Stimulation of tyrosine kinase activity in anti-phosphotyrosine immune complexes of Swiss 3T3 cell lysates occurs rapidly after addition of bombesin, vasopressin, and endothelin to intact cells.

Peptide mapping by limited proteolysis in sodium dodecyl sulfate and analysis by gel electrophoresis.

1977 • 5,640 citations

Signal transduction by receptors with tyrosine kinase activity

1990 • 5,528 citations

Oncogenes and signal transduction

1991 • 2,816 citations

Cloning and expression of a cDNA encoding an endothelin receptor

1990 • 2,590 citations

Cloning of a cDNA encoding a non-isopeptide-selective subtype of the endothelin receptor

1990 • 2,432 citations

Early Signals in the Mitogenic Response

1986 • 1,498 citations

Phospholipase C-γ is a substrate for the PDGF and EGF receptor protein-tyrosine kinases in vivo and in vitro

1989 • 978 citations

Signal Transduction by the Platelet-Derived Growth Factor Receptor

1989 • 653 citations

A novel vasoactive peptide endothelin stimulates mitogenesis through inositol lipid turnover in Swiss 3T3 fibroblasts

1989 • 485 citations

Bombesin stimulation of DNA synthesis and cell division in cultures of Swiss 3T3 cells.

1983 • 470 citations

Acid and base hydrolysis of phosphoproteins bound to Immobilon facilitates analysis of phosphoamino acids in gel-fractionated proteins

1989 • 469 citations

Molecular cloning of the bombesin/gastrin-releasing peptide receptor from Swiss 3T3 cells.

1991 • 330 citations

Serotonin stimulates DNA synthesis in fibroblasts acting through 5–HT1B receptors coupled to a Gi-protein

1988 • 277 citations

Diacylglycerol stimulates DNA synthesis and cell division in mouse 3T3 cells: role of Ca2+-sensitive phospholipid-dependent protein kinase.

1984 • 266 citations

Cloning and Functional Characterization of a Complementary DNA Encoding the Murine Fibroblast Bombesin/Gastrin-Releasing Peptide Receptor

1990 • 256 citations

Structure/function relationship of proteins belonging to the family of receptors coupled to GTP‐binding proteins

1991 • 241 citations

Early events elicited by bombesin and structurally related peptides in quiescent Swiss 3T3 cells. I. Activation of protein kinase C and inhibition of epidermal growth factor binding.

1986 • 225 citations

A role for neuropeptides in the control of cell proliferation

1987 • 225 citations

Vasopressin stimulation of mouse 3T3 cell growth.

1979 • 210 citations

High-affinity receptors for peptides of the bombesin family in Swiss 3T3 cells.

1985 • 202 citations

Endothelin, vasopressin, and angiotensin II enhance tyrosine phosphorylation by protein kinase C-dependent and -independent pathways in glomerular mesangial cells.

1991 • 195 citations

Synthetic peptide substrates for a tyrosine protein kinase.

1982 • 184 citations

Epidermal growth factor stimulates the phosphorylation of synthetic tyrosine-containing peptides by A431 cell membranes.

1982 • 166 citations

Early events elicited by bombesin and structurally related peptides in quiescent Swiss 3T3 cells. II. Changes in Na+ and Ca2+ fluxes, Na+/K+ pump activity, and intracellular pH.

1986 • 164 citations

Bombesin, vasopressin, and endothelin rapidly stimulate tyrosine phosphorylation in intact Swiss 3T3 cells.

1991 • 156 citations

Homologous and heterologous mitogenic desensitization of Swiss 3T3 cells to phorbol esters and vasopressin: Role of receptor and postreceptor steps

1984 • 154 citations

Phosphorylation of an acidic mol. wt. 80 000 cellular protein in a cell-free system and intact Swiss 3T3 cells: a specific marker of protein kinase C activity.

1986 • 147 citations

Temporal relationship between inositol polyphosphate formation and increases in cytosolic Ca2+ in quiescent 3T3 cells stimulated by platelet-derived growth factor, bombesin and vasopressin.

1988 • 125 citations

Bombesin, diacylglycerols, and phorbol esters rapidly stimulate the phosphorylation of an Mr = 80,000 protein kinase C substrate in permeabilized 3T3 cells. Effect of guanine nucleotides.

1988 • 120 citations

Angiotensin II stimulates protein-tyrosine phosphorylation in a calcium-dependent manner.

1990 • 118 citations

Bradykinin and bombesin rapidly stimulate tyrosine phosphorylation of a 120-kDa group of proteins in Swiss 3T3 cells.

1991 • 117 citations

Identification of a receptor for peptides of the bombesin family in Swiss 3T3 cells by affinity cross-linking.

1987 • 114 citations

Serum, like phorbol esters, rapidly activates protein kinase C in intact quiescent fibroblasts.

1985 • 110 citations

Arachidonic acid release by bombesin. A novel postreceptor target for heterologous mitogenic desensitization.

1990 • 76 citations

Pasteurella multocida toxin, a potent mitogen, increases inositol 1,4,5-trisphosphate and mobilizes Ca2+ in Swiss 3T3 cells.

1991 • 74 citations

Bradykinin transiently activates protein kinase C in Swiss 3T3 cells. Distinction from activation by bombesin and vasopressin.

1990 • 70 citations

Bombesin receptor in membranes from Swiss 3T3 cells. Binding characteristics, affinity labelling and modulation by guanine nucleotides

1990 • 65 citations

Vasopressin induces selective desensitization of its mitogenic response in Swiss 3T3 cells.

1983 • 56 citations

Bombesin enhancement of cAMP accumulation in swiss 3T3 cells: Evidence of a dual mechanism of action

1988 • 50 citations

Two Classes of Antagonist Interact with Receptors for the Mitogenic Neuropeptides Bombesin, Bradykinin, and Vasopressin

1988 • 48 citations

Reconstitution of the rat liver vasopressin receptor coupled to guanine nucleotide-binding proteins.

1987 • 46 citations

Bombesin stimulation of fibroblast mitogenesis: specific receptors, signal transduction and early events

1990 • 43 citations

Purification and characterization of the rat liver vasopressin (V1) receptor.

1987 • 39 citations

Vasopressin rapidly stimulates protein kinase C in quiescent Swiss 3T3 cells

1986 • 39 citations

Vasopressin rapidly stimulates protein kinase C in digitonin‐permeabilized swiss 3T3 cells: Involvement of a pertussis toxin‐insensitive guanine nucleotide binding protein

1989 • 31 citations

Characterization of a bombesin receptor on Swiss mouse 3T3 cells by affinity cross‐linking

1988 • 30 citations

Vasoactive intestinal contractor, a novel peptide, shares a common receptor with endothelin-1 and stimulates Ca2+ mobilization and DNA synthesis in Swiss 3T3 cells

1990 • 30 citations

Solubilization of the bombesin receptor from Swiss 3T3 cell membranes

1990 • 29 citations

Mitogenic signalling through the bombesin receptor: Role of a guanine nucleotide regulatory protein

1990 • 20 citations