Functional Evidence that BDNF Is an Anterograde Neuronal Trophic Factor in the CNS

PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT

1951 • 319,299 citations

Translational Findings on Brain-Derived Neurotrophic Factor and Anxiety: Contributions from Basic Research to Clinical Practice

2013 • 3,921 citations

Cell Death During Development of the Nervous System

1991 • 3,033 citations

Neurotrophins and Neuronal Plasticity

1995 • 1,937 citations

Nucleus locus ceruleus: new evidence of anatomical and physiological specificity

1983 • 1,877 citations

Purification of a new neurotrophic factor from mammalian brain.

1982 • 1,762 citations

The central adrenergic system. An immunofluorescence study of the location of cell bodies and their efferent connections in the rat utilizing dopamine‐B‐hydroxylase as a marker

1975 • 1,454 citations

Molecular cloning and expression of brain-derived neurotrophic factor

1989 • 1,453 citations

NT-3, BDNF, and NGF in the developing rat nervous system: Parallel as well as reciprocal patterns of expression

1990 • 1,238 citations

Recombinant BDNF Rescues Deficits in Basal Synaptic Transmission and Hippocampal LTP in BDNF Knockout Mice

1996 • 1,219 citations

Distribution of Brain-Derived Neurotrophic Factor (BDNF) Protein and mRNA in the Normal Adult Rat CNS: Evidence for Anterograde Axonal Transport

1997 • 1,093 citations

Mice lacking brain-derived neurotrophic factor develop with sensory deficits

1994 • 1,066 citations

Targeted disruption of the BDNF gene perturbs brain and sensory neuron development but not motor neuron development

1994 • 1,046 citations

Requirement for BDNF in Activity-Dependent Survival of Cortical Neurons

1994 • 974 citations

Neurotrophins regulate dendritic growth in developing visual cortex

1995 • 963 citations

Anterograde transport of brain-derived neurotrophic factor and its role in the brain

1997 • 853 citations

Ascending projections of the locus coeruleus in the rat. II. Autoradiographic study

1977 • 835 citations

The nerve growth factor: thirty-five years later.

1987 • 720 citations

Brain-derived neurotrophic factor prevents the death of motoneurons in newborn rats after nerve section

1992 • 712 citations

Ontogeny of monoamine neurons in the locus coeruleus, raphe nuclei and substantia nigra of the rat. I. Cell differentiation

1974 • 653 citations

Inhibition of Ocular Dominance Column Formation by Infusion of NT-4/5 or BDNF

1995 • 572 citations

Evidence that brain-derived neurotrophic factor is a trophic factor for motor neurons in vivo

1993 • 537 citations

Neurotrophin Regulation of Cortical Dendritic Growth Requires Activity

1996 • 503 citations

Nerve Growth Factor Treatment Increases Brain-Derived Neurotrophic Factor Selectively in TrkA-Expressing Dorsal Root Ganglion Cells and in Their Central Terminations within the Spinal Cord

1997 • 500 citations

Expression of brain-derived neurotrophic factor protein in the adult rat central nervous system

1997 • 500 citations

A radioautographic study of the efferent pathways of the nucleus locus coeruleus

1974 • 500 citations

Noradrenergic innervation of the adult rat hippocampal formation

1980 • 434 citations

Immunocytochemical localization of TrkB in the central nervous system of the adult rat

1997 • 426 citations

Ontogeny of monoamine neurons in the locus coeruleus, raphe nuclei and substantia nigra of the rat

1975 • 411 citations

Overexpression of the trk tyrosine kinase rapidly accelerates nerve growth factor-induced differentiation

1992 • 321 citations

Anterograde transport of neurotrophins and axodendritic transfer in the developing visual system

1996 • 284 citations

Developmental and mature expression of full-length and truncated TrkB, receptors in the rat forebrain

1996 • 281 citations

Synaptic Innervation Density Is Regulated by Neuron-Derived BDNF

1997 • 280 citations

Endogenous brain-derived neurotrophic factor is anterogradely transported in primary sensory neurons

1996 • 275 citations

Intraventricular administration of BDNF increases neuropeptide expression in newborn rat brain

1994 • 237 citations

Development of layer I and the subplate in the rat neocortex

1990 • 235 citations

Development of the noradrenergic innervation of neocortex

1979 • 212 citations

Transgenic Mice Expressing the Intracellular Domain of the p75 Neurotrophin Receptor Undergo Neuronal Apoptosis

1997 • 208 citations

Regulation of neurotrophin receptor expression during embryonic and postnatal development

1994 • 208 citations

Evidence for a neurotrophic role of noradrenaline neurons in the postnatal development of rat cerebral cortex

1982 • 208 citations

Regulated neurotrophin receptor responsiveness during neuronal migrationand early differentiation

1994 • 207 citations

Projections of the locus coeruleus and adjacent pontine tegmentum in the cat

1976 • 203 citations

The survival of developing neurons: A review of afferent control

1994 • 181 citations

Trk Receptors Function As Rapid Retrograde Signal Carriers in the Adult Nervous System

1997 • 176 citations

Brain-derived neurotrophic factor messenger RNA is expressed in the septum, hypothalamus and in adrenergic brain stem nuclei of adult rat brain and is increased by osmotic stimulation in the paraventricular nucleus

1995 • 171 citations

Naturally-occurring neuron death in the ciliary ganglion of the chick embryo following removal of preganglionic input: evidence for the role of afferents in ganglion cell survival

1987 • 154 citations

Modification of postnatal development of neocortex in rat brain with experimental deprivation of locus coeruleus

1974 • 145 citations

Innervation of embryonic rat cerebral cortex by catecholamine‐containing fibers

1980 • 133 citations

Detection of Brain-derived Neurotrophic Factor in a Vesicular Fraction of Brain Synaptosomes

1997 • 128 citations

Noradrenergic and locus coeruleus modulation of the perforant path-evoked potential in rat dentate gyrus supports a role for the locus coeruleus in attentional and memorial processes

1991 • 128 citations

Neuronal Heterotopias in the Developing Cerebral Cortex Produced by Neurotrophin-4

1997 • 125 citations

Neuronal death during development in the isthmo‐optic nucleus of the chick: Sustaining role of afferents from the tectum

1985 • 117 citations

Modification of neuron numbers in the visual system of the rat

1979 • 102 citations

Cell-specific expression from the human dopamine beta-hydroxylase promoter in transgenic mice is controlled via a combination of positive and negative regulatory elements

1994 • 77 citations

Some neuronal cell populations express human dopamine β-hydroxylase-lacZ transgenes transiently during embryonic development

1991 • 73 citations

BDNF‐activated Sianal Transduction in Rat Cortical Glial Cells

1995 • 62 citations

Distribution of catecholamines, serotonin, and their major metabolites in the rat cingulate, piriform-entorhinal, somatosensory, and visual cortex: A biochemical survey using high-performance liquid chromatography

1987 • 61 citations

Vertical compartmentation and cellular transformations in the germinal matrices of the embryonic rat cerebral cortex

1990 • 50 citations

Dual control by targets and afferents of developmental neuronal death in the mammalian central nervous system: A study in the parabigeminal nucleus of the rat

1987 • 41 citations

Development of dopamine‐beta hydroxylase—positive fiber innervation of the rat hippocampus

1993 • 32 citations

Effects of alpha-methyl-p-tyrosine on monoamines and catecholamine receptors in rat cerebral cortex and neostriatum

1988 • 26 citations

Development of neocortical afferent systems: studies in the reeler mouse.

1982 • 26 citations

Distribution of monoamines and metabolites in rabbit neostriatum, hippocampus and cortex

1989 • 25 citations

Effects of optic primordium removal on the development of the isthmo-optic nucleus in the duck (Anas platyrhynchos)

1975 • 20 citations

Alpha-adrenoceptors and monoamine contents in the cerebral cortex of the rodent Jaculus orientalis: Effects of acute cold exposure

1986 • 19 citations

In vitro effects of ethanol on the synthesis of ester-forms of riboflavin in the sciatic nerve tissue of rats

1987 • 2 citations