The Role of Glutathione in the Isomerization of Δ5-Androstene- 3,17-dione Catalyzed by Human Glutathione Transferase A1-1

The Glut athione S-Transferase Supergene Family: Regulation of GST and the Contribution of the lsoenzymes to Cancer Chemoprotection and Drug Resistance Part I

1995 • 3,492 citations

The kinetics of enzyme-catalyzed reactions with two or more substrates or products☆I. Nomenclature and rate equations

1963 • 2,095 citations

Structure and Mechanism in Protein Science

2017 • 2,079 citations

The kinetics of enzyme-catalyzed reactions with two or more substrates or products

1963 • 1,885 citations

Structure and Mechanism in Protein Science. A guide to Enzyme Catalysis and Protein Folding

2001 • 1,799 citations

Glutathione Transferases—Structure and Catalytic Activit

1988 • 1,751 citations

Structure, Catalytic Mechanism, and Evolution of the Glutathione Transferases

1997 • 1,136 citations

Identification of three classes of cytosolic glutathione transferase common to several mammalian species: correlation between structural data and enzymatic properties.

1985 • 1,081 citations

Theta, a new class of glutathione transferases purified from rat and man

1991 • 743 citations

Identification, Characterization, and Crystal Structure of the Omega Class Glutathione Transferases

2000 • 712 citations

Structure and function of glutathione S-transferases

1994 • 638 citations

Glutathione Transferases and Cancer

1992 • 548 citations

Zeta, a novel class of glutathione transferases in a range of species from plants to humans

1997 • 498 citations

Structure Determination and Refinement of Human Alpha Class Glutathione Transferase A1-1, and a Comparison with the Mu and Pi Class Enzymes

1993 • 449 citations

X‐ray crystal structures of cytosolic glutathione S‐transferases

1994 • 430 citations

Human glutathione transferase A4-4: an Alpha class enzyme with high catalytic efficiency in the conjugation of 4-hydroxynonenal and other genotoxic products of lipid peroxidation

1998 • 372 citations

Glutathione transferases catalyse the detoxication of oxidized metabolites (o-quinones) of catecholamines and may serve as an antioxidant system preventing degenerative cellular processes

1997 • 338 citations

Crystal Structures of a Schistosomal Drug and Vaccine Target: Glutathione S-Transferase fromSchistosoma japonicaand its Complex with the Leading Antischistomal Drug Praziquantel

1995 • 301 citations

Glutathione S-transferase class Kappa: characterization by the cloning of rat mitochondrial GST and identification of a human homologue

1996 • 298 citations

Subunit diversity and tissue distribution of human glutathione S-transferases: interpretations based on electrospray ionization-MS and peptide sequence-specific antisera

1997 • 231 citations

An Enzyme in Endocrine Tissues which Oxidizes Δ ⁵ -3 Hydroxy Steroids to α,β Unsaturated Ketones

1951 • 198 citations

Contribution of tyrosine 6 to the catalytic mechanism of isoenzyme 3-3 of glutathione S-transferase.

1992 • 177 citations

Relationship between the soluble glutathione-dependent delta 5-3-ketosteroid isomerase and the glutathione S-transferases of the liver.

1977 • 154 citations

Human placental 3β-hydroxy-5-ene-steroid dehydrogenase and steroid 5→ 4-ene-isomerase: Purification from mitochondria and kinetic profiles, biophysical characterization of the purified mitochondrial and microsomal enzymes

1989 • 149 citations

Characterization of rat spleen prostaglandin H <scp>d</scp>-isomerase as a sigma-class GSH transferase

1995 • 149 citations

Enzymic isomerization of Δ5-3-ketosteroids

1955 • 139 citations

Human Class Mu Glutathione Transferases, in Particular Isoenzyme M2-2, Catalyze Detoxication of the Dopamine Metabolite Aminochrome

1997 • 127 citations

Quantification of human hepatic glutathione S-transferases

1990 • 120 citations

The basic glutathione S-transferases from human livers are products of separate genes

1987 • 106 citations

Mutation of an evolutionarily conserved tyrosine residue in the active site of a human class Alpha glutathione transferase

1991 • 105 citations

Glutathione Transferases with Novel Active Sites Isolated by Phage Display from a Library of Random Mutants

1995 • 101 citations

Functional significance of arginine 15 in the active site of human class alpha glutathione transferase A1-1

1995 • 93 citations

The multiple murine 3β-hydroxysteroid dehydrogenase isoforms: Structure, function, and tissue- and developmentally specific expression

1997 • 87 citations

Cloning and heterologous expression of cDNA encoding class Alpha rat glutathione transferase 8-8, an enzyme with high catalytic activity towards genotoxic α,β-unsaturated carbonyl compounds

1992 • 86 citations

Purification and Properties of the Δ5-3β-Hydroxysteroid Dehydrogenase-Isomerase System of Sheep Adrenal Cortical Microsomes

1974 • 72 citations

Involvement of the Carboxyl Groups of Glutathione in the Catalytic Mechanism of Human Glutathione Transferase A1-1

1996 • 68 citations

Heterologous expression of recombinant human glutathione transferase A1-1 from a hepatoma cell line

1992 • 60 citations

Evolution of differential substrate specificities in Mu class glutathione transferases probed by DNA shuffling 1 1Edited by R. Huber

1999 • 55 citations

Evaluation of model discrimination, parameter estimation and goodness of fit in nonlinear regression problems by test statistics distributions

1995 • 54 citations

Mechanism-Based Phage Display Selection of Active-Site Mutants of Human Glutathione Transferase A1-1 Catalyzing S_NAr Reactions

1997 • 53 citations

Location of a potential transport binding site in a sigma class glutathione transferase by x-ray crystallography.

1996 • 46 citations

The C-Terminal Region of Human Glutathione Transferase A1-1 Affects the Rate of Glutathione Binding and the Ionization of the Active-Site Tyr9

1999 • 46 citations

The Conserved N-capping Box in the Hydrophobic Core of Glutathione S-Transferase P1–1 Is Essential for Refolding

1997 • 45 citations

Positioning of a spin-labeled substrate analog into the structure of .DELTA.5-3-ketosteroid isomerase by combined kinetic, magnetic resonance, and x-ray diffraction methods

1987 • 45 citations

Role of reduced glutathione in the Δ5-3-ketosteroid isomerase reaction of liver

1976 • 45 citations

Evidence for distinct dehydrogenase and isomerase sites within a single 3.beta.-hydroxysteroid dehydrogenase/5-ene-4-ene isomerase protein

1991 • 44 citations

Electrophilic Assistance by Asp-99 of 3-Oxo-Δ⁵-steroid Isomerase

1998 • 39 citations

Benzoic acid derivatives induce recovery of catalytic activity in the partially inactive Met208Lys mutant of human glutathione transferase A1-1 1 1Edited by A. R. Fersht

1999 • 35 citations

Site-directed mutagenesis identifies amino acid residues associated with the dehydrogenase and isomerase activities of human type I (placental) 3β-hydroxysteroid dehydrogenase/Isomerase

1998 • 34 citations

Contribution of amino acid residue 208 in the hydrophobic binding site to the catalytic mechanism of human glutathione transferase A1-1

1994 • 31 citations

Identification of the Nonsubstrate Steroid Binding Site of Rat Liver GlutathioneS-Transferase, Isozyme 1-1, by the Steroid Affinity Label, 3β-(Iodoacetoxy)dehydroisoandrosterone

1997 • 29 citations

Solution Structure of Δ⁵-3-Ketosteroid Isomerase Complexed with the Steroid 19-Nortestosterone Hemisuccinate^,

1998 • 28 citations

Solution Structure of Δ⁵-3-Ketosteroid Isomerase Complexed with the Steroid 19-Nortestosterone Hemisuccinate

1999 • 26 citations

Enzyme characteristics of two distinct forms of mouse 3 beta-hydroxysteroid dehydrogenase/delta 5-delta 4-isomerase complementary deoxyribonucleic acids expressed in COS-1 cells.

1993 • 24 citations

Probing Subunit Interactions in Alpha Class Rat Liver Glutathione S-Transferase with the Photoaffinity Label Glutathionyl S-[4-(Succinimidyl)benzophenone]

2000 • 23 citations

Active Site Phenylalanine of 3-Oxo-.DELTA.5-Steroid Isomerase is Catalytically Important for Proton Transfer

1995 • 13 citations