Functional analysis at the Cys706 residue of the retinoblastoma protein.

DNA sequencing with chain-terminating inhibitors

1977 • 69,181 citations

Single-step purification of polypeptides expressed in Escherichia coli as fusions with glutathione S-transferase

1988 • 6,107 citations

The Leucine Zipper: A Hypothetical Structure Common to a New Class of DNA Binding Proteins

1988 • 3,479 citations

The Human Papilloma Virus-16 E7 Oncoprotein Is Able to Bind to the Retinoblastoma Gene Product

1989 • 3,036 citations

Tumor Suppressor Genes

1991 • 1,784 citations

Redox Regulation of Fos and Jun DNA-Binding Activity in Vitro

1990 • 1,592 citations

SV40 large tumor antigen forms a specific complex with the product of the retinoblastoma susceptibility gene

1988 • 1,490 citations

The E2F transcription factor is a cellular target for the RB protein

1991 • 1,461 citations

Association between an oncogene and an anti-oncogene: the adenovirus E1A proteins bind to the retinoblastoma gene product

1988 • 1,440 citations

Monoclonal antibodies specific for simian virus 40 tumor antigens

1981 • 1,110 citations

The product of the retinoblastoma susceptibility gene has properties of a cell cycle regulatory element

1989 • 931 citations

Establishment and identification of small cell lung cancer cell lines having classic and variant features

1986 • 896 citations

The state of the p53 and retinoblastoma genes in human cervical carcinoma cell lines.

1991 • 857 citations

Tumor suppressor genes

1991 • 775 citations

Leucine Repeats and an Adjacent DNA Binding Domain Mediate the Formation of Functional cFos-cJun Heterodimers

1989 • 676 citations

Transformation of rat cells by DNA of human adenovirus 5

1973 • 664 citations

The retinoblastoma susceptibility gene encodes a nuclear phosphoprotein associated with DNA binding activity

1987 • 649 citations

Suppression of Tumorigenicity of Human Prostate Carcinoma Cells by Replacing a Mutated RB Gene

1990 • 606 citations

Frequent inactivation of the retinoblastoma anti-oncogene is restricted to a subset of human tumor cells.

1990 • 543 citations

Identification of cellular proteins that can interact specifically with the T/ElA-binding region of the retinoblastoma gene product

1991 • 541 citations

SV40 large T antigen binds preferentially to an underphosphorylated member of the retinoblastoma susceptibility gene product family

1989 • 508 citations

Molecular cloning, chromosomal mapping, and expression of the cDNA for p107, a retinoblastoma gene product-related protein

1991 • 464 citations

The retinoblastoma protein copurifies with E2F-I, an E1A-regulated inhibitor of the transcription factor E2F

1991 • 446 citations

Point Mutational Inactivation of the Retinoblastoma Antioncogene

1989 • 427 citations

Monoclonal antibodies specific for adenovirus early region 1A proteins: extensive heterogeneity in early region 1A products

1985 • 417 citations

Identification of a growth suppression domain within the retinoblastoma gene product.

1992 • 413 citations

The retinoblastoma protein is phosphorylated on multiple sites by human cdc2.

1991 • 343 citations

Cloning of cDNAs for cellular proteins that bind to the retinoblastoma gene product

1991 • 334 citations

The regions of the retinoblastoma protein needed for binding to adenovirus E1A or SV40 large T antigen are common sites for mutations.

1990 • 327 citations

Amino-terminal domains of c-myc and N-myc proteins mediate binding to the retinoblastoma gene product

1991 • 326 citations

Retinoblastoma cancer suppressor gene product is a substrate of the cell cycle regulator cdc2 kinase.

1991 • 304 citations

Structure and expression of the murine retinoblastoma gene and characterization of its encoded protein.

1989 • 248 citations

Mitosis-specific phosphorylation of p60c-src by p34cdc2-associated protein kinase

1989 • 239 citations

Interaction of p107 with Cyclin A Independent of Complex Formation with Viral Oncoproteins

1992 • 234 citations

A single amino acid substitution results in a retinoblastoma protein defective in phosphorylation and oncoprotein binding.

1990 • 204 citations

Two distinct and frequently mutated regions of retinoblastoma protein are required for binding to SV40 T antigen.

1990 • 204 citations

Definition of the minimal simian virus 40 large T antigen- and adenovirus E1A-binding domain in the retinoblastoma gene product.

1990 • 197 citations

Structure of the human retinoblastoma gene.

1989 • 193 citations

A cellular protein that competes with SV40 T antigen for binding to the retinoblastoma gene product

1991 • 153 citations

Transcriptional repression of the neu protooncogene by the adenovirus 5 E1A gene products.

1990 • 140 citations

Structure and expression of the human L-myc gene reveal a complex pattern of alternative mRNA processing.

1988 • 102 citations

Expression of RB and p53 proteins in HPV‐positive and HPV‐negative cervical carcinoma cell lines

1991 • 81 citations

Non-leucine residues in the leucine repeats of Fos and Jun contribute to the stability and determine the specificity of dimerization

1991 • 79 citations

Deletion of a splice donor site ablates expression of the following exon and produces an unphosphorylated RB protein unable to bind SV40 T antigen.

1990 • 52 citations

Hyperphosphorylation of the retinoblastoma gene product is determined by domains outside the simian virus 40 large-T-antigen-binding regions.

1990 • 50 citations

Oncogenes and tumor suppressor genes in human malignancies

1993 • 43 citations

The human L-myc gene encodes multiple nuclear phosphoproteins from alternatively processed mRNAs.

1988 • 36 citations

A single Cys706 to Phe substitution in the retinoblastoma protein causes the loss of binding to SV40 T antigen.

1990 • 28 citations