Hyperphosphorylation of the retinoblastoma gene product and altered subcellular distribution of E2F-1 during Alzheimer's disease and amyotrophic lateral sclerosis

Neuropathological stageing of Alzheimer-related changes

1991 • 14,533 citations

The retinoblastoma protein and cell cycle control

1995 • 4,873 citations

The Consortium to Establish a Registry for Alzheimer's Disease (CERAD)

1991 • 4,669 citations

The E2F transcription factor is a cellular target for the RB protein

1991 • 1,461 citations

Aging, energy, and oxidative stress in neurodegenerative diseases

1995 • 1,453 citations

Cdk Phosphorylation Triggers Sequential Intramolecular Interactions that Progressively Block Rb Functions as Cells Move through G1

1999 • 1,028 citations

Consensus Recommendations for the Postmortem Diagnosis of Alzheimer’s Disease

1997 • 938 citations

p53 and E2F-1 cooperate to mediate apoptosis.

1994 • 844 citations

E2F-1 Functions in Mice to Promote Apoptosis and Suppress Proliferation

1996 • 765 citations

Alzheimer's Disease: A Central Role for Amyloid

1994 • 749 citations

Functional Role of Caspase-1 and Caspase-3 in an ALS Transgenic Mouse Model

2000 • 700 citations

Aberrant RNA Processing in a Neurodegenerative Disease: the Cause for Absent EAAT2, a Glutamate Transporter, in Amyotrophic Lateral Sclerosis

1998 • 663 citations

Analysis of cell cycle-related gene expression in postmitotic neurons: Selective induction of cyclin D1 during programmed cell death

1994 • 576 citations

Immunohistochemical evidence for apoptosis in Alzheimerʼs disease

1994 • 569 citations

Ectopic Cell Cycle Proteins Predict the Sites of Neuronal Cell Death in Alzheimer’s Disease Brain

1998 • 537 citations

Heterodimerization of the transcription factors E2F-1 and DP-1 leads to cooperative trans-activation.

1993 • 498 citations

Inhibition of E2F-1 transactivation by direct binding of the retinoblastoma protein.

1993 • 460 citations

The T/E1A-binding domain of the retinoblastoma product can interact selectively with a sequence-specific DNA-binding protein

1991 • 420 citations

Abnormal expression of the cell cycle regulators P16 and CDK4 in Alzheimer's disease.

1997 • 417 citations

Glial cytokines in Alzheimer's disease: Review and pathogenic implications

1995 • 412 citations

Mitotic mechanisms in Alzheimer's disease?

1996 • 384 citations

Mutation of E2f-1 Suppresses Apoptosis and Inappropriate S Phase Entry and Extends Survival of Rb-Deficient Mouse Embryos

1998 • 375 citations

Neuronal Death in Amyotrophic Lateral Sclerosis Is Apoptosis

1999 • 354 citations

Glutamate, excitotoxicity and amyotrophic lateral sclerosis

1997 • 294 citations

Expression of the cyclin-dependent kinase inhibitor p16 in Alzheimerʼs disease

1996 • 244 citations

E2F-1 Potentiates Cell Death by Blocking Antiapoptotic Signaling Pathways

1999 • 244 citations

Cellular signaling roles of TGFβ, TNFα and βAPP in brain injury responses and Alzheimer's disease

1997 • 243 citations

Involvement of Cell Cycle Elements, Cyclin-dependent Kinases, pRb, and E2F·DP, in B-amyloid-induced Neuronal Death

1999 • 242 citations

DNA End Labeling (TUNEL) in Huntington's Disease and Other Neuropathological Conditions

1995 • 221 citations

The role of cell cycle‐mediated events in Alzheimer's disease

1999 • 220 citations

The induction of multiple cell cycle events precedes target-related neuronal death

1995 • 214 citations

Involvement of cytokines in normal CNS development and neurological diseases: Recent progress and perspectives

1998 • 212 citations

E2F1 Mediates Death of B-amyloid-treated Cortical Neurons in a Manner Independent of p53 and Dependent on Bax and Caspase 3

2000 • 203 citations

Changes of p53 in the Brains of Patients with Alzheimer's Disease

1997 • 177 citations

Mitotic phosphoepitopes precede paired helical filaments in Alzheimer’s disease

1998 • 177 citations

Involvement of Retinoblastoma Family Members and E2F/DP Complexes in the Death of Neurons Evoked by DNA Damage

2000 • 151 citations

Cell division and the nervous system: regulating the cycle from neural differentiation to death

1996 • 147 citations

The role of E2F in the mammalian cell cycle

1993 • 136 citations

Re-entry into the cell cycle: a mechanism for neurodegeneration in Alzheimer disease

1999 • 128 citations

Quantitative Decrease in Synaptophysin Message Expression and Increase in Cathepsin D Message Expression in Alzheimer Disease Neurons Containing Neurofibrillary Tangles

1999 • 125 citations

Regulation of E2F: a family of transcription factors involved in proliferation control

1999 • 120 citations

Transcription factor E2F binds DNA as a heterodimer.

1993 • 116 citations

Alteration of transcription factors NF-κB and STAT1 in Alzheimer's disease brains

1997 • 112 citations

Is Apoptosis Key in Alzheimer's Disease?

1998 • 100 citations

Signal transduction abnormalities in Alzheimer's disease: evidence of a pathogenic stimuli

1999 • 89 citations

Expression of Fos, Jun, and Krox Family Proteins in Alzheimer's Disease

1997 • 88 citations

Expression profiles of multiple genes in single neurons of Alzheimer’s disease

1998 • 86 citations

Mechanisms of cell death in Alzheimer disease — immunopathology

1998 • 78 citations

Functional roles of E2F in cell cycle regulation

1997 • 66 citations

Induction of Cell-Cycle Regulators in Simian Immunodeficiency Virus Encephalitis

2000 • 65 citations

Preclinical and subclinical events in motor neuron disease.

1988 • 61 citations

Aberrancies in signal transduction and cell cycle related events in Alzheimer’s disease

1998 • 56 citations

Cyclin-dependent Kinase 5 in Lewy Body-like Inclusions in Anterior Horn Cells of a Patient with Sporadic Amyotrophic Lateral Sclerosis

1997 • 54 citations

Cell and molecular neurobiology of presenilins: A role for the endoplasmic reticulum in the pathogenesis of Alzheimer's disease?

1997 • 54 citations

Cyclin dependent kinase-5 (CDK-5) phosphorylates neurofilament heavy (NF-H) chain to generate epitopes for antibodies that label neurofilament accumulations in amyotrophic lateral sclerosis (ALS) and is present in affected motor neurones in ALS

1999 • 52 citations

Regulation and Deregulation of E2F1 in Postmitotic Neurons Differentiated from Embryonal Carcinoma P19 Cells

1999 • 37 citations

Pathology of Motor System Disorder

1995 • 35 citations

Apoptosis in the brain. Physiology and pathology.

1995 • 32 citations

Immunolocalization and Redistribution of the FAC1 Protein in Alzheimerʼs Disease

1996 • 19 citations