Tumor necrosis factor blockade in actively induced experimental autoimmune encephalomyelitis prevents clinical disease despite activated T cell infiltration to the central nervous system

An endotoxin-induced serum factor that causes necrosis of tumors.

1975 • 4,522 citations

Tumor Necrosis Factor (TNF)

1985 • 1,932 citations

Direct expression cloning of vascular cell adhesion molecule 1, a cytokine-induced endothelial protein that binds to lymphocytes

1989 • 1,715 citations

Prevention of experimental autoimmune encephalomyelitis by antibodies against α4βl integrin

1992 • 1,711 citations

Randomised double-blind comparison of chimeric monoclonal antibody to tumour necrosis factor α (cA2) versus placebo in rheumatoid arthritis

1994 • 1,695 citations

The transmembrane form of tumor necrosis factor is the prime activating ligand of the 80 kDa tumor necrosis factor receptor

1995 • 1,311 citations

A highly sensitive cell line, WEHI 164 clone 13, for measuring cytotoxic factor/tumor necrosis factor from human monocytes

1986 • 1,282 citations

A novel form of TNF/cachectin is a cell surface cytotoxic transmembrane protein: Ramifications for the complex physiology of TNF

1988 • 1,105 citations

Treatment of Crohn's disease with anti-tumor necrosis factor chimeric monoclonal antibody (cA2)

1995 • 1,103 citations

Treatment of rheumatoid arthritis with chimeric monoclonal antibodies to tumor necrosis factor α

1993 • 1,031 citations

Anti-tumor necrosis factor ameliorates joint disease in murine collagen-induced arthritis.

1992 • 1,002 citations

Human tumor necrosis factor. Production, purification, and characterization.

1985 • 922 citations

Surface expression of alpha 4 integrin by CD4 T cells is required for their entry into brain parenchyma.

1993 • 837 citations

Chimeric anti-TNF-α monoclonal antibody cA2 binds recombinant transmembrane TNF-α and activates immune effector functions

1995 • 693 citations

An antibody to lymphotoxin and tumor necrosis factor prevents transfer of experimental allergic encephalomyelitis.

1990 • 692 citations

Isolation and direct characterization of resident microglial cells from the normal and inflamed central nervous system.

1991 • 675 citations

Normal adult ramified microglia separated from other central nervous system macrophages by flow cytometric sorting. Phenotypic differences defined and direct ex vivo antigen presentation to myelin basic protein-reactive CD4+ T cells compared.

1995 • 622 citations

Microglia in degenerative neurological disease

1993 • 594 citations

Antigens of activated rat T lymphocytes including a molecule of 50,000 Mr detected only on CD4 positive T blasts

1987 • 453 citations

Anti—tumor necrosis factor therapy abrogates autoimmune demyelination

1991 • 434 citations

Unraveling Function in the TNF Ligand and Receptor Families

1994 • 431 citations

The active form of tumor necrosis factor is a trimer.

1987 • 430 citations

Characterization of the MRC OX40 antigen of activated CD4 positive T lymphocytes--a molecule related to nerve growth factor receptor.

1990 • 375 citations

Macromolecular permeability across the blood-nerve and blood-brain barriers.

1994 • 343 citations

Tumor Necrosis Factor Alpha, Interleukin 1 and Related Cytokines in Brain Development: Normal and Pathological

1992 • 320 citations

Effect of tumor necrosis factor alpha on insulin-dependent diabetes mellitus in NOD mice. I. The early development of autoimmunity and the diabetogenic process.

1994 • 300 citations

Control of established experimental allergic encephalomyelitis by inhibition of tumor necrosis factor (TNF) activity within the central nervous system using monoclonal antibodies and TNF receptor‐immunoglobulin fusion proteins

1994 • 232 citations

Through thick and thin: Wasting, obesity, and TNFα

1993 • 223 citations

Crucial role of 55-kilodalton TNF receptor in TNF-induced adhesion molecule expression and leukocyte organ infiltration.

1996 • 188 citations

Experimental allergic encephalomyelitis in the absence of a classical delayed-type hypersensitivity reaction. Severe paralytic disease correlates with the presence of interleukin 2 receptor-positive cells infiltrating the central nervous system.

1987 • 182 citations

Prevention of chronic relapsing experimental autoimmune encephalomyelitis by soluble tumor necrosis factor receptor I

1995 • 177 citations

TNF-alpha- and IFN-gamma-mediated signal transduction pathways: effects on glial cell gene expression and function.

1995 • 172 citations

Studies on the mechanisms by which transforming growth factor-beta (TGF-beta) protects against allergic encephalomyelitis. Antagonism between TGF-beta and tumor necrosis factor.

1993 • 170 citations

The 26-kD transmembrane form of tumor necrosis factor alpha on activated CD4+ T cell clones provides a costimulatory signal for human B cell activation.

1993 • 168 citations

Inhibition of tumor necrosis factor activity minimizes target organ damage in experimental autoimmune uveoretinitis despite quantitatively normal activated T cell traffic to the retina

1996 • 145 citations

Experimental Allergic Encephalomyelitis in the Lewis Rat: Studies on the Mechanism of Recovery from Disease and Acquired Resistance to Reinduction

1979 • 134 citations

A novel addition to the T cell repertory. Cell surface expression of tumor necrosis factor/cachectin by activated normal human T cells.

1990 • 133 citations

TNF-α receptor fusion protein prevents experimental auto-immune encephalomyelitis and demyelination in Lewis rats: an overview

1997 • 132 citations

Vascular cell adhesion molecule-1 modulation by tumor necrosis factor in experimental allergic encephalomyelitis

1994 • 131 citations

Resident macrophages (ramified microglia) of the adult brown Norway rat central nervous system are constitutively major histocompatibility complex class II positive.

1993 • 100 citations

Target organ-specific up-regulation of the MRC OX-40 marker and selective production of Th1 lymphokine mRNA by encephalitogenic T helper cells isolated from the spinal cord of rats with experimental autoimmune encephalomyelitis.

1994 • 95 citations

In vivo treatment with monoclonal antibody 3.2.3 selectively eliminates natural killer cells in rats.

1990 • 89 citations

Isolation of encephalitogenic CD4+ T cell clones in the rat

1989 • 78 citations

Unimpaired autoreactive T-cell traffic within the central nervous system during tumor necrosis factor receptor-mediated inhibition of experimental autoimmune encephalomyelitis.

1995 • 66 citations

Inhibition of tumor necrosis factor is protective against neurologic dysfunction after active immunization of lewis rats with myelin basic protein

1995 • 62 citations

Functional comparisons of different tumour necrosis factor receptor/IgG fusion proteins

1995 • 59 citations

Synthesis and cell surface display of class II determinants by long‐term propagated rat T line cells

1987 • 27 citations