Chapter 20 Small-Molecule Inhibitors of Glutathione S-Transferase P1-1 as Anticancer Therapeutic Agents

GLUTATHIONE TRANSFERASES

2004 • 3,229 citations

The role of glutathione-S-transferase in anti-cancer drug resistance

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Glutathione-S-transferase family of enzymes

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Phase I clinical trial of the flavonoid quercetin: pharmacokinetics and evidence for in vivo tyrosine kinase inhibition.

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Ligandin: a Hepatic Protein which Binds Steroids, Bilirubin, Carcinogens and a Number of Exogenous Organic Anions

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An enzyme from rat liver catalysing conjugations with glutathione

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Glutathione S-Transferases - A Review

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Association Between Glutathione S-Transferase P1, T1, and M1 Genetic Polymorphism and Survival of Patients With Metastatic Colorectal Cancer

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Polymorphism at the Glutathione S-transferase GSTP1 Locus

2000 • 262 citations

Glutathione S-transferase GSTP1 is a susceptibility gene for occupational asthma induced by isocyanates

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Human Glutathione Transferase A3-3, a Highly Efficient Catalyst of Double-bond Isomerization in the Biosynthetic Pathway of Steroid Hormones

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The structures of human glutathione transferase P1-1 in complex with glutathione and various inhibitors at high resolution

1997 • 178 citations

Glutathione-associated enzymes in the human cell lines of the National Cancer Institute Drug Screening Program.

1996 • 176 citations

JS-K, a glutathione/glutathione S-transferase-activated nitric oxide donor of the diazeniumdiolate class with potent antineoplastic activity.

2003 • 155 citations

Glutathione S-transferase isoenzymes in rat brain neurons and glia

1993 • 147 citations

7-Nitro-2,1,3-benzoxadiazole Derivatives, a New Class of Suicide Inhibitors for Glutathione S-Transferases

2005 • 139 citations

Quantitative and qualitative changes in gene expression patterns characterize the activity of plaques in multiple sclerosis

2003 • 135 citations

Polymorphisms at the glutathione S‐transferase, GSTP1 locus: a novel mechanism for susceptibility and development of atopic airway inflammation

2000 • 127 citations

Isozyme-specific glutathione S-transferase inhibitors potentiate drug sensitivity in cultured human tumor cell lines

1996 • 116 citations

Signaling Through RAS-RAF-MEK-ERK: from Basics to Bedside

2007 • 111 citations

Tumor Cell Responses to a Novel GlutathioneS-Transferase–Activated Nitric Oxide-Releasing Prodrug

2004 • 111 citations

Proapoptotic Activity of New Glutathione S-Transferase Inhibitors

2005 • 111 citations

Glutathione S-transferase-mu (GSTM1) and -theta (GSTT1) genotypes in the etiology of prostate cancer.

1999 • 111 citations

Characterization and Localization of Glutathione‐S‐Transferases in Rat Brain and Binding of Hormones, Neurotransmitters, and Drugs

1988 • 108 citations

The chemistry and biology of inhibitors and pro-drugs targeted to glutathione S-transferases

2005 • 106 citations

Polymorphisms of glutathione-S-transferase genes (GSTP1, GSTM1 andGSTT1) and prostate-cancer risk

2001 • 104 citations

Inhibition of human glutathione S-transferase P1-1 by the flavonoid quercetin

2003 • 102 citations

Glutathione-S-transferase Activates Novel Alkylating Agents

1994 • 102 citations

Identification of mu-class glutathione transferases M2-2 and M3-3 as cytosolic prostaglandin E synthases in the human brain.

2000 • 101 citations

Cyclopentenone Prostaglandins as Potential Inducers of Phase II Detoxification Enzymes

2000 • 98 citations

The glutathione-binding site in glutathione S-transferases. Investigation of the cysteinyl, glycyl and γ-glutamyl domains

1990 • 98 citations

Identification and Characterization of Novel Rat and Human Gonad-Specific Organic Anion Transporters

2003 • 95 citations

Isoenzyme-specific glutathione-S-transferase inhibitors: design and synthesis

1994 • 88 citations

Glutathione S-transferase polymorphisms in MS

2000 • 87 citations

Structure and Function of the Xenobiotic Substrate-Binding Site and Location of a Potential Non-Substrate-Binding Site in a Class π Glutathione S-Transferase^,

1997 • 83 citations

Overexpression of Erythrocyte Glutathione S-Transferase in Uremia and Dialysis

1999 • 75 citations

Glutathione-S-transferases are major cytosolic thyroid hormone binding proteins

1989 • 69 citations

Inhibition of glutathione S‐transferases by antimalarial drugs possible implications for circumventing anticancer drug resistance

2001 • 65 citations

Design, Synthesis, and Evaluation of Latent Alkylating Agents Activated by Glutathione S-Transferase

1996 • 63 citations

Brostallicin, a novel anticancer agent whose activity is enhanced upon binding to glutathione.

2002 • 62 citations

Does glutathione S-transferase Pi (GST-Pi) a marker protein for cancer?

2003 • 62 citations

Simultaneous identification of GSTP1 Ile105→Val105 and Ala114→Val114 substitutions using an amplification refractory mutation systempolymerase chain reactionassay: studies in patients with asthma

2001 • 60 citations

Reversal of Multiple Drug Resistance in Cholangiocarcinoma by the GlutathioneS-Transferase-π-Specific InhibitorO¹-Hexadecyl-γ-glutamyl-S-benzylcysteinyl-D-phenylglycine Ethylester

2003 • 59 citations

Design, Synthesis, and Structure−Activity Relationships of Haloenol Lactones: Site-Directed and Isozyme-Selective Glutathione S-Transferase Inhibitors

2004 • 55 citations

GSTP1 and MDR1 Genotypes and Central Nervous System Relapse in Childhood Acute Lymphoblastic Leukemia

2005 • 54 citations

The Role of Glutathione in the Isomerization of Δ5-Androstene- 3,17-dione Catalyzed by Human Glutathione Transferase A1-1

2001 • 54 citations

Mechanism of the Glutathione Transferase-Catalyzed Conversion of Antitumor 2-Crotonyloxymethyl-2-cycloalkenones to GSH Adducts

2003 • 53 citations

Leukotriene C synthetase, a special glutathione S-transferase: Properties of the enzyme and inhibitor studies with special reference to the mode of action of U-60,257, a selective inhibitor of leukotriene synthesis

1984 • 47 citations

Glutathione S-transferase hGSTM3 and ageing-associated neurodegeneration: relationship to Alzheimer's disease

2004 • 46 citations

Binding of α‐tocopherylquinone, an oxidized form of α‐tocopherol, to glutathione‐S‐transferase in the liver cytosol

1998 • 45 citations

Lack of glutathione conjugation to adriamycin in human breast cancer MCF-7/DOX cells

2000 • 45 citations

Novel Class of Bivalent Glutathione S-Transferase Inhibitors

2003 • 45 citations

A functional glutathioneS‐transferase P1 gene polymorphism is associated with methamphetamine‐induced psychosis in Japanese population

2005 • 43 citations

Synthesis and structure–activity relationship of ethacrynic acid analogues on glutathione-s-transferase P1-1 activity inhibition

2005 • 42 citations

Cytotoxic α-Halogenoacrylic Derivatives of Distamycin A and Congeners

2004 • 42 citations

Distribution of glutathione S-transferase isoenzymes in human ovary

1991 • 41 citations

Identification of Yb-glutathione-S-transferase as a major rat liver protein labeled with dexamethasone 21-methanesulfonate.

1985 • 40 citations

Interaction of hemin with placental glutathione transferase

1990 • 39 citations

Phase I study of TLK286 (glutathione S-transferase P1-1 activated glutathione analogue) in advanced refractory solid malignancies.

2003 • 36 citations

Benastatins A and B, new inhibitors of glutathione S-transferase, produced by Streptomyces sp. MI384-DF12. I. Taxonomy, production, isolation, physico-chemical properties and biological activities.

1992 • 35 citations

Glutathione transferase P1-1: self-preservation of an anti-cancer enzyme

2003 • 35 citations

Synthesis and activity of novel glutathione analogues containing an urethane backbone linkage

2003 • 28 citations

Phosphono analogs of glutathione: inhibition of glutathione transferases, metabolic stability, and uptake by cancer cells

2000 • 25 citations

Benastatins C and D, new inhibitors of glutathione S-transferase, produced by Streptomyces sp. MI384-DF12. Production, isolation, structure determination and biological activities.

1993 • 25 citations

Glutathione and the response of malignant cells to chemotherapy

1998 • 24 citations

Solution Structure of Glutathione Bound to Human Glutathione Transferase P1-1: Comparison of NMR Measurements with the Crystal Structure

1998 • 23 citations

Inhibition of purified glutathione S-transferases by indomethacin

1984 • 18 citations

Glutathione and glutathione S-transferases as early markers for ovarian carcinomas: case series.

2001 • 17 citations

Glutathione S-transferase pi as a target for tricyclic antidepressants in human brain.

2004 • 16 citations

Bequinostatins A and B, new inhibitors of glutathione S-transferase, produced by Streptomyces sp. MI384-DF12. Production, isolation, structure determination and biological activities.

1993 • 13 citations

Functional Studies of Cysteine Residues in Human Glutathione S-Transferase P1-1 by Site-Directed Mutagenesis

2001 • 13 citations

Glutathione-S-transferase in rat ovary: its changes during estrous cycle and increase in its activity by estradiol-17 beta.

1996 • 12 citations

Current concepts of hepatic uptake, intracellular transport and biliary secretion of bile acids: Physiological basis and pathophysiological changes in cholestatic liver dysfunction*

1996 • 12 citations

Molecular Modeling, Synthesis, and Preliminary Biological Evaluation of Glutathione-S-Transferase Inhibitors as Potential Therapeutic Agents

2005 • 10 citations

Binding proteins for cyclic and linear oligopeptides in plasma membranes and the cytosol of rat hepatocytes

1997 • 10 citations

Distribution of alpha glutathione S‐transferase in ovarian neoplasms: an immunohistochemical study

2001 • 9 citations

Can glutathione‐S‐transferases function as intracellular heme carriers?

1989 • 9 citations

Decreased cytosolic levels of the heme binding Z protein in rat hepatocyte nodules and hepatocellular carcinomas

1988 • 7 citations

Distribution of 3α-hydroxysteroid dehydrogenase (bile acid binder) in rat small intestine: Comparison with glutathione S-transferase subunits

1994 • 5 citations