The Role of Tumor Necrosis Factor and Lymphotoxin in Lymphoid Organ Development

Immune and inflammatory responses in TNF alpha-deficient mice: a critical requirement for TNF alpha in the formation of primary B cell follicles, follicular dendritic cell networks and germinal centers, and in the maturation of the humoral immune response.

1996 • 1,167 citations

A Putative Chemokine Receptor, BLR1, Directs B Cell Migration to Defined Lymphoid Organs and Specific Anatomic Compartments of the Spleen

1996 • 1,125 citations

Two TNF receptors

1992 • 1,048 citations

Mice Lacking Expression of Secondary Lymphoid Organ Chemokine Have Defects in Lymphocyte Homing and Dendritic Cell Localization

1999 • 1,030 citations

A chemokine expressed in lymphoid high endothelial venules promotes the adhesion and chemotaxis of naive T lymphocytes

1998 • 1,001 citations

A B-cell-homing chemokine made in lymphoid follicles activates Burkitt's lymphoma receptor-1

1998 • 810 citations

B Cell–attracting Chemokine 1, a Human CXC Chemokine Expressed in Lymphoid Tissues, Selectively Attracts B Lymphocytes via BLR1/CXCR5

1998 • 807 citations

Characterization of tumor necrosis factor-deficient mice

1997 • 792 citations

LIGHT, a New Member of the TNF Superfamily, and Lymphotoxin α Are Ligands for Herpesvirus Entry Mediator

1998 • 760 citations

The Lymphotoxin β Receptor Controls Organogenesis and Affinity Maturation in Peripheral Lymphoid Tissues

1998 • 710 citations

Developing Lymph Nodes Collect CD4 + CD3 − LTβ + Cells That Can Differentiate to APC, NK Cells, and Follicular Cells but Not T or B Cells

1997 • 654 citations

Distinct Roles in Lymphoid Organogenesis for Lymphotoxins α and β Revealed in Lymphotoxin β–Deficient Mice

1997 • 590 citations

Lymphotoxin α/β and Tumor Necrosis Factor Are Required for Stromal Cell Expression of Homing Chemokines in B and T Cell Areas of the Spleen

1999 • 552 citations

Epstein-Barr Virus–induced Molecule 1 Ligand Chemokine Is Expressed by Dendritic Cells in Lymphoid Tissues and Strongly Attracts Naive T Cells and Activated B Cells

1998 • 479 citations

Lymphotoxin ?, a novel member of the TNF family that forms a heteromeric complex with lymphotoxin on the cell surface

1993 • 468 citations

Lymphotoxin-alpha-deficient mice. Effects on secondary lymphoid organ development and humoral immune responsiveness.

1995 • 436 citations

Surface lymphotoxin alpha/beta complex is required for the development of peripheral lymphoid organs.

1996 • 392 citations

Role of Lymphotoxin and the Type I TNF Receptor in the Formation of Germinal Centers

1996 • 386 citations

Abnormal development of secondary lymphoid tissues in lymphotoxin β-deficient mice

1997 • 365 citations

Distinct roles for lymphotoxin‐α and tumor necrosis factor in organogenesis and spatial organization of lymphoid tissue

1997 • 318 citations

Mature Follicular Dendritic Cell Networks Depend on Expression of Lymphotoxin β Receptor by Radioresistant Stromal Cells and of Lymphotoxin β and Tumor Necrosis Factor by B Cells

1999 • 314 citations

B Lymphocytes Induce the Formation of Follicular Dendritic Cell Clusters in a Lymphotoxin α–dependent Fashion

1998 • 296 citations

The Ligands and Receptors of the Lymphotoxin System

1995 • 262 citations

The Sequential Role of Lymphotoxin and B Cells in the Development of Splenic Follicles

1998 • 232 citations

Differentiation of follicular dendritic cells and full antibody responses require tumor necrosis factor receptor-1 signaling.

1996 • 217 citations

Peyer’s patch organogenesis is intact yet formation of B lymphocyte follicles is defective in peripheral lymphoid organs of mice deficient for tumor necrosis factor and its 55-kDa receptor

1997 • 205 citations

Multiple immune abnormalities in tumor necrosis factor and lymphotoxin-α double-deficient mice

1996 • 201 citations

Defective Peyer's patch organogenesis in mice lacking the 55-kD receptor for tumor necrosis factor.

1996 • 181 citations

Differentiation‐specific expression of a novel G protein‐coupled receptor from Burkitt's lymphoma

1992 • 147 citations

Distinct Roles of Lymphotoxin α and the Type I Tumor Necrosis Factor (TNF) Receptor in the Establishment of Follicular Dendritic Cells from Non–Bone Marrow–derived Cells

1997 • 131 citations

Disrupted splenic architecture, but normal lymph node development in mice expressing a soluble lymphotoxin-β receptor–IgG1 fusion protein

1996 • 125 citations

Mouse lymphotoxin-beta receptor. Molecular genetics, ligand binding, and expression.

1995 • 118 citations

Identification of a new mouse beta-chemokine, thymus-derived chemotactic agent 4, with activity on T lymphocytes and mesangial cells.

1997 • 118 citations

Induction of functional follicular dendritic cell development in severe combined immunodeficiency mice. Influence of B and T cells.

1993 • 112 citations

Independent signals regulate development of primary and secondary follicle structure in spleen and mesenteric lymph node

1997 • 105 citations

Selective disruption of lymphotoxin ligands reveals a novel set of mucosal lymph nodes and unique effects on lymph node cellular organization

1997 • 104 citations

Lymphotoxin is expressed as a heteromeric complex with a distinct 33-kDa glycoprotein on the surface of an activated human T cell hybridoma.

1992 • 97 citations

Compartments, domains and migration pathways of lymphoid cells in the splenic pulp

1985 • 87 citations

Lymph Node Germinal Centers Form in the Absence of Follicular Dendritic Cell Networks

1999 • 72 citations

The G protein‐coupled receptor BLR1 is involved in murine B cell differentiation and is also expressed in neuronal tissues

1993 • 67 citations

Crucial Role of Tumor Necrosis Factor Receptor 1 Expression on Nonhematopoietic Cells for B Cell Localization within the Splenic White Pulp

1998 • 65 citations

Tumor necrosis factor alpha is involved in mouse growth and lymphoid tissue development.

1992 • 64 citations

Effects of tumor necrosis factor and lymphotoxin on peripheral lymphoid tissue development

1998 • 56 citations

Generation of Splenic Follicular Structure and B Cell Movement in Tumor Necrosis Factor–deficient Mice

1998 • 53 citations

Lymphocyte homing: The scent of a follicle

1997 • 43 citations

Preparation and Characterization of Soluble Recombinant Heterotrimeric Complexes of Human Lymphotoxins and

1996 • 41 citations

The functional state of follicular dendritic cells in severe combined immunodeficient (SCID) mice: Role of the lymphocytes

1994 • 39 citations

Mutational Analysis of the Functional Domains of the Large Subunit of the Isozyme Form of Wheat Initiation Factor eIF4F

1996 • 36 citations

Characterization of the mouse lymphotoxin-beta gene.

1995 • 35 citations

Development of antigenic heterogeneity in the splenic meshwork of severe combined immunodeficient (SCID) mice after reconstitution with T and B lymphocytes

1993 • 23 citations

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