Overexpression of glyoxalase-I in bovine endothelial cells inhibits intracellular advanced glycation endproduct formation and prevents hyperglycemia-induced increases in macromolecular endocytosis.

Lipofection: a highly efficient, lipid-mediated DNA-transfection procedure.

1987 • 4,937 citations

Transformation of mammalian cells to antibiotic resistance with a bacterial gene under control of the SV40 early region promoter.

1982 • 2,753 citations

ADVANCED PROTEIN GLYCOSYLATION IN DIABETES AND AGING

1995 • 1,277 citations

Hyperglycemic Pseudohypoxia and Diabetic Complications

1993 • 1,025 citations

Sorbitol, Phosphoinositides, and Sodium-Potassium-ATPase in the Pathogenesis of Diabetic Complications

1987 • 905 citations

Pathogenic effects of advanced glycosylation: biochemical, biologic, and clinical implications for diabetes and aging.

1994 • 863 citations

The glyoxalase system: new developments towards functional characterization of a metabolic pathway fundamental to biological life

1990 • 792 citations

The Advanced Glycation End Product, N∊-(Carboxymethyl)lysine, Is a Product of both Lipid Peroxidation and Glycoxidation Reactions

1996 • 780 citations

Identification of Glyoxal and Arabinose as Intermediates in the Autoxidative Modification of Proteins by Glucose

1995 • 584 citations

N ε-(Carboxyethyl)lysine, a product of the chemical modification of proteins by methylglyoxal, increases with age in human lens proteins

1997 • 580 citations

Pharmacology of methylglyoxal: formation, modification of proteins and nucleic acids, and enzymatic detoxification-A role in pathogenesis and antiproliferative chemotherapy

1996 • 579 citations

NIDDM and Its Metabolic Control Predict Coronary Heart Disease in Elderly Subjects

1994 • 564 citations

Glyoxalase System in Clinical Diabetes Mellitus and Correlation with Diabetic Complications

1994 • 559 citations

N^ε-(Carboxymethyl)lysine Protein Adduct Is a Major Immunological Epitope in Proteins Modified with Advanced Glycation End Products of the Maillard Reaction

1996 • 427 citations

Nonenzymatic glycosylation in vitro and in bovine endothelial cells alters basic fibroblast growth factor activity. A model for intracellular glycosylation in diabetes.

1994 • 365 citations

Hyperglycemic pseudohypoxia and diabetic complications

1993 • 305 citations

Reduction of trioses by NADPH-dependent aldo-keto reductases. Aldose reductase, methylglyoxal, and diabetic complications.

1992 • 285 citations

BCL-2 expression or antioxidants prevent hyperglycemia-induced formation of intracellular advanced glycation endproducts in bovine endothelial cells.

1996 • 251 citations

Molecular characteristics of methylglyoxal-modified bovine and human serum albumins. Comparison with glucose-derived advanced glycation endproduct-modified serum albumins

1995 • 227 citations

The assay of methylglyoxal in biological systems byderivatization with 1,2-diamino-4,5-dimethoxybenzene

1992 • 220 citations

Expression of nerve growth factor in vivo from a defective herpes simplex virus 1 vector prevents effects of axotomy on sympathetic ganglia.

1992 • 203 citations

Pathways of Formation of Glycoxidation Products during Glycation of Collagen

1995 • 158 citations

Infection of cultured central nervous system neurons with a defective herpes simplex virus 1 vector results in stable expression of Escherichia coli beta-galactosidase.

1990 • 146 citations

Basic fibroblast growth factor is released from endothelial extracellular matrix in a biologically active form

1989 • 143 citations

Modification of the glyoxalase system in streptozotocin-induced diabetic rats

1993 • 143 citations

High <scp>D</scp>-Glucose–Induced Changes in Endothelial Ca2+/EDRF Signaling are Due to Generation of Superoxide Anions

1996 • 136 citations

Negative Association between Erythrocyte Reduced Glutathione Concentration and Diabetic Complications

1996 • 132 citations

Cellular and Molecular Abnormalities in the Vascular Endothelium of Diabetes Mellitus

1994 • 129 citations

Early Atherosclerosis Is Retarded by Improved Long-Term Blood Glucose Control in Patients With IDDM

1996 • 124 citations

Increase in 3-deoxyglucosone levels in diabetic rat plasma. Specific in vivo determination of intermediate in advanced Maillard reaction.

1994 • 96 citations

Two asialoglycoprotein receptor polypeptides in human hepatoma cells.

1987 • 95 citations

Method for Determination of Free Intracellular and Extracellular Methylglyoxal in Animal Cells Grown in Culture

1996 • 91 citations

Receptor-mediated endocytic uptake of methylglyoxal-modified serum albumin. Competition with advanced glycation end product-modified serum albumin at the advanced glycation end product receptor.

1994 • 89 citations

An improved preparation of 3-deoxy-d-erythro-hexos-2-ulose via the bis(benzoylhydrazone) and some related constitutional studies

1981 • 87 citations

Transsynaptic neuronal loss induced in hippocampal slice cultures by a herpes simplex virus vector expressing the GluR6 subunit of the kainate receptor.

1993 • 85 citations

Cloning and characterization of human colon glyoxalase-I.

1993 • 84 citations

Synthesis and chromatography of 1,2-diamino-4,5-dimethoxybenzene, 6,7-dimethoxy-2-methylquinoxaline and 6,7-dimethoxy-2,3-dimethylquinoxaline for use in a liquid chromatographic fluorimetric assay of methylglyoxal

1992 • 81 citations

In vivo glycation of aldehyde reductase, a major 3-deoxyglucosone reducing enzyme: identification of glycation sites

1995 • 66 citations

S-(N-Aryl-N-hydroxycarbamoyl)glutathione Derivatives Are Tight-Binding Inhibitors of Glyoxalase I and Slow Substrates for Glyoxalase II

1994 • 56 citations

3-Deoxyfructose Concentrations are Increased in Human Plasma and Urine in Diabetes

1994 • 50 citations

Sensitive determination of d-lactic acid in biological samples by high-performance liquid chromatography

1988 • 45 citations

Amadori rearrangement potential of hemoglobin at its glycation sites is dependent on the three-dimensional structure of protein

1992 • 43 citations

Probing the active site of glyoxalase I from human erythrocytes by use of the strong reversible inhibitor S-p-bromobenzylglutathione and metal substitutions

1981 • 43 citations

Early atherosclerosis is retarded by improved long-term blood glucose control in patients with IDDM

1996 • 42 citations

S-2-hydroxyacylglutathione-derivatives: enzymatic preparation, purification and characterisation

1991 • 28 citations

[87] Glyoxalase II from mouse liver

1982 • 28 citations

Functional characterization of the rat GAP-43 promoter

1994 • 26 citations

Measurement of acetol in serum

1985 • 26 citations

Increased endocytosis in retinal vascular endothelial cells grown in high glucose medium is modulated by inhibitors of nonenzymatic glycosylation

1995 • 24 citations

[86] Glyoxalase I from mouse liver

1982 • 18 citations

Retinal vascular endothelial cell endocytosis increases in early diabetes.

1995 • 15 citations

3-Deoxyfructose concentrations are increased in human plasma and urine in diabetes

1994 • 14 citations

Increased endocytosis in retinal vascular endothelial cells grown in high glucose medium is modulated by inhibitors of nonenzymatic glycosylation

1995 • 3 citations