Mitogenic stimulation of T cells reveals differing contributions for B7‐1 (CD80) and B7‐2 (CD86) costimulation

A Cell Culture Model for T Lymphocyte Clonal Anergy

1990 • 1,894 citations

B7-1 and B7-2 costimulatory molecules activate differentially the Th1/Th2 developmental pathways: Application to autoimmune disease therapy

1995 • 1,695 citations

CD28-mediated signalling co-stimulates murine T cells and prevents induction of anergy in T-cell clones

1992 • 1,573 citations

The B7 and CD28 receptor families

1994 • 1,342 citations

Differential T Cell Costimulatory Requirements in CD28-Deficient Mice

1993 • 1,271 citations

Long-Term Survival of Xenogeneic Pancreatic Islet Grafts Induced by CTLA4lg

1992 • 1,156 citations

Immunosuppression in Vivo by a Soluble Form of the CTLA-4 T Cell Activation Molecule

1992 • 820 citations

Role of the CD28 receptor in T-cell activation

1990 • 684 citations

Comparative analysis of B7-1 and B7-2 costimulatory ligands: expression and function.

1994 • 681 citations

CD28 activation pathway regulates the production of multiple T-cell-derived lymphokines/cytokines.

1989 • 662 citations

Differential effects of anti-B7-1 and anti-B7-2 monoclonal antibody treatment on the development of diabetes in the nonobese diabetic mouse.

1995 • 595 citations

Human T-cell clonal anergy is induced by antigen presentation in the absence of B7 costimulation.

1993 • 569 citations

T-Cell Proliferation Involving the CD28 Pathway Is Associated witH Cyclosporine-Resistant Interleukin 2 Gene Expression

1987 • 522 citations

Identification of an Alternative CTLA-4 Ligand Costimulatory for T Cell Activation

1993 • 517 citations

Absence of B7-dependent responses in CD28-deficient mice

1994 • 386 citations

Regulation of immunostimulatory function and costimulatory molecule (B7-1 and B7-2) expression on murine dendritic cells.

1994 • 379 citations

Uncovering of Functional Alternative CTLA-4 Counter-Receptor in B7-Deficient Mice

1993 • 369 citations

Murine B7-2, an alternative CTLA4 counter-receptor that costimulates T cell proliferation and interleukin 2 production.

1993 • 357 citations

B70/B7-2 is identical to CD86 and is the major functional ligand for CD28 expressed on human dendritic cells.

1994 • 347 citations

Reversal of in vitro T cell clonal anergy by IL-2 stimulation

1992 • 339 citations

The structure of the saccharide-binding site of concanavalin A.

1989 • 288 citations

The two-signal model of lymphocyte activation twenty-one years later

1992 • 233 citations

Lectin Receptors as Lymphocyte Surface Markers

1983 • 219 citations

The role of antigen-presenting B cells in T cell priming in vivo. Studies of B cell-deficient mice.

1988 • 199 citations

Distinct roles for B7-1 (CD-80) and B7-2 (CD-86) in the initiation of experimental allergic encephalomyelitis.

1995 • 194 citations

Ligand-receptor interactions required for commitment to the activation of the interleukin 2 gene.

1987 • 182 citations

IL-4 treatment of small splenic B cells induces costimulatory molecules B7-1 and B7-2.

1994 • 126 citations

Requirement for an Ia-Bearing Accessory Cell in Con A-Induced T Cell Proliferation

1978 • 103 citations

Phaseolus vulgaris phytohaemagglutinin (PHA) binds to the human T lymphocyte antigen receptor.

1984 • 84 citations

Reciprocal expression of co‐stimulatory molecules, B7‐1 and B7‐2, on murine T cells following activation

1995 • 78 citations

The genomic organization of the CD28 gene. Implications for the regulation of CD28 mRNA expression and heterogeneity.

1990 • 74 citations

Requirement of CD80 and CD86 Molecules for Antigen Presentation by Eosinophils

1996 • 67 citations

Are B lymphocytes the principal antigen-presenting cells in vivo?

1988 • 67 citations

Requirement for mitogen, T cell-accessory cell contact, and interleukin 1 in the induction of resting T-cell proliferation

1987 • 48 citations

Lectins in the isolation of receptors on lymphocytes

1987 • 4 citations