Vascular Endothelial Growth Factor Receptor-3

A novel vascular endothelial growth factor, VEGF-C, is a ligand for the Flt4 (VEGFR-3) and KDR (VEGFR-2) receptor tyrosine kinases.

1996 • 1,670 citations

Expression of the fms-like tyrosine kinase 4 gene becomes restricted to lymphatic endothelium during development.

1995 • 1,421 citations

Hyperplasia of Lymphatic Vessels in VEGF-C Transgenic Mice

1997 • 1,280 citations

Blood Vessel Formation: What Is Its Molecular Basis?

1996 • 1,242 citations

Vascular endothelial growth factor D (VEGF-D) is a ligand for the tyrosine kinases VEGF receptor 2 (Flk1) and VEGF receptor 3 (Flt4)

1998 • 1,192 citations

Proteolytic processing regulates receptor specificity and activity of VEGF-C

1997 • 773 citations

Vascular endothelial growth factor and its receptors

1996 • 686 citations

VEGF-C receptor binding and pattern of expression with VEGFR-3 suggests a role in lymphatic vascular development

1996 • 684 citations

On the origin of the lymphatic system from the veins and the development of the lymph hearts and thoracic duct in the pig

1902 • 542 citations

Endothelial receptor tyrosine kinases involved in angiogenesis.

1995 • 537 citations

VEGF and VEGF-C: Specific Induction of Angiogenesis and Lymphangiogenesis in the Differentiated Avian Chorioallantoic Membrane

1997 • 501 citations

Vascular endothelial growth factor-related protein: a ligand and specific activator of the tyrosine kinase receptor Flt4.

1996 • 406 citations

Lymphatic endothelium and Kaposi's sarcoma spindle cells detected by antibodies against the vascular endothelial growth factor receptor-3.

1998 • 315 citations

Identification of a c-fos-induced gene that is related to the platelet-derived growth factor/vascular endothelial growth factor family.

1996 • 315 citations

Molecular Cloning of a Novel Vascular Endothelial Growth Factor, VEGF-D

1997 • 305 citations

FLT4 receptor tyrosine kinase contains seven immunoglobulin-like loops and is expressed in multiple human tissues and cell lines.

1992 • 285 citations

A Recombinant Mutant Vascular Endothelial Growth Factor-C that Has Lost Vascular Endothelial Growth Factor Receptor-2 Binding, Activation, and Vascular Permeability Activities

1998 • 252 citations

Evidence for the origin of Kaposi's sarcoma from lymphatic endothelium.

1985 • 252 citations

Electron microscopic observations on lymphatic capillaries and the structural components of the connective tissue-lymph interface

1970 • 210 citations

Signaling angiogenesis and lymphangiogenesis

1998 • 182 citations

The FLT4 gene encodes a transmembrane tyrosine kinase related to the vascular endothelial growth factor receptor.

1993 • 164 citations

Signalling properties of FLT4, a proteolytically processed receptor tyrosine kinase related to two VEGF receptors.

1994 • 163 citations

STUDIES ON THE PERMEABILITY OF LYMPHATIC CAPILLARIES

1971 • 142 citations

血小板由来増殖因子/血管内皮増殖因子ファミリーと相関するc‐fos誘導性遺伝子の同定

1996 • 138 citations

FLT4, a novel class III receptor tyrosine kinase in chromosome 5q33-qter.

1992 • 121 citations

Expression of the avian VEGF receptor homologues Quek1 and Quek2 in blood-vascular and lymphatic endothelial and non-endothelial cells during quail embryonic development

1997 • 114 citations

Two human FLT4 receptor tyrosine kinase isoforms with distinct carboxy terminal tails are produced by alternative processing of primary transcripts.

1993 • 110 citations

Expression of FLT4 and its ligand VEGF-C in acute myeloid leukemia

1997 • 101 citations

Molecular cloning of murine FLT and FLT4.

1993 • 90 citations

Avian VEGF-C: cloning, embryonic expression pattern and stimulation of the differentiation of VEGFR2-expressing endothelial cell precursors

1998 • 85 citations

Chromosomal localization of FLT4, a novel receptor-type tyrosine kinase gene

1992 • 82 citations

Cytokine signaling through the novel tyrosine kinase RAFTK in Kaposi's sarcoma cells.

1997 • 72 citations

Mutation at tyrosine residue 1337 abrogates ligand-dependent transforming capacity of the FLT4 receptor.

1995 • 72 citations

Close physical linkage of the FLT1 and FLT3 genes on chromosome 13 in man and chromosome 5 in mouse.

1993 • 67 citations

Molecular cloning of Quek 1 and 2, two quail vascular endothelial growth factor (VEGF) receptor-like molecules

1996 • 52 citations

Biochemical characterization of two isoforms of FLT4, a VEGF receptor-related tyrosine kinase.

1995 • 45 citations

Ultrastructure of pulmonary lymphatic vessels.

1983 • 39 citations

Interaction with the Phosphotyrosine Binding Domain/Phosphotyrosine Interacting Domain of SHC Is Required for the Transforming Activity of the FLT4/VEGFR3 Receptor Tyrosine Kinase

1996 • 35 citations

Signal Transduction in Human Hematopoietic Cells by Vascular Endothelial Growth Factor Related Protein, a Novel Ligand for the FLT4 Receptor

1997 • 33 citations

Lymphaticovenous differentiation in Kaposi's sarcoma. Cellular phenotypes by stage.

1988 • 30 citations

FLT4 Receptor Tyrosine Kinase Gene Mapping to Chromosome Band 5q35 in Relation to the t(2;5), t(5;6), and t(3;5) Translocations

1993 • 18 citations

Construction of a 3-Mb Contig and Partial Transcript Map of the Central Region of Mouse Chromosome 11

1997 • 15 citations