The role of glutathione-S-transferase in anti-cancer drug resistance

Signal Transduction by the JNK Group of MAP Kinases

2000 • 4,096 citations

Mammalian thioredoxin is a direct inhibitor of apoptosis signal-regulating kinase (ASK) 1

1998 • 2,360 citations

Induction of Apoptosis by ASK1, a Mammalian MAPKKK That Activates SAPK/JNK and p38 Signaling Pathways

1997 • 2,284 citations

The p38 signal transduction pathway Activation and function

2000 • 1,560 citations

Regulation of JNK signaling by GSTp

1999 • 1,102 citations

Glutathione-Associated Enzymes In Anticancer Drug Resistance

2016 • 864 citations

Cytidine methylation of regulatory sequences near the pi-class glutathione S-transferase gene accompanies human prostatic carcinogenesis.

1994 • 840 citations

Ligandin: a Hepatic Protein which Binds Steroids, Bilirubin, Carcinogens and a Number of Exogenous Organic Anions

1971 • 570 citations

Glutathione S-Transferase Mu Modulates the Stress-activated Signals by Suppressing Apoptosis Signal-regulating Kinase 1

2001 • 397 citations

Increased skin tumorigenesis in mice lacking pi class glutathione S -transferases

1998 • 379 citations

Activation of apoptosis signal‐regulating kinase 1 by the stress‐induced activating phosphorylation of pre‐formed oligomer

2002 • 349 citations

Glutathione transferases catalyse the detoxication of oxidized metabolites (o-quinones) of catecholamines and may serve as an antioxidant system preventing degenerative cellular processes

1997 • 338 citations

Glutathione S-transferase P1–1 (GSTP1–1) Inhibits c-Jun N-terminal Kinase (JNK1) Signaling through Interaction with the C Terminus

2001 • 304 citations

Low levels of erythroid and myeloid progenitors in thrombopoietin-and c- mpl-deficient mice

1996 • 287 citations

Glutathione S-transferase p elicits protection against H2O2-induced cell death via coordinated regulation of stress kinases.

2000 • 263 citations

Gene microarray identification of redox and mitochondrial elements that control resistance or sensitivity to apoptosis

2000 • 259 citations

Fanconi anemia group C protein prevents apoptosis in hematopoietic cells through redox regulation of GSTP1

2001 • 247 citations

GSTP1 CpG Island Hypermethylation Is Responsible for the Absence of GSTP1 Expression in Human Prostate Cancer Cells

2001 • 243 citations

The Jun Kinase/Stress-activated Protein Kinase Pathway Functions to Regulate DNA Repair and Inhibition of the Pathway Sensitizes Tumor Cells to Cisplatin

1997 • 230 citations

Ethacrynic acid and piriprost as enhancers of cytotoxicity in drug resistant and sensitive cell lines.

1988 • 208 citations

Glutathione S-transferase GSTP1 is a susceptibility gene for occupational asthma induced by isocyanates

2002 • 206 citations

Role of mitogen-activated protein kinases in the response of tumor cells to chemotherapy

2001 • 196 citations

Glutathione-associated enzymes in the human cell lines of the National Cancer Institute Drug Screening Program.

1996 • 176 citations

Activation of the p38 Signaling Pathway by Heat Shock Involves the Dissociation of Glutathione S-Transferase Mu from Ask1

2002 • 175 citations

Pharmacologic or genetic manipulation of glutathione S-transferase P1-1 (GSTpi) influences cell proliferation pathways.

2001 • 164 citations

Biochemical characterization of Drosophila glutathione S-transferases D1 and D21.

1994 • 148 citations

Phase I study of thiotepa in combination with the glutathione transferase inhibitor ethacrynic acid.

1991 • 143 citations

Kinetic independence of the subunits of cytosolic glutathione transferase from the rat

1985 • 136 citations

Expression of human glutathione S-transferases in Saccharomyces cerevisiae confers resistance to the anticancer drugs adriamycin and chlorambucil

1990 • 130 citations

Cloning and characterization of two glutathione S-transferases from a DDT-resistant strain of Anopheles gambiae

1997 • 130 citations

A Prodrug Form of a Plasmodium falciparum Glutathione Reductase Inhibitor Conjugated with a 4-Anilinoquinoline

2001 • 126 citations

Glutathione S-Transferase of the Malarial Parasite Plasmodium falciparum: Characterization of a Potential Drug Target

2002 • 125 citations

Glutathione and glutathione-dependent enzymes in cancer drug resistance

1999 • 124 citations

Isozyme-specific glutathione S-transferase inhibitors potentiate drug sensitivity in cultured human tumor cell lines

1996 • 116 citations

The Cloning and Characterization of a New Stress Response Protein

1999 • 103 citations

Glutathione-S-transferase Activates Novel Alkylating Agents

1994 • 102 citations

Methyl-CpG Binding Domain Protein 2 Represses Transcription from Hypermethylated π-Class Glutathione S-Transferase Gene Promoters in Hepatocellular Carcinoma Cells

2002 • 100 citations

Characterization of glutathione S-transferase expression in lymphocytes from chronic lymphocytic leukemia patients.

1990 • 99 citations

Isoenzyme-specific glutathione-S-transferase inhibitors: design and synthesis

1994 • 88 citations

Free-Radical Intermediates in the Antiparasitic Action of Drugs and Phagocytic Cells

1984 • 86 citations

Vaccine Strategies against Schistosomiasis: From Concepts to Clinical Trials

2001 • 81 citations

Tumor efficacy and bone marrow-sparing properties of TER286, a cytotoxin activated by glutathione S-transferase.

1998 • 76 citations

Identification of Cysteine Residues Involved in Disulfide Formation in the Inactivation of Glutathione Transferase P-Form by Hydrogen Peroxide

1993 • 75 citations

The binding of porphyrins by ligandin

1978 • 72 citations

The glutathione conjugate of ethacrynic acid can bind to human pi class glutathione transferase P1‐1 in two different modes

1997 • 55 citations

Cellular Response to a GlutathioneS-Transferase P1-1 Activated Prodrug

2000 • 53 citations

Glutathione peptidomimetic drug modulator of multidrug resistance-associated protein.

1999 • 51 citations

Development of a vaccine strategy against human and bovine schistosomiasis: background and update

1995 • 51 citations

Glutathione S-Transferases: Structure, Function and Clinical Implications

2007 • 46 citations

Possible role of inhibition of glutathione S-transferase in the partial reversal of chlorambucil resistance by indomethacin in a Chinese hamster ovary cell line.

1989 • 44 citations

Reversing of chlorambucil resistance by ethacrynic acid in a B‐CLL patient

1993 • 37 citations

Phase I study of TLK286 (glutathione S-transferase P1-1 activated glutathione analogue) in advanced refractory solid malignancies.

2003 • 36 citations

Glutathione-dependent metabolism of cis-3-(9H-purin-6-ylthio)acrylic acid to yield the chemotherapeutic drug 6-mercaptopurine: evidence for two distinct mechanisms in rats.

1999 • 36 citations

Modulation of resistance to alkylating agents in cancer cell by gossypol enantiomers

1991 • 33 citations

Measurement of glutathione S-transferase P1-1 in plasma

1997 • 31 citations

Glutathione based approaches to improving cancer treatment

1998 • 31 citations

Activity of TER286 against human tumor colonyforming units

1997 • 23 citations

Mechanisms of inactivation of Schistosoma mansoni and mammalian glutathione S-transferase activity by the antischistosomal drug oltipraz

1992 • 22 citations

Low levels of erythroid and myeloid progenitors in thrombopoietin-and c- mpl-deficient mice

1996 • 18 citations

Expression of a Schistosoma mansoni 28-kilodalton glutathione S-transferase in the livers of transgenic mice and its effect on parasite infection

1997 • 11 citations

Geometrical Aspects of the Diffraction of Critically Incident Bulk Waves and Gaussian Beams

1994 • 10 citations