genetic Diseases of Premature Aging as Models of Senescence

1991 • 28 citations

Altered gene expression during cellular aging

1989 • 27 citations

Altered regulation of platelet-derived growth factor A-chain and c-fos gene expression in senescent progeria fibroblasts

1990 • 24 citations