Hypotonic activation of volume-sensitive outwardly rectifying chloride channels in cultured PASMCs is modulated by SGK

X-ray structure of a ClC chloride channel at 3.0 Å reveals the molecular basis of anion selectivity

2002 • 1,571 citations

Molecular Structure and Physiological Function of Chloride Channels

2002 • 1,234 citations

Ten years of protein kinase B signalling: a hard Akt to follow

2001 • 1,159 citations

Protein Kinase C Isotypes Controlled by Phosphoinositide 3-Kinase Through the Protein Kinase PDK1

1998 • 1,118 citations

PKB/Akt

2001 • 1,066 citations

Phosphoinositide 3-kinases: A conserved family of signal transducers

1997 • 944 citations

Protein Kinase SGK Mediates Survival Signals by Phosphorylating the Forkhead Transcription Factor FKHRL1 (FOXO3a)

2001 • 850 citations

Protein kinase C isozymes and the regulation of diverse cell responses

2000 • 730 citations

Epithelial sodium channel regulated by aldosterone-induced protein sgk

1999 • 728 citations

Phosphorylation of Nedd4-2 by Sgk1 regulates epithelial Na+ channel cell surface expression

2001 • 699 citations

The Rab GTPase family.

2001 • 682 citations

Structure and function of phosphoinositide 3-kinases

1998 • 666 citations

Electrolyte Transport in the Mammalian Colon: Mechanisms and Implications for Disease

2002 • 636 citations

Cellular and molecular physiology of volume-sensitive anion channels

1996 • 620 citations

Activation of serum- and glucocorticoid-regulated protein kinase by agonists that activate phosphatidylinositide 3-kinase is mediated by 3-phosphoinositide-dependent protein kinase-1 (PDK1) and PDK2

1999 • 598 citations

Serum and glucocorticoid-inducible kinase (SGK) is a target of the PI 3-kinase-stimulated signaling pathway

1999 • 555 citations

Barttin is a Cl- channel β-subunit crucial for renal Cl- reabsorption and inner ear K+ secretion

2001 • 545 citations

Characterization of sgk, a Novel Member of the Serine/Threonine Protein Kinase Gene Family Which Is Transcriptionally Induced by Glucocorticoids and Serum

1993 • 537 citations

Serum and Glucocorticoid-regulated Kinase Modulates Nedd4-2-mediated Inhibition of the Epithelial Na+Channel

2002 • 451 citations

Molecular identification of a volume-regulated chloride channel

1997 • 443 citations

Characterization of sgk, a novel member of the serine/threonine protein kinase gene family which is transcriptionally induced by glucocorticoids and serum.

1993 • 415 citations

Characterization of the structure and regulation of two novel isoforms of serum- and glucocorticoid-induced protein kinase

1999 • 396 citations

Properties of volume-regulated anion channels in mammalian cells

1997 • 357 citations

The Serum and Glucocorticoid Kinase sgk Increases the Abundance of Epithelial Sodium Channels in the Plasma Membrane of Xenopus Oocytes

1999 • 274 citations

Regulation and Physiological Roles of Serum- and Glucocorticoid-Induced Protein Kinase Isoforms

2001 • 270 citations

Stimulus-Dependent Regulation of Serum and Glucocorticoid Inducible Protein Kinase (SGK) Transcription, Subcellular Localization and Enzymatic Activity

2003 • 254 citations

Carboxyl-Terminal Modulator Protein (CTMP), a Negative Regulator of PKB/Akt and v-Akt at the Plasma Membrane

2001 • 254 citations

SGK integrates insulin and mineralocorticoid regulation of epithelial sodium transport

2001 • 214 citations

Regulation ofsgkby aldosterone and its effects on the epithelial Na⁺channel

2000 • 188 citations

Glucocorticoid Activation of Na+/H+Exchanger Isoform 3 Revisited

2002 • 180 citations

A Serine Residue in ClC-3 Links Phosphorylation–Dephosphorylation to Chloride Channel Regulation by Cell Volume

1999 • 159 citations

Hyperosmotic Stress Stimulates Promoter Activity and Regulates Cellular Utilization of the Serum- and Glucocorticoid-inducible Protein Kinase (Sgk) by a p38 MAPK-dependent Pathway

2000 • 156 citations

Activation of Serum- and Glucocorticoid-induced Protein Kinase (Sgk) by Cyclic AMP and Insulin

2001 • 140 citations

Akt-Dependent Potentiation of L Channels by Insulin-Like Growth Factor-1 Is Required for Neuronal Survival

1999 • 140 citations

IGF-1 up-regulates K+ channels via PI3-kinase, PDK1 and SGK1

2001 • 133 citations

BMK1 Mediates Growth Factor-induced Cell Proliferation through Direct Cellular Activation of Serum and Glucocorticoid-inducible Kinase

2001 • 131 citations

Cell Cycle and Hormonal Control of Nuclear-Cytoplasmic Localization of the Serum- and Glucocorticoid-inducible Protein Kinase, Sgk, in Mammary Tumor Cells

1999 • 129 citations

Functional and molecular expression of volume‐regulated chloride channels in canine vascular smooth muscle cells

1998 • 124 citations

The role of ClC‐3 in volume‐activated chloride currents and volume regulation in bovine epithelial cells demonstrated by antisense inhibition

2000 • 117 citations

Phosphatidylinositol 3-Kinase Contributes to Cell Volume Regulation through Effects on ATP Release

1998 • 114 citations

Regulation of the glutamate transporter EAAT1 by the ubiquitin ligase Nedd4‐2 and the serum and glucocorticoid‐inducible kinase isoforms SGK1/3 and protein kinase B

2003 • 111 citations

ClC-3 Is a Fundamental Molecular Component of Volume-sensitive Outwardly Rectifying Cl− Channels and Volume Regulation in HeLa Cells and Xenopus laevis Oocytes

2002 • 103 citations

Serum- and Glucocorticoid-inducible Kinase SGK Phosphorylates and Negatively Regulates B-Raf

2001 • 102 citations

Ubiquitin Modification of Serum and Glucocorticoid-induced Protein Kinase-1 (SGK-1)

2002 • 94 citations

Influence of Calcium on Regulatory Volume Decrease: Role of Potassium Channels

2000 • 92 citations

Profilin and Gelsolin Stimulate Phosphatidylinositol 3-Kinase Activity

1996 • 80 citations

Rho family GTP binding proteins are involved in the regulatory volume decrease process in NIH3T3 mouse fibroblasts

2002 • 79 citations

Functional effects of novel anti-ClC-3 antibodies on native volume-sensitive osmolyte and anion channels in cardiac and smooth muscle cells

2003 • 78 citations

Functional inhibition of native volume‐sensitive outwardly rectifying anion channels in muscle cells and Xenopus oocytes by anti‐ClC‐3 antibody

2001 • 78 citations

Properties and regulation of glutamine transporter SN1 by protein kinases SGK and PKB

2003 • 77 citations

RhoA exerts a permissive effect on volume-regulated anion channels in vascular endothelial cells

2002 • 70 citations

Molecular requirements for the regulation of the renal outer medullary K+ channel ROMK1 by the serum- and glucocorticoid-inducible kinase SGK1

2003 • 64 citations

Fundamental role of ClC-3 in volume-sensitive Cl^- channel function and cell volume regulation in AGS cells

2003 • 59 citations

Normal function of HERG K⁺ channels expressed in HEK293 cells requires basal protein kinase B activity

2002 • 58 citations

ClC chloride channels.

2001 • 55 citations

Negative charge at the consensus sequence for the serum- and glucocorticoid-inducible kinase, SGK1, determines pH sensitivity of the renal outer medullary K+ channel, ROMK1

2003 • 38 citations

Regulation of volume-sensitive outwardly rectifying anion channels in pulmonary arterial smooth muscle cells by PKC

2002 • 32 citations

From stones to bones: The biology of ClC chloride channels

2001 • 29 citations

AT₁ receptor inhibition does not reduce arterial wall hypertrophy or PDGF-A expression in renal hypertension

2000 • 29 citations

Inhibition of Mitogen-Activated Kinase Kinase Kinase 3 Activity through Phosphorylation by the Serum- and Glucocorticoid-Induced Kinase 1

2003 • 25 citations

Serum- and glucocorticoid-dependent kinase, cell volume, and the regulation of epithelial transport

2001 • 23 citations