Quantitative prediction of metabolic inhibition of midazolam by itraconazole and ketoconazole in rats: implication of concentrative uptake of inhibitors into liver.

PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT

1951 • 319,299 citations

A pharmacokinetic analysis program (multi) for microcomputer.

1981 • 2,465 citations

Oral first-pass elimination of midazolam involves both gastrointestinal and hepatic CYP3A-mediated metabolism*

1996 • 598 citations

Cyclosporin A drug interactions. Screening for inducers and inhibitors of cytochrome P-450 (cyclosporin A oxidase) in primary cultures of human hepatocytes and in liver microsomes.

1990 • 423 citations

Criteria of Viability of Isolated Liver Cells

1975 • 411 citations

Midazolam should be avoided in patients receiving the systemic antimycotics ketoconazole or itraconazole

1994 • 407 citations

A potentially hazardous interaction between erythromycin and midazolam

1993 • 352 citations

Ketoconazole and sulphaphenazole as the respective selective inhibitors of P4503A and 2C9

1995 • 295 citations

Triazolam biotransformation by human liver microsomes in vitro: effects of metabolic inhibitors and clinical confirmation of a predicted interaction with ketoconazole.

1996 • 220 citations

Recent advances in carrier-mediated hepatic uptake and biliary excretion of xenobiotics.

1996 • 218 citations

The Effect of the Systemic Antimycotics, Itraconazole and Fluconazole, on the Pharmacokinetics and Pharmacodynamics of Intravenous and Oral Midazolam

1996 • 217 citations

Inhibition and kinetics of cytochrome P4503A activity in microsomes from rat, human, and cdna-expressed human cytochrome P450.

1996 • 191 citations

Inhibition of human CYP3A catalyzed 1'-hydroxy midazolam formation by ketoconazole, nifedipine, erythromycin, cimetidine, and nizatidine.

1994 • 139 citations

In vitro forecasting of drugs which may interfere with the biotransformation of midazolam

1991 • 107 citations

Carrier-mediated transport in the hepatic distribution and elimination of drugs, with special reference to the category of organic cations

1990 • 95 citations

Effect of itraconazole and terbinafine on the pharmacokinetics and pharmacodynamics of midazolam in healthy volunteers

1995 • 92 citations

Cimetidine and ranitidine increase midazolam bioavailability

1987 • 84 citations

Method to estimate the rate and extent of intestinal absorption in conscious rats using an absorption probe and portal blood sampling.

1995 • 57 citations

Comparison of the hepatic uptake clearances of fifteen drugs with a wide range of membrane permeabilities in isolated rat hepatocytes and perfused rat livers.

1993 • 55 citations

Evaluation of intestinal absorption into the portal system in enterohepatic circulation by measuring the difference in portal-venous blood concentrations of diclofenac.

1995 • 43 citations

A pharmacokinetic interaction between roxithromycin and midazolam

1994 • 38 citations

Determination of protein binding byin vitro charcoal adsorption

1995 • 38 citations

Comparison of ketoconazole and fluconazole as cytochrome P450 inhibitors. Use of steady-state infusion approach to achieve plasma concentration-response relationships.

1996 • 34 citations

Carrier-mediated active transport of histamine H2 receptor antagonists, cimetidine and nizatidine, into isolated rat hepatocytes: contribution of type I system.

1994 • 31 citations

Local absorption kinetics of levofloxacin from intestinal tract into portal vein in conscious rat using portal-venous concentration difference.

1996 • 28 citations

Quantitative prediction of the interaction of midazolam and histamine H2 receptor antagonists in rats.

1998 • 15 citations

Alteration of Pharmacokinetic Features Caused by Drug Interactions.

1996 • 7 citations