Reduced susceptibility to collagen-induced arthritis in mice deficient in IFN-gamma receptor.

TH1 and TH2 Cells: Different Patterns of Lymphokine Secretion Lead to Different Functional Properties

1989 • 7,558 citations

Site-directed mutagenesis by gene targeting in mouse embryo-derived stem cells

1987 • 2,368 citations

Interferon-γ and B Cell Stimulatory Factor-1 Reciprocally Regulate Ig Isotype Production

1987 • 1,936 citations

Heterogeneity of Cytokine Secretion Patterns and Functions of Helper T Cells

1989 • 1,122 citations

Immunisation against heterologous type II collagen induces arthritis in mice

1980 • 1,025 citations

Nucleotide sequence and exact localization of the neomycin phosphotransferase gene from transposon Tn5

1982 • 936 citations

lnterleukin-13 is a new human lymphokine regulating inflammatory and immune responses

1993 • 877 citations

Suppression of arthritis by an inhibitor of nitric oxide synthase.

1993 • 662 citations

The nucleotide sequence and transcript map of the herpes simplex virus thymidine kinase gene

1980 • 556 citations

Lymphocytes recognize human vascular endothelial and dermal fibroblast Ia antigens induced by recombinant immune interferon

1983 • 487 citations

Cloning of the human gene for intercellular adhesion molecule 1 and analysis of its 5'-regulatory region. Induction by cytokines and phorbol ester.

1991 • 419 citations

Serum transfer of collagen-induced arthritis in mice.

1983 • 414 citations

Divergent T-cell cytokine patterns in inflammatory arthritis.

1994 • 388 citations

Prevention of type II collagen-induced arthritis by in vivo treatment with anti-L3T4.

1985 • 372 citations

Relationship between Th1/Th2 cytokine patterns and the arthritogenic response in collagen‐induced arthritis

1996 • 317 citations

Interleukin-10 expression and chemokine regulation during the evolution of murine type II collagen-induced arthritis.

1995 • 269 citations

Type II collagen-induced murine arthritis. I. Induction and perpetuation of arthritis require synergy between humoral and cell-mediated immunity.

1988 • 264 citations

γ-Interferon is one of several direct B cell-maturing lymphokines

1984 • 237 citations

Interferons as macrophage-activating factors. III. Preferential effects of interferon-gamma on the interleukin 1 secretory potential of fresh or aged human monocytes.

1985 • 217 citations

Genetic susceptibility to murine collagen II autoimmune arthritis. Proposed relationship to the IgG2 autoantibody subclass response, complement C5, major histocompatibility complex (MHC) and non-MHC loci.

1985 • 210 citations

Biphasic effect of interferon‐γ in murine collagen‐induced arthritis

1995 • 204 citations

Role of γ-interferon in antibody-producing responses

1984 • 203 citations

Administration of interleukin 12 in combination with type II collagen induces severe arthritis in DBA/1 mice.

1995 • 198 citations

The Th1/Th2 balance in autoimmunity

1995 • 198 citations

Homologous type II collagen induces chronic and progressive arthritis in mice

1986 • 196 citations

Cytokines in synovial fluid: II. The presence of tumour necrosis factor and interferon.

1988 • 191 citations

Manipulation of the Th1/Th2 balance in autoimmune disease

1996 • 186 citations

Reduced incidence and severity of collagen‐induced arthritis in interleukin‐12‐deficient mice

1996 • 180 citations

Prevention and reversal of cartilage degradation in rheumatoid arthritis by interleukin‐10 and interleukin‐4

1996 • 174 citations

In vivo administration with IL-1 accelerates the development of collagen-induced arthritis in mice.

1988 • 158 citations

Treatment with gamma-interferon triggers the onset of collagen arthritis in mice

1988 • 158 citations

Type II collagen-induced arthritis in mice. IV. Variations in immunogenetic regulation provide evidence for multiple arthritogenic epitopes on the collagen molecule.

1985 • 141 citations

Murine I-Aβ Chain Polymorphism: Nucleotide Sequences of Three Allelic I-Aβ Genes

1983 • 139 citations

Role of cytokines in inflammatory synovitis

1990 • 132 citations

Collagen-induced arthritis in CD4- or CD8-deficient mice: CD8+ T cells play a role in initiation and regulate recovery phase of collagen-induced arthritis.

1996 • 124 citations

IFN-γ Induces IL-12 mRNA Expression by a Murine Macrophage Cell Line, J774

1994 • 123 citations

Interferon gamma upregulates its own gene expression in mouse peritoneal macrophages.

1994 • 121 citations

Double‐blind trial of recombinant γ‐interferon versus placebo in the treatment of rheumatoid arthritis

1989 • 110 citations

Cloning and expression of the cDNA for the murine interferon gamma receptor.

1989 • 103 citations

IFN-γ enhances secretion of IgG2a from IgG2a-committed LPS-stimulated murine B cells: Implications for the role of IFN-γ in class switching

1991 • 100 citations

Regulation of the expression of ICAM-1 on human monocytes and monocytic tumor cell lines.

1992 • 99 citations

Characterization of the T cell determinants in the induction of autoimmune arthritis by bovine alpha 1(II)-CB11 in H-2q mice.

1994 • 97 citations

The effect of treatment with interferon-gamma on type II collagen-induced arthritis

1990 • 93 citations

IL-1, IL-4, and IFN-gamma differentially regulate cytokine production and cell surface molecule expression in cultured human thymic epithelial cells.

1991 • 87 citations

CD4+ T cells from collagen-induced arthritic mice are essential to transfer arthritis into severe combined immunodeficient mice

1994 • 74 citations

Localization of a critical restriction site on the I-A beta chain that determines susceptibility to collagen-induced arthritis in mice.

1989 • 71 citations

IgE class switching is critically dependent upon the nature of the B cell activator, in addition to the presence of IL-4.

1991 • 68 citations

IFN-gamma induces the expression of the genes for MHC class II I-A beta and tumor necrosis factor through a protein kinase C-independent pathway.

1991 • 67 citations

COLLAGEN ARTHRITIS—WHAT CAN IT TEACH US?

1994 • 63 citations

Collagen-induced arthritis in mice. Relationship of collagen-specific and total IgE synthesis to disease.

1991 • 59 citations

Reduced susceptibility to collagen-induced arthritis in mice deficient in intercellular adhesion molecule-1.

1996 • 59 citations

The role of the B cells in the adoptive transfer of collagen‐induced arthritis from DBA/1 (H‐2^q) to SCID (H−2^d) mice

1995 • 57 citations

Mechanisms of Immune Injury in Rheumatoid Arthritis: Evidence for the Involvement of T Cells and Heat‐Shock Protein

1990 • 50 citations

Prospective two-year followup of recombinant interferon-gamma in rheumatoid arthritis.

1990 • 45 citations

Structures on the I‐A molecule predisposing for susceptibility to type II collagen‐induced autoimmune arthritis

1990 • 45 citations

Accelerated onset of collagen-induced arthritis by remote inflammation

1994 • 42 citations

Adoptive Transfer of Susceptibility to Antigen-Induced Arthritis into Severe Combined Immunodeficient (SCID) MICE: Role of CD4+ and CD8+ T Cells

1996 • 40 citations

Suppression and augmentation of rat adjuvant arthritis with monoclonal anti-interferon-gamma antibody.

1989 • 36 citations

Short Paper: Leukotrien B₄-induced lnterleukin-1β in Synovial Cells from Patients with Rheumatoid Arthritis

1994 • 16 citations

Rapid identification of transgenic mice with PCR amplification of DNA from ear punching

1991 • 12 citations