Interaction with endothelial cells is a prerequisite for branching ductal-alveolar morphogenesis and hyperplasia of preneoplastic human breast epithelial cells: regulation by estrogen.

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

Vascular Endothelial Growth Factor Is a Secreted Angiogenic Mitogen

1989 • 4,988 citations

Tumor Cells Secrete a Vascular Permeability Factor That Promotes Accumulation of Ascites Fluid

1983 • 3,942 citations

Inhibition of vascular endothelial growth factor-induced angiogenesis suppresses tumour growth in vivo

1993 • 3,605 citations

Vascular endothelial growth factor (VEGF) and its receptors

1999 • 3,498 citations

Cancer metastasis and angiogenesis: An imbalance of positive and negative regulation

1991 • 2,774 citations

Vascular endothelial growth factor is a potential tumour angiogenesis factor in human gliomas in vivo

1992 • 2,293 citations

Pituitary follicular cells secrete a novel heparin-binding growth factor specific for vascular endothelial cells

1989 • 2,267 citations

Metastatic potential correlates with enzymatic degradation of basement membrane collagen

1980 • 1,778 citations

Vascular endothelial growth factor acts as a survival factor for newly formed retinal vessels and has implications for retinopathy of prematurity

1995 • 1,608 citations

Isolation and Characterization of a Spontaneously Immortalized Human Breast Epithelial Cell Line, MCF-10

1990 • 1,495 citations

Tumor vascular permeability factor stimulates endothelial cell growth and angiogenesis.

1989 • 1,282 citations

Suppression of ICE and Apoptosis in Mammary Epithelial Cells by Extracellular Matrix

1995 • 1,184 citations

SV40-transformed Human Lung Fibroblasts Secrete a 92-kDa Type IV Collagenase Which Is Identical to That Secreted by Normal Human Macrophages

1989 • 1,122 citations

H-ras oncogene-transformed human bronchial epithelial cells (TBE-1) secrete a single metalloprotease capable of degrading basement membrane collagen.

1988 • 1,050 citations

Regulators of Angiogenesis

1991 • 959 citations

Vascular permeability factor (vascular endothelial growth factor) gene is expressed differentially in normal tissues, macrophages, and tumors.

1992 • 900 citations

Tumor Growth and Neovascularization: An Experimental Model Using the Rabbit Cornea 2

1974 • 762 citations

Functional differentiation and alveolar morphogenesis of primary mammary cultures on reconstituted basement membrane

1989 • 700 citations

Differential Reactivity of a Novel Monoclonal Antibody (DF3) with Human Malignant versus Benign Breast Tumors

1984 • 583 citations

Identification of an Inhibitor of Neovascularization from Cartilage

1990 • 481 citations

In vitro angiogenesis on the human amniotic membrane: requirement for basic fibroblast growth factor-induced proteinases.

1989 • 462 citations

Vascular endothelial growth factor/vascular permeability factor expression in the rat uterus: rapid stimulation by estrogen correlates with estrogen-induced increases in uterine capillary permeability and growth.

1993 • 437 citations

Relation of vascular proliferation to tumor growth.

1976 • 413 citations

The Activation of Human Type IV Collagenase Proenzyme

1989 • 347 citations

Inhibition of angiogenesis by tissue inhibitor of metalloproteinase

1994 • 299 citations

MCF10AT: a model for the evolution of cancer from proliferative breast disease.

1996 • 298 citations

Type IV collagenase(s) and TIMPs modulate endothelial cell morphogenesis in vitro

1993 • 296 citations

Extracellular sequestration and release of fibroblast growth factor: a regulatory mechanism?

1991 • 284 citations

The Pathophysiology of Angiogenesis

1995 • 269 citations

Role of Interleukin-8 in Tumor Growth and Metastasis of Human Melanoma

1999 • 248 citations

Partial purification and characterization of a neutral protease which cleaves type IV collagen

1981 • 241 citations

Secretion of type IV collagenolytic protease and metastatic phenotype: induction by transfection with c-Ha-ras but not c-Ha-ras plus Ad2-E1a.

1987 • 226 citations

Expression of an Estrogen Receptor by Human Coronary Artery and Umbilical Vein Endothelial Cells

1996 • 218 citations

Reciprocal paracrine interactions between tumour cells and endothelial cells: the ‘angiogenesis progression’ hypothesis

1996 • 212 citations

Regulation of distinct steps of angiogenesis by different angiogenic molecules.

1998 • 208 citations

Xenograft Model of Progressive Human Proliferative Breast Disease

1993 • 204 citations

Mr 92,000 gelatinase release correlates with the metastatic phenotype in transformed rat embryo cells.

1990 • 202 citations

Vascular permeability factor (vascular endothelial growth factor) in guinea pig and human tumor and inflammatory effusions.

1993 • 192 citations

Regulation of Angiogenesis

1997 • 187 citations

Transformation of Human Breast Epithelial Cells by c‐Ha‐ras Oncogene

1991 • 162 citations

Expression of interleukin-8 receptors on tumor cells and vascular endothelial cells in human breast cancer tissue.

1998 • 141 citations

Induction and stimulation of 92-kDa gelatinase / type IV collagenase production in osteosarcoma and fibrosarcoma cell lines by tumor necrosis factor α

1990 • 124 citations

Over expression of vascular endothelial growth factor and its receptor during the development of estrogen-induced rat pituitary tumors may mediate estrogen-initiated tumor angiogenesis

1997 • 117 citations

Environmental Estrogen Stimulation of Growth and Estrogen Receptor Function in Preneoplastic and Cancerous Human Breast Cell Lines

1997 • 113 citations

Extracellular matrix as a solid-state regulator in angiogenesis: identification of new targets for anti-cancer therapy.

1992 • 113 citations

Estrogen regulates vascular endothelial growth/permeability factor expression in 7,12-dimethylbenz(a)anthracene-induced rat mammary tumors.

1996 • 113 citations

Estrogen receptor variants and mutations

1997 • 99 citations

Vascular Permeability Factor/Vascular Endothelial Growth Factor Inhibits Anchorage-Disruption-Induced Apoptosis in Microvessel Endothelial Cells by Inducing Scaffold Formation

1997 • 98 citations

How the extracellular matrix and macrophages contribute to angiogenesis-dependent diseases

1996 • 89 citations

Oestrogen receptor mutants and variants in breast cancer

1997 • 52 citations

Characterization of the estrogen receptor transfected MCF10A breast cell line 139B6

1996 • 49 citations

Direct action of estrogen on sequence of progression of human preneoplastic breast disease.

1998 • 49 citations

The role of estrogen receptor mutations in tamoxifen-stimulated breast cancer

1997 • 39 citations

Angiogenesis: A mechanism by which oncogenes and tumor suppressor genes regulate tumorigenesis

1993 • 31 citations

Transcriptional activation of functional endogenous estrogen receptor gene expression in MCF10AT cells: a model for early breast cancer.

1998 • 31 citations

Procollagenase activator produced by rabbit uterine cervical fibroblasts

1987 • 28 citations

The microvasculature of the 7,12-dimethylbenz(a)anthracene (DMBA)-induced rat mammary tumour

1991 • 22 citations

Effects of oestradiol and progesterone on the synthesis of DNA and the anti-haemophilic Factor VIII antigen in human endometrial endothelial cells in vitro: a pilot study

1986 • 13 citations

Hormone-dependent changes of blood vessels in DMBA-induced rat mammary carcinoma and its regression studied by 3H-thymidine autoradiography.

1985 • 7 citations