Contragestion and Other Clinical Applications of RU 486, an Antiprogesterone at the Receptor

The Steroid and Thyroid Hormone Receptor Superfamily

1988 • 7,590 citations

Gene regulation by steroid hormones

1989 • 3,466 citations

Primary structure and expression of a functional human glucocorticoid receptor cDNA

1985 • 1,851 citations

Nuclear receptors enhance our understanding of transcription regulation

1988 • 1,062 citations

The hormone-binding domains of the estrogen and glucocorticoid receptors contain an inducible transcription activation function

1988 • 588 citations

The common 90-kd protein component of non-transformed ‘8S’ steroid receptors is a heat-shock protein.

1985 • 527 citations

THALIDOMIDE AND LIMB DEFORMITIES

1962 • 461 citations

Complete amino acid sequence of the human progesterone receptor deduced from cloned cDNA

1987 • 419 citations

The Early History of Progesterone

1974 • 399 citations

RU 38486: Potent antiglucocorticoid activity correlated with strong binding to the cytosolic glucocorticoid receptor followed by an impaired activation

1984 • 372 citations

Mechanisms Regulating the Concentration and the Conformation of Progesterone Receptor(s) in the Uterus

1973 • 361 citations

Studies on the Mechanism of Steroid Hormone Regulation of Synthesis of Specific Proteins

1969 • 352 citations

Steroid Hormone Receptors

1976 • 345 citations

In vivo protein–DNA interactions in a glucocorticoid response element require the presence of the hormone

1986 • 328 citations

Specific glucocorticoid receptor binding to DNA reconstituted in a nucleosome.

1988 • 316 citations

Successful Treatment of Cushing’s Syndrome with the Glucocorticoid Antagonist RU 486*

1985 • 315 citations

The Antiprogestin Steroid RU 486 and Human Fertility Control

1985 • 298 citations

Cytoplasmic and Nuclear Estradiol and Progesterone Receptors in Human Endometrium*

1978 • 270 citations

A region in the steroid binding domain determines formation of the non-DNA-binding, 9 S glucocorticoid receptor complex.

1988 • 267 citations

Progesterone receptor blockage

1985 • 258 citations

URINARY INFECTION IN THE TWO SEXES

1966 • 235 citations

Termination of Early Pregnancy by the Progesterone Antagonist RU 486 (Mifepristone)

1986 • 234 citations

The New Steroid Analog RU 486 Inhibits Glucocorticoid Action in Man

1984 • 234 citations

Induction of Midcycle Gonadotropin Surge by Ovarian Steroids in Women: A Critical Evaluation*

1983 • 222 citations

Steroid-induced nuclear binding of glucocorticoid receptors in intact hepatoma cells

1973 • 221 citations

RU 486: a steroid with antiglucocorticosteroid activity that only disinhibits the human pituitary-adrenal system at a specific time of day.

1984 • 216 citations

Termination of very early pregnancy by RU 486 — An antiprogestational compound

1984 • 212 citations

Endometrial and Pituitary Responses to the Steroidal Antiprogestin RU 486in Postmenopausal Women

1985 • 193 citations

Multiple Human Progesterone Receptor Messenger Ribonucleic Acids and Their Autoregulation by Progestin Agonists and Antagonists in Breast Cancer Cells

1988 • 188 citations

Polypeptide components of two 8 S forms of chicken oviduct progesterone receptor.

1984 • 186 citations

Steroid-free glucocorticoid receptor binds specifically to mouse mammary tumour virus DNA

1986 • 185 citations

Sequence-specific DNA binding of the progesterone receptor to the uteroglobin gene: effects of hormone, antihormone and receptor phosphorylation.

1986 • 184 citations

Antiglucocorticosteroid effects suggest why steroid hormone is required for receptors to bind DNA in vivo but not in vitro

1987 • 179 citations

Receptors bound to antiprogestin form abortive complexes with hormone responsive elements

1988 • 164 citations

Progesterone in uterus and plasma. IV — Progesterone receptor(s) in guinea pig uterus cytosol

1970 • 157 citations

Disruption of Follicular Maturation and Delay of Ovulation after Administration of the Antiprogesterone RU486*

1987 • 156 citations

Effects of the Antiprogesterone Steroid RU 486 during Midluteal Phase in Normal Women

1985 • 139 citations

Induction of menstruation by an antiprogesterone steroid (RU 486) in primates: site of action, dose-response relationships, and hormonal effects

1983 • 138 citations

DNA binding properties of glucocorticosteroid receptors bound to the steroid antagonist RU-486.

1984 • 137 citations

A “Proportion Graph” Method for Measuring Binding Systems

1970 • 135 citations

Regio and stereospecific synthesis of 11β-substituted 19-norsteroids

1981 • 130 citations

The Antiprogestin RU38 486: Receptor-Mediated ProgestinVersusAntiprogestin Actions Screened in Estrogen-Insensitive T47D_COHuman Breast Cancer Cells*

1985 • 129 citations

Inhibition of glucocorticosteroid action in cultured L-929 mouse fibroblasts by RU 486, a new anti-glucocorticosteroid of high affinity for the glucocorticosteroid receptor

1983 • 125 citations

Interaction of the Mr = 90,000 heat shock protein with the steroid-binding domain of the glucocorticoid receptor.

1988 • 123 citations

Plasma concentrations and receptor binding of RU 486 and its metabolites in humans

1987 • 122 citations

Therapeutic abortion in early pregnancy with antiprogestogen RU486 alone or in combination with prostaglandin analogue (Gemeprost)

1986 • 120 citations

Studies on the mechanisms of action of progesterone antagonists

1986 • 105 citations

Blockade of the Spontaneous Midcycle Gonadotropin Surge in Monkeys by RU 486: A Progesterone Antagonist or AgonistÓ*

1986 • 105 citations

The antiprogestin RU486 in advanced breast cancer: preliminary clinical trial.

1987 • 99 citations

Birth Control after 1984

1970 • 97 citations

Amiloride-sensitive epithelial Na+ channels reconstituted into planar lipid bilayer membranes

1984 • 94 citations

17α-Alkynyl-11β,17-dihydroxyandrostane derivatives : A new class of potent glucocorticoids.

1981 • 94 citations

Inhibition of folliculogenesis and ovulation by the antiprogesterone RU 486.

1988 • 89 citations

Prostaglandins in Fertility Control

1972 • 88 citations

Vascular changes in the human endometrium following the administration of the progesterone antagonist RU 486

1989 • 88 citations

Effects of an Antiprogesterone (RU486) on the Hypothalamic-Hypophyseal-Ovarian-Endometrial Axis During the Luteal Phase of the Menstrual Cycle*

1988 • 86 citations

Physiology of Corpus Luteum VII. Maintenance of Pregnancy in Rabbit After Very Early Castration, by Corpus Luteum Extracts

1930 • 86 citations

Increased Adrenocorticotropin, Cortisol, and Arginine Vasopressin Secretion in Primates after the Antiglucocorticoid Steroid RU 486:Dose Response Relationships*

1985 • 85 citations

Temporal changes in uterine activity and prostaglandin response to RU486 in rhesus macaques in late gestation

1987 • 82 citations

Hormonal Regulation of Ovalbumin Synthesis in Chick Oviduct

1973 • 80 citations

The Progesterone Antagonist RU 486

1987 • 77 citations

Induced cervical ripening with mifepristone in first trimester abortion

1988 • 75 citations

Compared intracellular localization of the glucocorticosteroid and progesterone receptors: An immunocytochemicai study

1989 • 74 citations

Effects of the antiprogesterone RU 486 in normal women

1987 • 74 citations

Inhibition of folliculogenesis and ovulation by the antiprogesterone RU 486

1988 • 72 citations

The effect of RU486 administered during the proliferative and secretory phase of the cycle on the bleeding pattern, hormonal parameters and the endometrium

1988 • 70 citations

Morphologic response of endometrium to a progesterone receptor antagonist, RU486, in monkeys

1986 • 69 citations

Progesterone antagonist (RU 486) for cervical dilation, labor induction, and delivery in monkeys: Effectiveness in combination with oxytocin

1989 • 67 citations

Chick oviduct glucocorticosteroid receptor

1985 • 67 citations

The Effect of the Antiprogestins RU 486 and ZK 98734 on the Synthesis and Metabolism of Prostaglandins F_2αand E₂in Separated Cells from Early Human Decidua

1987 • 66 citations

The cDNA-derived amino acid sequence of chick heat shock protein Mr 90,000 (HSP 90) reveals A “DNA like” structure: Potential site of interaction with steroid receptors

1989 • 64 citations

Mechanism of action of an antiprogesterone, RU486, in the rabbit endometrium

1985 • 64 citations

The effects of progesterone receptor blockade in the luteal phase of normal fertile women

1988 • 62 citations

11β-substituted steroids, an original pathway to antihormones

1988 • 62 citations

Contragestion with late luteal administration of RU 486 (Mifepristone)

1988 • 58 citations

Monohydroxytamoxifen: An antioestrogen with high affinity for the chick oviduct oestrogen receptor

1979 • 53 citations

Transformation of calf uterine progesterone receptor: analysis of the process when receptor is bound to progesterone and RU38486

1987 • 51 citations

Contraceptive potential of RU 486 by ovulation inhibition: I. Pituitary versus ovarian action with blockade of estrogen induced endometrial proliferation

1989 • 50 citations

The Steroid/Thyroid Hormone Receptor Family and Gene Regulation

1989 • 49 citations

Glucocorticoid receptors bound to the antagonist RU486 are not downregulated despite their capacity to interact in vitro with defined gene regions

1987 • 47 citations

Early abortion with a single dose of the antiprogestin RU-486

1988 • 46 citations

Medical treatment of residual ectopic pregnancy: RU 486 and methotrexate

1987 • 46 citations

Covalent stabilization of the nontransformed chick oviduct cytosol progesterone receptor by chemical crosslinking

1988 • 46 citations

Screening of anti-progestagens by receptor studies and bioassays

1988 • 45 citations

Immunocytochemical localization of progesterone receptors in breast cancer with anti-human receptor monoclonal antibodies.

1988 • 45 citations

Script: interactive molecular geometrical treatments on the basis of computer-drawn chemical formula

1981 • 45 citations

Termination of early gestation with the anti-progestin steroid RU 486: Medium versus low dose

1987 • 45 citations

Induction of Avidin Formation in the Avian Oviduct by Stilbestrol Plus Progesterone

1943 • 44 citations

Efficacy of progesterone antagonist RU486 (Mifepristone) for pre-operative cervical dilatation during first trimester abortion

1988 • 43 citations

Competitive Progesterone Antagonists: Receptor Binding and Biologic Activity of Testosterone and 19-Nortestosterone Derivatives

1979 • 41 citations

ANTIFERTILITY ACTIONS OF THE PROGESTERONE ANTAGONIST RU 486 INCLUDE DIRECT INHIBITION OF PLACENTAL HORMONE SECRETION

1987 • 41 citations

Late postcoital treatment against pregnancy with antiprogesterone RU 486

1988 • 40 citations

Early pregnancy termination with antiprogestins: a comparative clinical study of RU 486 given in two dose regimens and Epostane

1987 • 39 citations

Uses of RU 486 for contragestion: An update

1987 • 39 citations

RU486 is not an antiprogestin in the hamster

1987 • 39 citations

Association of the glucocorticoid receptor binding subunit with the 90K nonsteroid-binding component is stabilized by both steroidal and nonsteroidal antiglucocorticoids in intact cells

1988 • 38 citations

The mechanism of action of steroid antagonists: Insights from crystallographic studies

1988 • 37 citations

Mifepristone (RU486) and therapeutic late pregnancy termination: a double-blind study of two different doses

1988 • 36 citations

X-ray crystallography of estrogens and their binding to receptor sites.

1972 • 33 citations

Pharmacodynamics of the antiprogesterone RU486 in women after oral administration

1988 • 33 citations

The use of interaction kinetics to distinguish potential antagonists from agonists

1980 • 32 citations

Antiprogestin-receptor complexes: Differences in the interaction of the antiprogestin RU38,486 and the progestin R5020 with the progesterone receptor of human breast cancer cells

1986 • 31 citations

Termination of early pregnancy by a single dose of mifepristone (RU 486), a progesterone antagonist

1988 • 30 citations

Late Luteal Phase Administration of RU486 for Three Successive Cycles Does Not Disrupt Bleeding Patterns or Ovulation*

1987 • 30 citations

Do antiestrogens and antiprogestins act as hormone antagonists or receptor-targeted drugs in breast cancer?

1987 • 29 citations

The effect of the antiprogestin mifepristone (RU 486) on maturation and in‐vitro fertilization of human oocytes

1988 • 27 citations

Efficacy of the antiprogestin mifepristone (RU 486) prior to prostaglandin termination of pregnancy

1989 • 26 citations

Interception IV: Failure of mifepristone (RU 486) as a monthly contragestive, “lunarette”

1987 • 26 citations

Prolactin stimulates Na+-K+-ATPase activity located in the outer renal medulla of the rat

1986 • 26 citations

Termination of Early Pregnancy by the 3β-Hydroxysteroid Dehydrogenase Inhibitor Epostane

1988 • 26 citations

The role of pre-ovulatory progesterone in the midcycle gonadotrophin surge, ovulation and subsequent luteal phase: studies with RU486 in rhesus monkeys

1988 • 25 citations

Effect of the antiprogestin RU486 on human ovarian steroidogenesis

1987 • 25 citations

The critical control of progesterone levels and pregnancy by antiprogesterone

1976 • 24 citations

Trophoblastic and decidual response to RU486: effects on human chorionic gonadotrophin, human placental lactogen, prolactin and pregnancy-associated plasma protein-A production in vitro

1986 • 24 citations

Levels of the antiprogestin RU 486 and its metabolites in human blood and follicular fluid following oral administration of a single dose

1989 • 24 citations

Transplacental passage of a progesterone antagonist in monkeys

1988 • 24 citations

Early Ultrastructural Changes in RU-486-Exposed Decidua

1985 • 19 citations

Termination of early human pregnancy with Epostane

1987 • 18 citations

Do Receptor-Associated Nuclear Proteins Explain Earliest Steps of Steroid Hormone Function?

1989 • 16 citations

The Glucocorticoid Antagonist 17α-Methyltestosterone Binds to the 10 S Glucocorticoid Receptor and Blocks Agonist-Mediated Dissociation of the 10 S Oligomer to the 4 S Deoxyribonucleic Acid-Binding Subunit

1989 • 14 citations

Pregnancy interruption with RU 486 in combination with dl-15-methyl-prostaglandin-F2α-methyl ester: The Chinese experience

1988 • 13 citations

Evidence for Reduced Catabolism by the Antiglucocorticoid RU 38486 in Acutely Uremic Rats

1987 • 13 citations

[New data on the hormonal requirement of the pregnant rabbit: partial pregnancies and fetal abnormalities after treatment with a hormonal antagonist given at a sub-abortive dosage].

1986 • 11 citations

Differences in the association of the progesterone receptor ligated by antiprogestin RU38486 or progestin ORG 2058 to chromatin components

1987 • 10 citations

Perspectives in human reproduction

1988 • 8 citations

Phase III-clinical trial with NORPLANTr∗∗-2 (covered rods). Report of a 24-month study

1988 • 6 citations

[Abortion induced by RU 486: importance of its combination with a prostaglandin derivative].

1988 • 5 citations

Problems of HIV infection for women in Africa.

1988 • 3 citations

[RU 486 and induction of labor in 3d trimester pregnancy interruptions. Preliminary clinical studies].

1988 • 3 citations

Endometriosis

1988 • 1 citations