Suppression of Cathepsins B and L Causes a Proliferation of Lysosomes and the Formation of Meganeurites in Hippocampus

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

A Rapid and Sensitive Method for the Quantitation of Microgram Quantities of Protein Utilizing the Principle of Protein-Dye Binding

1976 • 225,752 citations

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

1976 • 200,127 citations

Short-Term Effects of Nose-Only Cigarette Smoke Exposure on Glutathione Redox Homeostasis, Cytochrome P450 1A1/2 and Respiratory Enzyme Activities in Mice Tissues

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A simple method for organotypic cultures of nervous tissue

1991 • 3,075 citations

Functions of Lysosomes

1966 • 2,942 citations

A protein factor essential for microtubule assembly.

1975 • 2,863 citations

[41] Cathepsin B, cathepsin H, and cathepsin L

1981 • 1,678 citations

The Fine Structure of the Nervous System: Neurons and Their Supporting Cells

1991 • 1,522 citations

Differences in the pattern of hippocampal neuronal loss in normal ageing and Alzheimer's disease

1994 • 1,213 citations

Studies on the mechanisms of autophagy: formation of the autophagic vacuole.

1990 • 789 citations

ULTRASTRUCTURAL STUDIES IN ALZHEIMER'S PRESENILE DEMENTIA.

1964 • 646 citations

Enzymatically active lysosomal proteases are associated with amyloid deposits in Alzheimer brain.

1990 • 415 citations

Quantitative synaptic alterations in the human neocortex during normal aging

1993 • 408 citations

Identification of a novel microtubule binding and assembly domain in the developmentally regulated inter-repeat region of tau

1994 • 391 citations

Inhibition of proteolysis protects hippocampal neurons from ischemia.

1991 • 363 citations

Gene expression and cellular content of cathepsin D in Alzheimer's disease brain: Evidence for early up-regulation of the endosomal-lysosomal system

1995 • 359 citations

Studies on the mechanisms of autophagy: maturation of the autophagic vacuole.

1990 • 352 citations

Properties of the endosomal-lysosomal system in the human central nervous system: disturbances mark most neurons in populations at risk to degenerate in Alzheimer's disease

1996 • 346 citations

Distortion of neuronal geometry and formation of aberrant synapses in neuronal storage disease

1976 • 278 citations

Inhibitors of Lysosomal Enzymes: Accumulation of Lipofuscin-Like Dense Bodies in the Brain

1984 • 274 citations

Proteases and proteolysis in the lysosome

1992 • 240 citations

The Effects of Aging on Area 46 of the Frontal Cortex of the Rhesus Monkey

1994 • 237 citations

Lysosomal abnormalities in degenerating neurons link neuronal compromise to senile plaque development in Alzheimer disease

1994 • 214 citations

Time course of synaptic development in hippocampal organotypic cultures

1993 • 208 citations

Peptidyl diazomethyl ketones are specific inactivators of thiol proteinases.

1981 • 208 citations

LIPOPROTEIN PIGMENTS—THEIR RELATIONSHIP TO AGEING IN THE HUMAN NERVOUS SYSTEM

1974 • 207 citations

Age-Related Changes in Activities and Localizations of Cathepsins D, E, B, and L in the Rat Brain Tissues

1994 • 169 citations

Structural modifications associated with synaptic development in area CA1 of rat hippocampal organotypic cultures

1993 • 165 citations

LIPOPROTEIN PIGMENTS—THEIR RELATIONSHIP TO AGEING IN THE HUMAN NERVOUS SYSTEM

1974 • 159 citations

A time-lapse video image intensification analysis of cytoplasmic organelle movements during endosome translocation.

1984 • 158 citations

The effect of protease inhibitors and decreased temperature on the degradation of different classes of proteins in cultured hepatocytes

1979 • 157 citations

Electron microscopical studies on rat brain neurons. Localization of acid phosphatase and mode of formation of lipofuscin bodies

1972 • 146 citations

Intracellular Localization of Lipofuscin Age Pigments in the Nervous System

1964 • 137 citations

Participation of cathepsin L on bone resorption

1993 • 130 citations

Inhibition of proteolytic activity of calcium activated neutral protease by leupeptin and antipain

1978 • 130 citations

Cytosolic Proteolysis of τ by Cathepsin D in Hippocampus Following Suppression of Cathepsins B and L

1996 • 103 citations

Lipofuscin-Like Substances Accumulate Rapidly in Brain, Retina and Internal Organs with Cysteine Protease Inhibition

1990 • 100 citations

Stable maintenance of glutamate receptors and other synaptic components in long‐term hippocampal slices

1995 • 89 citations

Induction of calpain-mediated spectrin fragments by pathogenic treatments in long-term hippocampal slices.

1995 • 79 citations

Pigmentoarchitectonic pathology of the isocortex in juvenile neuronal ceroid-lipofuscinosis: Axonal enlargements in layer IIIab and cell loss in layer V

1979 • 75 citations

Induction of β-Amyloid-Containing Polypeptides in Hippocampus: Evidence for a Concomitant Loss of Synaptic Proteins and Interactions with an Excitotoxin

1994 • 72 citations

The selective role of cathepsins B and D in the lysosomal degradation of endogenous and exogenous proteins

1991 • 71 citations

Fine structure of meganeurites and secondary growth processes in feline GM1-gangliosidosis

1978 • 71 citations

Lysosome instability in aged rat brain

1989 • 71 citations

Anomalous accumulation of τ and ubiquitin immunoreactivities in rat brain caused by protease inhibition and by normal aging: a clue to PHF pathogenesis?

1989 • 65 citations

The Amount and Distribution of Pigments in Neurons and Glia of the Cerebral Cortex. Autofluorescent and Ultrastructural Studies

1969 • 64 citations

Aging in the rat olfactory bulb: Quantitative changes in mitral cell organelles and somato‐dendritic synapses

1979 • 64 citations

Translational suppression of calpain I reduces NMDA-induced spectrin proteolysis and pathophysiology in cultured hippocampal slices

1995 • 59 citations

Increase in cathepsin D activity in rat brain in aging

1989 • 58 citations

Translational suppression of calpain blocks long-term potentiation.

1996 • 55 citations

Evidence for decreased transport of tryptophan hydroxylase in Alzheimer's disease

1990 • 54 citations

Comparative behaviour of calpain and cathepsin B toward peptidyl acyloxymethyl ketones, sulphonium methyl ketones and other potential inhibitors of cysteine proteinases

1992 • 49 citations

Specific Assay Method for the Activities of Cathepsin L-Type Cysteine Proteinases

1994 • 45 citations

Neuronal aging in cultures; An electron-microscopic study

1973 • 43 citations

Ultrastructural observations on neuronal lipofuscin (age pigment) and dense bodies induced by a proteinase inhibitor, leupeptin, in rat hippocampus

1993 • 33 citations

β-amyloid precursor protein fragments and lysosomal dense bodies are found in rat brain neurons after ventricular infusion of leupeptin

1994 • 29 citations

Delineation of chicken cathepsin L secondary structure; relationship between pH dependence activity and helix content

1988 • 27 citations

Characterization of tau protein present in microtubules and paired helical filaments of Alzheimer's disease patient's brain

1990 • 26 citations

Spindle-shaped appendages of IIIab-pyramids filled with lipofuscin: A striking pathological change of the senescent human isocortex

1979 • 26 citations

Dendritic transport. II. Somatofugal movement of neuronal lysosomes induced by colchicine: evidence for a novel transport system in dendrites

1985 • 24 citations

Routes of excretion of neuronal lysosomal dense bodies after ventricular infusion of leupeptin in the rat: a study using ubiquitin and PGP 9.5 immunocytochemistry

1993 • 21 citations

Protease Inhibition Causes Some Manifestations of Aging and Alzheimer's Disease in Rodent and Primate Brain^a

1992 • 20 citations

Cathepsin L--a lysosomal cysteine proteinase.

1985 • 15 citations

Human cathepsins B, H and L: characterization by amino acid sequences and some kinetics of inhibition by the kininogens

1986 • 15 citations

Cytoskeletal changes in rat cortical neurons induced by long-term intraventricular infusion of leupeptin

1995 • 11 citations

Intraventricular infusion of leupeptin decreases Bmax of the D2 receptor in the striatum of young rats

1992 • 1 citations