Evaluation of intestinal absorption into the portal system in enterohepatic circulation by measuring the difference in portal-venous blood concentrations of diclofenac.

Physiological parameters in laboratory animals and humans.

1993 • 2,747 citations

Statistical moments in pharmacokinetics

1978 • 1,251 citations

Drug Absorption I: An In Situ Rat Gut Technique Yielding Realistic Absorption Rates

1969 • 354 citations

Influence of First-Pass Effect on Availability of Drugs on Oral Administration

1971 • 264 citations

Influence of Route of Administration on Drug Availability

1972 • 261 citations

Pharmacokinetics and Metabolism of the Anti-Inflammatory Agent Voltaren

1978 • 179 citations

Biotransformation of diclofenac sodium (Voltaren®) in animals and in man

1979 • 174 citations

Influence of the Route of Administration on the Area Under the Plasma Concentration-Time Curve

1969 • 140 citations

A rapid and sensitive high-performance liquid chromatographic method for the determination of diclofenac sodium in serum and its use in pharmacokinetic studies

1988 • 78 citations

Pharmacokinetics and bioavailability of diclofenac in the rat

1991 • 73 citations

Disposition of enalapril in the perfused rat intestine-liver preparation: absorption, metabolism and first-pass effect.

1985 • 60 citations

A new analysis method for disposition kinetics of enterohepatic circulation of diclofenac in rats.

1994 • 30 citations

Drug Absorption and Metabolism Studies by Use of Portal Vein Infusion in the Rat. I. Pyloric Vein Cannulation and Its Application to Study of First-Pass Effect on Bioavailability of Propranolol

1972 • 30 citations

Viability of the vascularly perfused, recirculating rat intestine and intestine-liver preparations

1989 • 27 citations

Gastrointestinal and hepatic first-pass elimination of 2',3'-dideoxyinosine in rats.

1993 • 25 citations

Lack of gastrointestinal metabolism of propranolol in dogs after portacaval transposition.

1982 • 24 citations

Disposition and enterohepatic circulation of diclofenac in dogs.

1980 • 24 citations

Theoretical Relationships between Area under the Curve and Route of Administration of Drugs and Their Precursors for Evaluating Sites and Pathways of Metabolism

1978 • 22 citations

Analysis of enterohepatic circulation of cefixime in rat by fast inverse Laplace transform (FILT)

1990 • 20 citations

A technique to study hepatic and intestinal drug metabolism separately in the dog.

1982 • 19 citations

Solvent drag in jejunal absorption of salicylic acid and antipyrine obtained by in situ single-pass perfusion method in rat.

1984 • 15 citations

Pharmacokinetics and enterohepatic circulation of 2-n-propyl-4-pentenoic acid in the rat.

1988 • 14 citations

Analysis of arterial–venous blood concentration difference of drugs based on recirculatory theory with fast inverse laplace transform (FILT)

1991 • 11 citations

An equation for the systemic availability of drugs undergoing simultaneous enterohepatic cycling, first-pass metabolism, and intestinal elimination.

1987 • 11 citations

Pharmacokinetics and enterohepatic circulation of (E)-2-ene valproic acid in the rat.

1990 • 10 citations

Enterohepatic circulation of clioquinol in the rat.

1984 • 5 citations