Analysis of XRN Orthologs by Complementation of Yeast Mutants and Localization of XRN–GFP Fusion Proteins

Deadenylation of the unstable mRNA encoded by the yeast MFA2 gene leads to decapping followed by 5'-->3' digestion of the transcript.

1994 • 511 citations

Yeast cells lacking 5'-->3' exoribonuclease 1 contain mRNA species that are poly(A) deficient and partially lack the 5' cap structure.

1993 • 378 citations

Isolation and characterization of RAT1: an essential gene of Saccharomyces cerevisiae required for the efficient nucleocytoplasmic trafficking of mRNA.

1992 • 370 citations

A Mouse Cytoplasmic Exoribonuclease (mXRN1p) with Preference for G4 Tetraplex Substrates

1997 • 341 citations

The 5′ end of yeast 5.8S rRNA is generated by exonucleases from an upstream cleavage site.

1994 • 308 citations

Multiple functions for the poly(A)-binding protein in mRNA decapping and deadenylation in yeast.

1995 • 278 citations

Nuclear localization signal(s) required for nuclear targeting of the maize regulatory protein Opaque-2.

1992 • 267 citations

Cloning vectors for the expression of green fluorescent protein fusion proteins in transgenic plants

1998 • 243 citations

[26] Vectors for constitutive and inducible gene expression in yeast

1991 • 230 citations

Processing of the Precursors to Small Nucleolar RNAs and rRNAs Requires Common Components

1998 • 216 citations

DST sequences, highly conserved among plant SAUR genes, target reporter transcripts for rapid decay in tobacco.

1993 • 208 citations

Rat1p and Xrn1p Are Functionally Interchangeable Exoribonucleases That Are Restricted to and Required in the Nucleus and Cytoplasm, Respectively

1997 • 196 citations

Novel features of the XRN-family in Arabidopsis : Evidence that AtXRN4, one of several orthologs of nuclear Xrn2p/Rat1p, functions in the cytoplasm

2000 • 160 citations

Fragments of the internal transcribed spacer 1 of pre-rRNA accumulate in Saccharomyces cerevisiae lacking 5'----3' exoribonuclease 1

1991 • 128 citations

[29] Measurement of mRNA decay rates in Saccharomyces cerevisiae

1991 • 120 citations

The effect of sequences with high AU content on mRNA stability in tobacco.

1993 • 115 citations

Saccharomyces cerevisiae RAI1 (YGL246c) Is Homologous to Human DOM3Z and Encodes a Protein That Binds the Nuclear Exoribonuclease Rat1p

2000 • 114 citations

Multiple regions of the Arabidopsis SAUR-AC1 gene control transcript abundance: the 3′ untranslated region functions as an mRNA instability determinant.

1996 • 98 citations

Regulation and Intracellular Localization of Saccharomyces cerevisiae Strand Exchange Protein 1 (Sep1/Xrn1/Kem1), a Multifunctional Exonuclease

1995 • 88 citations

Processing of the Intron-Encoded U18 Small Nucleolar RNA in the Yeast Saccharomyces cerevisiaeRelies on Both Exo- and Endonucleolytic Activities

1998 • 62 citations

Structural Modifications of RNA Influence the 5′ Exoribonucleolytic Hydrolysis by XRN1 and HKE1 ofSaccharomyces cerevisiae

1997 • 47 citations

The Role of mRNA Stability in the Control of Globin Gene Expression

1997 • 42 citations

Mutational analysis of the DST element in tobacco cells and transgenic plants: identification of residues critical for mRNA instability.

1996 • 38 citations

Deadenylation-Dependent and -Independent Decay Pathways for α1-Tubulin mRNA in Chlamydomonas reinhardtii

1998 • 24 citations

Identification of functional domains in the Sep1 protein (= Kem1, Xrn1), which is required for transition through meiotic prophase in Saccharomyces cerevisiae

1995 • 20 citations

Evidence for a 5′ → 3′ direction of hydrolysis by a 5′ mononucleotide-producing exoribonuclease from Saccharomyces cerevisiae

1979 • 16 citations