Cytotoxicity of advanced glycation endproducts is mediated by oxidative stress

Apoptosis and necrosis: two distinct events induced, respectively, by mild and intense insults with N-methyl-D-aspartate or nitric oxide/superoxide in cortical cell cultures.

1995 • 1,968 citations

Alpha-lipoic acid as a biological antioxidant

1995 • 1,920 citations

Enhanced cellular oxidant stress by the interaction of advanced glycation end products with their receptors/binding proteins

1994 • 1,311 citations

Iron accumulation in Alzheimer disease is a source of redox-generated free radicals

1997 • 1,304 citations

Advanced glycation end products contribute to amyloidosis in Alzheimer disease.

1994 • 791 citations

The Pathogenesis of Senile Plaques

1997 • 717 citations

APPSW Transgenic Mice Develop Age-related Aβ Deposits and Neuropil Abnormalities, but no Neuronal Loss in CA1

1997 • 640 citations

Amyloid-β peptide–Receptor for Advanced Glycation Endproduct interaction elicits neuronal expression of macrophage-colony stimulating factor: A proinflammatory pathway in Alzheimer disease

1997 • 416 citations

Mitochondrial membrane fluidity and oxidative damage to mitochondrial DNA in aged and AD human brain

1997 • 211 citations

Influence of advanced glycation end-products and AGE-inhibitors on nucleation-dependent polymerization of β-amyloid peptide

1997 • 171 citations

Decreased Catalase Activity but Unchanged Superoxide Dismutase Activity in Brains of Patients with Dementia of Alzheimer Type

1995 • 168 citations

Free radical damage, iron, and Alzheimer's disease

1995 • 133 citations

Cytosolic and Mitochondrial Systems for NADH- and NADPH-dependent Reduction of α-Lipoic Acid

1997 • 129 citations

Age, neurofibrillary changes, Aβ-amyloid and the onset of Alzheimer's disease

1996 • 119 citations

τ Protein from Alzheimer's Disease Patients Is Glycated at Its Tubulin‐Binding Domain

1995 • 107 citations

What's the RAGE? The receptor for advanced glycation end products (RAGE) and the dark side of glucose

1997 • 77 citations

The cognition-enhancing drug tenilsetam is an inhibitor of protein crosslinking by advanced glycosylation

1994 • 70 citations

Advanced glycation endproducts are associated with Hirano bodies in Alzheimer's disease

1998 • 57 citations

Formation of advanced glycation end (AGE) products in diabetes: prevention by pyruvate and alpha-keto glutarate.

1997 • 31 citations

Advanced glycosylation endproducts: Role in diabetic and non‐diabetic vascular disease

1994 • 28 citations

Inhibition of nitric oxide formation by aminoguanidine: An attempt to prevent insulin-dependent diabetes mellitus

1997 • 23 citations