A proximal promoter element in the hamster desmin upstream regulatory region is responsible for activation by myogenic determination factors.

Molecular cloning: A laboratory manual

1990 • 85,659 citations

Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei

1983 • 11,902 citations

Recombinant genomes which express chloramphenicol acetyltransferase in mammalian cells.

1982 • 8,069 citations

Single-step purification of polypeptides expressed in Escherichia coli as fusions with glutathione S-transferase

1988 • 6,107 citations

Expression of a single transfected cDNA converts fibroblasts to myoblasts

1987 • 3,373 citations

The protein Id: A negative regulator of helix-loop-helix DNA binding proteins

1990 • 2,273 citations

Interactions between heterologous helix-loop-helix proteins generate complexes that bind specifically to a common DNA sequence

1989 • 1,876 citations

The myoD Gene Family: Nodal Point During Specification of the Muscle Cell Lineage

1991 • 1,564 citations

Myogenin, a factor regulating myogenesis, has a domain homologous to MyoD

1989 • 1,286 citations

Activation of muscle-specific genes in pigment, nerve, fat, liver, and fibroblast cell lines by forced expression of MyoD.

1989 • 984 citations

Inactivation of MyoD in mice leads to up-regulation of the myogenic HLH gene Myf-5 and results in apparently normal muscle development

1992 • 973 citations

Functional activity of myogenic HLH proteins requires hetero-oligomerization with E12/E47-like proteins in vivo

1991 • 874 citations

A gene with homology to the myc similarity region of MyoD1 is expressed during myogenesis and is sufficient to activate the muscle differentiation program.

1989 • 863 citations

MyoD is a sequence-specific DNA binding protein requiring a region of myc homology to bind to the muscle creatine kinase enhancer

1989 • 861 citations

MyoD1: A Nuclear Phosphoprotein Requiring a Myc Homology Region to Convert Fibroblasts to Myoblasts

1988 • 839 citations

The MyoD DNA binding domain contains a recognition code for muscle-specific gene activation

1990 • 794 citations

Identification of MRF4: a new member of the muscle regulatory factor gene family.

1989 • 779 citations

MyoD family: a paradigm for development?

1990 • 776 citations

Cell-Specific Expression of the Rat Insulin Gene: Evidence for Role of Two Distinct 5′ Flanking Elements

1985 • 698 citations

Expression of two myogenic regulatory factors myogenin and MyoDl during mouse embryogenesis

1989 • 662 citations

A new myocyte-specific enhancer-binding factor that recognizes a conserved element associated with multiple muscle-specific genes.

1989 • 605 citations

Early expression of the myogenic regulatory gene, myf-5, in precursor cells of skeletal muscle in the mouse embryo

1991 • 548 citations

Myf-6, a new member of the human gene family of myogenic determination factors: evidence for a gene cluster on chromosome 12.

1990 • 508 citations

Positive autoregulation of the myogenic determination gene MyoD1

1989 • 492 citations

Herculin, a fourth member of the MyoD family of myogenic regulatory genes.

1990 • 482 citations

Two Distinct Transcription Factors that Bind the Immunoglobulin Enhancer μE5/κE2 Motif

1990 • 478 citations

MyoD converts primary dermal fibroblasts, chondroblasts, smooth muscle, and retinal pigmented epithelial cells into striated mononucleated myoblasts and multinucleated myotubes.

1990 • 393 citations

Differential expression of myogenic determination genes in muscle cells: possible autoactivation by the Myf gene products.

1989 • 349 citations

Muscle-specific transcriptional activation by MyoD.

1991 • 347 citations

Muscle-specific expression of the cardiac alpha-actin gene requires MyoD1, CArG-box binding factor, and Sp1.

1990 • 334 citations

Identification of a myocyte nuclear factor that binds to the muscle-specific enhancer of the mouse muscle creatine kinase gene.

1989 • 326 citations

HEB, a helix-loop-helix protein related to E2A and ITF2 that can modulate the DNA-binding ability of myogenic regulatory factors.

1992 • 312 citations

A Myogenic Cell Line with Altered Serum Requirements for Differentiation

1977 • 305 citations

Making muscle in mammals

1992 • 292 citations

The muscle regulatory gene, Myf-6, has a biphasic pattern of expression during early mouse development.

1991 • 265 citations

Myogenin induces the myocyte-specific enhancer binding factor MEF-2 independently of other muscle-specific gene products.

1991 • 264 citations

Two adjacent MyoD1-binding sites regulate expression of the acetylcholine receptor α-subunit gene

1990 • 261 citations

Paired MyoD-binding sites regulate myosin light chain gene expression.

1991 • 216 citations

Making muscle in mammals

1992 • 152 citations

A ubiquitous factor (HF-1a) and a distinct muscle factor (HF-1b/MEF-2) form an E-box-independent pathway for cardiac muscle gene expression.

1992 • 123 citations

Characterization of the hamster desmin gene: Expression and formation of desmin filaments in nonmuscle cells after gene transfer

1985 • 112 citations

Regulation of the mouse desmin gene: transactivation by MyoD, myogenin, MRF4 and Myf5

1993 • 104 citations

Multiple CArG boxes in the human cardiac actin gene promoter required for expression in embryonic cardiac muscle cells developing in vitro from embryonal carcinoma cells.

1991 • 81 citations

Heterodimers of myogenic helix-loop-helix regulatory factors and E12 bind a complex element governing myogenic induction of the avian cardiac alpha-actin promoter.

1991 • 74 citations

Detection and modulation in vivo of helix-loop-helix protein-protein interactions.

1993 • 73 citations

High level desmin expression depends on a muscle-specific enhancer.

1991 • 73 citations

Upstream regions of the hamster desmin and vimentin genes regulate expression during in vitro myogenesis.

1987 • 70 citations

Muscle basic helix-loop-helix proteins and the regulation of myogenesis

1992 • 69 citations

Multiple binding sites for myogenic regulatory factors are required for expression of the acetylcholine receptor gamma-subunit gene.

1991 • 67 citations

A single MEF-2 site is a major positive regulatory element required for transcription of the muscle-specific subunit of the human phosphoglycerate mutase gene in skeletal and cardiac muscle cells.

1992 • 63 citations

Differential trans-activation of muscle-specific regulatory elements including the mysosin light chain box by chicken MyoD, myogenin, and MRF4.

1992 • 57 citations

The 5′-flanking region of the mouse muscle nicotinic acetylcholine receptor β subunit gene promotes expression in cultured muscle cells and is activated by MRF4, myogenin and myoD

1992 • 54 citations

Intermediate filament cDNAs from BHK-21 cells: demonstration of distinct genes for desmin and vimentin in all vertebrate classes.

1984 • 46 citations

Different E-box regulatory sequences are functionally distinct when placed within the context of the troponin I enhancer

1992 • 43 citations

Mesodermal mixed tumor

1983 • 34 citations

Identification of two silencers flanking an AP-1 enhancer in the vimentin promoter

1992 • 33 citations

Tissue-specific expression of a vimentin-desmin hybrid gene in transgenic mice.

1988 • 32 citations

5′ Flanking sequence of the hamster desmin gene

1988 • 5 citations