Human Ether-a-gogo Related Gene (HERG) K Channels as Pharmacological Targets

Oxidative Stress, Glutamate, and Neurodegenerative Disorders

1993 • 3,746 citations

Preliminary Report: Effect of Encainide and Flecainide on Mortality in a Randomized Trial of Arrhythmia Suppression after Myocardial Infarction

1989 • 3,227 citations

A mechanistic link between an inherited and an acquird cardiac arrthytmia: HERG encodes the IKr potassium channel

1995 • 2,391 citations

Goodman and Gilman's The Pharmacological Basis of Therapeutics

1996 • 2,325 citations

A molecular basis for cardiac arrhythmia: HERG mutations cause long QT syndrome

1995 • 2,263 citations

Positional cloning of a novel potassium channel gene: KVLQT1 mutations cause cardiac arrhythmias

1996 • 1,746 citations

Coassembly of KVLQT1 and minK (IsK) proteins to form cardiac IKS potassium channel

1996 • 1,741 citations

SCN5A mutations associated with an inherited cardiac arrhythmia, long QT syndrome

1995 • 1,686 citations

KvLQT1 and IsK (minK) proteins associate to form the IKS cardiac potassium current

1996 • 1,585 citations

Two components of cardiac delayed rectifier K+ current. Differential sensitivity to block by class III antiarrhythmic agents.

1990 • 1,467 citations

Effect of d-sotalol on mortality in patients with left ventricular dysfunction after recent and remote myocardial infarction

1996 • 1,352 citations

HERG, a Human Inward Rectifier in the Voltage-Gated Potassium Channel Family

1995 • 1,216 citations

Cardiac Electrophysiology: From Cell to Bedside

1995 • 1,173 citations

A family of potassium channel genes related to eag in Drosophila and mammals.

1994 • 960 citations

Female gender as a risk factor for torsades de pointes associated with cardiovascular drugs

1993 • 843 citations

Long QT Syndrome Patients With Mutations of the SCN5A and HERG Genes Have Differential Responses to Na ⁺ Channel Blockade and to Increases in Heart Rate

1995 • 801 citations

The long QT syndromes: A critical review, new clinical observations and a unifying hypothesis

1988 • 801 citations

The inward rectification mechanism of the HERG cardiac potassium channel

1996 • 754 citations

The long QT syndrome

1997 • 709 citations

Female Gender as a Risk Factor for Torsades de Pointes Associated With Cardiovascular Drugs

1993 • 702 citations

Multiple Mechanisms in the Long-QT Syndrome

1996 • 631 citations

Mechanism of the Cardiotoxic Actions of Terfenadine

1993 • 627 citations

17-β Estradiol Protects Neurons from Oxidative Stress-Induced Cell Death in Vitro

1995 • 612 citations

Torsades de pointes occurring in association with terfenadine use

1990 • 550 citations

Spectrum of HERG K+-channel dysfunction in an inherited cardiac arrhythmia.

1996 • 465 citations

The early events of oxygen and glucose deprivation: setting the scene for neuronal death?

1994 • 401 citations

Molecular determinants for activation and inactivation of HERG, a human inward rectifier potassium channel.

1996 • 313 citations

HERG, a Primary Human Ventricular Target of the Nonsedating Antihistamine Terfenadine

1996 • 294 citations

Cardiac Actions of Antihistamines

1996 • 261 citations

21-Aminosteroids attenuate excitotoxic neuronal injury in cortical cell cultures

1990 • 248 citations

A novel inward‐rectifying K+ current with a cell‐cycle dependence governs the resting potential of mammalian neuroblastoma cells.

1995 • 247 citations

High affinity open channel block by dofetilide of HERG expressed in a human cell line.

1996 • 243 citations

Ether-à-go-go encodes a voltage-gated channel permeable to K+ and Ca2+ and modulated by cAMP

1993 • 240 citations

Blockade of HERG channels expressed in Xenopus oocytes by the histamine receptor antagonists terfenadine and astemizole

1996 • 227 citations

The inhibitory effect of the antipsychotic drug haloperidol on HERG potassium channels expressed in Xenopus oocytes

1997 • 225 citations

Cardiac Electrophysiological Actions of the Histamine H₁-Receptor Antagonists Astemizole and Terfenadine Compared With Chlorpheniramine and Pyrilamine

1995 • 214 citations

Myocardial consequences of reperfusion

1987 • 212 citations

Molecular Physiology and Pharmacology of HERG

1996 • 205 citations

Ibutilide, a Methanesulfonanilide Antiarrhythmic, Is a Potent Blocker of the Rapidly Activating Delayed Rectifier K ⁺ Current (I _Kr ) in AT-1 Cells

1995 • 189 citations

A Novel Role for HERG K⁺ Channels: Spike‐Frequency Adaptation

1997 • 180 citations

Terfenadine A Review of its Pharmacodynamic Properties and Therapeutic Efficacy

1985 • 175 citations

Tissue and Species Distribution of mRNA for the i _kr -like K ⁺ Channel, ERG

1997 • 174 citations

Loratadine

1994 • 173 citations

Cardiotoxic effect with convulsions in terfenadine overdose.

1989 • 168 citations

Torsade de pointes after astemizole overdose.

1986 • 157 citations

Genetic Approaches to Cardiovascular Disease

1995 • 139 citations

The Long QT Syndrome

1998 • 130 citations

Four Novel KVLQT1 and Four Novel HERG Mutations in Familial Long-QT Syndrome

1997 • 117 citations

TheDrosophila ergK⁺Channel Polypeptide Is Encoded by the Seizure Locus

1997 • 113 citations

A HERG‐like K+ channel in rat F‐11 DRG cell line: pharmacological identification and biophysical characterization.

1996 • 106 citations

Oxygen free radicals and calcium homeostasis in the heart

1994 • 96 citations

The Human ∆1261 Mutation of the HERG Potassium Channel Results in a Truncated Protein That Contains a Subunit Interaction Domain and Decreases the Channel Expression

1997 • 93 citations

Mechanisms and control of repolarization

1993 • 91 citations

Regulation of the human ether-a-gogo related gene (HERG) K⁺channels by reactive oxygen species

1997 • 90 citations

Single HERG delayed rectifier K+ channels expressed in Xenopus oocytes

1997 • 85 citations

A mutation in HERG Associated with Notched T waves in Long QT Syndrome

1996 • 83 citations

Missense Mutation in the Pore Region of HERG Causes Familial Long QT Syndrome

1996 • 78 citations

Specific IK1 blockade: a new antiarrhythmic mechanism? Effect of RP58866 on ventricular arrhythmias in rat, rabbit, and primate.

1993 • 78 citations

TheseizureLocus Encodes theDrosophilaHomolog of the HERG Potassium Channel

1997 • 75 citations

Temporal Relation Between Long-Lasting Aftercontractions and Action Potentials in Cat Papillary Muscles

1968 • 73 citations

Chapter 6 Role of superoxide dismutase in ischemic brain injury: reduction of edema and infarction in transgenic mice following focal cerebral ischemia

1993 • 73 citations

Regulation of Potassium Channels by Nonsedating Antihistamines

1995 • 67 citations

Novel missense mutation in the cyclic nucleotide-binding domain ofHERG causes long QT syndrome

1996 • 62 citations

Mechanism of Action Potential Prolongation by RP 58866 and Its Active Enantiomer, Terikalant

1996 • 55 citations

Suppression of mammalian K+ channel family by ebastine.

1997 • 50 citations

Arrhythmia control by prolonging repolarization: The concept and its potential therapeutic impact

1993 • 49 citations

Role of the ISK protein in the IminK channel complex

1997 • 37 citations

Cloned Human Inward Rectifier K ⁺ Channel as a Target for Class III Methanesulfonanilides

1995 • 29 citations

Sweetclover-Weevil Feeding Deterrent B: Isolation and Identification

1969 • 23 citations

Structural motifs underlying voltage-dependent K+ channel function

1995 • 4 citations